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I. Mathews · SciRah

Researcher profile · Semantic Scholar

I. Mathews

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I. Mathews — researcher profile on SciRah

h-index: 35
Works: 158
Citations: 3,675

Most-cited papers

An engineered Axl ‘decoy receptor’ effectively silences the Gas6/Axl signaling axis
Mihalis S. Kariolis, Y. Miao, Douglas S. Jones, Shiven Kapur +3 more
2014Nature Chemical Biology139 citations Open access
Semantic Scholar
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis
K. Hotta, X. Chen, Robert S Paton, A. Minami +7 more
2012Nature102 citations Open access
Semantic Scholar
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies
Mihalis S. Kariolis, Y. Miao, Anh Diep, Shannon E. Nash +9 more
2017Journal of Clinical Investigation97 citations Open access
Semantic Scholar
Electrostatic control of photoisomerization pathways in proteins
M. Romei, Chi-Yun Lin, I. Mathews, S. Boxer
2020Science95 citations Open access
Semantic Scholar
Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
Brian Sanders, S. Pokhrel, Audrey D. Labbe, I. Mathews +29 more
2023Nature Communications90 citations Open access
Semantic Scholar
Structural and Functional Studies of trans-Encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein Molecule*
S. Tollefsen, K. Hotta, X. Chen, B. Simonsen +4 more
2012Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Enhanced active-site electric field accelerates enzyme catalysis
Chu Zheng, Zhe Ji, I. Mathews, S. Boxer
2023Nature Chemistry83 citations Open access
Semantic Scholar
Protein sequence design with a learned potential
Namrata Anand, Raphael R. Eguchi, I. Mathews, Carla P. Perez +3 more
2022Nature Communications75 citations Open access
Semantic Scholar
X-ray absorption spectroscopic investigation of the electronic structure differences in solution and crystalline oxyhemoglobin
Samuel A. Wilson, E. Green, I. Mathews, M. Benfatto +3 more
2013Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase
F. Wong, Xi Jin, I. Mathews, D. Cane +1 more
2011Biochemistry74 citations Open access
Semantic Scholar
Modular polyketide synthase contains two reaction chambers that operate asynchronously
S. Bagde, I. Mathews, J. Fromme, Chu-Young Kim
2021Science63 citations Open access
Semantic Scholar
Unified Model for Photophysical and Electro-Optical Properties of Green Fluorescent Proteins
Chi-Yun Lin, M. Romei, L. Oltrogge, I. Mathews +1 more
2019Journal of the American Chemical Society63 citations Open access
Semantic Scholar
Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase
W. S. Childers, Qing-Ping Xu, Thomas H. Mann, I. Mathews +3 more
2014PLoS Biology60 citations Open access
Semantic Scholar
Use of transmission electron microscopy to identify nanocrystals of challenging protein targets
Hilary P. Stevenson, A. Makhov, Monica Calero, A. L. Edwards +12 more
2014Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
Semantic Scholar
Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter
C. Khantwal, Sherwin J. Abraham, Wei Han, T. Jiang +9 more
2016eLife44 citations Open access
Semantic Scholar
Structure and Functional Binding Epitope of V-domain Ig Suppressor of T-cell Activation (VISTA)
Nishant Mehta, Sainiteesh Maddineni, I. Mathews, Andres Parra Sperberg +2 more
2019bioRxiv43 citations Open access
Semantic Scholar
Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module
Xiu-Yuan Li, N. Sevillano, Florencia La Greca, L. Deis +7 more
2018Journal of the American Chemical Society43 citations Open access
Semantic Scholar
Folate binding site of flavin-dependent thymidylate synthase
Eric M Koehn, Laura L. Perissinotti, Salah Moghram, Arjun Prabhakar +3 more
2012Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
Semantic Scholar
Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase from Thermoplasma acidophilum, an essential enzyme in the biosynthesis of archaeal membrane lipids
Qing-Ping Xu, T. Eguchi, I. Mathews, C. Rife +13 more
2010Journal of Molecular Biology37 citations Open access
Semantic Scholar
Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex
T. Matsui, S. Gu, K. Lam, Lester G. Carter +3 more
2014Journal of Molecular Biology33 citations Open access
Semantic Scholar
Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of β-Lactamases
Zhe Ji, J. Kozuch, I. Mathews, Christian S. Diercks +3 more
2022Journal of the American Chemical Society32 citations Open access
Semantic Scholar
A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle
T. Chavan, Ricky C. Cheng, T. Jiang, I. Mathews +5 more
2020eLife31 citations Open access
Semantic Scholar
Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants
A. Garcia, I. Mathews, N. Horikoshi, T. Matsui +3 more
2022Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
Mikhail A. Hameedi, É. Prates, M. Garvin, I. Mathews +14 more
2022Nature Communications26 citations Open access
