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A. Stamford · SciRah

Researcher profile · Semantic Scholar

A. Stamford

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A. Stamford — researcher profile on SciRah

h-index: 32
Works: 106
Citations: 3,401

Most-cited papers

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients
M. Kennedy, A. Stamford, Xia Chen, K. Cox +20 more
2016Science Translational Medicine386 citations
Semantic Scholar
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
L. Lama, C. Adura, Wei Xie, D. Tomita +20 more
2019Nature Communications272 citations Open access
Semantic Scholar
Characterization of the Potent and Highly Selective A2A Receptor Antagonists Preladenant and SCH 412348 [7-[2-[4-2,4-Difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in Rodent Models of Movement Disorders and Depression
R. Hodgson, R. Bertorelli, Geoffrey B. Varty, J. Lachowicz +14 more
2009Journal of Pharmacology and Experimental Therapeutics152 citations
Semantic Scholar
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
J. Cumming, Elizabeth Smith, Lingyan Wang, J. Misiaszek +18 more
2012Bioorganic & Medicinal Chemistry Letters146 citations Open access
Semantic Scholar
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
Jack D. Scott, D. Demong, T. Greshock, Kallol Basu +41 more
2017Journal of Medicinal Chemistry138 citations Open access
Semantic Scholar
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Jack D. Scott, Sarah W. Li, A. Brunskill, Xia Chen +26 more
2016Journal of Medicinal Chemistry135 citations Open access
Semantic Scholar
Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
B. Neustadt, Jin-Song Hao, N. Lindo, W. Greenlee +11 more
2007Bioorganic & Medicinal Chemistry Letters119 citations Open access
Semantic Scholar
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
Zhao-Ning Zhu, Zhongxiang Sun, Yuanzan Ye, J. Voigt +17 more
2010Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders.
R. Hodgson, P. Bédard, Geoffrey B. Varty, T. Kazdoba +10 more
2010Experimental Neurology100 citations
Semantic Scholar
Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.
E. Parker, M. van Heek, A. Stamford
2002European Journal of Pharmacology99 citations
Semantic Scholar
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction
A. Stamford, Jack D. Scott, Sarah W. Li, S. Babu +23 more
2012ACS Medicinal Chemistry Letters97 citations Open access
Semantic Scholar
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Yu-Sen Wang, C. Strickland, J. Voigt, M. Kennedy +12 more
2010Journal of Medicinal Chemistry91 citations Open access
Semantic Scholar
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
H. Ahn, A. Bercovici, George Boykow, Alan Bronnenkant +32 more
1997Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
U. Iserloh, Yu-Sheng Wu, J. Cumming, J. Pan +8 more
2008Bioorganic & Medicinal Chemistry Letters75 citations Open access
Semantic Scholar
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex
Jason J. Kwon, B. Hajian, Yuemin Bian, L. C. Young +21 more
2022Nature67 citations Open access
Semantic Scholar
Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story.
A. Stamford, C. Strickland
2013Current Opinion in Chemical Biology62 citations
Semantic Scholar
Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
U. Iserloh, J. Pan, A. Stamford, M. Kennedy +7 more
2008Bioorganic & Medicinal Chemistry Letters62 citations Open access
Semantic Scholar
Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists.
H. Ahn, L. Arik, G. Boykow, D. Burnett +7 more
1999Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.
J. Cumming, T. Le, S. Babu, C. Carroll +24 more
2008Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Inhibition of 3-Phosphoglycerate Dehydrogenase (PHGDH) by Indole Amides Abrogates de novo Serine Synthesis in Cancer Cells
Edouard Mullarky, Jiayi Xu, A. Robin, D. Huggins +13 more
2019Bioorganic & Medicinal Chemistry Letters53 citations Open access
Semantic Scholar
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
Mihirbaran Mandal, Zhao-Ning Zhu, J. Cumming, Xiao-Xiang Liu +23 more
2012Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
J. Cumming, S. Babu, Ying Huang, C. Carrol +19 more
2010Bioorganic & Medicinal Chemistry Letters50 citations Open access
Semantic Scholar
One-Step Synthesis of Biphenylacetic Acids via Pd/C-Catalyzed Arylation
D. Gala, A. Stamford, J. Jenkins, M. Kugelman
199750 citations
Semantic Scholar
