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C. Yam · SciRah

Researcher profile · Semantic Scholar

C. Yam

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C. Yam — researcher profile on SciRah

h-index: 25
Works: 159
Citations: 1,661

Most-cited papers

Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer.
S. Tolaney, E. de Azambuja, K. Kalinsky, S. Loi +16 more
2026New England Journal of Medicine69 citations
Semantic Scholar
MRI-based digital models forecast patient-specific treatment responses to neoadjuvant chemotherapy in triple-negative breast cancer
Cheng-Yue Wu, Angela M. Jarrett, Zi-Jian Zhou, N. Elshafeey +14 more
2022Cancer Research67 citations Open access
Semantic Scholar
Sacituzumab govitecan (SG) + pembrolizumab (pembro) vs chemotherapy (chemo) + pembro in previously untreated PD-L1–positive advanced triple-negative breast cancer (TNBC): Primary results from the randomized phase 3 ASCENT-04/KEYNOTE-D19 study.
S. Tolaney, E. de Azambuja, K. Kalinsky, S. Loi +16 more
2025Journal of Clinical Oncology64 citations Open access
Semantic Scholar
Prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer using deep learning on multiparametric MRI
Zi-Jian Zhou, B. Adrada, R. Candelaria, N. Elshafeey +23 more
2023Scientific Reports46 citations Open access
Semantic Scholar
Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors
Yu-Yi Chu, C. Yam, H. Yamaguchi, M. Hung
2022Journal of Biomedical Sciences41 citations Open access
Semantic Scholar
MRI-based digital twins to improve treatment response of breast cancer by optimizing neoadjuvant chemotherapy regimens
Cheng-Yue Wu, E. Lima, Casey E. Stowers, Zhan Xu +5 more
2025npj Digital Medicine40 citations Open access
Semantic Scholar
Monitoring response to neoadjuvant chemotherapy in triple negative breast cancer using circulating tumor DNA
Jennifer H. Chen, Sridevi Addanki, Dhruvajyoti Roy, Roland L. Bassett +17 more
2024BMC Cancer35 citations Open access
Semantic Scholar
A model combining pretreatment MRI radiomic features and tumor-infiltrating lymphocytes to predict response to neoadjuvant systemic therapy in triple-negative breast cancer.
J. E. Jimenez, Abeer H. Abdelhafez, E. Mittendorf, N. Elshafeey +15 more
2022European Journal of Radiology33 citations
Semantic Scholar
A Radiomics Model Based on Synthetic MRI Acquisition for Predicting Neoadjuvant Systemic Treatment Response in Triple-Negative Breast Cancer.
K. Hwang, N. Elshafeey, A. Kotrotsou, Hui-Qin Chen +22 more
2023Radiology: Imaging Cancer29 citations Open access
Semantic Scholar
Phase 2 study of neoadjuvant enzalutamide and paclitaxel for luminal androgen receptor-enriched TNBC: Trial results and insights into “ARness”
B. Lim, S. Seth, C. Yam, Lei Huo +27 more
2024Cell Reports Medicine26 citations Open access
Semantic Scholar
Real-world use patterns, effectiveness, and tolerability of sacituzumab govitecan for second-line and later-line treatment of metastatic triple-negative breast cancer in the United States
K. Kalinsky, L. Spring, C. Yam, M. Bhave +7 more
2024Breast Cancer Research and Treatment24 citations Open access
Semantic Scholar
Multiparametric MRI–based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer
Rania M. M. Mohamed, B. Panthi, B. Adrada, M. Boge +25 more
2024Scientific Reports21 citations Open access
Semantic Scholar
Assessment of Response to Neoadjuvant Systemic Treatment in Triple-Negative Breast Cancer Using Functional Tumor Volumes from Longitudinal Dynamic Contrast-Enhanced MRI
B. Panthi, B. Adrada, R. Candelaria, M. Guirguis +27 more
2023Cancers20 citations Open access
Semantic Scholar
TRPS1 and GATA3 Expression in Invasive Breast Carcinoma With Apocrine Differentiation.
Jing Wang, Yan Peng, Hong-Xia Sun, P. Aung +5 more
2023Archives of Pathology & Laboratory Medicine18 citations Open access
Semantic Scholar
NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression
T. Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas +23 more
2024Nature Communications17 citations
Semantic Scholar
Predictive Roles of Baseline Stromal Tumor-Infiltrating Lymphocytes and Ki-67 in Pathologic Complete Response in an Early-Stage Triple-Negative Breast Cancer Prospective Trial
N. Abuhadra, R. Sun, C. Yam, G. Rauch +26 more
2023Cancers17 citations Open access
Semantic Scholar
Deep Learning for Fully Automatic Tumor Segmentation on Serially Acquired Dynamic Contrast-Enhanced MRI Images of Triple-Negative Breast Cancer
