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R. Sciotti · SciRah

Researcher profile · Semantic Scholar

R. Sciotti

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R. Sciotti — researcher profile on SciRah

h-index: 26
Works: 70
Citations: 2,201

Most-cited papers

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.
C. J. Carlson, Sandra L Koterski, R. Sciotti, Germán Braillard Poccard +1 more
2003Diabetes235 citations
Semantic Scholar
A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*
R. Somwar, Sandra L Koterski, G. Sweeney, R. Sciotti +6 more
2002Journal of Biological Chemistry141 citations Open access
Semantic Scholar
3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.
S. Djuric, N. Bamaung, A. Basha, Hua-Qing Liu +25 more
2000Journal of Medicinal Chemistry122 citations
Semantic Scholar
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine
B. Pybus, J. Sousa, Xian-Nu Jin, J. Ferguson +9 more
2012Malaria Journal118 citations Open access
Semantic Scholar
Enantioselective Total Synthesis of (-)-Chlorothricolide
W. Roush, R. Sciotti
1994101 citations
Semantic Scholar
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
A. Nagle, Agnes Biggart, Céline Be, H. Srinivas +39 more
2020Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
Enantioselective Total Synthesis of (−)-Chlorothricolide via the Tandem Inter- and Intramolecular Diels−Alder Reaction of a Hexaenoate Intermediate
W. Roush, R. Sciotti
199892 citations
Semantic Scholar
Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery
William G Devine, Jennifer L. Woodring, U. Swaminathan, E. Amata +9 more
2015Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
Diana Caridha, B. Vesely, K. Van Bocxlaer, B. Arana +8 more
2019International Journal for Parasitology: Drugs and Drug Resistance67 citations Open access
Semantic Scholar
Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity.
E. Sharlow, Stephanie S. Leimgruber, S. Murray, Ana Lira +9 more
2014ACS Chemical Biology63 citations
Semantic Scholar
5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.
J. Starr, R. Sciotti, D. Hanna, M. Huband +11 more
2009Bioorganic & Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis
K. Van Bocxlaer, Diana Caridha, Chad C. Black, B. Vesely +8 more
2019International Journal for Parasitology: Drugs and Drug Resistance62 citations Open access
Semantic Scholar
Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics
Chau T. Vuong, Lisa H. Xie, Brittney M. J. Potter, Jing Zhang +17 more
2015Antimicrobial Agents and Chemotherapy47 citations Open access
Semantic Scholar
Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery
G. Patel, N. Roncal, Patricia J. Lee, Susan E. Leed +4 more
2014MedChemComm47 citations Open access
Semantic Scholar
Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria
Lisa Frueh, Yue-Xin Li, M. Mather, Qi-Gui Li +16 more
2017ACS Infectious Diseases45 citations Open access
Semantic Scholar
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus
Igor M. Opsenica, J. Burnett, R. Gussio, Dejan M. Opsenica +11 more
2011Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Repurposing Screen Identifies Unconventional Drugs With Activity Against Multidrug Resistant Acinetobacter baumannii
Yu-Shan Cheng, Wei Sun, Miao Xu, M. Shen +3 more
2019Frontiers in Cellular and Infection Microbiology42 citations Open access
Semantic Scholar
The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
Travis R. Helgren, R. Sciotti, Patricia J. Lee, Sandra Duffy +4 more
2015Bioorganic & Medicinal Chemistry Letters41 citations
Semantic Scholar
The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.
R. Sciotti, Marina A. Pliushchev, P. Wiedeman, D. Balli +7 more
2002Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721
D. Madar, H. Kopecká, D. Pireh, J. Pease +4 more
200137 citations
Semantic Scholar
Drug discovery algorithm for cutaneous leishmaniasis.
M. Grogl, M. Hickman, W. Ellis, T. Hudson +5 more
2013American Journal of Tropical Medicine and Hygiene33 citations Open access
Semantic Scholar
Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development
Kelly A. Bachovchin, Amrita Sharma, Seema Bag, Dana M. Klug +12 more
2018Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box against Intracellular Leishmania major Amastigotes
Mozna H. Khraiwesh, Susan E. Leed, N. Roncal, Jacob D. Johnson +7 more
2016American Journal of Tropical Medicine and Hygiene31 citations Open access
Semantic Scholar
EVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA
Jennifer L. Woodring, G. Patel, Jessey Erath, R. Behera +6 more
2014MedChemComm31 citations Open access
Semantic Scholar
Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria
Milica Videnović, Dejan M. Opsenica, J. Burnett, L. Gomba +9 more
