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S. Urban · SciRah

Researcher profile · Semantic Scholar

S. Urban

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S. Urban — researcher profile on SciRah

h-index: 35
Works: 73
Citations: 5,233

Most-cited papers

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.
S. Urban, J. R. Lee, M. Freeman
2001Cell590 citations Open access
Semantic Scholar
Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila.
J. R. Lee, S. Urban, Clare Garvey, M. Freeman
2001Cell384 citations Open access
Semantic Scholar
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.
S. Urban, M. Freeman
2003Molecules and Cells257 citations Open access
Semantic Scholar
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
Zhuoru Wu, N. Yan, Liang Feng, A. Oberstein +6 more
2006Nature Structural &Molecular Biology251 citations
Semantic Scholar
A family of Rhomboid intramembrane proteases activates all Drosophila membrane‐tethered EGF ligands
S. Urban, J. R. Lee, M. Freeman
2002EMBO Journal245 citations Open access
Semantic Scholar
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma.
F. Brossier, T. Jewett, L. Sibley, S. Urban
2005Proceedings of the National Academy of Sciences of the United States of America230 citations Open access
Semantic Scholar
Two Plasmodium Rhomboid Proteases Preferentially Cleave Different Adhesins Implicated in All Invasive Stages of Malaria
Rosanna P. Baker, R. Wijetilaka, S. Urban
2006PLoS Pathogens226 citations Open access
Semantic Scholar
A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.
J. Wasserman, S. Urban, Matthew Freeman
2000Genes & Development199 citations Open access
Semantic Scholar
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity.
S. Urban, M. Wolfe
2005Proceedings of the National Academy of Sciences of the United States of America193 citations Open access
Semantic Scholar
Membrane Protein Structure, Function and Dynamics: A Perspective from Experiments and Theory
Z. Cournia, T. Allen, I. Andricioaei, B. Antonny +25 more
2015Journal of Membrane Biology190 citations Open access
Semantic Scholar
Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids.
O. Lohi, S. Urban, M. Freeman
2004Current Biology167 citations Open access
Semantic Scholar
Intramembrane proteolysis controls diverse signalling pathways throughout evolution.
S. Urban, M. Freeman
2002Current Opinion in Genetics and Development157 citations
Semantic Scholar
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate
Rosanna P. Baker, Keith E. Young, Liang Feng, Yi-Gong Shi +1 more
2007Proceedings of the National Academy of Sciences of the United States of America150 citations Open access
Semantic Scholar
Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids.
S. Urban, D. Schlieper, M. Freeman
2002Current Biology138 citations Open access
Semantic Scholar
Rhomboid proteins: conserved membrane proteases with divergent biological functions.
S. Urban
2006Genes & Development135 citations Open access
Semantic Scholar
Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity
S. Dickey, Rosanna P. Baker, Sangwoo Cho, S. Urban
2013Cell128 citations Open access
Semantic Scholar
Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms
S. Urban
2009Nature Reviews Microbiology112 citations Open access
Semantic Scholar
Architectural and thermodynamic principles underlying intramembrane protease function
Rosanna P. Baker, S. Urban
2012Nature Chemical Biology105 citations Open access
Semantic Scholar
Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics
Syed M. Moin, S. Urban
2012eLife101 citations Open access
Semantic Scholar
An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion.
Leigh A. Baxt, Rosanna P. Baker, Upinder Singh, S. Urban
2008Genes & Development100 citations Open access
Semantic Scholar
Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion
Alex J. B. Kreutzberger, Ming Ji, J. Aaron, Ljubica Mihaljević +1 more
2019Science88 citations Open access
Semantic Scholar
The rhomboid protease family: a decade of progress on function and mechanism
S. Urban, S. Dickey
2011Genome Biology86 citations Open access
Semantic Scholar
Lack of correlation between ATM protein expression and tumour cell radiosensitivity.
D. W. Chan, D. Gately, S. Urban, A. Galloway +3 more
1998International Journal of Radiation Biology75 citations
Semantic Scholar
Crystal structures and inhibition kinetics reveal a two-stage catalytic mechanism with drug design implications for rhomboid proteolysis
Sangwoo Cho, S. Dickey, S. Urban
2016Molecules and Cells71 citations Open access
Semantic Scholar
An Arabidopsis Rhomboid homolog is an intramembrane protease in plants