Zhan Xu, David E Rauch, Rania M. M. Mohamed, Sanaz Pashapoor +27 more
2023Cancers16 citations Open access
Semantic Scholar
Molecular characterization and prospective evaluation of pathological response and outcomes with neoadjuvant therapy in metaplastic triple-negative breast cancer
C. Yam, N. Abuhadra, R. Sun, B. Adrada +23 more
2022Clinical Cancer Research15 citations Open access
Semantic Scholar
A phase II study of neoadjuvant atezolizumab and nab-paclitaxel in patients with anthracycline-resistant early-stage triple-negative breast cancer
C. Yam, E. Mittendorf, H. Garber, R. Sun +21 more
2023Breast Cancer Research and Treatment14 citations
Semantic Scholar
Quantitative Apparent Diffusion Coefficients from Peritumoral Regions as Early Predictors of Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer
Benjamin C. Musall, B. Adrada, R. Candelaria, Rania M. M. Mohamed +24 more
2022Journal of Magnetic Resonance Imaging14 citations Open access
Semantic Scholar
Deep Learning Models Based on Pretreatment MRI and Clinicopathological Data to Predict Responses to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer
Zhan Xu, Zi-Jian Zhou, J. Son, Hao-Nan Feng +24 more
2025Cancers13 citations Open access
Semantic Scholar
Combining Biology-based and MRI Data-driven Modeling to Predict Response to Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.
Casey E. Stowers, Cheng-Yue Wu, Zhan Xu, Sidharth Kumar +6 more
2024Radiology: Artificial Intelligence11 citations Open access
Semantic Scholar
Longitudinal dynamic contrast-enhanced MRI radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer
B. Panthi, Rania M. M. Mohamed, B. Adrada, M. Boge +25 more
2023Frontiers in Oncology10 citations Open access
Semantic Scholar
Axillary Nodal Metastases Conversion and Perioperative Complications with Neoadjuvant Pembrolizumab Therapy in Triple-Negative Breast Cancer
Ashley A. Woodfin, C. Yam, M. Teshome, H. Kuerer +5 more
2023Annals of Surgical Oncology10 citations
Semantic Scholar
Personalizing neoadjuvant chemotherapy regimens for triple-negative breast cancer using a biology-based digital twin
Chase Christenson, Cheng-Yue Wu, D. Hormuth, Jingfei Ma +3 more
2025npj Systems Biology and Applications9 citations Open access
Semantic Scholar
Genomic and transcriptomic analyses identify distinctive features of triple-negative inflammatory breast cancer
Xiaoping Wang, Li Zhao, Xing-Zhi Song, Xiao-Gang Wu +19 more
2024npj Precision Oncology9 citations Open access
Semantic Scholar
Targeting the Epidermal Growth Factor Receptor Pathway in Chemotherapy-Resistant Triple-Negative Breast Cancer: A Phase II Study
C. Yam, M. Patel, Holly Hill, Ryan Sun +35 more
2024Cancer Research Communications8 citations Open access
Semantic Scholar
Comprehensive Analysis Identifies Variability in PI3K Pathway Alterations in Triple-Negative Breast Cancer Subtypes
R. Basho, Li Zhao, J. White, Lei Huo +17 more
2024JCO Precision Oncology8 citations
Semantic Scholar
Ecotypes of triple-negative breast cancer in response to chemotherapy
Yun Yan, Yi-Yun Lin, T. Kumar, S. Bai +19 more
2026Nature7 citations Open access
Semantic Scholar
Maintenance pembrolizumab therapy in patients with metastatic HER2-negative breast cancer with prior response to chemotherapy
T. Iwase, Evan N Cohen, Hui Gao, Angela Alexander +17 more
2024Clinical Cancer Research7 citations
Semantic Scholar
Diffusion Tensor Imaging for Characterizing Changes in Triple-Negative Breast Cancer During Neoadjuvant Systemic Therapy
Benjamin C. Musall, David E Rauch, Rania M. M. Mohamed, B. Panthi +25 more
2024Journal of Magnetic Resonance Imaging6 citations Open access
Semantic Scholar
PTEN in triple-negative breast carcinoma: protein expression and genomic alteration in pretreatment and posttreatment specimens
Hui Chen, Qing-Qing Ding, Laila Khazai, Li Zhao +30 more
2023Therapeutic Advances in Medical Oncology6 citations Open access
Semantic Scholar
Early tumor volume reduction by breast DCE MRI predicts pathologic complete response to neoadjuvant therapy in triple negative breast cancer
M. Guirguis, B. Adrada, C. Yam, D. Tripathy +26 more
2025npj Breast Cancer5 citations Open access
Semantic Scholar
An Annotated Biobank of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-Naïve and Longitudinal Samples During Neoadjuvant Chemotherapy
Amanda L. Rinkenbaugh, Yuan Qi, Shirong Cai, Jiansu Shao +20 more
