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R. Ulrich · SciRah

Researcher profile · Semantic Scholar

R. Ulrich

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R. Ulrich — researcher profile on SciRah

h-index: 39
Works: 114
Citations: 8,539

Most-cited papers

Mapping the Genetic Architecture of Gene Expression in Human Liver
E. Schadt, C. Molony, E. Chudin, K. Hao +27 more
2008PLoS Biology1,067 citations Open access
Semantic Scholar
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.
B. Lannutti, Sarah A. Meadows, Sarah E. M. Herman, A. Kashishian +10 more
2011Blood777 citations Open access
Semantic Scholar
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia.
Jennifer R. Brown, J. Byrd, S. Coutre, D. Benson +15 more
2014Blood621 citations Open access
Semantic Scholar
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.
K. Glaser, M. Staver, J. Waring, Joshua D. Stender +2 more
2003Molecular Cancer Therapeutics561 citations
Semantic Scholar
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
B. Zinker, C. Rondinone, J. Trevillyan, R. Gum +18 more
2002Proceedings of the National Academy of Sciences of the United States of America406 citations Open access
Semantic Scholar
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
J. Waring, R. Jolly, R. Ciurlionis, P. Lum +6 more
2001Toxicology and Applied Pharmacology367 citations
Semantic Scholar
Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
T. Barf, T. Covey, R. Izumi, Bas van de Kar +11 more
2017Journal of Pharmacology and Experimental Therapeutics366 citations Open access
Semantic Scholar
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity.
J. Waring, R. Ciurlionis, R. Jolly, M. Heindel +1 more
2001Toxicology Letters321 citations
Semantic Scholar
Enhancement of adipocyte differentiation by an insulin-sensitizing agent.
R. F. Kletzien, S. Clarke, R. Ulrich
1992Molecular Pharmacology300 citations
Semantic Scholar
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Xia Yang, Bin Zhang, C. Molony, E. Chudin +15 more
2010Genome Research283 citations Open access
Semantic Scholar
Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma.
I. Flinn, B. Kahl, J. Leonard, R. Furman +14 more
2014Blood221 citations Open access
Semantic Scholar
Drug-induced phospholipidosis: issues and future directions
M. Reasor, K. Hastings, R. Ulrich
2006Expert Opinion on Drug Safety216 citations
Semantic Scholar
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
R. Gum, Lori L Gaede, Sandra L Koterski, M. Heindel +6 more
2003Diabetes203 citations Open access
Semantic Scholar
Toxicogenomics and drug discovery: will new technologies help us produce better drugs?
R. Ulrich, S. Friend
2002Nature reviews. Drug discovery183 citations
Semantic Scholar
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
C. Rondinone, J. Trevillyan, Jill E. Clampit, R. Gum +10 more
2002Diabetes166 citations
Semantic Scholar
Idiosyncratic toxicity: a convergence of risk factors.
R. Ulrich
2007Annual Review of Medicine128 citations
Semantic Scholar
Drug-induced corneal epithelial changes.
M. Raizman, P. Hamrah, E. Holland, Terry Kim +3 more
2017Survey of ophthalmology123 citations Open access
Semantic Scholar
The Bruton’s tyrosine kinase (BTK) inhibitor acalabrutinib demonstrates potent on-target effects and efficacy in two mouse models of chronic lymphocytic leukemia
Sarah E. M. Herman, A. Montraveta, C. Niemann, H. Mora-Jensen +16 more
2016Clinical Cancer Research119 citations Open access
Semantic Scholar
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice
A. D. De Souza, Xudong Dai, Andy G. Spencer, Tom W. Reppen +11 more
2006Nucleic Acids Research108 citations Open access
Semantic Scholar
Clinical Safety and Activity In a Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, In Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
B. Kahl, J. Byrd, I. Flinn, N. Wagner-Johnston +12 more
2010105 citations
Semantic Scholar
In vitro human tissue models in risk assessment: report of a consensus-building workshop.
J. Macgregor, J. Collins, Y. Sugiyama, C. Tyson +15 more
2001Toxicological Sciences99 citations Open access
Semantic Scholar
Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression.
D. Hartley, Xudong Dai, Yudong He, Edward J. Carlini +6 more
2004Molecular Pharmacology82 citations
Semantic Scholar
Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor.
J. Waring, R. Gum, D. Morfitt, R. Jolly +5 more
2002Toxicology82 citations
Semantic Scholar
Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression.
R. Ulrich, J. C. Rockett, G. Gibson, S. Pettit
2004Environmental Health Perspectives79 citations Open access
Semantic Scholar
Phase I study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia.
S. Coutre, John C. Byrd, R. Furman, Jennifer R. Brown +12 more
2011Journal of Clinical Oncology76 citations
Semantic Scholar
Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).
R. Gum, D. Hickman, Jane A. Fagerland, Matthew Heindel +5 more
2001Biochemical Pharmacology55 citations
Semantic Scholar
The impact of genomics-based technologies on drug safety evaluation.
J. Waring, R. Ulrich
2000Annual Review of Pharmacology and Toxicology52 citations
Semantic Scholar
Development of a DNA Microarray for Toxicology Based on Hepatotoxin-Regulated Sequences
J. Waring, G. Cavet, R. Jolly, J. Mcdowell +8 more
2002EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences51 citations Open access
Semantic Scholar
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
R. Gum, Lori L Gaede, M. Heindel, J. Waring +7 more
2003Molecular Endocrinology50 citations Open access
Semantic Scholar
