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L. Brinen · SciRah

Researcher profile · Semantic Scholar

L. Brinen

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L. Brinen — researcher profile on SciRah

h-index: 36
Works: 105
Citations: 4,105

Most-cited papers

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
S. Lesley, P. Kuhn, A. Godzik, A. Deacon +24 more
2002Proceedings of the National Academy of Sciences of the United States of America368 citations Open access
Semantic Scholar
Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design*
I. Kerr, J. H. Lee, C. Farady, R. Marion +10 more
2009Journal of Biological Chemistry238 citations Open access
Semantic Scholar
Two approaches to discovering and developing new drugs for Chagas disease
J. McKerrow, P. Doyle, J. Engel, L. Podust +7 more
2009Memórias do Instituto Oswaldo Cruz166 citations Open access
Semantic Scholar
Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity
I. Kerr, J. H. Lee, K. Pandey, Amanda Harrison +3 more
2009Journal of Medicinal Chemistry165 citations Open access
Semantic Scholar
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
C. Caffrey, E. Hansell, Kimberley D. Lucas, L. Brinen +8 more
2001Molecular and biochemical parasitology (Print)164 citations
Semantic Scholar
A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines.
R. Fuller, J. Cardellina, Yōkō Kato, L. Brinen +3 more
1992Journal of Medicinal Chemistry143 citations
Semantic Scholar
Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy
K. Brak, I. Kerr, Kimberly T. Barrett, Nobuhiro Fuchi +7 more
2010Journal of Medicinal Chemistry122 citations Open access
Semantic Scholar
The Cathepsin B of Toxoplasma gondii,Toxopain-1, Is Critical for Parasite Invasion and Rhoptry Protein Processing*
Xu-Chu Que, H. Ngo, J. Lawton, M. Gray +6 more
2002Journal of Biological Chemistry112 citations Open access
Semantic Scholar
Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2.
P. S. Sijwali, L. Brinen, Philip J. Rosenthal
2001Protein Expression and Purification106 citations
Semantic Scholar
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
L. Brinen, E. Hansell, Jianming Cheng, William R. Roush +2 more
2000Structure100 citations Open access
Semantic Scholar
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Stephanie X. Wang, K. Pandey, J. Somoza, P. S. Sijwali +5 more
2006Proceedings of the National Academy of Sciences of the United States of America92 citations Open access
Semantic Scholar
Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica*
Colin M. Stack, C. Caffrey, S. Donnelly, A. Seshaadri +11 more
2008Journal of Biological Chemistry91 citations Open access
Semantic Scholar
In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi
Yen-Ting Chen, L. Brinen, I. Kerr, E. Hansell +3 more
2010PLoS Neglected Tropical Diseases89 citations Open access
Semantic Scholar
Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
Youngchool Choe, L. Brinen, M. S. Price, J. Engel +11 more
2005Bioorganic & Medicinal Chemistry88 citations
Semantic Scholar
Cruzain : the path from target validation to the clinic.
M. Sajid, S. Robertson, L. Brinen, J. McKerrow
2011Advances in Experimental Medicine and Biology86 citations
Semantic Scholar
Protease Trafficking in Two Primitive Eukaryotes Is Mediated by a Prodomain Protein Motif*
J. A. Huete-Pérez, J. Engel, L. Brinen, J. Mottram +1 more
1999Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain.
L. Huang, L. Brinen, J. Ellman
2003Bioorganic & Medicinal Chemistry81 citations
Semantic Scholar
Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei
I. Kerr, Peng Wu, Rachael Marion-Tsukamaki, Z. Mackey +1 more
2010PLoS Neglected Tropical Diseases78 citations Open access
Semantic Scholar
Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica.
Xu-Chu Que, L. Brinen, P. S. Perkins, S. Herdman +5 more
2002Molecular and biochemical parasitology (Print)77 citations
Semantic Scholar
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Stephanie X. Wang, K. Pandey, J. Scharfstein, J. Whisstock +9 more
2007Structure75 citations Open access
Semantic Scholar
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases
Clifford Bryant, I. Kerr, M. Debnath, K. Ang +8 more
2009Bioorganic & Medicinal Chemistry Letters73 citations Open access
Semantic Scholar
A Novel Entamoeba histolytica Cysteine Proteinase, EhCP4, Is Key for Invasive Amebiasis and a Therapeutic Target*
Chen He, George P. Nora, Eric L Schneider, I. Kerr +17 more
2010Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Structures of the efrapeptins : potent inhibitors of mitochondrial ATPase from the fungus Tolypocladium niveum
S. Gupta, S. Krasnoff, D. Roberts, J. Renwick +2 more
199162 citations
Semantic Scholar
New polychlorinated amino acid derivatives from the marine sponge Dysidea herbacea
M. D. Unson, C. B. Rose, D. Faulkner, L. Brinen +2 more
199361 citations
Semantic Scholar
HIV inhibitory natural products. 3. Diterpenes from and
K. Gustafson, M. H. Munro, J. Blunt, J. Cardellina +7 more
199158 citations
Semantic Scholar
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 Å resolution
P. Kuhn, S. Lesley, I. Mathews, J. Cànaves +38 more
