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J. Manautou · SciRah

Researcher profile · Semantic Scholar

J. Manautou

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J. Manautou — researcher profile on SciRah

h-index: 44
Works: 167
Citations: 6,618

Most-cited papers

The growth of siRNA-based therapeutics: updated clinical studies
M. Zhang, R. Bahal, T. Rasmussen, J. Manautou +1 more
2021Biochemical Pharmacology419 citations Open access
Semantic Scholar
ACETAMINOPHEN; FROM LIVER TO BRAIN: NEW INSIGHTS INTO DRUG PHARMACOLOGICAL ACTION AND TOXICITY
C. Ghanem, M. Pérez, J. Manautou, A. Mottino
2016Pharmacological Research339 citations Open access
Semantic Scholar
Molecular mechanisms underlying chemical liver injury
Xin-Sheng Gu, J. Manautou
2012Expert Reviews in Molecular Medicine318 citations Open access
Semantic Scholar
Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease
Rhiannon N. Hardwick, Daniel W. Ferreira, Vijay R More, April D. Lake +4 more
2013Drug Metabolism And Disposition117 citations Open access
Semantic Scholar
Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu +4 more
2022Drug Metabolism And Disposition109 citations Open access
Semantic Scholar
Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2
Liming Chen, J. Manautou, T. Rasmussen, Xiao-Bo Zhong
2019Acta Pharmaceutica Sinica B66 citations Open access
Semantic Scholar
Green Tea Extract Provides Extensive Nrf2-Independent Protection Against Lipid Accumulation and NFκB Pro- Inflammatory Responses During Nonalcoholic Steatohepatitis In Mice Fed A High-Fat Diet
Jinhui Li, Teryn N. Sapper, E. Mah, Swetha Rudraiah +7 more
2016Molecular Nutrition & Food Research65 citations Open access
Semantic Scholar
Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.
X. Wen, B. Buckley, E. Mccandlish, Michael J. Goedken +4 more
2014American Journal of Pathology63 citations Open access
Semantic Scholar
Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
Julia M. Migliorati, Sun-Na Liu, A. Liu, Anagha Gogate +5 more
2022Drug Metabolism And Disposition62 citations Open access
Semantic Scholar
Altered Regulation of Hepatic Efflux Transporters Disrupts Acetaminophen Disposition in Pediatric Nonalcoholic Steatohepatitis
M. Canet, M. Merrell, Rhiannon N. Hardwick, A. Bataille +7 more
2015Drug Metabolism And Disposition62 citations Open access
Semantic Scholar
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Sheyda Ranjbar, Xiao-Bo Zhong, J. Manautou, Xiu-Ling Lu
2023Advanced Drug Delivery Reviews55 citations Open access
Semantic Scholar
Mechanisms of Action of the US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs
Angela Sang, S. Zhuo, Adara Bochanis, J. Manautou +3 more
2024BioDrugs51 citations Open access
Semantic Scholar
Nedosiran, a Candidate siRNA Drug for the Treatment of Primary Hyperoxaluria: Design, Development, and Clinical Studies.
A. Liu, Jenny Zhao, Milan Shah, Julia M. Migliorati +5 more
2022ACS Pharmacology & Translational Science46 citations Open access
Semantic Scholar
Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver
Yifan Bao, Pei Wang, Xueyan Shao, Jun-Jie Zhu +7 more
2020Drug Metabolism And Disposition43 citations Open access
Semantic Scholar
Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells.
Yue Yang, Minkyung Bae, Young-Ki Park, Yoojin Lee +5 more
2017Journal of Nutritional Biochemistry42 citations Open access
Semantic Scholar
CYP2E1-Dependent and Leptin-Mediated Hepatic CD57 Expression on CD8+ve T Cells aid Progression of Environment-Linked Nonalcoholic Steatohepatitis
R. Seth, Suvarthi Das, Ashutosh Kumar, Anindya Chanda +5 more
2013Toxicology and Applied Pharmacology38 citations Open access
Semantic Scholar
Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice.
C. Ghanem, Swetha Rudraiah, A. Bataille, Maria Vigo +2 more
2015Biochemical Pharmacology33 citations Open access
Semantic Scholar
Is Nuclear Factor Erythroid 2–Related Factor 2 Responsible for Sex Differences in Susceptibility to Acetaminophen-Induced Hepatotoxicity in Mice?
Philip R. Rohrer, Swetha Rudraiah, Michael J. Goedken, J. Manautou
2014Drug Metabolism And Disposition33 citations Open access
