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R. Blanqué · SciRah

Researcher profile · Semantic Scholar

R. Blanqué

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R. Blanqué — researcher profile on SciRah

h-index: 16
Works: 37
Citations: 963

Most-cited papers

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.
K. Aoki, H. Saito, C. Itzstein, M. Ishiguro +13 more
2006Journal of Clinical Investigation134 citations Open access
Semantic Scholar
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fib
N. Desroy, Christopher Housseman, Xavier Bock, A. Joncour +26 more
2017Journal of Medicinal Chemistry125 citations Open access
Semantic Scholar
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer.
G. van der Horst, C. van den Hoogen, J. Buijs, H. Cheung +9 more
2011Neoplasia100 citations Open access
Semantic Scholar
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
Mathieu Pizzonero, S. Dupont, Marielle Babel, Stéphane Beaumont +27 more
2014Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Hypothermia as an indicator of the acute effects of lipopolysaccharides : Comparison with serum levels of IL1β, IL6 and TNFα
R. Blanqué, C. Meakin, S. Millet, C. Gardner
199664 citations
Semantic Scholar
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
F. Brebion, R. Gosmini, P. Deprez, M. Varin +17 more
2021Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Discovery of 9-cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Frédéric Labéguère, S. Dupont, Luke J. Alvey, F. Soulas +27 more
2020Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Bone-Resorbing Cytokines from Peripheral Blood Mononuclear Cells after Hormone Replacement Therapy: A Longitudinal Study
O. Bernard-Poenaru, C. Roux, R. Blanqué, C. Gardner +2 more
2001Osteoporosis International41 citations
Semantic Scholar
Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator.
F. Nique, Séverine Hebbe, N. Triballeau, C. Peixoto +16 more
2012Journal of Medicinal Chemistry40 citations
Semantic Scholar
Pharmacological characterization of GLPG1972/S201086, a potent and selective small molecule inhibitor of ADAMTS5.
P. Clément-Lacroix, C. Little, Margaret M. Smith, C. Cottereaux +16 more
2021Osteoarthritis and Cartilage26 citations Open access
Semantic Scholar
Factors influencing the effect of the soluble IL-6 receptor on IL-6 responses in HepG2 hepatocytes.
J. Paysant, R. Blanqué, M. Vasse, C. Soria +2 more
2000Cytokine24 citations
Semantic Scholar
Hypothermia as an indicator of the acute effects of lipopolysaccharides: comparison with serum levels of IL1 beta, IL6 and TNF alpha.
R. Blanqué, C. Meakin, S. Millet, C. Gardner
1996General Pharmacology23 citations
Semantic Scholar
Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization
R. Blanqué, L. Lepescheux, M. Auberval, D. Minet +5 more
2014BMC Musculoskeletal Disorders21 citations Open access
Semantic Scholar
The use of TNF family ligands and receptors and agents which modify their interaction as therapeutic agents.
M. Gardnerova, R. Blanqué, C. Gardner
2000Current Drug Targets21 citations
Semantic Scholar
Selective Enhancement of LPS-Induced Serum TNF-α Production by Carrageenan Pretreatment in Mice
R. Blanqué, C. Meakin, S. Millet, C. Gardner
199821 citations
Semantic Scholar
Dual mechanisms of action of interferon-γ in potentiating responses to LPS in mice IL1, TNFα and IL6 production in serum and hypothermia
R. Blanqué, C. Meakin, S. Millet, C. Gardner
199917 citations
Semantic Scholar
GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA
P. Clément-Lacroix, C. Little, S. Meurisse, R. Blanqué +13 more
201716 citations Open access
Semantic Scholar
Mechanisms involved in prostaglandin-induced increase in bone resorption in neonatal mouse calvaria.
C. Gardner, R. Blanqué, C. Cottereaux
2001Prostaglandins, Leukotrienes and Essential Fatty Acids16 citations
Semantic Scholar
Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases
Oscar Mammoliti, S. Martina, Pieter Claes, Ghjuvanni Coti +14 more
2024Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis
A. Taneja, J. Desrivot, P. Diderichsen, R. Blanqué +5 more
2019Clinical Pharmacokinetics11 citations Open access
Semantic Scholar
Selective enhancement of LPS-induced serum TNF-alpha production by carrageenan pretreatment in mice.
R. Blanqué, C. Meakin, S. Millet, C. Gardner
1998General Pharmacology11 citations
Semantic Scholar
Increases in osteocalcin after ovariectomy are amplified by LPS injection: strain differences in bone remodelling.
R. Blanqué, C. Cottereaux, C. Gardner
1998General Pharmacology10 citations
Semantic Scholar
