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L. Schuchter · SciRah

Researcher profile · Semantic Scholar

L. Schuchter

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L. Schuchter — researcher profile on SciRah

h-index: 77
Works: 285
Citations: 31K

Most-cited papers

Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response
Gang Chen, Alexander C. Huang, Wei Zhang, Gao Zhang +35 more
2018Nature2,534 citations Open access
Semantic Scholar
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Alexander C. Huang, M. Postow, R. Orlowski, R. Mick +30 more
2017Nature1,544 citations Open access
Semantic Scholar
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
O. Khan, Josephine R. Giles, Sierra J. McDonald, Sasikanth Manne +21 more
2019Nature1,436 citations Open access
Semantic Scholar
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Jean-Christophe Beltra, Sasikanth Manne, Mohamed S. Abdel-Hakeem, M. Kurachi +16 more
2020Immunity979 citations Open access
Semantic Scholar
A Single Dose of Neoadjuvant PD-1 Blockade Predicts Clinical Outcomes in Resectable Melanoma
Alexander C. Huang, R. Orlowski, Xiao-Wei Xu, R. Mick +33 more
2019Nature Medicine628 citations Open access
Semantic Scholar
Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy
Ying Zhang, R. Kurupati, Ling Liu, Xiangyang Zhou +16 more
2017Cancer Cell585 citations Open access
Semantic Scholar
Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer
J. Tchou, Yang-Bing Zhao, B. Levine, Paul J. L. Zhang +22 more
2017Cancer immunology research360 citations Open access
Semantic Scholar
Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial
J. Weber, G. Gibney, R. Sullivan, J. Sosman +13 more
2016The Lancet Oncology304 citations Open access
Semantic Scholar
Overall Survival and Durable Responses in Patients With BRAF V600-Mutant Metastatic Melanoma Receiving Dabrafenib Combined With Trametinib.
G. Long, J. Weber, J. Infante, Kevin B. Kim +22 more
2016Journal of Clinical Oncology290 citations
Semantic Scholar
PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.
Vito W. Rebecca, Michael C. Nicastri, C. Fennelly, Cynthia I Chude +20 more
2018Cancer Discovery211 citations Open access
Semantic Scholar
Long-Term Outcomes in Patients With BRAF V600-Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib.
G. Long, Z. Eroglu, J. Infante, S. Patel +15 more
2017Journal of Clinical Oncology209 citations Open access
Semantic Scholar
Machine Learning Approaches to Predict 6-Month Mortality Among Patients With Cancer
Ravi B. Parikh, Christopher R. Manz, C. Chivers, S. H. Regli +7 more
2019JAMA Network Open208 citations Open access
Semantic Scholar
PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas
Hezhe Lu, Shu-Jing Liu, Gao Zhang, Bin Wu +37 more
2017Nature162 citations Open access
Semantic Scholar
Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer
T. Kwak, Fang Wang, Hui Deng, T. Condamine +18 more
2020Cell Reports157 citations Open access
Semantic Scholar
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
R. Somasundaram, Gao Zhang, M. Fukunaga-Kalabis, Michela Perego +49 more
2017Nature Communications137 citations Open access
Semantic Scholar
ICAM-1-mediated Adhesion is a Prerequisite for Exosome-induced T Cell Suppression
Wei Zhang, Wen-Qun Zhong, Bei-Ke Wang, Jie-Gang Yang +16 more
2022Developmental Cell130 citations Open access
Semantic Scholar
Association of antibiotic exposure with survival and toxicity in patients with melanoma receiving immunotherapy.
J. Mohiuddin, B. Chu, A. Facciabene, K. Poirier +15 more
2020Journal of the National Cancer Institute128 citations Open access
Semantic Scholar
Timing of Onset of Adverse Cutaneous Reactions Associated With Programmed Cell Death Protein 1 Inhibitor Therapy
Leo L. Wang, Gopal Patel, Zelma Chiesa-Fuxench, S. McGettigan +4 more
2018JAMA dermatology117 citations Open access
Semantic Scholar
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
Josephine R. Giles, Sasikanth Manne, Elizabeth Freilich, D. Oldridge +18 more
2022Immunity105 citations Open access
Semantic Scholar
Best Practices for Reducing Unplanned Acute Care for Patients With Cancer.
N. Handley, L. Schuchter, J. Bekelman
2018Journal of Oncology Practice103 citations Open access
Semantic Scholar
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
Laura M. McLane, S. Ngiow, Ze-Yu Chen, John Attanasio +14 more
2021Cell Reports102 citations Open access
Semantic Scholar
A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours
A. Maity, R. Mick, Alexander C. Huang, Sangeeth M. George +16 more
2018British Journal of Cancer98 citations Open access
Semantic Scholar
Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.
H. Burstein, L. Krilov, J. Aragon-Ching, N. Baxter +19 more
2017Journal of Clinical Oncology98 citations Open access
Semantic Scholar
The State of Melanoma: Challenges and Opportunities
G. Merlino, M. Herlyn, D. Fisher, B. Bastian +38 more
2016Pigment Cell & Melanoma Research98 citations Open access
Semantic Scholar
Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma
Ileabett M. Echevarría-Vargas, P. Reyes-Uribe, Adam N. Guterres, Xiang-Fan Yin +25 more
2018EMBO Molecular Medicine85 citations Open access
Semantic Scholar
Patient-derived melanoma organoid models facilitate the assessment of immunotherapies
Lingling Ou, Shu-Jing Liu, Huai-Shang Wang, Ye-Ye Guo +19 more
