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R. Amaravadi · SciRah

Researcher profile · Semantic Scholar

R. Amaravadi

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R. Amaravadi — researcher profile on SciRah

h-index: 75
Works: 240
Citations: 32K

Most-cited papers

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Alexander C. Huang, M. Postow, R. Orlowski, R. Mick +30 more
2017Nature1,544 citations Open access
Semantic Scholar
Targeting autophagy in cancer
A. Onorati, M. Dyczynski, R. Ojha, R. Amaravadi
2018Cancer1,437 citations Open access
Semantic Scholar
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
O. Khan, Josephine R. Giles, Sierra J. McDonald, Sasikanth Manne +21 more
2019Nature1,436 citations Open access
Semantic Scholar
Autophagy in major human diseases
D. Klionsky, G. Petroni, R. Amaravadi, E. Baehrecke +55 more
2021EMBO Journal1,411 citations Open access
Semantic Scholar
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Jean-Christophe Beltra, Sasikanth Manne, Mohamed S. Abdel-Hakeem, M. Kurachi +16 more
2020Immunity979 citations Open access
Semantic Scholar
Targeting Autophagy in Cancer: Recent Advances and Future Directions
R. Amaravadi, A. Kimmelman, Jayanta Debnath
2019Cancer Discovery758 citations Open access
Semantic Scholar
A Single Dose of Neoadjuvant PD-1 Blockade Predicts Clinical Outcomes in Resectable Melanoma
Alexander C. Huang, R. Orlowski, Xiao-Wei Xu, R. Mick +33 more
2019Nature Medicine628 citations Open access
Semantic Scholar
Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy
Ying Zhang, R. Kurupati, Ling Liu, Xiangyang Zhou +16 more
2017Cancer Cell585 citations Open access
Semantic Scholar
SIRT1 is downregulated by autophagy in senescence and aging
Caiyue Xu, Lu Wang, Parinaz Fozouni, G. Evjen +14 more
2020Nature Cell Biology427 citations Open access
Semantic Scholar
Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations
C. Kugel, Stephen M. Douglass, Marie R. Webster, Amanpreet Kaur +39 more
2018Clinical Cancer Research338 citations Open access
Semantic Scholar
Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial.
T. Karasic, M. O'Hara, A. Loaiza-Bonilla, K. Reiss +10 more
2019JAMA Oncology278 citations Open access
Semantic Scholar
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials
C. Axfors, A. Schmitt, P. Janiaud, Janneke van'T Hooft +90 more
2021Nature Communications276 citations Open access
Semantic Scholar
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
S. Vijayaraghavan, Cansu Karakas, I. Doostan, Xian Chen +13 more
2017Nature Communications263 citations Open access
Semantic Scholar
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy
M. Noman, S. Parpal, K. van Moer, Malina Xiao +9 more
2020Science Advances220 citations Open access
Semantic Scholar
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression
Feven Tameire, I. Verginadis, N. Leli, Christine Polte +15 more
2019Nature Cell Biology219 citations Open access
Semantic Scholar
PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.
Vito W. Rebecca, Michael C. Nicastri, C. Fennelly, Cynthia I Chude +20 more
2018Cancer Discovery211 citations Open access
Semantic Scholar
Regulation of autophagy by canonical and non-canonical ER stress responses
M. Bhardwaj, Nektaria Maria Leli, C. Koumenis, R. Amaravadi
2019Seminars in Cancer Biology194 citations Open access
Semantic Scholar
PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas
Hezhe Lu, Shu-Jing Liu, Gao Zhang, Bin Wu +37 more
2017Nature162 citations Open access
Semantic Scholar
Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer
T. Kwak, Fang Wang, Hui Deng, T. Condamine +18 more
2020Cell Reports157 citations Open access
Semantic Scholar
Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma
N. Haas, L. Appleman, M. Stein, M. Redlinger +11 more
2019Clinical Cancer Research132 citations Open access
Semantic Scholar
ICAM-1-mediated Adhesion is a Prerequisite for Exosome-induced T Cell Suppression
Wei Zhang, Wen-Qun Zhong, Bei-Ke Wang, Jie-Gang Yang +16 more
2022Developmental Cell130 citations Open access
Semantic Scholar
Association of antibiotic exposure with survival and toxicity in patients with melanoma receiving immunotherapy.
J. Mohiuddin, B. Chu, A. Facciabene, K. Poirier +15 more
2020Journal of the National Cancer Institute128 citations Open access
Semantic Scholar
Recent advances in targeting autophagy in cancer
Vaibhav Jain, M. Singh, R. Amaravadi
2023TIPS - Trends in Pharmacological Sciences120 citations
Semantic Scholar
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
Josephine R. Giles, Sasikanth Manne, Elizabeth Freilich, D. Oldridge +18 more
2022Immunity105 citations Open access
Semantic Scholar
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
Laura M. McLane, S. Ngiow, Ze-Yu Chen, John Attanasio +14 more
2021Cell Reports102 citations Open access
Semantic Scholar
Lysosomal Biology in Cancer
C. Fennelly, R. Amaravadi
2017Methods in molecular biology90 citations Open access
Semantic Scholar
Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma
Ileabett M. Echevarría-Vargas, P. Reyes-Uribe, Adam N. Guterres, Xiang-Fan Yin +25 more
2018EMBO Molecular Medicine85 citations Open access
Semantic Scholar
Patient-derived melanoma organoid models facilitate the assessment of immunotherapies
Lingling Ou, Shu-Jing Liu, Huai-Shang Wang, Ye-Ye Guo +19 more
2023EBioMedicine83 citations Open access
Semantic Scholar
HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors
Lei Guan, Bin Wu, Ting Li, Lynn A. Beer +24 more
2022Nature Communications78 citations Open access
Semantic Scholar
PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma
Gaurav Sharma, R. Ojha, Estela Noguera-Ortega, Vito W. Rebecca +16 more
2020JCI Insight78 citations Open access
Semantic Scholar
Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
P. Shah, Alexander C. Huang, Xiao-Wei Xu, R. Orlowski +21 more
2023Cancer Research Communications77 citations Open access
Semantic Scholar
ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma
R. Ojha, N. Leli, A. Onorati, S. Piao +24 more
2018Cancer Discovery74 citations Open access
Semantic Scholar
Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts and PDX models
Janice M. Santiago-O'Farrill, S. J. Weroha, X. Hou, A. Oberg +14 more
2019Cancer73 citations Open access
Semantic Scholar
Genetic and genomic characterization of 462 melanoma patient-derived xenografts, tumor biopsies and cell lines
Bradley Garman, Ioannis Anastopoulos, C. Krepler, Patricia A. Brafford +30 more
2017Cell Reports69 citations Open access
Semantic Scholar
Anti-CTLA4 activates intratumoral NK cells and combination with IL15/IL15Rα complexes enhances tumor control
E. Sanseviero, E. M. O’Brien, Jenna R. Karras, T. Shabaneh +15 more
2019Cancer immunology research66 citations Open access
Semantic Scholar
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy
E. Tcyganov, E. Sanseviero, D. Marvel, T. Beer +27 more
2022Cancer Cell58 citations Open access
Semantic Scholar
BAMM (BRAF Autophagy and MEK inhibition in Melanoma): A phase I/II trial of dabrafenib, trametinib and hydroxychloroquine in advanced BRAFV600-mutant melanoma
J. Mehnert, T. Mitchell, Alexander C. Huang, T. Aleman +18 more
2022Clinical Cancer Research58 citations Open access
Semantic Scholar
Paradoxical role for wild type p53 in driving therapy resistance in melanoma
Marie R. Webster, Mitchell E. Fane, Gretchen M. Alicea, Subhasree Basu +28 more
2019Molecules and Cells51 citations Open access
Semantic Scholar
Lysosomal lipid peroxidation regulates tumor immunity
M. Bhardwaj, J. J. Lee, Amanda M. Versace, S. Harper +12 more
2023Journal of Clinical Investigation49 citations Open access
Semantic Scholar
Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma1
Terence P. F. Gade, E. Tucker, Michael S. Nakazawa, S. Hunt +10 more
2017Radiology45 citations Open access
Semantic Scholar
Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities
Z. Eroglu, S. Holmen, Qing Chen, N. Khushalani +23 more
2019Pigment Cell & Melanoma Research39 citations Open access
Semantic Scholar
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma
Gao Zhang, Lawrence Wu, I. Mender, Michal Barzily-Rokni +40 more
2018Clinical Cancer Research37 citations Open access
Semantic Scholar
A multicenter phase I study evaluating dual PI3K and BRAF inhibition with PX-866 and vemurafenib in patients with advanced BRAF V600 mutant solid tumors
C. Yam, Xiao-Wei Xu, M. Davies, P. Gimotty +17 more
2017Clinical Cancer Research35 citations Open access
Semantic Scholar
Long-term outcomes to neoadjuvant pembrolizumab based on pathological response for patients with resectable stage III/IV cutaneous melanoma
C. Sharon, G. Tortorello, K. Ma, A. Huang +11 more
2023Annals of Oncology34 citations Open access
Semantic Scholar
Targeting UGCG overcomes resistance to lysosomal autophagy inhibition
Vaibhav Jain, S. Harper, Amanda M. Versace, Dylan Fingerman +12 more
2022Cancer Discovery33 citations Open access
Semantic Scholar
ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma
A. Ndoye, A. Budina-Kolomets, C. Kugel, Marie R. Webster +18 more
2017Cancer Research33 citations Open access
Semantic Scholar
Phase I Trial of Regorafenib, Hydroxychloroquine, and Entinostat in Metastatic Colorectal Cancer
T. J. Brown, T. Karasic, C. Schneider, U. Teitelbaum +8 more
2021The Oncologist32 citations Open access
Semantic Scholar
FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA
Akosua A. Nti, Leona W. Serrano, H. Sandhu, K. Uyhazi +12 more
2019Retina31 citations Open access
Semantic Scholar
Preclinical platforms to study therapeutic efficacy of human γδ T cells
Lingling Ou, Huai-Shang Wang, Hui Huang, Zhiyan Zhou +11 more
2022Clinical and Translational Medicine30 citations Open access
Semantic Scholar
Dichotomous and stable gamma delta T-cell number and function in healthy individuals
Lingling Ou, Huai-Shang Wang, Qin Liu, Jie Zhang +17 more
2021Journal for ImmunoTherapy of Cancer28 citations Open access
Semantic Scholar

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