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D. Burnett · SciRah

Researcher profile · Semantic Scholar

D. Burnett

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D. Burnett — researcher profile on SciRah

h-index: 25
Works: 91
Citations: 2,994

Most-cited papers

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
M. Garcia-Calvo, Jeanmarie Lisnock, H. Bull, B. Hawes +20 more
2005Proceedings of the National Academy of Sciences of the United States of America783 citations Open access
Semantic Scholar
Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.
S. Rosenblum, T. Huynh, A. Afonso, Harry R. Davis +3 more
1998Journal of Medicinal Chemistry330 citations
Semantic Scholar
2-Azetidinones as inhibitors of cholesterol absorption.
D. Burnett, M. Caplen, Harry R. Davis, R. Burrier +1 more
1994Journal of Medicinal Chemistry195 citations Open access
Semantic Scholar
The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.
S. Altmann, H. Davis, Xiao-Rui Yao, M. Laverty +10 more
2002Biochimica et Biophysica Acta166 citations
Semantic Scholar
β-lactam cholesterol absorption inhibitors
D. Burnett
2004120 citations
Semantic Scholar
Pyrrolizidinone and indolizidinone synthesis: generation and intramolecular addition of .alpha.-acylamino radicals to olefins and allenes
D. Burnett, Joong-Kwon Choi, D. Hart, Yeun‐Min Tsai
1984118 citations
Semantic Scholar
2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.
J. Clader, D. Burnett, M. Caplen, M. Domalski +8 more
1996Journal of Medicinal Chemistry111 citations
Semantic Scholar
Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461.
Brian G. Salisbury, H. Davis, R. Burrier, D. Burnett +12 more
1995Atherosclerosis107 citations
Semantic Scholar
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Wen-Lian Wu, D. Burnett, Richard T. Spring, W. Greenlee +5 more
2005Journal of Medicinal Chemistry89 citations
Semantic Scholar
Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists.
H. Ahn, L. Arik, G. Boykow, D. Burnett +7 more
1999Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.
Zhongxiang Sun, Theodros Asberom, T. Bara, C. Bennett +36 more
2012Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
β-Stannyl enones as radical traps: a very direct route to PGF2α
G. Keck, D. Burnett
198747 citations
Semantic Scholar
Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
Wen-Lian Wu, Jin-Song Hao, M. Domalski, D. Burnett +12 more
2016ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Asymmetric synthesis and absolute stereochemistry of cholesterol absorption inhibitor, SCH 48461
D. Burnett
199440 citations
Semantic Scholar
Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides
M. E. Browne, D. Burnett, M. Caplen, Lian-Yong Chen +8 more
199538 citations
Semantic Scholar
Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.
Wen-Lian Wu, D. Burnett, M. Domalski, W. Greenlee +6 more
2007Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Julie Lee, Li-Xin Song, Giuseppe Terracina, T. Bara +7 more
2011Biochemistry33 citations
Semantic Scholar
Modification of the clozapine structure by parallel synthesis.
Jing Su, Hai-Qun Tang, B. Mckittrick, D. Burnett +4 more
2006Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.
Xian-Hai Huang, Wei Zhou, Xiao-Xiang Liu, Hongmei Li +23 more
2012ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.
T. Sasikumar, Li Qiang, D. Burnett, W. Greenlee +7 more
2009Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
.beta.-Lactams from esters and sulfenimines: a new route to monobactams
D. Burnett, D. Hart, Jun Liu
198628 citations
Semantic Scholar
Iminoheterocycles as gamma-secretase modulators.
J. Caldwell, C. Bennett, Troy Mccracken, R. Mazzola +14 more
2010Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.
C. Bennett, D. Burnett, W. Greenlee, C. Knutson +10 more
2012Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
T. Sasikumar, Li Qiang, D. Burnett, D. Cole +6 more
2010Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
D. Burnett, M. Caplen, M. E. Browne, Hongrong Zhau +3 more
2002Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
E. Smith, S. Sorota, Hyunjin Kim, B. Mckittrick +18 more
2010Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties.
T. Sasikumar, Li Qiang, D. Burnett, W. Greenlee +5 more
2010Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Synthesis of 3-(1-hydroxyethyl)-2-azetidinones via ester-imine condensations
D. Burnett, J. Gallucci, D. Hart
198523 citations
Semantic Scholar
Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
M. Bursavich, B. Harrison, Raksha A. Acharya, Don Costa +14 more
2017Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.
Thavalakulamgara K. Sasikumar, D. Burnett, Hong-Tao Zhang, April Smith-Torhan +2 more
2006Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Conformational effects on the oxidative coupling of benzyltetrahydroisoquinolines to morphinan and aporphine alkaloids
D. Burnett, D. Hart
198719 citations
Semantic Scholar
Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.
Zhiqiang Zhao, Dmitri A Pissarnitski, H. Josien, Wen-Lian Wu +10 more
2015Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease
J. Blain, M. Bursavich, E. Freeman, Lori A. Hrdlicka +12 more
2016Alzheimer's Research & Therapy17 citations Open access
Semantic Scholar
Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
Wen-Lian Wu, D. Burnett, M. Caplen, M. Domalski +8 more
2006Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.
Dmitri A Pissarnitski, Zhiqiang Zhao, D. Cole, Wen-Lian Wu +9 more
2016Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Ruo Xu, D. Cole, Ted Asberom, T. Bara +20 more
2010Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.
T. Sasikumar, Li Qiang, D. Burnett, W. Greenlee +5 more
2006Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.
Wen-Lian Wu, M. Domalski, D. Burnett, H. Josien +16 more
2012ACS Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Wen-Lian Wu, Theodros Asberom, T. Bara, C. Bennett +19 more
2013Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.
Stephanie Brumfield, Peter Korakas, L. S. Silverman, D. Tulshian +14 more
2012Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.
Wen-Lian Wu, M. Caplen, M. Domalski, Hong-Tao Zhang +2 more
2002Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
An enzymatic synthesis of glucuronides of azetidinone-based cholesterol absorption inhibitors.
Paula Reiss, D. Burnett, A. Zaks
1999Bioorganic & Medicinal Chemistry12 citations
Semantic Scholar
Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.
M. Bursavich, B. Harrison, Raksha A. Acharya, Don Costa +14 more
2021Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
T. Sasikumar, D. Burnett, Theodros Asberom, Wen-Lian Wu +7 more
2010Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.
Jing Su, Hai-Qun Tang, B. Mckittrick, H. Gu +11 more
2007Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Discovery and characterization of novel TRPML1 agonists.
Xiaowen Peng, Christopher J. Holler, Anna-Maria F. Alves, Michelle G. Oliviera +12 more
2023Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Strategic and Tactical Approaches to the Synthesis of 5,6-Dihydro-[1,2,4]oxadiazines
J. Veerman, Yorik B. Bruseker, B. C. V. van Esseveldt, R. Glen +8 more
20168 citations Open access
Semantic Scholar
SCH 48461, a novel inhibitor of cholesterol absorption
E. Sybertz, H. Davis, B. Salisbury, R. Burrier +2 more
19948 citations
Semantic Scholar
Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.
T. Sasikumar, D. Burnett, W. Greenlee, Michelle D. Smith +3 more
2010Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG.
Jing Su, B. Mckittrick, Hai-Qun Tang, D. Burnett +10 more
2007Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar

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