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Patricia A. Brafford · SciRah

Researcher profile · Semantic Scholar

Patricia A. Brafford

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Patricia A. Brafford — researcher profile on SciRah

h-index: 27
Works: 57
Citations: 6,237

Most-cited papers

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
A. Roesch, M. Fukunaga-Kalabis, E. C. Schmidt, S. Zabierowski +6 more
2010Cell1,218 citations Open access
Semantic Scholar
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
Sydney M. Shaffer, Margaret C. Dunagin, Stefan R. Torborg, E. Torre +13 more
2017Nature1,168 citations Open access
Semantic Scholar
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
K. Hoek, N. Schlegel, Patricia A. Brafford, A. Sucker +8 more
2006Pigment Cell Research561 citations
Semantic Scholar
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
K. Smalley, N. Haass, Patricia A. Brafford, Mercedes I. Lioni +2 more
2006Molecular Cancer Therapeutics465 citations Open access
Semantic Scholar
Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility
Amanpreet Kaur, B. Ecker, Stephen M. Douglass, C. Kugel +26 more
2018Cancer Discovery349 citations Open access
Semantic Scholar
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.
Zhao-Jun Liu, M. Xiao, K. Balint, K. Smalley +5 more
2006Cancer Research281 citations
Semantic Scholar
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.
Gao Zhang, Dennie T. Frederick, Lawrence Wu, Zhi Wei +38 more
2016Journal of Clinical Investigation238 citations Open access
Semantic Scholar
Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion.
K. Smalley, Patricia A. Brafford, N. Haass, J. Brandner +2 more
2005American Journal of Pathology160 citations Open access
Semantic Scholar
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
R. Somasundaram, Thomas Connelly, R. Choi, Hyeree Choi +53 more
2021Nature Communications159 citations Open access
Semantic Scholar
PLX4032, a Potent Inhibitor of the B-Raf V600E Oncogene, Selectively Inhibits V600E-positive Melanomas
John T. Lee, Ling Li, Patricia A. Brafford, Marcia van den Eijnden +7 more
2010Pigment Cell & Melanoma Research155 citations Open access
Semantic Scholar
A comprehensive patient-derived xenograft collection representing the heterogeneity of melanoma
C. Krepler, Katrin Sproesser, Patricia A. Brafford, M. Beqiri +50 more
2017Cell Reports134 citations Open access
Semantic Scholar
Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies
C. Krepler, M. Xiao, Katrin Sproesser, Patricia A. Brafford +18 more
2015Clinical Cancer Research132 citations Open access
Semantic Scholar
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells.
Mercedes I. Lioni, Patricia A. Brafford, Claudia D. Andl, A. Rustgi +3 more
2007American Journal of Pathology132 citations Open access
Semantic Scholar
Mutant V600E BRAF Increases Hypoxia Inducible Factor-1α Expression in Melanoma
Suresh M. Kumar, Hong Yu, R. Edwards, Lian-Jun Chen +5 more
2007125 citations Open access
Semantic Scholar
Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes
C. Pinnix, John T. Lee, Zhao-Jun Liu, R. Mcdaid +15 more
2009Cancer Research115 citations Open access
Semantic Scholar
Defining the Conditions for the Generation of Melanocytes from Human Embryonic Stem Cells
D. Fang, K. Leishear, Thiennga K. Nguyen, R. Finko +8 more
2006Stem Cells108 citations
Semantic Scholar
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma.
Suresh M. Kumar, Hong Yu, R. Edwards, Lian-Jun Chen +5 more
2007Cancer Research85 citations
Semantic Scholar
A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.
E. George, Hyoung Kim, C. Krepler, Brandon M. Wenz +19 more
2017JCI Insight72 citations Open access
Semantic Scholar
Genetic and genomic characterization of 462 melanoma patient-derived xenografts, tumor biopsies and cell lines
Bradley Garman, Ioannis Anastopoulos, C. Krepler, Patricia A. Brafford +30 more
2017Cell Reports69 citations Open access
Semantic Scholar
Distinct histone modifications denote early stress-induced drug tolerance in cancer
A. Al Emran, D. Marzese, D. R. Menon, M. Stark +16 more
2017OncoTarget67 citations Open access
Semantic Scholar
MAPK activation predicts poor outcome and the MEK inhibitor, selumetinib, reverses antiestrogen resistance in high grade serous ovarian cancer
K. Hew, P. Miller, D. El-Ashry, Jun Sun +11 more
2015Clinical Cancer Research56 citations Open access
Semantic Scholar
Selective evolutionary pressure from the tissue microenvironment drives tumor progression.
K. Smalley, Patricia A. Brafford, M. Herlyn
2005Seminars in Cancer Biology55 citations
Semantic Scholar
Epigenetic state determines inflammatory sensing in neuroblastoma
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, Mengming Michael Dong +14 more
2021Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma
Gao Zhang, Lawrence Wu, I. Mender, Michal Barzily-Rokni +40 more
2018Clinical Cancer Research37 citations Open access
Semantic Scholar
ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma
A. Ndoye, A. Budina-Kolomets, C. Kugel, Marie R. Webster +18 more
2017Cancer Research33 citations Open access