2002Proteins: Structure, Function, and Bioinformatics55 citations Open access
Semantic Scholar
Structure of Efrapeptins From the Fungus Tolypocladium Niveum: Peptide Inhibitors of Mitochondrial ATPase
S. Gupta, S. Krasnoff, D. Roberts, J. Renwick +2 more
199255 citations
Semantic Scholar
New Chlorophyll-A-Related Compounds Isolated as Antioxidants from Marine Bivalves
N. Watanabe, Ken-ichi Yamamoto, Hiromi Ihshikawa, A. Yagi +3 more
199353 citations
Semantic Scholar
Plakinidines: Cytotoxic alkaloid pigments from the fijian sponge plakortis sp.
R. West, C. Mayne, C. Ireland, L. Brinen +1 more
199048 citations
Semantic Scholar
Stability for function trade-offs in the enolase superfamily "catalytic module".
R. Nagatani, Ana González, B. Shoichet, L. Brinen +1 more
2007Biochemistry46 citations
Semantic Scholar
The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin
Robert C. Huang, Xu-Chu Que, K. Hirata, L. Brinen +5 more
2008Molecular and biochemical parasitology (Print)45 citations Open access
Semantic Scholar
X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
L. Brinen, W. Willett, C. Craik, R. J. Fletterick
1996Biochemistry41 citations
Semantic Scholar
Crystal structure of an iron‐containing 1,3‐propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 Å resolution
R. Schwarzenbacher, F. von Delft, J. Cànaves, L. Brinen +39 more
2003Proteins: Structure, Function, and Bioinformatics37 citations Open access
Semantic Scholar
Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 Å resolution
E. Santelli, R. Schwarzenbacher, D. Mcmullan, T. Biorac +42 more
2004Proteins: Structure, Function, and Bioinformatics36 citations
Semantic Scholar
Chlorophyllonic acid and methyl ester, a new chlorophyll a related compound isolated as an antioxidant from short-necked clam, ruditapes philippinarum
Ken-ichi Yamamoto, K. Sakata, N. Watanabe, A. Yagi +2 more
199235 citations
Semantic Scholar
Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster.
W. Ayer, Mark Sun, L. M. Browne, L. Brinen +1 more
1992Journal of Natural Products33 citations
Semantic Scholar
HIV Inhibitory Natural Products. Part 3. Diterpenes from Homalanthus acuminatus and Chrysobalanus icaco.
Kr Gustafson, M. H. Munro, J. Blunt, J. Cardellina +7 more
199133 citations
Semantic Scholar
Crystal structure of a tandem cystathionine‐β‐synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 Å resolution
Mitchell D. Miller, R. Schwarzenbacher, F. von Delft, P. Abdubek +45 more
2004Proteins: Structure, Function, and Bioinformatics32 citations
Semantic Scholar
Crystal structure of a PIN (PilT N‐terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Å resolution
I. Levin, R. Schwarzenbacher, R. Page, P. Abdubek +47 more
2004Proteins: Structure, Function, and Bioinformatics32 citations Open access
Semantic Scholar
Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.
Daniel R. Schroeder, Kimberly L. Colson, S. Klohr, Mike S. Lee +3 more
1996Journal of antibiotics (Tokyo. 1968)30 citations Open access
Semantic Scholar
Absolute Stereochemistry of (+)-Gigantecin from Annona coriacea (Annonaceae)
Jingjia Yu, X. Hu, D. K. Ho, M. Bean +4 more
199430 citations
Semantic Scholar
The Major Secreted Cathepsin L1 Protease of the Liver Fluke, Fasciola hepatica
Colin M. Stack, S. Donnelly, J. Lowther, Wei-bo Xu +3 more
2007Journal of Biological Chemistry29 citations Open access
Semantic Scholar
The extended interactions and Gla domain of blood coagulation factor Xa.
Stephanie X. Wang, E. Hur, C. A. Sousa, L. Brinen +2 more
2003Biochemistry29 citations
Semantic Scholar
Delocalizing trypsin specificity with metal activation.
W. Willett, L. Brinen, R. J. Fletterick, C. Craik
1996Biochemistry29 citations Open access
Semantic Scholar
Crystal structure of a novel manganese‐containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution
L. Jaroszewski, R. Schwarzenbacher, F. von Delft, D. Mcmullan +43 more
2004Proteins: Structure, Function, and Bioinformatics27 citations Open access
Semantic Scholar
A pterocarpan and two isoflavans from alfalfa
G. Spencer, Barry E. Jones, R. Plattner, D. Barnekow +2 more
199125 citations
Semantic Scholar
Crystal structure of an Udp‐n‐acetylmuramate‐alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 Å resolution
G. Spraggon, R. Schwarzenbacher, A. Kreusch, Christian C. Lee +46 more
2004Proteins: Structure, Function, and Bioinformatics24 citations
Semantic Scholar
Crystal structure of O‐acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 Å resolution
A. Heine, J. Cànaves, F. von Delft, L. Brinen +40 more
2004Proteins: Structure, Function, and Bioinformatics22 citations Open access
Semantic Scholar
Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 Å resolution
R. Schwarzenbacher, F. von Delft, L. Jaroszewski, P. Abdubek +45 more
2004Proteins: Structure, Function, and Bioinformatics20 citations Open access
Semantic Scholar
Crystal structure of a putative PII‐like signaling protein (TM0021) from Thermotoga maritima at 2.5 Å resolution
R. Schwarzenbacher, F. von Delft, P. Abdubek, Eileen Ambing +45 more
2004Proteins: Structure, Function, and Bioinformatics18 citations Open access
Semantic Scholar

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