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J. Schuetz · SciRah

Researcher profile · Semantic Scholar

J. Schuetz

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J. Schuetz — researcher profile on SciRah

h-index: 79
Works: 297
Citations: 26K

Most-cited papers

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma
Min Pan, William C. Wright, R. Chapple, Asif Zubair +26 more
2021Nature Communications79 citations Open access
Semantic Scholar
Expression and regulation of ABC transporter genes during liver regeneration
J. Ros, J. Schuetz, M. Geuken, K. Streetz +6 more
201879 citations
Semantic Scholar
Obstacles to Brain Tumor Therapy: Key ABC Transporters
Juwina Wijaya, Y. Fukuda, J. Schuetz
2017International Journal of Molecular Sciences76 citations Open access
Semantic Scholar
Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions
Rebecca R. Crawford, P. Potukuchi, E. Schuetz, J. Schuetz
2018Drug Metabolism And Disposition56 citations Open access
Semantic Scholar
Regulation of gene expression by miR-144/451 during mouse erythropoiesis.
Peng Xu, L. Palmer, Christophe Lechauve, Guowei Zhao +10 more
2019Blood49 citations Open access
Semantic Scholar
ABCB6, an ABC transporter impacting drug response and disease
Rebba C. Boswell-Casteel, Y. Fukuda, J. Schuetz
2017AAPS Journal48 citations Open access
Semantic Scholar
Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.
Y. Fukuda, Yao Wang, Shang-Li Lian, J. Lynch +10 more
2017JCI Insight48 citations Open access
Semantic Scholar
Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency
Jillian L. Ellis, K. Bove, Erin G. Schuetz, D. Leino +4 more
2018Hepatology46 citations Open access
Semantic Scholar
The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6
Y. Fukuda, P. Cheong, J. Lynch, Cheryl A. Brighton +13 more
2016Nature Communications44 citations Open access
Semantic Scholar
Maternal bile acid transporter deficiency promotes neonatal demise
Yuanyuan Zhang, Fei Li, Yao Wang, A. Pitre +10 more
2015Nature Communications40 citations Open access
Semantic Scholar
Linker domains: why ABC transporters ‘live in fragments no longer’.
R. Ford, Dominic Marshall-Sabey, J. Schuetz
2019TIBS -Trends in Biochemical Sciences. Regular ed38 citations Open access
Semantic Scholar
ABCG2 transporter expression impacts Group3 Medulloblastoma response to chemotherapy
Marie Morfouace, S. Cheepala, Sadhana Jackson, Y. Fukuda +8 more
2015Cancer Research38 citations Open access
Semantic Scholar
Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced Diarrhea*
Changsuk Moon, Wei-Qiang Zhang, Aixia Ren, K. Arora +11 more
2015Journal of Biological Chemistry34 citations Open access
Semantic Scholar
ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket
T. Gose, Talha Shafi, Y. Fukuda, Sourav Das +9 more
2020The FASEB Journal32 citations Open access
Semantic Scholar
ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression
C. D. Drenberg, S. Hu, L. Li, D. Buelow +5 more
2016Clinical and Translational Science31 citations Open access
Semantic Scholar
Investigation of the importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in the active efflux of anionic drugs across the blood–brain barrier
Kayoko Kanamitsu, H. Kusuhara, J. Schuetz, K. Takeuchi +1 more
2017Journal of Pharmacy and Science30 citations Open access
Semantic Scholar
Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumor growth and sensitizes to irinotecan in vivo
J. Murray, E. Valli, Denise M. T. Yu, Alan M Truong +17 more
2017European Journal of Cancer27 citations Open access
Semantic Scholar
A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer
T. Nakanishi, Y. Ohno, Rika Aotani, Shio Maruyama +6 more
2017Scientific Reports26 citations Open access
Semantic Scholar
An unexpected protein interaction promotes drug resistance in leukemia
A. Pitre, Y. Ge, Wen-Wei Lin, Yao Wang +16 more
2017Nature Communications25 citations Open access
Semantic Scholar
Leukemia and ABC Transporters
Y. Fukuda, Shang-Li Lian, J. Schuetz
2015Advances in Cancer Research23 citations Open access
Semantic Scholar
The imipridone ONC213 targets α-ketoglutarate dehydrogenase to induce mitochondrial stress and suppress oxidative phosphorylation in acute myeloid leukemia
Yongwei Su, J. Carter, Xinyu Li, Yu Fukuda +30 more
2024Cancer Research20 citations
Semantic Scholar
Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters
S. Ganguly, David B. Finkelstein, T. Shaw, Ryan D. Michalek +7 more
2021PLoS ONE20 citations Open access
Semantic Scholar
The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
Kaitlyn H. Smith, Amit Budhraja, J. Lynch, K. Roberts +7 more
2020Molecular Cancer Research20 citations Open access
Semantic Scholar
The net electrostatic potential and hydration of ABCG2 affect substrate transport
T. Gose, Heather M. Aitken, Yao Wang, J. Lynch +8 more
2023Nature Communications17 citations Open access
Semantic Scholar
Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice
V. Zoufal, S. Mairinger, M. Krohn, T. Wanek +8 more
