Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Y. Qian · SciRah

Researcher profile · Semantic Scholar

Y. Qian

Share profile

Y. Qian — researcher profile on SciRah

h-index: 33
Works: 79
Citations: 6,396

Most-cited papers

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
Jing Lu, Y. Qian, M. Altieri, Han-Qing Dong +7 more
2015Chemistry and Biology963 citations Open access
Semantic Scholar
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Kanak Raina, Jing Lu, Y. Qian, M. Altieri +10 more
2016Proceedings of the National Academy of Sciences of the United States of America732 citations Open access
Semantic Scholar
The Advantages of Targeted Protein Degradation over Inhibition: a RTK Case Study
G. Burslem, Blake E. Smith, Ashton C Lai, S. Jaime-Figueroa +9 more
2017Cell Chemical Biology571 citations Open access
Semantic Scholar
Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes (*)
Edwina C. Lerner, Y. Qian, M. Blaskovich, R. Fossum +6 more
1995Journal of Biological Chemistry380 citations Open access
Semantic Scholar
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
Edwina C. Lerner, Tingjun Zhang, David B. Knowles, Y. Qian +2 more
1997Oncogene248 citations
Semantic Scholar
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
Jia-Zhi Sun, Y. Qian, A. Hamilton, S. Sebti
1998Oncogene243 citations Open access
Semantic Scholar
MDM2-recruiting PROTAC Offers Superior, Synergistic Anti-proliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
J. Hines, Schan Lartigue, Han-Qing Dong, Y. Qian +1 more
2018Cancer Research239 citations Open access
Semantic Scholar
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
A. Crew, Kanak Raina, Han-Qing Dong, Y. Qian +11 more
2017Journal of Medicinal Chemistry208 citations Open access
Semantic Scholar
The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner*
A. Vogt, Jia-Zhi Sun, Y. Qian, A. Hamilton +1 more
1997Journal of Biological Chemistry205 citations Open access
Semantic Scholar
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
E. Bernhard, W. Mckenna, A. Hamilton, S. Sebti +3 more
1998Cancer Research197 citations
Semantic Scholar
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia.
M. J. Kelly, S. Pietranico-Cole, J. Douglas Larigan, Nancy-Ellen Haynes +15 more
2014Journal of Medicinal Chemistry188 citations Open access
Semantic Scholar
Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor(*)
Edwina C. Lerner, Y. Qian, A. Hamilton, S. Sebti
1995Journal of Biological Chemistry180 citations Open access
Semantic Scholar
Novel BET protein Proteolysis Targeting Chimera (BET-PROTAC) exerts superior lethal activity than Bromodomain Inhibitor (BETi) against post-myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells
Dyana T. Saenz, W. Fiskus, Y. Qian, T. Manshouri +17 more
2017Leukemia160 citations Open access
Semantic Scholar
p21WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA
J. Adnane, Francisco A. Bizouarn, Y. Qian, A. D. Hamilton +1 more
1998Molecular and Cellular Biology158 citations Open access
Semantic Scholar
BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against Mantle Cell Lymphoma cells
Baohua Sun, W. Fiskus, Y. Qian, K. Rajapakshe +14 more
2017Leukemia152 citations
Semantic Scholar
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
Karine Miquel, A. Pradines, Jia-Zhi Sun, Y. Qian +3 more
1997Cancer Research148 citations
Semantic Scholar
Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation*
T. Mcguire, Y. Qian, A. Vogt, A. Hamilton +1 more
1996Journal of Biological Chemistry119 citations Open access
Semantic Scholar
A Non-peptide Mimetic of Ras-CAAX: Selective Inhibition of Farnesyltransferase and Ras Processing (*)
A. Vogt, Y. Qian, M. Blaskovich, R. Fossum +2 more
1995Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Abstract P5-04-18: ARV-471, an oral estrogen receptor PROTAC degrader for breast cancer
J. Flanagan, Y. Qian, S. Gough, M. Andreoli +10 more
2019Poster Session Abstracts94 citations
Semantic Scholar
RUNX1 targeted therapy for AML expressing somatic or germline mutation in RUNX1.
Christopher P. Mill, W. Fiskus, C. Dinardo, Y. Qian +16 more
2019Blood87 citations Open access
Semantic Scholar
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
W. W. Stark, M. Blaskovich, Bruce A. Johnson, Y. Qian +5 more
1998American Journal of Physiology - Lung cellular and Molecular Physiology86 citations
Semantic Scholar
Inhibition of Protein Geranylgeranylation Causes a Superinduction of Nitric-oxide Synthase-2 by Interleukin-1β in Vascular Smooth Muscle Cells*
J. Finder, J. Litz, M. Blaskovich, T. Mcguire +4 more
1997Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
A. Vasudevan, Y. Qian, A. Vogt, M. Blaskovich +3 more
1999Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma
Xiao-Hui Zhang, Hans C. Lee, F. Shirazi, V. Baladandayuthapani +18 more
2018Leukemia76 citations Open access
Semantic Scholar
The Geranylgeranyltransferase I Inhibitor GGTI-298 Induces Hypophosphorylation of Retinoblastoma and Partner Switching of Cyclin-dependent Kinase Inhibitors
Jia-Zhi Sun, Y. Qian, Zhi Chen, J. Marfurt +2 more
1999Journal of Biological Chemistry62 citations Open access
Semantic Scholar
BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment.
S. Piya, H. Mu, Seemana Bhattacharya, P. Lorenzi +13 more
2019Journal of Clinical Investigation55 citations Open access
Semantic Scholar
Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.
Y. Qian, M. Hamilton, A. Sidduri, Stephen B. Gabriel +17 more
2012Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Abstract 44: The discovery of ARV-471, an orally bioavailable estrogen receptor degrading PROTAC for the treatment of patients with breast cancer
Lawrence B Snyder, J. Flanagan, Y. Qian, S. Gough +14 more
2021Experimental and Molecular Therapeutics54 citations
Semantic Scholar
Interdomain Interactions in the Tumor Suppressor Discs Large Regulate Binding to the Synaptic Protein GukHolder*
Y. Qian, K. Prehoda
2006Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Targeting Nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML
Dyana T. Saenz, W. Fiskus, T. Manshouri, Christopher P. Mill +20 more
2018Leukemia39 citations Open access
Semantic Scholar
Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells.
Yonglin Ren, Liang Guo, Xiaoyan Tang, S. Apparsundaram +11 more
2013Microvascular Research38 citations
Semantic Scholar
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
Y. Qian, S. Wertheimer, Mushtaq Ahmad, A. Cheung +19 more
2011Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Development of lysophosphatidic acid pathway modulators as therapies for fibrosis.
D. Budd, Y. Qian
2013Future Medicinal Chemistry34 citations
Semantic Scholar
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors.
Y. Qian, Mushtaq Ahmad, Shao-Qing Chen, P. Gillespie +10 more
2011Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators.
Y. Qian, D. Bolin, K. Conde-Knape, P. Gillespie +7 more
2013Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Junko Ohkanda, Jeffrey W. Lockman, M. Kothare, Y. Qian +3 more
2002Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Peptidomimetic inhibitors of p21ras farnesyltransferase: Hydrophobic functionalization leads to disruption of p21ras membrane association in whole cells
Y. Qian, M. Blaskovich, C. Seong, A. Vogt +2 more
199428 citations
Semantic Scholar
Deconstructing estradiol: removal of B-ring generates compounds which are potent and subtype-selective estrogen receptor agonists.
Muhammad Asim, Mohamed El-Salfiti, Y. Qian, Christine Choueiri +9 more
2009Bioorganic & Medicinal Chemistry Letters17 citations
Semantic Scholar
Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists.
A. Sidduri, D. Budd, M. Fuentes, T. Lambros +7 more
2014Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs.
Y. Qian, K. Conde-Knape, S. Erickson, F. Falcioni +7 more
2013Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes.
Y. Qian, W. L. Corbett, S. Berthel, D. Choi +14 more
2013ACS Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.
Wei-Ya Yun, Mushtaq Ahmad, Ying-Si Chen, P. Gillespie +8 more
2011Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
M. Kothare, Junko Ohkanda, Jeffrey W. Lockman, Y. Qian +3 more
200012 citations
Semantic Scholar
BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825, Causes Sustained Degradation of BRD4 and Modulation of Chemokine Receptors, Cell Adhesion and Metabolic Targets in Leukemia Resulting in Profound Anti-Leukemic Effects
S. Piya, Seemana Bhattacharya, H. Mu, P. Lorenzi +9 more
201611 citations
Semantic Scholar
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Junko Ohkanda, C. Strickland, M. Blaskovich, Dora Carrico +9 more
2006Organic and biomolecular chemistry10 citations
Semantic Scholar
Potent, selective MCH-1 receptor antagonists.
S. Erickson, B. Banner, S. Berthel, K. Conde-Knape +17 more
2008Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
W. W. Stark, M. Blaskovich, B. Johnson, Y. Qian +5 more
1998American Journal of Physiology8 citations
Semantic Scholar
Inhibitor GGTI-298 through a Transforming Growth Factor b- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA
J. Adnane, Francisco A. Bizouarn, Y. Qian, A. Hamilton +2 more
19987 citations
Semantic Scholar
BRD4 Degradation By Protacs Represents a More Effective Therapeutic Strategy Than BRD4 Inhibitors in DLBCL
Jing Lu, Y. Qian, Kanak Raina, M. Altieri +7 more
20155 citations Open access
Semantic Scholar
PROTAC BET degraders are more broadly effective than BET inhibitors
J. Winkler, Kanak Raina, M. Altieri, Han-Qing Dong +7 more
20164 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

S. Sebti×20
Invite
S. Sebti — researcher profile on SciRah
A. Hamilton×19
Invite
A. Hamilton — researcher profile on SciRah
C. Crews×15
Invite
C. Crews — researcher profile on SciRah
Kanak Raina×10
Invite
Kanak Raina — researcher profile on SciRah

×10

Invite

M. Blaskovich — researcher profile on SciRah

Invite

A. Crew — researcher profile on SciRah

Invite

K. Coleman — researcher profile on SciRah

Han-Qing Dong×7

Invite

Han-Qing Dong — researcher profile on SciRah

Invite

A. Vogt — researcher profile on SciRah

K. Conde-Knape×7

Invite

K. Conde-Knape — researcher profile on SciRah

Invite

Jia-Zhi Sun — researcher profile on SciRah

P. Gillespie×6

Invite

P. Gillespie — researcher profile on SciRah