Semantic Scholar
Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments.
E. Agathokleous, D. Barceló, M. Aschner, R. Azevedo +35 more
2022Environmental Science and Technology32 citations Open access
Semantic Scholar
Nephrotoxicity of marketed antisense oligonucleotide drugs
Hangyu Wu, Aniket Wahane, Feryal Alhamadani, Kristy Zhang +7 more
2022Current Opinion in Toxicology31 citations Open access
Semantic Scholar
Reduced in vivo toxicity of doxorubicin by encapsulation in cholesterol-containing self-assembled nanoparticles.
Laura González-Fajardo, Lalit H. Mahajan, Dennis Ndaya, Derek Hargrove +5 more
2016Pharmacological Research30 citations
Semantic Scholar
Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions.
Daniel W. Ferreira, P. Naquet, J. Manautou
2015Current Medicinal Chemistry30 citations
Semantic Scholar
Faculty Opinions recommendation of Role of bile acids in liver injury and regeneration following acetaminophen overdose.
J. Manautou
201629 citations
Semantic Scholar
Enhanced Hepatotoxicity by Acetaminophen in Vanin-1 Knockout Mice is Associated with Deficient Proliferative and Immune Responses
Daniel W. Ferreira, Michael J. Goedken, Samuel Rommelaere, Lionel Chasson +3 more
2016Biochimica et Biophysica Acta28 citations Open access
Semantic Scholar
Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.
Swetha Rudraiah, Philip R. Rohrer, Igor Gurevich, Michael J. Goedken +3 more
2014Toxicological Sciences28 citations Open access
Semantic Scholar
Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America
S. Offor, C. Amadi, I. Chijioke-Nwauche, J. Manautou +1 more
2022Toxicology Reports27 citations Open access
Semantic Scholar
The Gut Microbiome and Xenobiotics: Identifying Knowledge Gaps.
V. Sutherland, C. Mcqueen, D. Mendrick, D. Gulezian +13 more
2020Toxicological Sciences27 citations Open access
Semantic Scholar
Emerging Therapeutic Modalities against COVID-19
Shipra Malik, Anisha Gupta, Xiao-Bo Zhong, T. Rasmussen +2 more
2020Pharmaceuticals26 citations Open access
Semantic Scholar
Antioxidant fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. induce nuclear translocation of Nrf2 in HC-04 cells
F. Njayou, A. Amougou, Romeo Fouemene Tsayem, Jacqueline Njikam Manjia +4 more
2015Cell stress & chaperones (Print)26 citations Open access
Semantic Scholar
Analysis of Changes in Hepatic Gene Expression in a Murine Model of Tolerance to Acetaminophen Hepatotoxicity (Autoprotection)
M. O'Connor, P. Koza-Taylor, S. Campion, L. Aleksunes +4 more
2013Toxicology and Applied Pharmacology26 citations Open access
Semantic Scholar
Cholesterol-Secreting and Statin-Responsive Hepatocytes from Human ES and iPS Cells to Model Hepatic Involvement in Cardiovascular Health
W. Krueger, Borko Tanasijevic, Vanessa Barber, A. Flamier +3 more
2013PLoS ONE25 citations Open access
Semantic Scholar
Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells
Liming Chen, Pei Wang, J. Manautou, Xiao-Bo Zhong
2020Molecular Pharmacology24 citations Open access
Semantic Scholar
Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics.
C. Ghanem, J. Manautou
2019Current Medicinal Chemistry23 citations
Semantic Scholar
Differential Fmo3 Gene Expression in Various Liver Injury Models Involving Hepatic Oxidative Stress in Mice
Swetha Rudraiah, Jamie E. Moscovitz, Ajay C. Donepudi, S. Campion +3 more
2014Toxicology23 citations Open access
Semantic Scholar
Alterations of Cytochrome P450–Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice
Yifan Bao, M. Phan, Jun-Jie Zhu, Xiaochao Ma +2 more
2021Drug Metabolism And Disposition22 citations Open access
Semantic Scholar
Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin
Anagha Gogate, Jordyn Belcourt, Milan Shah, A. Wang +11 more
2023Pharmacological Reviews21 citations Open access
Semantic Scholar
Casimersen for the treatment of Duchenne muscular dystrophy.
S. Zakeri, S. P. Pradeep, V. Kasina, A. Laddha +2 more
2022TIPS - Trends in Pharmacological Sciences21 citations
Semantic Scholar
Gender-Specific Expression of ATP-binding Cassette (Abc) Transporters and Cytoprotective Genes in Mouse Choroid Plexus
Katiria Flores, J. Manautou, J. Renfro