2018Molecular Imaging and Biology17 citations Open access
Semantic Scholar
A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin
J. Lynch, Yao Wang, Yuxin Li, Kanisha Kavdia +7 more
2023Communications Biology16 citations Open access
Semantic Scholar
AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors
Domiziana Cecchini, AkshatKumar Nigam, Ming Tang, Joana C. Reis +43 more
2026bioRxiv15 citations Open access
Semantic Scholar
How Cryo-EM Has Expanded Our Understanding of Membrane Transporters
S. Baril, T. Gose, J. Schuetz
2023Drug Metabolism And Disposition11 citations Open access
Semantic Scholar
Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice.
Irene Hernández-Lozano, T. Wanek, M. Sauberer, T. Filip +6 more
2021European Journal of Pharmaceutical Sciences11 citations Open access
Semantic Scholar
Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity
Chengcheng Liu, L. Janke, Jun J. Yang, W. Evans +2 more
2017Cancer Chemotherapy and Pharmacology11 citations Open access
Semantic Scholar
Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length
Shariq S Ansari, M. Dillard, Yan Zhang, Mary Ashley Austria +13 more
2024Journal of Cell Biology9 citations Open access
Semantic Scholar
Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes
Ajay C. Donepudi, Yoojin Lee, Ji-Young Lee, J. Schuetz +1 more
2021The FASEB Journal9 citations Open access
Semantic Scholar
Development and validation of an LC-MS/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: application to cerebral microdialysis study
Sreenath Nair, Abigail D. Davis, O. Campagne, J. Schuetz +1 more
2021Journal of Pharmaceutical and Biomedical Analysis8 citations Open access
Semantic Scholar
Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death
Jessica A. Morgan, J. Lynch, J. Panetta, Yao Wang +8 more
2015Scientific Reports8 citations Open access
Semantic Scholar
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance
T. Gose, A. Rasouli, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen +7 more
2024Drug resistance updates7 citations
Semantic Scholar
ABCC4 Impacts Megakaryopoiesis and Protects Megakaryocytes against 6-Mercaptopurine Induced Cytotoxicity
Sabina Ranjit, Yao Wang, Jingwen Zhu, S. Cheepala +7 more
2023Drug resistance updates7 citations Open access
Semantic Scholar
Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study
Sreenath Nair, Abigail D. Davis, O. Campagne, J. Schuetz +1 more
2022Molecules7 citations Open access
Semantic Scholar
Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis
Xiujie Li-Harms, Jingjun Lu, Yu Fukuda, J. Lynch +15 more
2025Science Advances6 citations Open access
Semantic Scholar
The role of ATP-binding Cassette subfamily B member 6 in the inner ear
S. Baril, K. Wilson, M. Shaik, Yu Fukuda +16 more
2024Nature Communications6 citations Open access
Semantic Scholar
An ABC transporter drives the Sonic Hedgehog pathway contributing to medulloblastoma pathogenesis
Juwina Wijaya, BaoHan T. Vo, Jing-Jing Liu, Bei-Si Xu +9 more
2020Cancer Research6 citations Open access
Semantic Scholar
Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment
Juwina Wijaya, T. Gose, J. Schuetz
2020Pharmacological Reviews6 citations Open access
Semantic Scholar
Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity
Ajay C. Donepudi, Michael J. Goedken, J. Schuetz, J. Manautou
2019Toxicology Reports6 citations Open access
Semantic Scholar
Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis
Xiujie Li-Harms, Jingjun Lu, Yu Fukuda, J. Lynch +14 more
2024bioRxiv4 citations
Semantic Scholar
Lack of multidrug-resistance associated protein 4 prolongs partial hepatectomy-induced hepatic steatosis.
Ajay C. Donepudi, Gregory J. Smith, O. Aladelokun, Yoojin Lee +7 more
2020Toxicological Sciences4 citations Open access
Semantic Scholar
Heme Interaction with the Pyruvate Dehydrogenase Complex: A Novel Strategy to Promote Hypoxic Survival
J. Lynch, Y. Fukuda, Partha Krishnamurthy, Juwina Wijaya +11 more
2019The FASEB Journal4 citations
Semantic Scholar
Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles
Carla O'Reilly, Ji-Hoon Cho, Qian Qi, Jennifer L. Peters +7 more
2019Experimental Cell Research4 citations Open access
Semantic Scholar
Sonic Hedgehog Activates Prostaglandin Signaling to Stabilize Primary Cilium Length
S. Ansari, M. Dillard, Yan Zhang, Mary Ashley Austria +8 more
2023bioRxiv3 citations Open access
Semantic Scholar
"OMICs" reveal the molecular basis of a rare blood group.
J. Schuetz
2020Blood2 citations Open access
Semantic Scholar
AI-enhanced adaptive virtual screening of large libraries for ligand discovery.
Domiziana Cecchini, AkshatKumar Nigam, Ming Tang, Joana C. Reis +44 more
2026Nature Biotechnology1 citations Open access
Semantic Scholar
Protein Kinase A and assembly of an ABCC4 protein network
Jing-Wen Zhu, Sabina Ranjit, T. Gose, Amanda Nourse +10 more
2025Nature Communications1 citations Open access
Semantic Scholar

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