M. Kanaoka, S. Urban, M. Freeman, K. Okada
2005FEBS Letters68 citations Open access
Semantic Scholar
Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis
S. Urban
2010Biochemical Journal67 citations Open access
Semantic Scholar
Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
Wojciech Paslawski, O. Lillelund, Juliette Kristensen, N. Schafer +3 more
2015Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
Semantic Scholar
A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells
A. Riestra, Shiv K Gandhi, M. Sweredoski, A. Moradian +3 more
2015PLoS Pathogens59 citations Open access
Semantic Scholar
Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication
Fabiola Parussini, Qing Tang, Syed M. Moin, J. Mital +2 more
2012Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells
S. Urban, Rosanna P. Baker
2008Biological chemistry42 citations Open access
Semantic Scholar
A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP
Jiwon Hwang, Diedre Ribbens, S. Raychaudhuri, L. Cairns +4 more
2016EMBO Journal41 citations Open access
Semantic Scholar
An Internal Water-Retention Site in the Rhomboid Intramembrane Protease GlpG Ensures Catalytic Efficiency
Yan-Zi Zhou, Syed M. Moin, S. Urban, Ying-Kai Zhang
2012Structure40 citations Open access
Semantic Scholar
Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating
Rosanna P. Baker, S. Urban
2015Nature39 citations Open access
Semantic Scholar
Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases.
S. Urban, Yi-Gong Shi
2008Current Opinion in Structural Biology39 citations Open access
Semantic Scholar
Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells.
A. Catania, S. Urban, Elizabeth Yan, C. Hao +2 more
2001Neuro-Oncology39 citations Open access
Semantic Scholar
EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development
S. Urban, Gemma Brown, M. Freeman
2004Development35 citations Open access
Semantic Scholar
Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release
Sangwoo Cho, Rosanna P. Baker, Ming Ji, S. Urban
2019Nature Structural & Molecular Biology32 citations Open access
Semantic Scholar
Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism
S. Urban, S. Urban, K. Fischer, D. Tyrrell
2001Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
A subset of membrane-altering agents and γ-secretase modulators provoke non-substrate cleavage by rhomboid proteases
S. Urban, Syed M. Moin
2014Cell Reports24 citations Open access
Semantic Scholar
Mechanisms and cellular functions of intramembrane proteases.
S. Urban
2013Biochimica et Biophysica Acta24 citations Open access
Semantic Scholar
Proinflammatory and prothrombotic effects on human vascular endothelial cells of Immune-cell-derived LIGHT
S. Çelik, Vijay Shankar, A. Richter, H. Hippe +8 more
2009European Journal of Medical Research22 citations Open access
Semantic Scholar
Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail
Shruthi Krishnamurthy, Bin Deng, R. del Río, Kerry R. Buchholz +5 more
2016mBio19 citations Open access
Semantic Scholar
Designed parasite-selective rhomboid inhibitors block invasion and clear blood-stage malaria
Shiv K Gandhi, Rosanna P. Baker, Sangwoo Cho, S. Stanchev +2 more
2020Cell Chemical Biology18 citations Open access
Semantic Scholar
An aminopepetidase in the Drosophila testicular niche acts in germline stem cell maintenance and spermatogonial dedifferentiation
C. Lim, Shiv K Gandhi, M. Biniossek, Li-Juan Feng +3 more
2015Cell Reports17 citations Open access
Semantic Scholar
Nicastrin guards Alzheimer’s gate
S. Urban
2016Proceedings of the National Academy of Sciences of the United States of America14 citations Open access
Semantic Scholar
SnapShot: Cartography of Intramembrane Proteolysis.
S. Urban
2016Cell13 citations Open access
Semantic Scholar
Decoding the Functional Evolution of an Intramembrane Protease Superfamily by Statistical Coupling Analysis
Ljubica Mihaljević, S. Urban
2020Structure12 citations Open access
Semantic Scholar
A guide to the rhomboid protein superfamily in development and disease.
S. Urban
2016Seminars in Cell and Developmental Biology12 citations
Semantic Scholar
Single-Molecule Analyses Reveal Rhomboid Proteins Are Strict and Functional Monomers in the Membrane.
Alex J. B. Kreutzberger, S. Urban
2018Biophysical Journal11 citations Open access
Semantic Scholar
KOMPEITO, an Atypical Arabidopsis Rhomboid-Related Gene, Is Required for Callose Accumulation and Pollen Wall Development
M. Kanaoka, K. Shimizu, Bo Xie, S. Urban +3 more
2022International Journal of Molecular Sciences10 citations Open access
Semantic Scholar

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