2023EBioMedicine83 citations Open access
Semantic Scholar
HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors
Lei Guan, Bin Wu, Ting Li, Lynn A. Beer +24 more
2022Nature Communications78 citations Open access
Semantic Scholar
Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
P. Shah, Alexander C. Huang, Xiao-Wei Xu, R. Orlowski +21 more
2023Cancer Research Communications77 citations Open access
Semantic Scholar
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
R. Herati, D. Knorr, Laura A. Vella, L. Silva +24 more
2022Nature Immunology75 citations Open access
Semantic Scholar
ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma
R. Ojha, N. Leli, A. Onorati, S. Piao +24 more
2018Cancer Discovery74 citations Open access
Semantic Scholar
Genetic and genomic characterization of 462 melanoma patient-derived xenografts, tumor biopsies and cell lines
Bradley Garman, Ioannis Anastopoulos, C. Krepler, Patricia A. Brafford +30 more
2017Cell Reports69 citations Open access
Semantic Scholar
Anti-CTLA4 activates intratumoral NK cells and combination with IL15/IL15Rα complexes enhances tumor control
E. Sanseviero, E. M. O’Brien, Jenna R. Karras, T. Shabaneh +15 more
2019Cancer immunology research66 citations Open access
Semantic Scholar
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy
E. Tcyganov, E. Sanseviero, D. Marvel, T. Beer +27 more
2022Cancer Cell58 citations Open access
Semantic Scholar
BAMM (BRAF Autophagy and MEK inhibition in Melanoma): A phase I/II trial of dabrafenib, trametinib and hydroxychloroquine in advanced BRAFV600-mutant melanoma
J. Mehnert, T. Mitchell, Alexander C. Huang, T. Aleman +18 more
2022Clinical Cancer Research58 citations Open access
Semantic Scholar
ALDH1 bio-activates nifuroxazide to eradicate ALDHHigh melanoma-initiating cells
Sana Sarvi, Richard Crispin, Yuting Lu, Li-Fan Zeng +16 more
2018Cell Chemical Biology54 citations Open access
Semantic Scholar
Paradoxical role for wild type p53 in driving therapy resistance in melanoma
Marie R. Webster, Mitchell E. Fane, Gretchen M. Alicea, Subhasree Basu +28 more
2019Molecules and Cells51 citations Open access
Semantic Scholar
A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy
S. Weiss, M. Sznol, M. Shaheen, M. Berciano-Guerrero +13 more
2023Clinical Cancer Research44 citations Open access
Semantic Scholar
Accelerating the Delivery of Cancer Care at Home During the Covid-19 Pandemic
A. Laughlin, Michael Begley, Timothy Delaney, L. Zinck +5 more
2020Nejm Catalyst Innovations in Care Delivery44 citations
Semantic Scholar
Clinician perspectives on machine learning prognostic algorithms in the routine care of patients with cancer: a qualitative study
Ravi B. Parikh, Christopher R. Manz, M. N. Nelson, Chalanda N. Evans +7 more
2022Supportive Care in Cancer40 citations Open access
Semantic Scholar
HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors
A. Budina-Kolomets, Marie R. Webster, J. Leu, Matthew Jennis +16 more
2016Cancer Research38 citations Open access
Semantic Scholar
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma
Gao Zhang, Lawrence Wu, I. Mender, Michal Barzily-Rokni +40 more
2018Clinical Cancer Research37 citations Open access
Semantic Scholar
A multicenter phase I study evaluating dual PI3K and BRAF inhibition with PX-866 and vemurafenib in patients with advanced BRAF V600 mutant solid tumors
C. Yam, Xiao-Wei Xu, M. Davies, P. Gimotty +17 more
2017Clinical Cancer Research35 citations Open access
Semantic Scholar
Long-term outcomes to neoadjuvant pembrolizumab based on pathological response for patients with resectable stage III/IV cutaneous melanoma
C. Sharon, G. Tortorello, K. Ma, A. Huang +11 more
2023Annals of Oncology34 citations Open access
Semantic Scholar
Acute Exudative Paraneoplastic Polymorphous Vitelliform Maculopathy During Vemurafenib and Pembrolizumab Treatment for Metastatic Melanoma
H. Sandhu, A. Kolomeyer, Marisa K. Lau, C. Shields +3 more
2017Retinal cases & brief reports33 citations Open access
Semantic Scholar
FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA
Akosua A. Nti, Leona W. Serrano, H. Sandhu, K. Uyhazi +12 more
2019Retina31 citations Open access
Semantic Scholar
Preclinical platforms to study therapeutic efficacy of human γδ T cells
Lingling Ou, Huai-Shang Wang, Hui Huang, Zhiyan Zhou +11 more
2022Clinical and Translational Medicine30 citations Open access
Semantic Scholar
Improving the Safety of Oral Chemotherapy at an Academic Medical Center.
N. Shah, E. Casella, D. Capozzi, S. McGettigan +3 more
2016Journal of Oncology Practice30 citations Open access
Semantic Scholar
Dichotomous and stable gamma delta T-cell number and function in healthy individuals
Lingling Ou, Huai-Shang Wang, Qin Liu, Jie Zhang +17 more
2021Journal for ImmunoTherapy of Cancer28 citations Open access
Semantic Scholar
Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma
T. Gangadhar, Samantha L. Savitch, S. Yee, Wei Xu +19 more
2017Pigment Cell & Melanoma Research28 citations Open access
Semantic Scholar
Reaffirming and Clarifying the American Society of Clinical Oncology’s Policy Statement on the Critical Role of Phase I Trials in Cancer Research and Treatment
J. Weber, Laura A. Levit, P. Adamson, S. Bruinooge +10 more
2016Journal of Clinical Oncology24 citations Open access
Semantic Scholar

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