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H. Klock · SciRah

Researcher profile · Semantic Scholar

H. Klock

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H. Klock — researcher profile on SciRah

h-index: 32
Works: 146
Citations: 3,835

Most-cited papers

The Polymerase Incomplete Primer Extension (PIPE) method applied to high-throughput cloning and site-directed mutagenesis.
H. Klock, S. Lesley
2009Methods in molecular biology311 citations
Semantic Scholar
Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts
H. Klock, Eric J. Koesema, M. Knuth, S. Lesley
2008Proteins: Structure, Function, and Bioinformatics267 citations
Semantic Scholar
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency
Rodolfo Gonzalez, L. Jennings, M. Knuth, A. Orth +19 more
2010Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions
Woj M. Wojtowicz, Jost Vielmetter, Ricardo A. Fernandes, D. Siepe +14 more
2020Cell91 citations Open access
Semantic Scholar
Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells
Pamela Y. Ting, Albert E. Parker, J. Lee, Christopher Trussell +17 more
2018Nature Methods82 citations
Semantic Scholar
Crystal structures of two novel dye‐decolorizing peroxidases reveal a β‐barrel fold with a conserved heme‐binding motif
C. Zubieta, S. Krishna, M. Kapoor, P. Kozbial +40 more
2007Proteins: Structure, Function, and Bioinformatics82 citations
Semantic Scholar
Structural Basis of Murein Peptide Specificity of a γ-D-glutamyl-L-diamino Acid Endopeptidase
Qing-Ping Xu, S. Sudek, D. Mcmullan, Mitchell D. Miller +49 more
2009Structure77 citations Open access
Semantic Scholar
Identification and structural characterization of heme binding in a novel dye‐decolorizing peroxidase, TyrA
C. Zubieta, Rosanne Joseph, S. Krishna, D. Mcmullan +43 more
2007Proteins: Structure, Function, and Bioinformatics71 citations
Semantic Scholar
Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.
Shu-Lin Han, Vicki W. Zhou, Shifeng Pan, Yi Liu +8 more
2005Bioorganic & Medicinal Chemistry Letters69 citations Open access
Semantic Scholar
On the use of DXMS to produce more crystallizable proteins: Structures of the T. maritima proteins TM0160 and TM1171
G. Spraggon, D. Pantazatos, H. Klock, Ian A. Wilson +2 more
2004Protein Science64 citations Open access
Semantic Scholar
TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells
Jonathan S. Yen, M. Fiorino, Yi Liu, Steven Paula +11 more
2018Scientific Reports53 citations Open access
Semantic Scholar
Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination
L. Columbus, J. Lipfert, H. Klock, I. Millett +2 more
2006Protein Science52 citations Open access
Semantic Scholar
Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold
C. Rife, R. Schwarzenbacher, D. Mcmullan, P. Abdubek +40 more
2005Proteins: Structure, Function, and Bioinformatics50 citations
Semantic Scholar
A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors.
Vicki W. Zhou, Shu-Lin Han, A. Brinker, H. Klock +2 more
2004Analytical Biochemistry49 citations
Semantic Scholar
Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that may Discriminate Substrates During DNA Repair
D. Das, D. Moiani, H. Axelrod, Mitchell D. Miller +43 more
2010Journal of Molecular Biology42 citations Open access
Semantic Scholar
Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase from Thermoplasma acidophilum, an essential enzyme in the biosynthesis of archaeal membrane lipids
Qing-Ping Xu, T. Eguchi, I. Mathews, C. Rife +13 more
2010Journal of Molecular Biology37 citations Open access
Semantic Scholar
A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome
M. Didonato, A. Deacon, H. Klock, D. Mcmullan +1 more
2004Journal of Structural and Functional Genomics37 citations
Semantic Scholar
Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Phosphopantetheinyl Transferases.
