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D. Winkler · SciRah

Researcher profile · Semantic Scholar

D. Winkler

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D. Winkler — researcher profile on SciRah

h-index: 17
Works: 21
Citations: 4,479

Most-cited papers

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
D. Winkler, M. Sutherland, James C. Geoghegan, Changpu Yu +9 more
2003EMBO Journal1,142 citations Open access
Semantic Scholar
PI3Kγ is a molecular switch that controls immune suppression
Megan M. Kaneda, K. Messer, N. Ralainirina, Hongying Li +19 more
2016Nature1,113 citations Open access
Semantic Scholar
Overcoming Resistance to Checkpoint Blockade Therapy by Targeting PI3K-γ in Myeloid Cells
O. de Henau, M. Rausch, D. Winkler, L. Campesato +20 more
2016Nature816 citations Open access
Semantic Scholar
Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.
M. Sutherland, James C. Geoghegan, Changpu Yu, E. Turcott +3 more
2004Bone266 citations
Semantic Scholar
PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
D. Winkler, K. Faia, J. P. DiNitto, Janid A. Ali +23 more
2013Chemistry and Biology257 citations Open access
Semantic Scholar
Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins*
D. Winkler, M. K. Kung Sutherland, E. Ojala, E. Turcott +5 more
2005Journal of Biological Chemistry168 citations Open access
Semantic Scholar
Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.
Catherine A. Evans, Tao Liu, André Lescarbeau, S. Nair +21 more
2016ACS Medicinal Chemistry Letters138 citations Open access
Semantic Scholar
Noggin and Sclerostin Bone Morphogenetic Protein Antagonists Form a Mutually Inhibitory Complex*
D. Winkler, Changpu Yu, James C. Geoghegan, E. Ojala +4 more
2004Journal of Biological Chemistry102 citations Open access
Semantic Scholar
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Jun Kuai, B. Gregory, A. Hill, D. Pittman +17 more
2009Rheumatology94 citations Open access
Semantic Scholar
Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts.
M. Sutherland, James C. Geoghegan, Changpu Yu, D. Winkler +1 more
2004Bone88 citations
Semantic Scholar
Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-α Production in a Receptor for Advanced Glycation End Product-Dependent Manner
B. Ruan, Xin Li, Aaron Winkler, K. Cunningham +10 more
2010Journal of Immunology82 citations Open access
Semantic Scholar
Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system.
H. Cho, S. Ramer, M. Itoh, D. Winkler +5 more
1991Biochemistry52 citations
Semantic Scholar
Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity*
D. Winkler, R. Cutler, J. Drugan, S. Campbell +2 more
1998Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression
Megan M. Kaneda, K. Messer, N. Ralainirina, Hongying Li +19 more
2016Nature41 citations Open access
Semantic Scholar
Identification and Characterization of Mutations in Ha-Ras That Selectively Decrease Binding to cRaf-1*
D. Winkler, Jeffrey C. Johnson, Jonathan A. Cooper, A. Vojtek
1997Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
Mayuko Uehara, Martina M. McGrath, S. Ohori, Z. Solhjou +11 more
2017Nature Communications24 citations Open access
Semantic Scholar
The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation
Honyin Chiu, Sharmila Mallya, Phuongthao Nguyen, A. Mai +7 more
2017Frontiers in Immunology22 citations Open access
Semantic Scholar
Product-Dependent Manner Receptor for Advanced Glycation End Production in a a Complex Stimulate IFN-Complement C3a, CpG Oligos, and DNA/C3a
Janet E. Paulsen, Ling Lin, D. Winkler, J. Fitz +11 more
20100 citations
Semantic Scholar
Direct interaction of receptor for advanced glycation end products with CPGa and complement component C3a augments interferon alpha in human PBMCs
Xin Li, Jun Kuai, K. Cunningham, B. Ruan +7 more
20090 citations
Semantic Scholar
Binding antibodies sclerostin
H. Lu, C. Pászty, M. Robinson, A. Henry +5 more
20060 citations
Semantic Scholar
sclerostin-specific antibodies and methods for increasing bone mineralization
D. Winkler, Ji-Ye Shi, J. Latham
20040 citations
Semantic Scholar

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J. Latham×7
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