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Janid A. Ali · SciRah

Researcher profile · Semantic Scholar

Janid A. Ali

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Janid A. Ali — researcher profile on SciRah

h-index: 13
Works: 23
Citations: 1,810

Most-cited papers

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.
Janid A. Ali, A. P. Jackson, Alison J. Howells, A. Maxwell
1993Biochemistry307 citations
Semantic Scholar
PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
D. Winkler, K. Faia, J. P. DiNitto, Janid A. Ali +23 more
2013Chemistry and Biology257 citations Open access
Semantic Scholar
Kinetic Measurement of the Step Size of DNA Unwinding by Escherichia coli UvrD Helicase
Janid A. Ali, T. Lohman
1997Science254 citations
Semantic Scholar
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
J. Sydor, E. Normant, C. Pien, J. R. Porter +19 more
2006Proceedings of the National Academy of Sciences of the United States of America228 citations
Semantic Scholar
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
J. Ge, E. Normant, J. R. Porter, Janid A. Ali +11 more
2006Journal of Medicinal Chemistry189 citations Open access
Semantic Scholar
Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.
Catherine A. Evans, Tao Liu, André Lescarbeau, S. Nair +21 more
2016ACS Medicinal Chemistry Letters138 citations Open access
Semantic Scholar
DNA unwinding step-size of E. coli RecBCD helicase determined from single turnover chemical quenched-flow kinetic studies.
A. Lucius, A. Vindigni, R. Gregorian, Janid A. Ali +3 more
2002Journal of Molecular Biology92 citations
Semantic Scholar
Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.
Janid A. Ali, G. Orphanides, Anthony Maxwell
1995Biochemistry81 citations
Semantic Scholar
Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
Tao Liu, S. Nair, André Lescarbeau, Jitendra D. Belani +17 more
2012Journal of Medicinal Chemistry74 citations Open access
Semantic Scholar
Kinetic Mechanism for Formation of the Active, Dimeric UvrD Helicase-DNA Complex*
N. K. Maluf, Janid A. Ali, T. Lohman
2003Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
R. Manam, K. McArthur, T. Chao, J. Weiss +8 more
2008Journal of Medicinal Chemistry53 citations
Semantic Scholar
Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo
B. Tillotson, K. Slocum, J. Coco, Nigel Whitebread +9 more
2010Journal of Biological Chemistry45 citations Open access
Semantic Scholar
HSP90 Inhibition Enhances Antimitotic Drug-Induced Mitotic Arrest and Cell Death in Preclinical Models of Non-Small Cell Lung Cancer
B. C. O'Connell, Katie M. O'Callaghan, B. Tillotson, M. Douglas +9 more
2014PLoS ONE18 citations Open access
Semantic Scholar
Abstract ND01: KSQ-4279: A first-in-class USP1 inhibitor for the treatment of cancers with homologous recombination deficiencies
L. Cadzow, E. Tobin, P. Sullivan, S. Shenker +19 more
2022Cancer Research7 citations
Semantic Scholar
Anti-Tumor Activity of IPI-504, a Novel Hsp90 Inhibitor in Multiple Myeloma.
V. Palombella, E. Normant, Janid A. Ali, J. Barrett +20 more
20046 citations
Semantic Scholar
Abstract B029: The potent and selective phosphoinositide-3-kinase-gamma inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment
J. Kutok, Janid A. Ali, Erin E Brophy, Alfredo C Castro +22 more
20161 citations
Semantic Scholar
Abstract A192: The potent and selective phosphoinositide-3-kinase-γ inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment
Karen McGovern, Janid A. Ali, Erin E Brophy, Alfredo C Castro +21 more
20151 citations
Semantic Scholar
Heat Shock Protein 90 ( Hsp 90 ) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo
B. Tillotson, K. Slocum, J. Coco, Nigel Whitebread +7 more
20101 citations
Semantic Scholar
Abstract 4973: A novel cellular class I phosphoinositide-3-kinase (PI3K) isoform-specific occupancy assay demonstrates a direct correlation between PI3K isoform activity and phospho-AKT levels
L. Gu, Erin E Brophy, E. Murphy, B. Tillotson +3 more
20150 citations
Semantic Scholar
Combination of IPI-504 and docetaxel (DTX) improves efficacy in NSCLC xenograft models.
B. C. O'Connell, Katie M. O'Callaghan, B. Tillotson, M. Douglas +9 more
20140 citations Open access
Semantic Scholar
Abstract 3433: Deciphering the mechanism of synergy between the Heat Shock Protein 90 inhibitor retaspimycin HCl and docetaxel in preclinical models of non-small cell lung cancer.
Katie M. O'Callaghan, B. C. O'Connell, B. Tillotson, M. Douglas +8 more
20130 citations
Semantic Scholar
Anticorps anti-acide gras amide hydrolase 2 et leurs utilisations
Janid A. Ali, J. Brownell, Erin E Brophy, Thomas T. Tibbitts
20100 citations
Semantic Scholar
The ATPase reaction of DNA gyrase
Janid A. Ali
19930 citations
Semantic Scholar

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