Semantic Scholar
MCU controls melanoma progression through a redox‐controlled phenotype switch
Ioana Stejerean‐Todoran, Katharina M. Zimmermann, C. S. Gibhardt, A. Vultur +26 more
2022EMBO Reports32 citations Open access
Semantic Scholar
Targeting RRM2 and Mutant BRAF is a Novel Combinatorial Strategy for Melanoma
N. Fatkhutdinov, Katrin Sproesser, C. Krepler, Qin Liu +4 more
2016Molecular Cancer Research28 citations Open access
Semantic Scholar
Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Jianglan Liu, Vito W. Rebecca, A. Kossenkov, Thomas Connelly +44 more
2021Cancer Research22 citations Open access
Semantic Scholar
Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity
Xue Zhang, Shishir M. Pant, Cecily C. Ritch, Hsin-Yao Tang +15 more
2024Nature Communications21 citations Open access
Semantic Scholar
Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma
C. Krepler, M. Xiao, M. Samanta, A. Vultur +14 more
2016OncoTarget21 citations Open access
Semantic Scholar
PIM kinases as therapeutic targets against advanced melanoma
B. Shannan, Andrea Watters, Quan Chen, Stefan Mollin +17 more
2016OncoTarget18 citations Open access
Semantic Scholar
Unraveling the mysteries of IGF-1 signaling in melanoma.
John T. Lee, Patricia A. Brafford, M. Herlyn
2008Journal of Investigative Dermatology17 citations Open access
Semantic Scholar
Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma
Alexander Schäfer, Bénédicte Haenig, Julie Erupathil, Panja Strickner +11 more
2021Oncogene12 citations
Semantic Scholar
Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies
Sabrina Cappello, Hsu‐Min Sung, Christian Ickes, C. S. Gibhardt +20 more
2021Cancer Research11 citations Open access
Semantic Scholar
A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells
Ioana Stejerean‐Todoran, P. Gimotty, Andrea Watters, Patricia A. Brafford +20 more
2022Neuro-Oncology8 citations Open access
Semantic Scholar
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells
D. M. Iascone, Xue Zhang, Patricia A. Brafford, C. Mesaros +10 more
2024Proceedings of the National Academy of Sciences of the United States of America7 citations Open access
Semantic Scholar
Gene expression profiling of melanoma cells – searching the haystack
Patricia A. Brafford, M. Herlyn
2005Journal of Translational Medicine7 citations Open access
Semantic Scholar
1205Lu is Human Melanoma Depending on the Source
Patricia A. Brafford, Katrin Sproesser, C. Krepler, M. Herlyn
20166 citations Open access
Semantic Scholar
Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
Sydney M. Shaffer, Margaret C. Dunagin, Stefan R. Torborg, E. Torre +13 more
2018Nature4 citations Open access
Semantic Scholar
Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells
Yao-Yu Gong, Hongguang Shao, Yu Li, Patricia A. Brafford +6 more
2022Cancer Research Communications1 citations Open access
Semantic Scholar
Dermatology Research
A. Al Emran, D. Marzese, D. R. Menon, M. Stark +14 more
20181 citations Open access
Semantic Scholar
Epigenetic remodelling of H3K9Me3 leads to early stress induced drug tolerance in cancer
A. Al Emran, D. R. Menon, D. Marzese, H. Hammerlindl +11 more
20161 citations
Semantic Scholar
The effects of combined MEK inhibition and antiestrogen therapy in the treatment of ovarian cancer
K. Hew, P. Miller, D. El-Ashry, Zhi Wei +7 more
20151 citations
Semantic Scholar
Differential expression of connexins in melanoma and adjacent epidermis
N. Haass, J. Brandner, Patricia A. Brafford, E. Wladykowski +4 more
20041 citations
Semantic Scholar
393 DISP-10 is a novel CAR T and tumor-specific virus combination undergoing clinical development that is designed for use as a universal treatment for epithelial tumors
Lisa Cucolo, Surabhi Srinivasan, Tatiana M Garcia-Bates, Nicholas Grams +14 more
2025Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Abstract A01: A comprehensive collection of patient derived xenografts of human melanoma with clinical, genomic, and biological characterization
C. Krepler, Katrin Sproesser, M. Beqiri, M. Xiao +17 more
20160 citations
Semantic Scholar
Abstract B46: Use of a novel orthotopic ovarian cancer transplant patient derived xenograft model as a preclinical platform for bench to bedside research.
E. George, Hyoung Kim, C. Krepler, J. Tanyi +11 more
20160 citations
Semantic Scholar
Abstract A02: A novel orthotopic ovarian patient derived xenograft model platform to investigate novel therapies for BRCA deficient ovarian cancers
E. George, Hyoung Kim, J. Tanyi, Ryan L. Ragland +15 more
20160 citations
Semantic Scholar
MAPK activation predicts poor outcome and the MEK inhibitor , selumetinib , reverses antiestrogen resistance in high grade serous ovarian cancer
K. Hew, P. Miller, D. El-Ashry, Jun Sun +13 more
20150 citations
Semantic Scholar
Abstract 2842: Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models of melanoma identify c-Met as an effective second line combination therapy target
C. Krepler, M. Xiao, Katrin Sproesser, Patricia A. Brafford +14 more
20150 citations
Semantic Scholar

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K. Smalley — researcher profile on SciRah