Profiling of hepatic gene expression in rats treated with fibric acid analogs.
Paul D. Cornwell, A. D. De Souza, R. Ulrich
2004Mutation research48 citations
Semantic Scholar
PROFILING THE HEPATIC EFFECTS OF FLUTAMIDE IN RATS: A MICROARRAY COMPARISON WITH CLASSICAL ARYL HYDROCARBON RECEPTOR LIGANDS AND ATYPICAL CYP1A INDUCERS
K. Coe, S. Nelson, R. Ulrich, Yudong He +5 more
2006Drug Metabolism And Disposition47 citations
Semantic Scholar
Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle.
A. D. De Souza, Paul D. Cornwell, Xudong Dai, Michelle J. Caguyong +1 more
2006Toxicological Sciences46 citations
Semantic Scholar
Gene Expression Profiling of Multiple Histone Deacetylase ( HDAC ) Inhibitors : Defining a Common Gene Set Produced by HDAC Inhibition in T 24 and MDA Carcinoma Cell Lines
K. Glaser, M. Staver, J. Waring, Joshua D. Stender +2 more
200346 citations
Semantic Scholar
PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.
J. Waring, R. Ciurlionis, Jill E. Clampit, S. Morgan +9 more
2003Molecular and Cellular Endocrinology41 citations
Semantic Scholar
Identification of potential pharmacological and toxicological targets differentiating structural analogs by a combination of transcriptional profiling and promoter analysis in LS-180 and Caco-2 adenocarcinoma cell lines
D. Hartley, Xudong Dai, J. Yabut, X. Chu +7 more
2006Pharmacogenetics & Genomics40 citations
Semantic Scholar
A digitized-fluorescence-imaging study of mitochondrial Ca2+ increase by doxorubicin in cardiac myocytes.
E. Chacon, R. Ulrich, Daniel Acosta
1992Biochemical Journal40 citations Open access
Semantic Scholar
Molecular profiling approaches for identifying novel biomarkers.
Wendy J. Bailey, R. Ulrich
2004Expert Opinion on Drug Safety39 citations
Semantic Scholar
The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.
R. Sciotti, Marina A. Pliushchev, P. Wiedeman, D. Balli +7 more
2002Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome
J. G. Slatter, Ian E. Templeton, John C. Castle, Amit V. Kulkarni +7 more
2006Xenobiotica; the fate of foreign compounds in biological systems36 citations
Semantic Scholar
An in Vitro Fluorescence Assay for the Detection of Drug-Induced Cytoplasmic Lamellar Bodies
R. Ulrich, K. Kilgore, Elena L. Sun, C. Cramer +1 more
199136 citations
Semantic Scholar
Clinical Pharmacokinetics of CAL-101, a p110δ Isoform-Selective PI3K Inhibitor, Following Single- and Multiple-Dose Administration In Healthy Volunteers and Patients with Hematological Malignancies
H. K. Webb, Hao Chen, A. Yu, S. Peterman +4 more
201035 citations
Semantic Scholar
The toxicogenomics of nuclear receptor agonists.
R. Ulrich
2003Current Opinion in Chemical Biology35 citations
Semantic Scholar
Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status.
J. Waring, R. Ciurlionis, R. Jolly, M. Heindel +3 more
2003Toxicology in Vitro34 citations
Semantic Scholar
Evidence that the nonparenchymal cells of the liver are the principal source of cholesteryl ester transfer protein in primates.
M. Pape, R. Ulrich, T. Rea, K. Marotti +1 more
1991Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Insulin Secretory Defect in Zucker fa/fa Rats Is Improved by Ameliorating Insulin Resistance
C. D. de Souza, Jen H. Yu, D. D. Robinson, R. Ulrich +1 more
1995Diabetes33 citations
Semantic Scholar
Microvesicular Steatosis Induced by a Short Chain Fatty Acid: Effects on Mitochondrial Function and Correlation with Gene Expression
R. Jolly, R. Ciurlionis, D. Morfitt, M. Helgren +3 more
2004Toxicologic pathology (Print)31 citations Open access
Semantic Scholar
Combined BTK and PI3Kδ inhibition with acalabrutinib and ACP-319 improves survival and tumor control in CLL mouse model
C. Niemann, H. Mora-Jensen, Eman L. Dadashian, Fanny Krantz +8 more
2017Clinical Cancer Research30 citations Open access
Semantic Scholar
ACP-196 Is a Second Generation Inhibitor of Bruton Tyrosine Kinase (BTK) with Enhanced Target Specificity
Bonnie K. Harrington, Michael Gulrajani, T. Covey, A. Kaptein +7 more
201522 citations
Semantic Scholar
Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia.
P. Lum, Yudong He, J. G. Slatter, J. Waring +11 more
2007Genomics20 citations Open access
Semantic Scholar
Emerging technologies for accelerated toxicity evaluation of potential drug candidates.
M. D. Todd, R. Ulrich
1999Current opinion in drug discovery & development18 citations
Semantic Scholar

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J. Waring×14
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J. Waring — researcher profile on SciRah
B. Lannutti×8
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B. Lannutti — researcher profile on SciRah
R. Gum×8
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R. Gum — researcher profile on SciRah
R. Jolly×7
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R. Jolly — researcher profile on SciRah

×7

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Xudong Dai — researcher profile on SciRah

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J. Byrd — researcher profile on SciRah

R. Ciurlionis×6

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R. Ciurlionis — researcher profile on SciRah

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P. Lum — researcher profile on SciRah

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S. Peterman — researcher profile on SciRah

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A. Yu — researcher profile on SciRah

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B. Zinker — researcher profile on SciRah

C. Rondinone×5

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C. Rondinone — researcher profile on SciRah