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J. Voigt · SciRah

Researcher profile · Semantic Scholar

J. Voigt

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J. Voigt — researcher profile on SciRah

h-index: 24
Works: 61
Citations: 2,090

Most-cited papers

Comparison of the NCI Open Database with Seven Large Chemical Structural Databases
J. Voigt, B. Bienfait, Shaomeng Wang, M. Nicklaus
2001Journal of chemical information and computer sciences209 citations
Semantic Scholar
Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.
Claudio N. Cavasotto, A. Orry, N. Murgolo, M. Czarniecki +9 more
2008Journal of Medicinal Chemistry171 citations Open access
Semantic Scholar
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
J. Cumming, Elizabeth Smith, Lingyan Wang, J. Misiaszek +18 more
2012Bioorganic & Medicinal Chemistry Letters146 citations Open access
Semantic Scholar
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Jack D. Scott, Sarah W. Li, A. Brunskill, Xia Chen +26 more
2016Journal of Medicinal Chemistry135 citations Open access
Semantic Scholar
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
Zhao-Ning Zhu, Zhongxiang Sun, Yuanzan Ye, J. Voigt +17 more
2010Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
Enhanced CACTVS Browser of the Open NCI Database
W. Ihlenfeldt, J. Voigt, B. Bienfait, Frank Oellien +1 more
2002Journal of chemical information and computer sciences111 citations
Semantic Scholar
Comparison of Random Forest and Pipeline Pilot Naïve Bayes in Prospective QSAR Predictions
Bin Chen, R. Sheridan, V. Hornak, J. Voigt
2012Journal of Chemical Information and Modeling103 citations
Semantic Scholar
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction
A. Stamford, Jack D. Scott, Sarah W. Li, S. Babu +23 more
2012ACS Medicinal Chemistry Letters97 citations Open access
Semantic Scholar
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Yu-Sen Wang, C. Strickland, J. Voigt, M. Kennedy +12 more
2010Journal of Medicinal Chemistry91 citations Open access
Semantic Scholar
Metal-dependent inhibition of HIV-1 integrase.
N. Neamati, Zhaiwei Lin, R. Karki, A. Orr +12 more
2002Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.
J. Baleja, J. Cherry, Zhiguo Liu, Hua-Ying Gao +4 more
2006Antiviral Research74 citations Open access
Semantic Scholar
Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors.
T. R. Burke, Z. Yao, Ding-Guo Liu, J. Voigt +1 more
2001Biopolymers63 citations
Semantic Scholar
Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.
J. Cumming, T. Le, S. Babu, C. Carroll +24 more
2008Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
PROSIT: Pseudo-Rotational Online Service and Interactive Tool, Applied to a Conformational Survey of Nucleosides and Nucleotides
Guang-Yu Sun, J. Voigt, I. V. Filippov, V. Márquez +1 more
2004Journal of Chemical Information and Modeling52 citations
Semantic Scholar
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
Mihirbaran Mandal, Zhao-Ning Zhu, J. Cumming, Xiao-Xiang Liu +23 more
2012Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
J. Cumming, S. Babu, Ying Huang, C. Carrol +19 more
2010Bioorganic & Medicinal Chemistry Letters50 citations Open access
Semantic Scholar
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.
Zhongxiang Sun, Theodros Asberom, T. Bara, C. Bennett +36 more
2012Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
D. Wyss, Yu-Sen Wang, Hugh L. Eaton, C. Strickland +3 more
2012Topics in current chemistry45 citations
Semantic Scholar
Enantioselective Synthesis of Nonphosphorus-Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides
T. R. Burke, Zhu-Jun Yao, He Zhao, G. Milne +3 more
199843 citations
Semantic Scholar
Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
David B. Belanger, Patrick J. Curran, A. Hruza, J. Voigt +5 more
2010Bioorganic & Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.
Mihirbaran Mandal, Yu-Sheng Wu, J. Misiaszek, Guo-Qing Li +30 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.
Tao Yu, J. Tagat, A. Kerekes, R. Doll +22 more
2010ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Iminoheterocycles as gamma-secretase modulators.
J. Caldwell, C. Bennett, Troy Mccracken, R. Mazzola +14 more
2010Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.
Ding-Guo Liu, Yang Gao, J. Voigt, Kyeong Lee +4 more
2003Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
An Efficient Synthesis of Conformationally Restricted Peptides Containing β-Aminocyclopropanecarboxylic Acids
J. Voigt, M. Noltemeyer, O. Reiser
199722 citations
Semantic Scholar
