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P. Changelian · SciRah

Researcher profile · Semantic Scholar

P. Changelian

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P. Changelian — researcher profile on SciRah

h-index: 31
Works: 54
Citations: 6,559

Most-cited papers

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
J. Hanke, J. Gardner, R. Dow, P. Changelian +4 more
1996Journal of Biological Chemistry2,031 citations Open access
Semantic Scholar
Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor
P. Changelian, M. Flanagan, D. J. Ball, Craig R Kent +55 more
2003Science628 citations Open access
Semantic Scholar
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
M. Flanagan, T. Blumenkopf, W. Brissette, Matthew F. Brown +19 more
2010Journal of Medicinal Chemistry332 citations Open access
Semantic Scholar
A new modality for immunosuppression: targeting the JAK/STAT pathway
J. O'Shea, Marko Pesu, D. Borie, P. Changelian
2004Nature reviews. Drug discovery302 citations
Semantic Scholar
PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
D. Winkler, K. Faia, J. P. DiNitto, Janid A. Ali +23 more
2013Chemistry and Biology257 citations Open access
Semantic Scholar
Jakinibs: A New Class of Kinase Inhibitors in Cancer and Autoimmune Disease
A. Kontzias, Alexander M. Kotlyar, A. Laurence, P. Changelian +1 more
2012Current opinion in pharmacology (Print)225 citations Open access
Semantic Scholar
The Novel JAK‐3 Inhibitor CP‐690550 Is a Potent Immunosuppressive Agent in Various Murine Models
E. Kudlacz, Bret D. Perry, P. Sawyer, M. Conklyn +4 more
2004American Journal of Transplantation220 citations Open access
Semantic Scholar
Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation
A. Holdorf, Jonathan M. Green, S. Levin, Michael F. Denny +5 more
1999Journal of Experimental Medicine211 citations Open access
Semantic Scholar
Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
A. Milici, E. Kudlacz, Laurent P. Audoly, S. Zwillich +1 more
2008Arthritis Research & Therapy165 citations Open access
Semantic Scholar
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
Min Chen, Alan Cheng, Yi-Qing Chen, Anka Hymel +6 more
1997Proceedings of the National Academy of Sciences of the United States of America162 citations Open access
Semantic Scholar
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
Yong-Jie Zhou, Min Chen, N. Cusack, Lida H. Kimmel +11 more
2001Molecules and Cells148 citations Open access
Semantic Scholar
Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis.
M. Boy, Cunshan Wang, Bethanie E. Wilkinson, V. Chow +6 more
2009Journal of Investigative Dermatology147 citations Open access
Semantic Scholar
Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor.
P. Changelian, Ping Feng, Timothy King, J. Milbrandt
1989Proceedings of the National Academy of Sciences of the United States of America146 citations Open access
Semantic Scholar
Translational and clinical advances in JAK‐STAT biology: The present and future of jakinibs
M. Gadina, Catrina Johnson, D. Schwartz, M. Bonelli +5 more
2018Journal of Leukocyte Biology136 citations Open access
Semantic Scholar
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
Yong-Jie Zhou, Eric P. Hanson, Yi-Qing Chen, K. Magnuson +5 more
1997Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
Semantic Scholar
Jak3 and the pathogenesis of severe combined immunodeficiency.
J. O'Shea, M. Husa, Denisenko Li, S. Hofmann +5 more
2004Molecular Immunology126 citations
Semantic Scholar
Immunosuppression by the JAK3 Inhibitor CP-690,550 Delays Rejection and Significantly Prolongs Kidney Allograft Survival in Nonhuman Primates
D. Borie, P. Changelian, M. Larson, Ming-Sing Si +15 more
