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G. Smyth · SciRah

Researcher profile · Semantic Scholar

G. Smyth

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G. Smyth — researcher profile on SciRah

h-index: 101
Works: 374
Citations: 181K

Most-cited papers

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads
Yang Liao, G. Smyth, Wei Shi
2018bioRxiv2,645 citations Open access
Semantic Scholar
Nonlinear Regression
G. Smyth
2019Handbook of Regression Analysis With Applications in R1,035 citations
Semantic Scholar
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast
B. Pal, Yun-Shun Chen, F. Vaillant, Bianca D. Capaldo +12 more
2021EMBO Journal415 citations Open access
Semantic Scholar
Generalized Linear Models With Examples in R
P. Dunn, G. Smyth
2018325 citations
Semantic Scholar
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
J. Baell, D. Leaver, S. Hermans, Gemma L. Kelly +48 more
2018Nature279 citations Open access
Semantic Scholar
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity
Cyril Seillet, Kylie Luong, Julie Tellier, N. Jacquelot +9 more
2019Nature Immunology209 citations
Semantic Scholar
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
S. Hogg, Olga Motorna, L. Cluse, Timothy M. Johanson +38 more
2021Molecules and Cells156 citations Open access
Semantic Scholar
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
Caleb A. Dawson, B. Pal, F. Vaillant, Luke C. Gandolfo +8 more
2020Nature Cell Biology149 citations
Semantic Scholar
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.
Anne C. Rios, Bianca D. Capaldo, F. Vaillant, B. Pal +13 more
2019Cancer Cell140 citations Open access
Semantic Scholar
The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.
Ajithkumar Vasanthakumar, Yang Liao, Peggy P. Teh, M. Pascutti +17 more
2017Cell Reports131 citations Open access
Semantic Scholar
Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
Raymond K. H. Yip, Joel S. Rimes, Bianca D. Capaldo, F. Vaillant +10 more
2021Nature Communications102 citations Open access
Semantic Scholar
Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures
Xue-Yi Dong, Mei-Hong Du, Q. Gouil, L. Tian +8 more
2023bioRxiv98 citations Open access
Semantic Scholar
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC‐SCRIPT
Michael Chopin, Aaron T. L. Lun, Y. Zhan, J. Schreuder +14 more
2019Immunity95 citations Open access
Semantic Scholar
Transcription-factor-mediated supervision of global genome architecture maintains B cell identity
Timothy M. Johanson, Aaron T. L. Lun, H. Coughlan, Tania Tan +3 more
2018Nature Immunology95 citations
Semantic Scholar
Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate
Timothy J. Peters, Michael J. Buckley, Yun-Shun Chen, G. Smyth +2 more
2021Nucleic Acids Research92 citations Open access
Semantic Scholar
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
T. Sidwell, Yang Liao, A. Garnham, Ajithkumar Vasanthakumar +13 more
2020Nature Communications85 citations Open access
Semantic Scholar
Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer
James R. Whittle, F. Vaillant, Elliot E. Surgenor, A. Policheni +16 more
2020Clinical Cancer Research80 citations Open access
Semantic Scholar
Differential co-expression-based detection of conditional relationships in transcriptional data: comparative analysis and application to breast cancer
D. Bhuva, J. Cursons, G. Smyth, Melissa J. Davis
2019Genome Biology66 citations Open access
Semantic Scholar
Loss of NF‐&kgr;B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT‐1‐Dependent Manner
L. O'Reilly, T. Putoczki, L. Mielke, J. Low +20 more
2018Immunity65 citations Open access
Semantic Scholar
The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.
Yu-Qing Yang, A. Kueh, Zoe L. Grant, Waruni Abeysekera +10 more
2021Blood64 citations Open access
Semantic Scholar
Single cell transcriptome atlas of mouse mammary epithelial cells across development
B. Pal, Yun-Shun Chen, M. Milevskiy, F. Vaillant +9 more
2021Breast Cancer Research61 citations Open access
Semantic Scholar
A guide to creating design matrices for gene expression experiments
C. Law, Kathleen Zeglinski, Xue-Yi Dong, M. Alhamdoosh +2 more
2020F1000Research59 citations Open access
Semantic Scholar
Multi-level remodelling of chromatin underlying activation of human T cells
N. Bediaga, H. Coughlan, Timothy M. Johanson, A. Garnham +7 more
2021Scientific Reports57 citations Open access
Semantic Scholar
An Erg-driven transcriptional program controls B cell lymphopoiesis
Ashley P Ng, H. Coughlan, S. Hediyeh-zadeh, K. Behrens +24 more
2020Nature Communications54 citations Open access
Semantic Scholar
Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.
A. R. D. Delbridge, A. Kueh, F. Ke, N. Zamudio +18 more
2019Cell Reports53 citations Open access
Semantic Scholar
Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
W. C. Aw, Samuel G. Towarnicki, Richard G Melvin, N. Youngson +9 more