Cross-Docking of Inhibitors into CDK2 Structures. 1
J. Duca, V. Madison, J. Voigt
2008Journal of Chemical Information and Modeling20 citations
Semantic Scholar
Discovery of potent iminoheterocycle BACE1 inhibitors.
J. Caldwell, R. Mazzola, James Durkin, Joseph Chen +15 more
2014Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.
Dmitri A Pissarnitski, Zhiqiang Zhao, D. Cole, Wen-Lian Wu +9 more
2016Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
eCounterscreening: Using QSAR Predictions to Prioritize Testing for Off-Target Activities and Setting the Balance between Benefit and Risk
R. Sheridan, D. McMasters, J. Voigt, M. Wildey
2015Journal of Chemical Information and Modeling16 citations
Semantic Scholar
Cross-Docking of Inhibitors into CDK2 Structures. 2
J. Voigt, C. Elkin, V. Madison, J. Duca
2008Journal of Chemical Information and Modeling14 citations
Semantic Scholar
Synthesis of Fmoc-protected 4-carboxydifluoromethyl-L-phenylalanine: A phosphotyrosyl mimetic of potential use for signal transduction studies
Zhu-Jun Yao, Yang Gao, J. Voigt, H. Ford +1 more
199914 citations
Semantic Scholar
PROSIT, AN ONLINE SERVICE TO CALCULATE PSEUDOROTATIONAL PARAMETERS OF NUCLEOSIDES AND NUCLEOTIDES
Guang-Yu Sun, J. Voigt, V. Márquez, M. Nicklaus
2005Nucleosides, Nucleotides & Nucleic Acids12 citations
Semantic Scholar
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.
M. Voss, M. P. Rainka, Mike Fleming, Lisa H. Peterson +6 more
2012Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
A New Approach to β- and γ-Amino Esters and Amino Aldehydes by Regioselective Ozonolysis of 2,3-Dihydropyrroles and 1,2,3,4-Tetrahydropyridines
C. Bubert, J. Voigt, Silvia Biasetton, O. Reiser
19949 citations
Semantic Scholar
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
B. Mckittrick, J. Caldwell, T. Bara, G. Boykow +30 more
2015Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
Dmitri A Pissarnitski, Theodros Asberom, T. Bara, A. Buevich +17 more
2007Bioorganic & Medicinal Chemistry Letters8 citations
Semantic Scholar
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability
Andrew Mulato, E. Lansdon, R. Aoyama, J. Voigt +23 more
2024Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar
ErratumErratum to “Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors” [Bioorg. Med. Chem. Lett. 18 (2008) 3236–3241]
J. Cumming, T. Le, S. Babu, C. Carroll +24 more
20084 citations
Semantic Scholar
PROSIT: Pseudo‐Rotational Online Service and Interactive Tool, Applied to a Conformational Survey of Nucleosides and Nucleotides.
Guang-Yu Sun, J. Voigt, I. V. Filippov, V. Márquez +1 more
20044 citations
Semantic Scholar
Acylsulfonamide‐Containing PTP1B Inhibitors Designed to Mimic an Enzyme‐Bound Water of Hydration.
Ding-Guo Liu, Yang Gao, J. Voigt, Kyeong Lee +4 more
20043 citations
Semantic Scholar
Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers
Richard C. Centore, L. M. Soares, Rishi G. Vaswani, Kana Ichikawa +22 more
2021Experimental and Molecular Therapeutics2 citations
Semantic Scholar
Targeted analytical evaluation of a large small molecule chemical database
J. Kelley, C. C. Lai, J. Barchi, M. Nicklaus +4 more
20022 citations
Semantic Scholar
Potent Non Phosphate-Containing Grb2 SH2 Domain Inhibitors
R. BurkeTerrence, Yang Gao, Zhu-Jun Yao, J. Voigt +2 more
20002 citations
Semantic Scholar
A New Approach to β‐ and γ‐Amino Esters (III) and Amino Aldehydes (IV) by Regioselective Ozonolysis of 2,3‐Dihydropyrroles and 1,2,3,4‐Tetrahydropyridines (I).
C. Bubert, J. Voigt, S. Biasetton, O. Reiser
19942 citations
Semantic Scholar
Discovery of a Potent and Injectable Inhibitor of Aurora Kinases A and B based on the Imidazo-[1, 2-a]-Pyrazine Core
Tao Yu, J. Tagat, A. Kerekes, R. Doll +22 more
20101 citations
Semantic Scholar
Cross‐Docking of Inhibitors into CDK2 Structures. Part 1.
J. Duca, V. Madison, J. Voigt
20081 citations
Semantic Scholar
Enantioselective Synthesis of Nonphosphorus‐Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides.
T. R. Jun. Burke, Zhu-Jun Yao, He Zhao, G. Milne +3 more
19981 citations
Semantic Scholar
CCDC 1451339: Experimental Crystal Structure Determination
Jack D. Scott, Sarah W. Li, A. Brunskill, Xia Chen +26 more
20160 citations
Semantic Scholar
New Chemical Entities Entering Phase III Trials in 2015
A. Schrier, E. Canales, A. S. Lee, Nathan E. Wright +2 more
20160 citations
Semantic Scholar
P3‐272: Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease
Matthew E. Kennedy, Xia Chen, R. Kuvelkar, J. Cumming +13 more
20100 citations Open access
Semantic Scholar

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