2005Transplantation109 citations Open access
Semantic Scholar
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
E. Kudlacz, M. Conklyn, C. Andresen, Carrie Whitney-Pickett +1 more
2008European Journal of Pharmacology106 citations
Semantic Scholar
The specificity of JAK3 kinase inhibitors.
P. Changelian, D. Moshinsky, Cyrille Kuhn, M. Flanagan +10 more
2008Blood104 citations Open access
Semantic Scholar
α-fetoprotein inhibits macrophage expression of Ia antigens
Christopher Y. H. Lu, P. Changelian, E. Unanue
1984102 citations
Semantic Scholar
PMA induces the ligand-independent internalization of CR1 on human neutrophils.
P. Changelian, R. Jack, L. A. Collins, D. Fearon
1985Journal of Immunology93 citations
Semantic Scholar
Effects of JAK3 Inhibition with CP-690,550 on Immune Cell Populations and Their Functions in Nonhuman Primate Recipients of Kidney Allografts
Ricardo T. Paniagua, Ming-Sing Si, M. Flores, G. Rousvoal +6 more
2005Transplantation78 citations Open access
Semantic Scholar
The JAK3 inhibitor CP‐690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing
M. Conklyn, C. Andresen, P. Changelian, E. Kudlacz
2004Journal of Leukocyte Biology71 citations
Semantic Scholar
JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants.
D. Borie, J. O'Shea, P. Changelian
2004Trends in Molecular Medicine71 citations
Semantic Scholar
Combined Use of the JAK3 Inhibitor CP-690,550 with Mycophenolate Mofetil to Prevent Kidney Allograft Rejection in Nonhuman Primates
D. Borie, M. Larson, M. Flores, Andrew C. Campbell +9 more
2005Transplantation66 citations Open access
Semantic Scholar
New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway
J. O'Shea, Heiyoung Park, Marko Pesu, D. Borie +1 more
2005Current Opinion in Rheumatology61 citations Open access
Semantic Scholar
Translating JAKs to Jakinibs
M. Gadina, Danielle A Chisolm, Rachael L. Philips, Iain B. McInness +2 more
2020Journal of Immunology49 citations Open access
Semantic Scholar
Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation
Yong-Jie Zhou, K. Magnuson, T. Cheng, M. Gadina +6 more
2000Molecular and Cellular Biology47 citations Open access
Semantic Scholar
Alpha-fetoprotein inhibits macrophage expression of Ia antigens.
C.-Y. Lu, P. Changelian, E. Unanue
1984Journal of Immunology41 citations
Semantic Scholar
Ecto-5′-Nucleotidase (CD73) Attenuates Allograft Airway Rejection through Adenosine 2A Receptor Stimulation
T. Ohtsuka, P. Changelian, Diane Bouïs, Kathleen R. Noon +3 more
2010Journal of Immunology39 citations Open access
Semantic Scholar
JAK3 inhibition as a new concept for immune suppression.
D. Borie, Ming-Sing Si, R. Morris, B. Reitz +1 more
2003Current opinion in investigational drugs34 citations
Semantic Scholar
Substrate-based kinase activity inference identifies MK2 as driver of colitis
S. Strasser, Phaedra C. Ghazi, A. Starchenko, M. Boukhali +12 more
2019Integrative Biology24 citations Open access
Semantic Scholar
HSP90 Inhibition Enhances Antimitotic Drug-Induced Mitotic Arrest and Cell Death in Preclinical Models of Non-Small Cell Lung Cancer
B. C. O'Connell, Katie M. O'Callaghan, B. Tillotson, M. Douglas +9 more
2014PLoS ONE18 citations Open access
Semantic Scholar
In vivo augmentation of IFN-gamma with a rIL-12 human/mouse chimera: pleiotropic effects against infectious agents in mice and rats.
R. Gladue, A. Laquerre, H. Magna, L. Carroll +3 more
1994Cytokine17 citations
Semantic Scholar
Purification of the growth-associated protein GAP-43 by reversed phase chromatography: amino acid sequence analysis and cDNA identification.
P. Changelian, K. Meiri, D. Soppet, Helen Valenza +2 more
1990Brain Research15 citations
Semantic Scholar
Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation
