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C. Rondinone · SciRah

Researcher profile · Semantic Scholar

C. Rondinone

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C. Rondinone — researcher profile on SciRah

h-index: 42
Works: 106
Citations: 6,905

Most-cited papers

Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.
E. Blanchette-Mackie, N. Dwyer, T. Barber, R. A. Coxey +5 more
1995Journal of Lipid Research485 citations
Semantic Scholar
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
B. Zinker, C. Rondinone, J. Trevillyan, R. Gum +18 more
2002Proceedings of the National Academy of Sciences of the United States of America406 citations Open access
Semantic Scholar
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
T. Pederson, D. Kramer, C. Rondinone
2001Diabetes331 citations
Semantic Scholar
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
C. Rondinone, Ling-Mei Wang, P. Lönnroth, C. Wesslau +2 more
1997Proceedings of the National Academy of Sciences of the United States of America305 citations Open access
Semantic Scholar
Adipocyte-derived hormones, cytokines, and mediators
C. Rondinone
2006Endocrine286 citations
Semantic Scholar
LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.
Xuecai Ge, Hong Yang, M. Bednarek, Hadas Galon-Tilleman +12 more
2017Cell Metabolism261 citations Open access
Semantic Scholar
On the Control of Lipolysis in Adipocytes
C. Londos, D. Brasaemle, Charles J. Schultz, Diane C. Adler-Wailes +3 more
1999Annals of the New York Academy of Sciences258 citations
Semantic Scholar
MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study.
P. Ambery, V. Parker, M. Stumvoll, M. Posch +9 more
2018The Lancet252 citations
Semantic Scholar
Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
Michelle L. Boland, R. Laker, Karly M. Mather, A. Nawrocki +16 more
2020Nature Metabolism240 citations Open access
Semantic Scholar
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.
C. J. Carlson, Sandra L Koterski, R. Sciotti, Germán Braillard Poccard +1 more
2003Diabetes235 citations
Semantic Scholar
Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates
S. Henderson, A. Konkar, D. C. Hornigold, J. Trevaskis +18 more
2016Diabetes, obesity and metabolism219 citations Open access
Semantic Scholar
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
R. Gum, Lori L Gaede, Sandra L Koterski, M. Heindel +6 more
2003Diabetes203 citations Open access
Semantic Scholar
BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis
B. Gustafson, A. Hammarstedt, S. Hedjazifar, Jenny M. Hoffmann +4 more
2015Diabetes196 citations
Semantic Scholar
Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
Eugenia Carvalho, P. Jansson, M. Axelsen, J. Eriksson +5 more
1999The FASEB Journal169 citations Open access
Semantic Scholar
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
C. Rondinone, J. Trevillyan, Jill E. Clampit, R. Gum +10 more
2002Diabetes166 citations
Semantic Scholar
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
B. Szczepankiewicz, Christi Kosogof, L. Nelson, Gang Liu +22 more
2006Journal of Medicinal Chemistry164 citations Open access
Semantic Scholar
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation.
C. J. Carlson, M. White, C. Rondinone
2004Biochemical and Biophysical Research Communications - BBRC162 citations
Semantic Scholar
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
Gang Liu, Z. Xin, Z. Pei, P. Hajduk +10 more
2003Journal of Medicinal Chemistry158 citations Open access
Semantic Scholar
A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*
R. Somwar, Sandra L Koterski, G. Sweeney, R. Sciotti +6 more
2002Journal of Biological Chemistry141 citations Open access
Semantic Scholar
Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats.
D. Kramer, R. Shapiro, A. Adler, E. Bush +1 more
2001Metabolism: Clinical and Experimental104 citations
Semantic Scholar
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
Gang Liu, Z. Xin, Heng Liang, C. Abad-Zapatero +12 more
2003Journal of Medicinal Chemistry102 citations Open access
Semantic Scholar
A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice
M. Pilar Valdecantos, V. Pardo, Laura Ruiz, L. Castro-Sánchez +17 more
2017Hepatology98 citations Open access
Semantic Scholar
Aldosterone stimulated differentiation of mouse 3T3-L1 cells into adipocytes.
C. Rondinone, D. Rodbard, M. Baker
1993Endocrinology97 citations
Semantic Scholar
Protein–Tyrosine Phosphatase 1B–Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-α–Induced Insulin Resistance
I. Nieto-Vázquez, S. Fernández-Veledo, C. De Álvaro, C. Rondinone +2 more
2007Diabetes84 citations Open access
Semantic Scholar
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus
C. Rondinone, Eugenia Carvalho, C. Wesslau, Ulf P. G. Smith
1999Diabetologia82 citations Open access
Semantic Scholar
Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Hongyu Zhao, Gang Liu, Z. Xin, Michael D. Serby +12 more
2004Bioorganic & Medicinal Chemistry Letters79 citations Open access
Semantic Scholar
Phosphorylation of PDE3B by Phosphatidylinositol 3-Kinase Associated with the Insulin Receptor*
C. Rondinone, Eugenia Carvalho, Tova Rahn, V. Manganiello +2 more