Jan Grünewald, H. Klock, Susan E. Cellitti, B. Bursulaya +16 more
2015Bioconjugate chemistry36 citations
Semantic Scholar
Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain
Qing-Ping Xu, A. Bateman, R. Finn, P. Abdubek +48 more
2010Journal of Molecular Biology36 citations Open access
Semantic Scholar
Homogeneous High-Throughput Screening Assays for HIV-1 Integrase 3β-Processing and Strand Transfer Activities
Yu Wang, H. Klock, H. Yin, Karen C. Wolff +9 more
2005Journal of biomolecular screening36 citations Open access
Semantic Scholar
Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 Å resolution
E. Santelli, R. Schwarzenbacher, D. Mcmullan, T. Biorac +42 more
2004Proteins: Structure, Function, and Bioinformatics36 citations
Semantic Scholar
Structural Analysis of Papain-Like NlpC/P60 Superfamily Enzymes with a Circularly Permuted Topology Reveals Potential Lipid Binding Sites
Qing-Ping Xu, N. Rawlings, Hsiu-Ju Chiu, L. Jaroszewski +8 more
2011PLoS ONE34 citations Open access
Semantic Scholar
Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein
D. Das, M. Hervé, J. Feuerhelm, C. Farr +10 more
2011PLoS ONE32 citations Open access
Semantic Scholar
Crystal structure of a tandem cystathionine‐β‐synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 Å resolution
Mitchell D. Miller, R. Schwarzenbacher, F. von Delft, P. Abdubek +45 more
2004Proteins: Structure, Function, and Bioinformatics32 citations
Semantic Scholar
Methods and Results for Semi-automated Cloning Using Integrated Robotics
H. Klock, Aprilfawn White, Eric J. Koesema, S. Lesley
2005Journal of Structural and Functional Genomics31 citations
Semantic Scholar
Structure of the pilus assembly protein TadZ from Eubacterium rectale: Implications for polar localization
Qing-Ping Xu, Beat Christen, Hsiu-Ju Chiu, L. Jaroszewski +10 more
2012Molecular Microbiology30 citations Open access
Semantic Scholar
Crystal structure of the Fic (Filamentation Induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 Å resolution
D. Das, S. Krishna, D. Mcmullan, Mitchell D. Miller +47 more
2009Proteins: Structure, Function, and Bioinformatics29 citations Open access
Semantic Scholar
Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 Å resolution
Qing-Ping Xu, R. Schwarzenbacher, S. Sri Krishna, D. Mcmullan +41 more
200628 citations
Semantic Scholar
NMR for structural proteomics of Thermotoga maritima: Screening and structure determination
W. Peti, Touraj Etezady-Esfarjani, T. Herrmann, H. Klock +2 more
2004Journal of Structural and Functional Genomics28 citations
Semantic Scholar
Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes
Qing-Ping Xu, G. V. van Wezel, Hsiu-Ju Chiu, L. Jaroszewski +8 more
2012PLoS ONE27 citations Open access
Semantic Scholar
Structural and Functional Characterizations of SsgB, a Conserved Activator of Developmental Cell Division in Morphologically Complex Actinomycetes*
Qing-Ping Xu, Bjørn A. Traag, J. Willemse, D. Mcmullan +54 more
2009Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Crystal structure of a novel manganese‐containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution
L. Jaroszewski, R. Schwarzenbacher, F. von Delft, D. Mcmullan +43 more
2004Proteins: Structure, Function, and Bioinformatics27 citations Open access
Semantic Scholar
Structure of a Virulence Regulatory Factor CvfB Reveals a Novel Winged-helix RNA Binding Module
Yasuhiko Matsumoto, Qing-Ping Xu, S. Miyazaki, C. Kaito +12 more
2010Structure24 citations Open access
Semantic Scholar
Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution
D. Das, P. Kozbial, H. Axelrod, Mitchell D. Miller +53 more
2009Proteins: Structure, Function, and Bioinformatics24 citations Open access
Semantic Scholar
Structure and Function of a Novel ld-Carboxypeptidase A Involved in Peptidoglycan Recycling
