Yi-Gong Shi

Most-cited papers

Molecular Architecture of the SARS-CoV-2 Virus
H. Yao, Yutong Song, Yong Chen, N. Wu +14 more
2020bioRxiv949 citations Open access
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Sampling the conformational space of the catalytic subunit of human γ-secretase
Xiao-Chen Bai, E. Rajendra, Guanghui Yang, Yi-Gong Shi +1 more
2015bioRxiv549 citations Open access
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An atomic structure of human γ-secretase
Xiao-Chen Bai, Chuangye Yan, Guanghui Yang, P. Lu +5 more
2015Nature491 citations Open access
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Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution
Zhen Yan, Xiao-Chen Bai, Chuangye Yan, Jian-Ping Wu +8 more
2014Nature387 citations Open access
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Mechanistic insights into precursor messenger RNA splicing by the spliceosome
Yi-Gong Shi
2017Nature reviews. Molecular cell biology360 citations
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PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling.
Xia Lin, Xue-Yan Duan, Yao-Yun Liang, Ying Su +10 more
2016Cell343 citations Open access
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Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
Lin-Feng Sun, R. Zhou, Guanghui Yang, Yi-Gong Shi
2016Proceedings of the National Academy of Sciences of the United States of America332 citations Open access
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Structure of a yeast spliceosome at 3.6-angstrom resolution
Chuangye Yan, Jing Hang, R. Wan, Min Huang +2 more
2015Science332 citations
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Three-dimensional structure of human γ-secretase
P. Lu, Xiao-Chen Bai, D. Ma, T. Xie +7 more
2014Nature330 citations Open access
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A glimpse of structural biology through X-ray crystallography.
Yi-Gong Shi
2014Cell320 citations Open access
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Recognition of the amyloid precursor protein by human γ-secretase
R. Zhou, Guanghui Yang, Xue-Fei Guo, Qiang Zhou +2 more
2019Science267 citations
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Structure of a yeast activated spliceosome at 3.5 Å resolution
Chuangye Yan, R. Wan, R. Bai, Gaoxingyu Huang +1 more
2016Science253 citations
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An Atomic Structure of the Human Spliceosome.
Xiaofeng Zhang, Chuangye Yan, Jing Hang, L. Finci +2 more
2017Cell242 citations Open access
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Structural and functional diversity calls for a new classification of ABC transporters
C. Thomas, S. Aller, K. Beis, E. Carpenter +39 more
2020FEBS Letters240 citations Open access
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Structure of the human PKD1-PKD2 complex
Q. Su, Feizhuo Hu, Xiaofei Ge, Jianlin Lei +5 more
2018Science239 citations
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An atomic structure of the human 26S proteasome
Xiuliang Huang, B. Luan, Jian-Ping Wu, Yi-Gong Shi
2016Nature Structural &Molecular Biology232 citations
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Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1
Mengying Zhou, Yi-Ni Li, Qi Hu, Xiao-Chen Bai +4 more
2015Genes & Development231 citations Open access
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Structural basis of Notch recognition by human γ-secretase
Guanghui Yang, R. Zhou, Qiang Zhou, Xue-Fei Guo +4 more
2018Nature217 citations
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Structure of the human activated spliceosome in three conformational states
Xiaofeng Zhang, Chuangye Yan, X. Zhan, Lijia Li +2 more
2018Cell Research196 citations Open access
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Structural basis of pre-mRNA splicing
Jing Hang, R. Wan, Chuangye Yan, Yi-Gong Shi
2015Science185 citations
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Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution
R. Wan, Chuangye Yan, R. Bai, Gaoxingyu Huang +1 more
2016Science178 citations
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Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models
C. Benetatos, Y. Mitsuuchi, J. Burns, E. Neiman +17 more
2014Molecular Cancer Therapeutics168 citations Open access
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The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
R. Wan, Chuangye Yan, R. Bai, Lin Wang +3 more
2016Science157 citations
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Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome.
Chuangye Yan, R. Wan, Yi-Gong Shi
2019Cold Spring Harbor Perspectives in Biology155 citations Open access
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Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.
S. Condon, Y. Mitsuuchi, Yi-Jun Deng, M. Laporte +25 more
2014Journal of Medicinal Chemistry154 citations
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Structural basis of γ-secretase inhibition and modulation by small molecule drugs.
