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C. Farady · SciRah

Researcher profile · Semantic Scholar

C. Farady

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C. Farady — researcher profile on SciRah

h-index: 21
Works: 44
Citations: 2,995

Most-cited papers

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lorenzo Sborgi, S. Rühl, E. Mulvihill, J. Pipercevic +6 more
2016EMBO Journal1,083 citations Open access
Semantic Scholar
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly
Kai-Wen W. Chen, B. Demarco, Rosalie Heilig, K. Shkarina +4 more
2019EMBO Journal342 citations Open access
Semantic Scholar
Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design*
I. Kerr, J. H. Lee, C. Farady, R. Marion +10 more
2009Journal of Biological Chemistry238 citations Open access
Semantic Scholar
Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition.
C. Dekker, H. Mattes, Michael Wright, Andreas Boettcher +8 more
2021Journal of Molecular Biology159 citations
Semantic Scholar
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after histidine 157
D. Feuerbach, P. Schindler, Carmen Barske, S. Joller +18 more
2017bioRxiv157 citations Open access
Semantic Scholar
Mechanisms Of Macromolecular Protease Inhibitors
C. Farady, C. Craik
2010ChemBioChem136 citations Open access
Semantic Scholar
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway
A. Bhatt, A. Welm, C. Farady, M. Vásquez +2 more
2007Proceedings of the National Academy of Sciences of the United States of America101 citations Open access
Semantic Scholar
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm
S. Rai, Élodie Grockowiak, N. Hansen, D. Luque Paz +7 more
2022Nature Communications73 citations Open access
Semantic Scholar
Clonal hematopoiesis of indeterminate potential with loss of Tet2 enhances risk for atrial fibrillation through Nlrp3 inflammasome activation
A. Lin, Aneesh C. Bapat, Ling Xiao, A. Niroula +15 more
2024Circulation72 citations Open access
Semantic Scholar
Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.
C. Farady, P. Egea, Eric L Schneider, Molly R. Darragh +1 more
2008Journal of Molecular Biology71 citations Open access
Semantic Scholar
Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GvHD.
Brent H. Koehn, A. Saha, Cameron McDonald-Hyman, Michael Loschi +21 more
2019Blood58 citations Open access
Semantic Scholar
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).
C. Farady, Jeonghoon Sun, Molly R. Darragh, S. Miller +1 more
2007Journal of Molecular Biology58 citations Open access
Semantic Scholar
Improving the species cross-reactivity of an antibody using computational design
C. Farady, Benjamin D. Sellers, M. Jacobson, C. Craik
2009Bioorganic & Medicinal Chemistry Letters52 citations Open access
Semantic Scholar
A Reverse Binding Motif that Contributes to Specific Protease Inhibition by Antibodies
Eric L Schneider, Melody S. Lee, A. Baharuddin, D. Goetz +4 more
2011Journal of Molecular Biology51 citations Open access
Semantic Scholar
Specific Targeting of Proteolytic Activity for Tumor Detection in vivo
Molly R. Darragh, Eric L Schneider, Jianlong Lou, P. Phojanakong +4 more
2010Cancer Research48 citations Open access
Semantic Scholar
Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase‐1 knockout
Holger Laux, Sandrine Romand, Sandro Nuciforo, C. Farady +5 more
2018Biotechnology and Bioengineering45 citations
Semantic Scholar
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.
J. Velcicky, P. Janser, N. Gommermann, Silke Brenneisen +14 more
2024Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.
Angela Mackay, J. Velcicky, N. Gommermann, Henri Mattes +22 more
2024Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells
S. Rai, Yang Zhang, Élodie Grockowiak, Quentin Kimmerlin +13 more
2023bioRxiv37 citations Open access
Semantic Scholar
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis
E. Neuwirt, G. Magnani, Tamara Ćiković, Svenja Wöhrle +23 more
2023Science Signaling23 citations
Semantic Scholar
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner.
Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko +37 more
2025Cell Chemical Biology22 citations
Semantic Scholar
Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.
Adeline Unterreiner, Joëlle Rubert, Muriel Kauffmann, Alice Fruhauf +8 more
2021Biochemical and Biophysical Research Communications - BBRC14 citations
Semantic Scholar
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Kenji Namoto, F. Sirockin, H. Sellner, C. Wiesmann +11 more
2018Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells.
Adeline Unterreiner, Natacha Stoehr, C. Huppertz, T. Calzascia +2 more
2017Immunology Letters12 citations
Semantic Scholar
Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation
Diane Heiser, Joëlle Rubert, Adeline Unterreiner, C. Maurer +5 more
2021bioRxiv11 citations Open access
Semantic Scholar
Fragment-based protein-protein interaction antagonists of a viral dimeric protease
J. Gable, Gregory M. Lee, T. M. Acker, Kaitlin R. Hulce +5 more
2016ChemMedChem11 citations Open access
Semantic Scholar
Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement.
J. Velcicky, Jean-Baptiste Langlois, Michael Wright, P. Janser +28 more
2025Journal of Medicinal Chemistry9 citations
Semantic Scholar
HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent
Long-Long Wang, Shi-Hua Shi, Adeline Unterreiner, R. Kapetanovic +10 more
2024Journal of Biological Chemistry5 citations Open access
Semantic Scholar
HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent
Long-Long Wang, Adeline Unterreiner, R. Kapetanovic, Selma Aslani +6 more
2023bioRxiv5 citations Open access
Semantic Scholar
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko +37 more
2024bioRxiv4 citations Open access
Semantic Scholar
Phosphorylation meets proteolysis.
M. Renatus, C. Farady
2012Structure3 citations Open access
Semantic Scholar
Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome
E. Neuwirt, G. Magnani, Tamara Ćiković, Anna Kostina +19 more
2022bioRxiv2 citations Open access
Semantic Scholar
Protease Inhibitors: Mechanisms
C. Farady, C. Craik
20082 citations
Semantic Scholar
NLRP3 acts as a direct sensor of intracellular potassium ions
Ana Tapia-Abellán, Lukas Funk, Tobias Schäfer, Jelena Grga +15 more
2026bioRxiv1 citations Open access
Semantic Scholar
Accurate and reliable detection of clonal hematopoiesis in plasma cell-free DNA
A. Parker, J. V. Van Amburg, Y. Pershad, David A. Ong +7 more
2025Blood Advances1 citations
Semantic Scholar
[18F]NP3‐627, a Candidate PET Imaging Agent Targeting the NLRP3 Inflammasome in the Central Nervous System
David Whitehead, Christian Fischer, E. Briard, C. Farady +9 more
2024ChemMedChem1 citations
Semantic Scholar
Kallikrein-related Peptidase 7
C. Farady, L. Mayr, F. Kolb
20131 citations
Semantic Scholar
Predictive molecular signatures for successful tapering of canakinumab in systemic juvenile idiopathic arthritis.
Tanja Hinze, Claas H. Hinze, C. Kessel, E. Verweyen +9 more
2026Annals of the Rheumatic Diseases0 citations Open access
Semantic Scholar
Degradation of recombinant proteins by CHO host cell proteases is prevented by Matriptase-1 knock-out
Holger Laux, Sandrine Romand, Sandro Nuciforo, C. Farady +5 more
20180 citations
Semantic Scholar
Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2
C. Farady, Eric L Schneider, P. Egea, D. Goetz +1 more
20080 citations
Semantic Scholar
Clavulanic Acid bound to Elastase
C. Farady, M. Navia
20080 citations
Semantic Scholar
The mechanism of inhibition of antibody-based inhibitors of the serine protease MT -SP1
C. Farady
20080 citations
Semantic Scholar
Award Number: W81XWH-05-1-0300 TITLE: Structural Characterization and Determinants of Specificity of Single-Chain Antibody Inhibitors of Membrane-Type Serine Protease 1 PRINCIPAL INVESTIGATOR:
C. Farady
20060 citations
Semantic Scholar
Structural Characterization and Determinants of Specificity of Single-Chain Antibody Inhibitors of Membrane-Type Serine Protease 1
C. Farady
20060 citations Open access
Semantic Scholar

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