Effects of SK&F 86002 on cytokine-stimulated IL6 production in cultured neonatal mouse calvaria and SaOS2 osteoblastic cells: the role of prostaglandins and other mechanisms of action.
R. Blanqué, C. Cottereaux, C. Gardner
1997Drugs under experimental and clinical research10 citations
Semantic Scholar
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor GLPG1690 in a mouse model for IPF
M. Ongenaert, S. Dupont, R. Blanqué, R. Brys +2 more
20169 citations
Semantic Scholar
ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model
P. Clément-Lacroix, S. Meurisse, L. Lepescheux, D. Merciris +14 more
20187 citations Open access
Semantic Scholar
Dual mechanisms of action of interferon-gamma in potentiating responses to LPS in mice: IL1, TNFalpha and IL6 production in serum and hypothermia.
R. Blanqué, C. Meakin, S. Millet, C. Gardner
1999General Pharmacology7 citations
Semantic Scholar
Favorable human safety, pharmacokinetics and pharmacodynamics of the autotaxin inhibitor GLPG1690, a potential new treatment in COPD
E. V. D. Aar, Liesbeth Fagard, J. Desrivot, S. Dupont +5 more
20156 citations
Semantic Scholar
Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment
R. Blanqué, N. Desroy, S. Dupont, C. Cottereaux +7 more
20154 citations
Semantic Scholar
GPR84 inhibition as a novel therapeutic approach in IBD: mechanistic and translational studies
S. Dupont, I. Arijs, R. Blanqué, D. Laukens +14 more
20154 citations Open access
Semantic Scholar
Phasic production of urinary pyridinium crosslinks in mice: The effect of ovariectomy
R. Blanqué, C. Cottereaux, C. Gardner
2001Calcified Tissue International3 citations
Semantic Scholar
GLPG2737, a CFTR Inhibitor, Prevents Cyst Growth in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease
Vincent Dumont, Sandrine Meurisse, Katleen Verdonck, Valérie Salgues +13 more
2025American Journal of Nephrology2 citations Open access
Semantic Scholar
OP0258 Efficacy of the highly selective adamts-5 inhibitor glpg1972 in the rat meniscectomy model
L. Lepescheux, P. Clément-Lacroix, D. Merciris, S. Meurisse +14 more
2018FRIDAY, 15 JUNE 20182 citations Open access
Semantic Scholar
P133 In vitro pharmacological profile of GLPG3667 suggests differentiation from the TYK2 inhibitors deucravacitinib and TAK-279 at their clinical dose regimens
W. Hettema, P. Nolain, I. Parent, R. Blanqué +5 more
2024Journal of Crohn's & Colitis1 citations Open access
Semantic Scholar
AB0144 PHARMACOLOGICAL CHARACTERIZATION OF GLPG3667, A SELECTIVE TYK2 INHIBITOR, SUPPORTS DEVELOPMENT IN DERMATOMYOSITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS
R. Aggarwal, E. Morand, R. Blanqué, K. Shoji +16 more
2023Annals of the Rheumatic Diseases1 citations Open access
Semantic Scholar
OP0180 Pharmacological characterization of the ADAMTS-5 inhibitor GLPG1972: an oral anti-catabolic agent for the treatment of osteoarthritis
P. Clément-Lacroix, C. Little, R. Blanqué, S. Meurisse +13 more
20171 citations Open access
Semantic Scholar
FRI0428 The JAK1-selective inhibitor, filgotinib, inhibits inflammation pathways observed in an IL23-induced psoriatic arthritis mouse model
R. Blanqué, Maté Ongenaert, C. David, C. Robin-Jagerschmidt +5 more
20171 citations Open access
Semantic Scholar
Pharmacological Characterization of GLPG3667, a Tyrosine Kinase 2-Selective Inhibitor, for the Treatment of Inflammatory and Autoimmune Diseases
C. Cottereaux, May-Linda Lepage, I. Parent, M. Colli +13 more
2026Inflammation0 citations Open access
Semantic Scholar
Abstract 4485: ASTU-045, a novel METTL3 inhibitor with anti-tumor activity in the MC38 syngeneic mouse model.
L. Mevellec, N. George, L. Waeckel, Rémi Longuespée +7 more
2026Cancer Research0 citations
Semantic Scholar
Discovery of GLPG4471, a potent and selective IRAK4 inhibitor for the treatment of inflammatory and autoimmune diseases.
Oscar Mammoliti, Florence Bonnaterre, Gregory Newsome, R. Akkari +22 more
2025Bioorganic & Medicinal Chemistry Letters0 citations
Semantic Scholar
Autotaxin Inhibitorsin IPF: Elucidation of a Novel Binding Mode for GLPG1690
B. Heckmann, R. Blanqué, N. Triballeau, N. Desroy +5 more
2019A108. PATHOPHYSIOLOGY IN DIFFUSE PARENCHYMAL LUNG DISEASES0 citations
Semantic Scholar
GLPG0492, a novel SARM, prevents skeletal muscle atrophy in a mouse hindlimb immobilization model hindlimb immobilization model
M. Auberval, R. Blanqué, C. Cottereaux, L. Lepescheux +3 more
20110 citations
Semantic Scholar
Étude de l'implication de l'IL-1β, de l'IL-6 et de TRANCE sur le développement des ostéoclastes et la résorption osseuse
R. Blanqué
20010 citations
Semantic Scholar

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