Semantic Scholar
The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography
I. Mathews, Kim Allison, Thomas Robbins, A. Lyubimov +8 more
2017Biochemistry24 citations Open access
Semantic Scholar
Treponema denticola PurE Is a bacterial AIR carboxylase.
S. Tranchimand, C. Starks, I. Mathews, S. C. Hockings +1 more
2011Biochemistry23 citations
Semantic Scholar
Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein
J. Blair, Qing-Ping Xu, W. S. Childers, I. Mathews +4 more
2013Structure22 citations Open access
Semantic Scholar
Crystal structure of the glutamate receptor GluA1 amino-terminal domain
G. Yao, Y. Zong, S. Gu, Jie Zhou +3 more
2011Biochemical Journal22 citations Open access
Semantic Scholar
ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain.
R. Celikel, V. Veldore, I. Mathews, K. Devine +1 more
2012Acta Crystallographica Section D: Biological Crystallography18 citations Open access
Semantic Scholar
Photosynthetic reaction center variants made via genetic code expansion show Tyr at M210 tunes the initial electron transfer mechanism
J. Weaver, Chi-Yun Lin, K. Faries, I. Mathews +4 more
2021Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Energetic Basis and Design of Enzyme Function Demonstrated Using GFP, an Excited-State Enzyme
Chi-Yun Lin, M. Romei, I. Mathews, S. Boxer
2022Journal of the American Chemical Society12 citations Open access
Semantic Scholar
Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
Qian Wang, Ning Liu, Ya-Ming Deng, Yuze Guan +8 more
2023Nature Communications11 citations Open access
Semantic Scholar
Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design
I. Mathews
2013Journal of Bioterrorism & Biodefense11 citations Open access
Semantic Scholar
Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction
D. Cogan, Xiu-Yuan Li, N. Sevillano, I. Mathews +3 more
2020Journal of the American Chemical Society10 citations Open access
Semantic Scholar
Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase
Xiu-Yuan Li, N. Sevillano, Florencia La Greca, J. Hsu +4 more
2018Biochemistry9 citations Open access
Semantic Scholar
Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi
P. Gade, A. Erlandson, A. Ullah, Xi Chen +3 more
2023Scientific Reports7 citations Open access
Semantic Scholar
Reproducibility of protein x-ray diffuse scattering and potential utility for modeling atomic displacement parameters
Z. Su, M. Dasgupta, F. Poitevin, I. Mathews +4 more
2021bioRxiv7 citations Open access
Semantic Scholar
Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
Mikhail A. Hameedi, É. Prates, M. Garvin, I. Mathews +14 more
2021bioRxiv5 citations Open access
Semantic Scholar
Potent and Selective Covalent Inhibitors of the Papain-like Protease from SARS-CoV-2
Brian Sanders, S. Pokhrel, Audrey D. Labbe, I. Mathews +29 more
2021Research Square4 citations Open access
Semantic Scholar
Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase
Katarina M. Guzman, D. Cogan, Krystal L Brodsky, Alexander M. Soohoo +6 more
2023Biochemistry3 citations Open access
Semantic Scholar
Energetic basis of excited-state enzyme design and function
Chi-Yun Lin, M. Romei, I. Mathews, S. Boxer
20212 citations Open access
Semantic Scholar
Unified Model for Photophysical and Electro-Optical Properties of Green Fluorescent Proteins
Chi-Yun Lin, M. Romei, L. Oltrogge, I. Mathews +1 more
2020Biophysical Journal2 citations Open access
Semantic Scholar
A unifying electrostatic basis for designing enzymes faster than natural ones.
Chu Zheng, Zhe Ji, I. Mathews, S. Boxer
2023Biophysical Journal1 citations Open access
Semantic Scholar
Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).
S. Mashayekh, L. Stunkard, M. Kienle, I. Mathews +1 more
2022Biochemistry1 citations Open access
Semantic Scholar
Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl−/H+ transport cycle
T. Chavan, Ricky C. Cheng, T. Jiang, I. Mathews +5 more
2019bioRxiv1 citations Open access
Semantic Scholar
Remote laboratory training for high school students: grocery store based hands-on project in protein crystallography.
Alison Fox, A. Teteris, I. Mathews
2023Journal of Applied Crystallography0 citations Open access
Semantic Scholar
Wild-type Pseudomonas fluorescens isocyanide hydratase (WT-3) at 274K, Refmac5-refined
Z. Su, M. Dasgupta, F. Poitevin, I. Mathews +4 more
20210 citations
Semantic Scholar
Pseudomonas fluorescens G150T isocyanide hydratase (G150T-2) at 274K, Refmac5-refined
Z. Su, M. Dasgupta, F. Poitevin, I. Mathews +4 more
20210 citations
Semantic Scholar
Pseudomonas fluorescens G150T isocyanide hydratase (G150T-3) at 274K, Refmac5-refined
Z. Su, M. Dasgupta, F. Poitevin, I. Mathews +4 more
20210 citations
Semantic Scholar
Pseudomonas fluorescens G150A isocyanide hydratase (G150A-3) at 274K, Refmac5-refined
Z. Su, M. Dasgupta, F. Poitevin, I. Mathews +4 more
20210 citations
Semantic Scholar

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