2000Journal of Biological Chemistry76 citations Open access
Semantic Scholar
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment.
Cathleen E. Berg, B. Lavan, C. Rondinone
2002Biochemical and Biophysical Research Communications - BBRC73 citations
Semantic Scholar
Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4
Eugenia Carvalho, C. Rondinone, U. Smith
2000Molecular and Cellular Biochemistry72 citations
Semantic Scholar
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Hongyu Zhao, Michael D. Serby, Z. Xin, B. Szczepankiewicz +16 more
2006Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
MEDI0382, a GLP‐1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single‐dose, healthy‐subject, randomized, Phase 1 study
Philip Ambery, S. Klammt, M. Posch, M. Petrone +4 more
2018British Journal of Clinical Pharmacology66 citations Open access
Semantic Scholar
Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor γ Coactivator 1β and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice*
Ruojing Yang, Denise M. Wilcox, D. Haasch, P. Jung +12 more
2007Journal of Biological Chemistry66 citations Open access
Semantic Scholar
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes.
Ulf Smith, Eugenia Carvalho, Erifili Mosialou, Francesco Beguinot +2 more
2000Biochemical and Biophysical Research Communications - BBRC65 citations
Semantic Scholar
JNK: bridging the insulin signaling and inflammatory pathway.
Gang Liu, C. Rondinone
2005Current opinion in investigational drugs61 citations
Semantic Scholar
Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum‐deprived hepatocytes
Á. González-Rodríguez, Ó. Escribano, Javier Alba, C. Rondinone +2 more
2007Journal of Cellular Physiology58 citations
Semantic Scholar
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Mei Liu, Sanyi Wang, Jill E. Clampit, R. Gum +7 more
2007Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
R. Gum, Lori L Gaede, M. Heindel, J. Waring +7 more
2003Molecular Endocrinology50 citations Open access
Semantic Scholar
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Á. González-Rodríguez, Jill E. Clampit, Ó. Escribano, M. Benito +2 more
2007Endocrinology46 citations
Semantic Scholar
Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression
Sonia Fernández-Veledo, I. Nieto-Vázquez, C. Rondinone, Margarita Lorenzo
2006Diabetologia46 citations Open access
Semantic Scholar
Perilipin: possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells.
C. Londos, J. Gruia-Gray, D. Brasaemle, C. Rondinone +5 more
1996International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity46 citations
Semantic Scholar
Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.
Soledad Miranda, Á. González-Rodríguez, Jesús Revuelta-Cervantes, C. Rondinone +1 more
2010Cellular Signalling43 citations Open access
Semantic Scholar
Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.
Jill E. Clampit, J. Meuth, Harriet T. Smith, R. M. Reilly +3 more
2003Biochemical and Biophysical Research Communications - BBRC43 citations
Semantic Scholar
Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes
B. Boland, Charles Brown, Michelle L. Boland, J. Cann +8 more
2018Diabetes42 citations Open access
Semantic Scholar
PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.
J. Waring, R. Ciurlionis, Jill E. Clampit, S. Morgan +9 more
2003Molecular and Cellular Endocrinology41 citations
Semantic Scholar
PKCθ is a key player in the development of insulin resistance
D. Haasch, Cathleen E. Berg, Jill E. Clampit, T. Pederson +3 more
200639 citations
Semantic Scholar
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
Y. Qian, S. Wertheimer, Mushtaq Ahmad, A. Cheung +19 more
2011Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling*
Hadas Galon-Tilleman, Hong Yang, M. Bednarek, Sandra M. Spurlock +10 more
2016Journal of Biological Chemistry34 citations Open access
Semantic Scholar
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
J. Dreyfuss, Yixing Yuchi, Xue-hong Dong, V. Efthymiou +17 more
2021Nature Communications33 citations Open access
Semantic Scholar
Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease.
Marcela Herrera, M. Söderberg, A. Sabirsh, B. Valastro +11 more
2017AJP - Renal Physiology32 citations Open access
Semantic Scholar
Okadaic Acid Exerts a Full Insulin-like Effect on Glucose Transport and Glucose Transporter 4 Translocation in Human Adipocytes
C. Rondinone, Ulf Smith
1996Journal of Biological Chemistry31 citations Open access
Semantic Scholar

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J. Trevillyan×14
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J. Trevillyan — researcher profile on SciRah
Jill E. Clampit×10
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M. Jirousek×9
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R. Gum×8
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Gang Liu — researcher profile on SciRah

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B. Zinker — researcher profile on SciRah

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R. Ulrich — researcher profile on SciRah

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A. Konkar — researcher profile on SciRah