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Q. Deng · SciRah

Researcher profile · Semantic Scholar

Q. Deng

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Q. Deng — researcher profile on SciRah

h-index: 16
Works: 34
Citations: 656

Most-cited papers

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Hong C. Shen, Fa-Xiang Ding, Q. Deng, L. Wilsie +16 more
2009Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Hong C. Shen, Fa-Xiang Ding, Subharekha Raghavan, Q. Deng +20 more
2010Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Molecular Simulations Identify Binding Poses and Approximate Affinities of Stapled α-Helical Peptides to MDM2 and MDMX.
Joseph A. Morrone, Alberto Pérez, Q. Deng, Sookhee N. Ha +5 more
2017Journal of Chemical Theory and Computation43 citations Open access
Semantic Scholar
Identification of Leu276 of the S1P1 Receptor and Phe263 of the S1P3 Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies
Q. Deng, Joseph A. Clemas, G. Chrebet, P. Fischer +7 more
2007Molecular Pharmacology40 citations Open access
Semantic Scholar
Binding site analysis of c-Myb: screening of potential binding sites by using the mutation matrix derived from systematic binding affinity measurements.
Q. Deng, S. Ishii, A. Sarai
1996Nucleic Acids Research40 citations Open access
Semantic Scholar
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Hong C. Shen, Fa-Xiang Ding, Siyi Wang, Q. Deng +20 more
2009Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Hong C. Shen, Fa-Xiang Ding, S. Luell, M. Forrest +19 more
2007Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
A new class of glycogen phosphorylase inhibitors.
Zhijian Lu, Joann Bohn, R. Bergeron, Q. Deng +10 more
2003Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.
K. Rosauer, A. Ogawa, C. A. Willoughby, K. Ellsworth +6 more
2003Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.
Hong C. Shen, Fa-Xiang Ding, Q. Deng, Suo-Yu S. Xu +11 more
2009Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Cell-Based Assays to Detect Inhibitors of Fungal mRNA Capping Enzymes and Characterization of Sinefungin as a Cap Methyltransferase Inhibitor
G. Chrebet, D. Wisniewski, A. L. Perkins, Q. Deng +3 more
2005Journal of biomolecular screening30 citations Open access
Semantic Scholar
Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.
Q. Deng, Jessica L. Frie, Daria M. Marley, Richard T. Beresis +10 more
2008Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Photoredox Ni-catalyzed peptide C(sp2)–O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization
Hyelee Lee, Nicolas Boyer, Q. Deng, Hai-Young Kim +2 more
2019Chemical Science23 citations Open access
Semantic Scholar
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Hong C. Shen, Fa-Xiang Ding, Q. Deng, Suo-Yu S. Xu +13 more
2009Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
Simon Ng, Alexander C. Brueckner, Soheila Bahmanjah, Q. Deng +13 more
2021Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
Hong C. Shen, M. Szymonifka, Divya Kharbanda, Q. Deng +13 more
2007Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Conformational Strain of Macrocyclic Peptides in Ligand-Receptor Complexes Based on Advanced Refinement of Bound-State Conformers.
Alexander C. Brueckner, Q. Deng, A. E. Cleves, C. Lesburg +4 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Modeling aided design of potent glycogen phosphorylase inhibitors.
Q. Deng, Zhijian Lu, Joann Bohn, K. Ellsworth +7 more
2005Journal of Molecular Graphics and Modelling12 citations
Semantic Scholar
XGen: Real-Space Fitting of Complex Ligand Conformational Ensembles to X-Ray Electron Density Maps.
Ajay N. Jain, A. E. Cleves, Alexander C. Brueckner, C. Lesburg +3 more
2020Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Q. Deng, Yeon-Hee Lim, Rajan Anand, Younong Yu +13 more
2015Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
Zhijian Lu, Yi-Heng Chen, J. Napolitano, Gayle E. Taylor +17 more
2012Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes.
A. Palani, A. Nawrocki, F. Orvieto, E. Bianchi +15 more
2022ACS Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Fragment-Based Lead Discovery of a Novel Class of Small Molecule Inhibitors of Neuropeptide B/W Receptor Subtype 1 (GPR7).
Remond Moningka, F. A. Romero, N. B. Hastings, Zhiqian Guo +9 more
2020Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.
Jian Liu, Patrick P Shao, D. Guiadeen, Arto D Krikorian +9 more
2020Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
The discovery of potent antagonists of NPBWR1 (GPR7).
F. A. Romero, N. B. Hastings, Remond Moningka, Zhiqian Guo +9 more
2012Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.
X. Fradera, Q. Deng, Abdelganhi Achab, Yudith Garcia +13 more
2021Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity.
Chunhui Huang, A. Palani, Zhiqiang Yang, Q. Deng +7 more
2022ACS Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Novel 3,4‐Dihydroquinolin‐2(1H)‐one Inhibitors of Human Glycogen Phosphorylase a.
K. Rosauer, A. Ogawa, C. A. Willoughby, K. Ellsworth +6 more
20042 citations
Semantic Scholar
Receptor Mapping by Comparative Molecular Field Analysis of Phospholipase A2 Inhibitors
Q. Deng, Bin Cao, Lu-Hua Lai
19951 citations
Semantic Scholar
Drug Design: Structure-based design of potent glycogen phosphorylase inhibitors
Q. Deng
20100 citations
Semantic Scholar
Inhibitor design for human rheumatoid arthitic synovial fluid phospholipase A2
Q. Deng, L. Lai, Y. Luo, X.-J. Xu
19930 citations Open access
Semantic Scholar
Conformational analysis of dynorphin(1–13)
Q. Deng, L. Lai, Yu-Zhen Han, Xiao-Jie Xu
19930 citations
Semantic Scholar
Constraint peptide conformational analysis by Monte Carlo simulated annealing
L.-Y. Wang, Q. Deng, L. Lai, Yu-Zhen Han +1 more
19930 citations Open access
Semantic Scholar
A new protein molecular modeling and design system-pepmods
X. Xu, L. Lai, Y. Luo, C. Qu +3 more
19910 citations
Semantic Scholar

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