2025Cancer Research4 citations
Semantic Scholar
Imaging and Tumor Biomarkers based Multivariable Model for Early Prediction of Pathologic Complete Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer
B. Adrada, M. Guirguis, Lei Huo, C. Yam +24 more
2025JCO Precision Oncology4 citations
Semantic Scholar
Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer
H. Garber, S. Basu, Sonali Jindal, Zhong He +8 more
2024OncoTarget4 citations Open access
Semantic Scholar
Targeting chemotherapy resistance in mesenchymal triple-negative breast cancer: A phase II trial of neoadjuvant angiogenic and mTOR inhibition with chemotherapy
N. Abuhadra, R. Sun, Roland L. Jr Bassett, L. Huo +25 more
2023Investigational new drugs4 citations
Semantic Scholar
Predicting pathological complete response to neoadjuvant systemic therapy for triple-negative breast cancers using deep learning on multiparametric MRIs
Zi-Jian Zhou, B. Adrada, R. Candelaria, N. Elshafeey +23 more
2023Annual International Conference of the IEEE Engineering in Medicine and Biology Society3 citations Open access
Semantic Scholar
Characteristics and clinical outcome of BRCA germline mutation carriers with advanced breast cancer treated with PARP (poly ADP-ribose polymerase) inhibitors: A single institution experience.
F. N. Akkoc Mustafayev, M. Munsell, A. Gutierrez-Barrera, C. Yam +2 more
2023Journal of Clinical Oncology2 citations Open access
Semantic Scholar
Abstract P3-02-04: Phase II study of Pembrolizumab Maintenance treatment in patients with HER2-negative inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC) after response to chemotherapy
T. Iwase, Angela Alexander, Vivian Chiv, M. Kai +18 more
2023Cancer Research2 citations
Semantic Scholar
The ARTEMIS trial identifies immune activation as a key predictor of neoadjuvant chemotherapy response in triple-negative breast cancer
S. Seth, C. Yam, L. Huo, B. Lim +26 more
2026Breast Cancer Research1 citations Open access
Semantic Scholar
Real-world clinical utility of comprehensive genomic and transcriptomic profiling in metastatic breast cancer (mBC).
Akshara Singareeka-Raghavendra, Artem Tarasov, J. Mouabbi, A. Evdokimova +16 more
2026Journal of Clinical Oncology1 citations
Semantic Scholar
Measuring KEYNOTE-522 response from TNBC patient biopsies ex vivo using the E-slice assay.
Kyuson Yun, Viridiana Leyva-Aranda, C. Yam, Reece Kang +9 more
2026Journal of Clinical Oncology1 citations
Semantic Scholar
Abstract CT172: A phase II trial of adjuvant PD-1 blockade with endocrine therapy in hormone receptor positive inflammatory breast cancer: Circulating biomarkers and molecular correlates of clinical outcomes
R. Upadhyay, A. Alexander, Q. Ye, Ken Chen +14 more
2026Cancer Research1 citations
Semantic Scholar
Abstract P4-08-22: Overcoming Olaparib Resistance in BRCA-Mutated Triple-Negative Breast Cancer: Synergistic Potential of DNA Repair Pathway Inhibitors
Diana Hawkins-Westergard, Anya Dimitrijevic, C. Yam, R. Layman +3 more
2025Clinical Cancer Research1 citations
Semantic Scholar
Abstract 6245: Predicting and optimizing the response of breast cancer patients to neoadjuvant therapy using a multiscale computational model
Mahesh Nandyala, Cheng-Yue Wu, Casey E. Stowers, R. Patel +5 more
2025Cancer Research1 citations
Semantic Scholar
Abstract P3-09-21: Phase IB/II Trial of Alpelisib with iNOS Inhibitor and Nab-paclitaxel in Patients with HER2 negative Metastatic or Locally Advanced Metaplastic Breast Cancer
P. Niravath, Kai Sun, Hanh Mai, C. Yam +8 more
2025Clinical Cancer Research1 citations
Semantic Scholar
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naïve and longitudinal samples throughout neoadjuvant chemotherapy
Amanda L. Rinkenbaugh, Yuan Qi, Shirong Cai, Jiansu Shao +20 more
2024bioRxiv1 citations Open access
Semantic Scholar
Abstract 1395: Genomic and transcriptomic analyses identify distinct features of triple-negative inflammatory breast cancer
Xiaoping Wang, Li Zhao, T. Semba, Xing-Zhi Song +15 more
2023Cancer Research1 citations
Semantic Scholar
Abstract P6-01-06: Multi-Parametric MRI-Based Radiomics Models from Tumor and Peritumoral Regions as Potential Predictors of Treatment Response to Neoadjuvant Systemic Therapy in Triple Negative Breast Cancer Patients
Rania M. M. Mohamed, B. Panthi, B. Adrada, R. Candelaria +35 more
2023Cancer Research1 citations
Semantic Scholar

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