2018PLoS Genetics53 citations Open access
Semantic Scholar
Dysregulated IL-1&bgr;-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine
Man Lyang Kim, W. Martin, G. Minigo, J. Keeble +6 more
2018Circulation50 citations Open access
Semantic Scholar
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence.
Nai-Yang Fu, B. Pal, Yun-Shun Chen, F. Jackling +14 more
2018Developmental Cell48 citations Open access
Semantic Scholar
Targeting triple-negative breast cancers with the Smac-mimetic birinapant
N. Lalaoui, D. Merino, Göknur Giner, F. Vaillant +16 more
2020Cell Death and Differentiation47 citations Open access
Semantic Scholar
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
Helen M. McRae, A. Garnham, Yifang Hu, Matthew T. Witkowski +23 more
2019Blood46 citations Open access
Semantic Scholar
Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development
B. Aubrey, A. Janic, Yun-Shun Chen, Catherine Chang +11 more
2018Genes & Development43 citations Open access
Semantic Scholar
Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome
Alexandra J Roth-Schulze, M. Penno, K. Ngui, H. Oakey +21 more
2021Microbiome41 citations Open access
Semantic Scholar
Dividing out quantification uncertainty allows efficient assessment of differential transcript expression with edgeR
Pedro L. Baldoni, Yun-Shun Chen, S. Hediyeh-zadeh, Yang Liao +4 more
2023bioRxiv40 citations Open access
Semantic Scholar
R code and downstream analysis objects for the scRNA-seq atlas of normal and tumorigenic human breast tissue
Yun-Shun Chen, B. Pal, G. Lindeman, J. Visvader +1 more
2022Scientific Data39 citations Open access
Semantic Scholar
Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice
P. Arandjelovic, Youry Kim, James P. Cooney, Simon P. Preston +13 more
2023Cell Reports Medicine37 citations Open access
Semantic Scholar
Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT
Shengbo Zhang, H. Coughlan, Mitra Ashayeripanah, Simona Seizova +12 more
2021Science immunology35 citations
Semantic Scholar
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.
A. Kueh, M. Bergamasco, Anna Quaglieri, B. Phipson +13 more
2023Cell Reports34 citations Open access
Semantic Scholar
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest
Johannes Wichmann, Catherine Pitt, S. Eccles, A. Garnham +9 more
2022Cell Death and Disease34 citations Open access
Semantic Scholar
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.
Anne C. Rios, Bianca D. Capaldo, F. Vaillant, B. Pal +13 more
2019Cancer Cell33 citations Open access
Semantic Scholar
The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21
D. Zotos, Isaak Quast, Connie S. N. Li-Wai-Suen, C. McKenzie +5 more
2021Nature Communications30 citations Open access
Semantic Scholar
MOZ directs the distal-less homeobox gene expression program during craniofacial development
H. Vanyai, A. Garnham, R. May, Helen M. McRae +5 more
2019Development29 citations Open access
Semantic Scholar
Extracellular Vesicles in Synovial Fluid from Rheumatoid Arthritis Patients Contain miRNAs with Capacity to Modulate Inflammation
Andrew D. Foers, A. Garnham, S. Chatfield, G. Smyth +4 more
2021International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells
A. Kueh, S. Eccles, L. Tang, A. Garnham +5 more
2019Molecular and Cellular Biology26 citations Open access
Semantic Scholar
Pre-mitotic genome re-organisation bookends the B cell differentiation process
Wing-Fuk Chan, H. Coughlan, Jie H. S. Zhou, Christine R. Keenan +5 more
2021Nature Communications25 citations Open access
Semantic Scholar
Procalcitonin and Interleukin-10 May Assist in Early Prediction of Bacteraemia in Children With Cancer and Febrile Neutropenia
Marcel Doerflinger, G. Haeusler, Connie S. N. Li-Wai-Suen, J. Clark +9 more
2021Frontiers in Immunology25 citations Open access
Semantic Scholar
No counts, no variance: allowing for loss of degrees of freedom when assessing biological variability from RNA-seq data
Aaron T. L. Lun, G. Smyth
2017Statistical Applications in Genetics and Molecular Biology25 citations
Semantic Scholar
Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development
Timothy M. Johanson, H. Coughlan, Aaron T. L. Lun, N. Bediaga +5 more
2018PLoS Genetics24 citations Open access
Semantic Scholar
Unraveling the timeline of gene expression: A pseudotemporal trajectory analysis of single-cell RNA sequencing data
Jinming Cheng, G. Smyth, Yun-Shun Chen
2023bioRxiv23 citations Open access
Semantic Scholar
Modeling group heteroscedasticity in single-cell RNA-seq pseudo-bulk data
Yue You, Xue-Yi Dong, Y. K. Wee, M. Maxwell +5 more
2023Genome Biology23 citations Open access
Semantic Scholar
Neither random nor censored: estimating intensity-dependent probabilities for missing values in label-free proteomics
Meng-Bo Li, G. Smyth
2023Bioinform.20 citations Open access
Semantic Scholar

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