2017Toxicology20 citations Open access
Semantic Scholar
Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac
R. Scialis, I. Csanaky, Michael J. Goedken, J. Manautou
2015Drug Metabolism And Disposition19 citations Open access
Semantic Scholar
Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to d-lactate
Christopher Masterjohn, E. Mah, Youngki Park, Rui-Song Pei +3 more
2013Experimental biology and medicine19 citations
Semantic Scholar
Multivalent Lactobionic Acid and N-Acetylgalactosamine-conjugated Peptide Nucleic Acids for Efficient in vivo Targeting of Hepatocytes
Vikas Kumar, Aniket Wahane, Anisha Gupta, J. Manautou +1 more
2023Advanced Healthcare Materials18 citations
Semantic Scholar
Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver
Liming Chen, Pei Wang, R. Bahal, J. Manautou +1 more
2019PLoS ONE18 citations Open access
Semantic Scholar
Rubescins A, B and C: new havanensin type limonoids from root bark of Trichilia rubescens (Meliaceae).
Armelle Tsamo Tontsa, P. Mkounga, F. Njayou, J. Manautou +3 more
2013Chemical and pharmaceutical bulletin18 citations Open access
Semantic Scholar
Acute Acetaminophen Intoxication Induces Direct Neurotoxicity in Rats Manifested as Astrogliosis and Decreased Dopaminergic Markers in Brain Areas Associated With Locomotor Regulation.
Maria Vigo, M. Pérez, Fernanda De Fino, G. Gomez +6 more
2019Biochemical Pharmacology15 citations
Semantic Scholar
Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity
R. Scialis, J. Manautou
2016Journal of Pharmacology and Experimental Therapeutics15 citations Open access
Semantic Scholar
The antitripanocide Benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)
J. P. Rigalli, V. Perdomo, Nadia Ciriaci, D. Antonio +8 more
201615 citations
Semantic Scholar
Impact of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) on the expression and function of hepatobiliary transporters: A comprehensive mechanistic review.
Ankit P. Laddha, Lindsey Dzielak, Cedric Lewis, Raymond Xue +1 more
2024Biochimica et Biophysica Acta - Molecular Basis of Disease12 citations Open access
Semantic Scholar
Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice
Gregory J. Smith, J. Cichocki, Bennett Doughty, J. Manautou +2 more
2015Environmental Health Perspectives12 citations Open access
Semantic Scholar
Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2–Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury
Ankit P. Laddha, Hang-Yu Wu, J. Manautou
2024Drug Metabolism And Disposition11 citations Open access
Semantic Scholar
Role and Regulation of Hepatobiliary ATP-Binding Cassette Transporters during Chemical-Induced Liver Injury
C. Ghanem, J. Manautou
2022Drug Metabolism And Disposition11 citations Open access
Semantic Scholar

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Xiao-Bo Zhong×10
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Xiao-Bo Zhong — researcher profile on SciRah
R. Bahal×9
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R. Bahal — researcher profile on SciRah
T. Rasmussen×7
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T. Rasmussen — researcher profile on SciRah
Swetha Rudraiah×7
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Swetha Rudraiah — researcher profile on SciRah

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C. Ghanem — researcher profile on SciRah

Michael J. Goedken×6

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Michael J. Goedken — researcher profile on SciRah

Daniel W. Ferreira×4

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Daniel W. Ferreira — researcher profile on SciRah

Theodore P. Rasmussen×4

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Theodore P. Rasmussen — researcher profile on SciRah

Xin-Sheng Gu×3

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Xin-Sheng Gu — researcher profile on SciRah

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Liming Chen — researcher profile on SciRah

Philip R. Rohrer×3

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Philip R. Rohrer — researcher profile on SciRah

L. Aleksunes×3

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L. Aleksunes — researcher profile on SciRah