2014Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?
N. Terzić, Jelena Konstantinović, Miklós Tot, Jovana Burojević +13 more
2016Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
Baljinder Singh, Jean A. Bernatchez, Laura-Isobel McCall, C. M. Calvet +20 more
2020ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity
Igor M. Opsenica, Miklós Tot, L. Gomba, J. Nuss +4 more
2013Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites
William G Devine, Sarah M. Thomas, Jessey Erath, Kelly A. Bachovchin +6 more
2017ACS Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice.
Igor M. Opsenica, Tatjana Ž Verbić, Miklós Tot, R. Sciotti +4 more
2015Bioorganic & Medicinal Chemistry23 citations
Semantic Scholar
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
D. Dorjsuren, Richard T. Eastman, K. Wicht, D. Jansen +26 more
2021Scientific Reports22 citations Open access
Semantic Scholar
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials
Rozalia A. Dodean, Papireddy Kancharla, Yue-Xin Li, V. Meléndez +35 more
2019Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Optimization of Physicochemical Properties for 4-Anilinoquinazoline Inhibitors of Trypanosome Proliferation
Jennifer L. Woodring, Kelly A. Bachovchin, Kimberly G. Brady, Mitchell F Gallerstein +7 more
2017European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Solid phase synthesis of ureas of secondary amines via carbamoyl chloride
Gary T. Wang, Yuanwei Chen, Sheldon Wang, R. Sciotti +1 more
199721 citations
Semantic Scholar
Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pf PI4KIIIβ).
K. Krishnan, Peter D. Ziniel, Hao Li, Xiu-Li Huang +21 more
2020ACS Pharmacology & Translational Science19 citations Open access
Semantic Scholar
Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners
Jelena Konstantinović, Milica Videnović, J. Srbljanović, O. Djurković-Djaković +3 more
2017Molecules19 citations Open access
Semantic Scholar
Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum.
E. Milner, Sean Gardner, J. Moon, K. Grauer +19 more
2011Journal of Medicinal Chemistry19 citations
Semantic Scholar
Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered In Vivo Screening Paradigm for Development of Drugs To Treat Cutaneous Leishmaniasis
Diana Caridha, Sandi Parriot, T. Hudson, T. Lang +10 more
2017Antimicrobial Agents and Chemotherapy18 citations Open access
Semantic Scholar
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy
E. Milner, J. Sousa, B. Pybus, Jennifer M. Auschwitz +18 more
2012European journal of drug metabolism and pharmacokinetics18 citations
Semantic Scholar
Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques
P. Vanachayangkul, R. Im-erbsin, Anchalee Tungtaeng, Chanikarn Kodchakorn +15 more
2020Antimicrobial Agents and Chemotherapy17 citations Open access
Semantic Scholar
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials
Papireddy Kancharla, Rozalia A. Dodean, Yue-Xin Li, S. Pou +38 more
2020Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever
S. Marcsisin, Xian-Nu Jin, T. Bettger, Nicholas McCulley +8 more
2013Malaria Journal17 citations Open access
Semantic Scholar
Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation
N. Mehta, Lori Ferrins, Susan E. Leed, R. Sciotti +1 more
2018ACS Infectious Diseases16 citations Open access
Semantic Scholar
Studies on the Synthesis of Chlorothricolide: Diastereo- and Enantioselective Syntheses of Model Top-Half Spirotetronate Units
W. Roush, R. Sciotti
199814 citations
Semantic Scholar
Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation.
Jennifer L. Woodring, R. Behera, Amrita Sharma, J. Wiedeman +12 more
2018ACS Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Anilinoquinoline based inhibitors of trypanosomatid proliferation
Lori Ferrins, Amrita Sharma, Sarah M. Thomas, N. Mehta +8 more
2018PLoS Neglected Tropical Diseases11 citations Open access
Semantic Scholar
Development of a p38 Kinase Binding Assay for High Throughput Screening
U. Warrior, X. Chiou, M. Sheets, R. Sciotti +8 more
1999Journal of biomolecular screening11 citations Open access
Semantic Scholar
Review: Drug Discovery Algorithm for Cutaneous Leishmaniasis
M. Grogl, M. Hickman, W. Ellis, T. Hudson +6 more
20139 citations
Semantic Scholar
Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus Infections
Sydney Drury, A. Miller, Clare L. Laut, Alec B. Walter +17 more
2021Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Structure-activity relationship (SAR): effort towards blocking N-glucuronidation of indazoles (PF-03376056) by human UGT1A enzymes.
K. Rose, Young-Sun Yang, R. Sciotti, H. Cai
2009Drug Metabolism Letters8 citations
Semantic Scholar

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