D. Das, M. Hervé, M. Elsliger, R. U. Kadam +10 more
2013Journal of Bacteriology23 citations Open access
Semantic Scholar
Structural and Sequence Analysis of Imelysin-Like Proteins Implicated in Bacterial Iron Uptake
Qing-Ping Xu, N. Rawlings, C. Farr, Hsiu-Ju Chiu +11 more
2011PLoS ONE23 citations Open access
Semantic Scholar
Crystal structure of O‐acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 Å resolution
A. Heine, J. Cànaves, F. von Delft, L. Brinen +40 more
2004Proteins: Structure, Function, and Bioinformatics22 citations Open access
Semantic Scholar
Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima
G. Jason Forse, N. Ram, D. Rey Banatao, D. Cascio +4 more
2010Protein Science20 citations Open access
Semantic Scholar
Crystal structure of an indigoidine synthase A (IndA)‐like protein (TM1464) from Thermotoga maritima at 1.90 Å resolution reveals a new fold
I. Levin, Mitchell D. Miller, R. Schwarzenbacher, D. Mcmullan +46 more
2005Proteins: Structure, Function, and Bioinformatics18 citations Open access
Semantic Scholar
Crystal structure of a putative PII‐like signaling protein (TM0021) from Thermotoga maritima at 2.5 Å resolution
R. Schwarzenbacher, F. von Delft, P. Abdubek, Eileen Ambing +45 more
2004Proteins: Structure, Function, and Bioinformatics18 citations Open access
Semantic Scholar
Crystal structure of a single‐stranded DNA‐binding protein (TM0604) from Thermotoga maritima at 2.60 Å resolution
M. Didonato, S. Sri Krishna, R. Schwarzenbacher, D. Mcmullan +41 more
2006Proteins: Structure, Function, and Bioinformatics17 citations Open access
Semantic Scholar
Improved protein identification using automated high mass measurement accuracy MALDI FT-ICR MS peptide mass fingerprinting
D. Horn, E. Peters, H. Klock, Andrew Meyers +1 more
200417 citations
Semantic Scholar
Crystal structure of S‐adenosylmethionine:tRNA ribosyltransferase‐isomerase (QueA) from Thermotoga maritima at 2.0 Å resolution reveals a new fold
I. Mathews, R. Schwarzenbacher, D. Mcmullan, P. Abdubek +41 more
2005Proteins: Structure, Function, and Bioinformatics16 citations Open access
Semantic Scholar
Crystal structure of an alanine‐glyoxylate aminotransferase from Anabaena sp. at 1.70 Å resolution reveals a noncovalently linked PLP cofactor
Gye Won Han, R. Schwarzenbacher, R. Page, L. Jaroszewski +48 more
2005Proteins: Structure, Function, and Bioinformatics16 citations
Semantic Scholar
A Structural Basis for the Regulatory Inactivation of DnaA
Qing-Ping Xu, D. Mcmullan, P. Abdubek, T. Astakhova +40 more
2008Journal of Molecular Biology15 citations Open access
Semantic Scholar
Optimization of an Enzymatic Antibody-Drug Conjugation Approach Based on Coenzyme A Analogs.
Jan Grünewald, Yunho Jin, Julie Vance, J. Read +9 more
2017Bioconjugate chemistry14 citations
Semantic Scholar
The Structure of Mlc Titration Factor A (MtfA/YeeI) Reveals a Prototypical Zinc Metallopeptidase Related to Anthrax Lethal Factor
Qing-Ping Xu, Anna-Katharina Göhler, Anne Kosfeld, D. Carlton +10 more
2012Journal of Bacteriology14 citations Open access
Semantic Scholar
Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 Å resolution reveals a new fold
R. Schwarzenbacher, D. Mcmullan, S. Krishna, Qing-Ping Xu +24 more
2006Proteins: Structure, Function, and Bioinformatics14 citations Open access
Semantic Scholar
Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 Å resolution
G. Han, R. Schwarzenbacher, D. Mcmullan, P. Abdubek +40 more
2005Proteins: Structure, Function, and Bioinformatics14 citations Open access
Semantic Scholar
Crystal structure of a ribose‐5‐phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 Å resolution
Qing-Ping Xu, R. Schwarzenbacher, D. Mcmullan, F. von Delft +38 more
2004Proteins: Structure, Function, and Bioinformatics14 citations
Semantic Scholar

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