L. Suarez-Lopez, Bing Shui, Douglas K. Brubaker, M. Hill +6 more
2021iScience14 citations Open access
Semantic Scholar
Quantitative Analysis of the Immunosuppressant CP-690,550 in Whole Blood by Column-Switching High-Performance Liquid Chromatography and Mass Spectrometry Detection
Ricardo T. Paniagua, Andrew C. Campbell, P. Changelian, B. Reitz +2 more
2005Therapeutic Drug Monitoring12 citations
Semantic Scholar
Role of tyrosine kinases in lymphocyte activation: Targets for drug intervention
J. Hanke, B. Pollok, P. Changelian
1995Inflammation Research10 citations
Semantic Scholar
ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201
P. Changelian, Canxin Xu, Steve Mnich, Heidi R. Hope +18 more
2023JID Innovations7 citations Open access
Semantic Scholar
The Potent PI3K-δ,γ Inhibitor, IPI-145, Exhibits Preclinical Activity In Murine and Human T-Cell Acute Lymphoblastic Leukemia
Xiao-Hang Huang, J. Proctor, Ya-Ling Yang, Xiuhua Gao +6 more
20134 citations
Semantic Scholar
Jak3 Inhibition With Cp-690,550 Prevents Obliterative Bronchiolitis In A Rat Tracheal Transplant Model.
G. Rousvoal, Sally Zhang, G. Berry, M. Lau +7 more
20043 citations
Semantic Scholar
Abstract B101: TNFR-MK2 Signaling Drives Autophagy and Resistance to KRAS/MAPK Inhibition in Pancreatic Cancer
O. B. Pereye, I. Khawar, Qing Wei, Richard Kurupi +12 more
2025Cancer Research1 citations
Semantic Scholar
Inhibitors Targeting JAK3
G. Chan, P. Changelian
20121 citations
Semantic Scholar
Janus kinase 3 inhibition for immunosuppression: getting closer to the starting line
D. Borie, R. Starr, S. Hendry, P. Changelian +1 more
20051 citations
Semantic Scholar
PREVENTION OF OBLITERATIVE BRONCHIOLITIS BY JAK 3 INHIBITION WITH CP-690,550 IS ACCOMPANIED BY A DISTINCT GROWTH FACTOR GENE EXPRESSION PROFILE.
Sally Zhang, M. Lau, G. Berry, M. Larson +8 more
20041 citations Open access
Semantic Scholar
31 TARGETING OF THE TEC KINASE ITK, THE MOLECULAR TARGET OF CYCLOSPORINE A, DRIVES RESOLUTION OF T CELL-MEDIATED COLITIS
K. Lechner, S. Wirtz, R. Atreya, A. August +4 more
20210 citations
Semantic Scholar
1064 JAK kinase inhibitors efficiaous in models of murine contact hypersensitivity
P. Changelian, S. Mnich, C. Xu, S. Hockerman +3 more
20180 citations Open access
Semantic Scholar
Combination of IPI-504 and docetaxel (DTX) improves efficacy in NSCLC xenograft models.
B. C. O'Connell, Katie M. O'Callaghan, B. Tillotson, M. Douglas +9 more
20140 citations Open access
Semantic Scholar
Inhibitor Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3
P. Changelian
20130 citations
Semantic Scholar
Abstract 3433: Deciphering the mechanism of synergy between the Heat Shock Protein 90 inhibitor retaspimycin HCl and docetaxel in preclinical models of non-small cell lung cancer.
Katie M. O'Callaghan, B. C. O'Connell, B. Tillotson, M. Douglas +8 more
20130 citations
Semantic Scholar

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D. Borie×11
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D. Borie — researcher profile on SciRah
E. Kudlacz×9
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J. O'Shea×8
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W. Brissette — researcher profile on SciRah

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Ming-Sing Si — researcher profile on SciRah

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M. Larson — researcher profile on SciRah

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J. Kutok — researcher profile on SciRah

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Sally Zhang — researcher profile on SciRah

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G. Rousvoal — researcher profile on SciRah