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
D. Wyss, Yu-Sen Wang, Hugh L. Eaton, C. Strickland +3 more
2012Topics in current chemistry45 citations
Semantic Scholar
Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
Wen-Lian Wu, Jin-Song Hao, M. Domalski, D. Burnett +12 more
2016ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Targeting eIF4A Dependent Translation of KRAS Signaling Molecules
Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan +22 more
2021Cancer Research39 citations Open access
Semantic Scholar
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors.
Christopher J. Bungard, Peter D. Williams, J. Schulz, Catherine M. Wiscount +25 more
2017ACS Medicinal Chemistry Letters37 citations Open access
Semantic Scholar
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.
Mihirbaran Mandal, Yu-Sheng Wu, J. Misiaszek, Guo-Qing Li +30 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.
Yan Xia, S. Chackalamannil, W. Greenlee, Charles L. Jayne +9 more
2011Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Small-molecule inhibition of the acyl-lysine reader ENL as a strategy against acute myeloid leukemia
Yi-Man Liu, Qing-Lan Li, Fatemeh Alikarami, Declan R. Barrett +28 more
2022Cancer Discovery35 citations Open access
Semantic Scholar
CNS Amyloid-β, Soluble APP-α and -β Kinetics during BACE Inhibition
J. Dobrowolska, Maria S. Michener, Guo-Xin Wu, B. Patterson +17 more
2014Journal of Neuroscience35 citations Open access
Semantic Scholar
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.
Craig D. Boyle, Ruo Xu, Theodros Asberom, S. Chackalamannil +17 more
2005Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior.
R. Hodgson, D. Mullins, Sherry X. Lu, M. Guzzi +7 more
2014European Journal of Pharmacology30 citations
Semantic Scholar
Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones.
J. Harris, B. Neustadt, Hong-Tao Zhang, J. Lachowicz +4 more
2009Bioorganic & Medicinal Chemistry Letters30 citations
Semantic Scholar
Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.
Y. Wang, S. Chackalamannil, Zhi-Yong Hu, Craig D. Boyle +15 more
2002Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.
Dmitri A Pissarnitski, Theodros Asberom, Craig D. Boyle, S. Chackalamannil +13 more
2004Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Discovery of potent iminoheterocycle BACE1 inhibitors.
J. Caldwell, R. Mazzola, James Durkin, Joseph Chen +15 more
2014Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.
D. Demong, X. Dai, Joyce Hwa, Michael Miller +33 more
2014Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Formal olefination and acylaziridination of imidazolones.
X. Dai, Michael W. Miller, A. Stamford
2010Organic Letters17 citations
Semantic Scholar
Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines.
B. Neustadt, Hong Liu, Jin-Song Hao, W. Greenlee +10 more
2009Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.
Jack D. Scott, Michael W. Miller, Sarah W. Li, Sue-Ing Lin +13 more
2009Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Discovery of novel orally active ureido NPY Y5 receptor antagonists.
Guo-Qing Li, A. Stamford, Ying Huang, K. Cheng +13 more
2008Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
A chemical strategy toward novel brain-penetrant EZH2 inhibitors
R. Liang, D. Tomita, Yusuke Sasaki, J. Ginn +13 more
2021bioRxiv14 citations Open access
Semantic Scholar
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
Mihirbaran Mandal, K. Mitra, D. Grotz, Xin-Jie Lin +19 more
2018Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.
Gang Zhou, R. Aslanian, G. Gallo, Tanweer A. Khan +12 more
2016Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Convenient route to γ-nitro-α-amino acids: conjugate addition of nitroalkanes to dehydroalanine derivatives
M. Crossley, Y.-M. Fung, Jeffrey J. Potter, A. Stamford
199813 citations
Semantic Scholar
A novel method for the preparation of 4-arylimidazolones.
D. Demong, Irene Ng, Michael W. Miller, A. Stamford
2013Organic Letters12 citations
Semantic Scholar
Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes.
Ping Liu, Zhi-Yong Hu, Byron G DuBois, C. Moyes +27 more
2015ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Q. Deng, Yeon-Hee Lim, Rajan Anand, Younong Yu +13 more
2015Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand.
D. Mullins, N. Adham, D. Hesk, Yu-Sheng Wu +7 more
2008European Journal of Pharmacology11 citations
Semantic Scholar

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