Guanghui Yang, R. Zhou, Xue-Fei Guo, Chuangye Yan +2 more
2020Cell145 citations Open access
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How Is Precursor Messenger RNA Spliced by the Spliceosome?
R. Wan, R. Bai, X. Zhan, Yi-Gong Shi
2019Annual Review of Biochemistry145 citations
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Structure of a human catalytic step I spliceosome
X. Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei +1 more
2018Science142 citations
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Structure of a yeast step II catalytically activated spliceosome
Chuangye Yan, R. Wan, R. Bai, Gaoxingyu Huang +1 more
2017Science132 citations
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Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme
Yi-Ni Li, Mengying Zhou, Qi Hu, Xiao-Chen Bai +3 more
2017Proceedings of the National Academy of Sciences of the United States of America125 citations Open access
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Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis
Gaoxingyu Huang, Yanqing Zhang, Xue-Chen Zhu, Chao Zeng +7 more
2020Cell Research116 citations Open access
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Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
Qi Hu, Di Wu, Wen Chen, Zhen Yan +4 more
2014Proceedings of the National Academy of Sciences of the United States of America113 citations Open access
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Structures of the human pre-catalytic spliceosome and its precursor spliceosome
X. Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei +1 more
2018Cell Research106 citations Open access
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Structural basis of human γ-secretase assembly
Lin-Feng Sun, Lingyun Zhao, Guanghui Yang, Chuangye Yan +7 more
2015Proceedings of the National Academy of Sciences of the United States of America104 citations Open access
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Recognition of the Amyloid Precursor Protein by Human gamma-secretase
R. Zhou, G.-H. Yang, Xue-Fei Guo, Qiang Zhou +2 more
201995 citations
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Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae.
R. Wan, Chuangye Yan, R. Bai, Jianlin Lei +1 more
2017Cell94 citations Open access
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Structures of the human spliceosomes before and after release of the ligated exon
Xiaofeng Zhang, X. Zhan, Chuangye Yan, Wenyu Zhang +3 more
2018Cell Research90 citations Open access
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Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae.
R. Bai, Chuangye Yan, R. Wan, Jianlin Lei +1 more
2017Cell88 citations Open access
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Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation
R. Bai, R. Wan, Chuangye Yan, Jianlin Lei +1 more
2018Science87 citations
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Structure of the activated human minor spliceosome
R. Bai, R. Wan, Lin Wang, Kui Xu +3 more
2021Science85 citations
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The Spliceosome: A Protein-Directed Metalloribozyme.
Yi-Gong Shi
2017Journal of Molecular Biology85 citations Open access
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Structure of an endogenous yeast 26S proteasome reveals two major conformational states
B. Luan, Xiuliang Huang, Jian-Ping Wu, Z. Mei +7 more
2016Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
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Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching
R. Wan, R. Bai, Chuangye Yan, Jianlin Lei +1 more
2018bioRxiv81 citations Open access
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Classification and nomenclature of metacaspases and paracaspases: no more confusion with caspases
E. A. Minina, J. Staal, V. E. Alvarez, J. A. Berges +44 more
2020Molecules and Cells75 citations Open access
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Cryo-EM structure of gamma secretase in complex with a Notch fragment
G.-H. Yang, R. Zhou, Qiang Zhou, Xue-Fei Guo +4 more
201875 citations
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Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state
Xi Zhang, Qifan Wang, Jian-Ping Wu, Jia-Wei Wang +2 more
2018Proceedings of the National Academy of Sciences of the United States of America72 citations Open access
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Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
P. Lu, D. Ma, Chuangye Yan, Xin-Qi Gong +2 more
2014Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
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Crystal structure of the γ-secretase component nicastrin
T. Xie, Chuangye Yan, R. Zhou, Yan-Yu Zhao +5 more
2014Proceedings of the National Academy of Sciences of the United States of America65 citations Open access
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Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex
Yanqing Zhang, Sai Li, Chao Zeng, Gaoxingyu Huang +11 more
2020Cell Research61 citations Open access
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Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx
T. Jiang, Minhao Liu, Jian-Ping Wu, Yi-Gong Shi
2016Proceedings of the National Academy of Sciences of the United States of America61 citations Open access
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