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Chu-Huang Chen · SciRah

Researcher profile · Semantic Scholar

Chu-Huang Chen

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Chu-Huang Chen — researcher profile on SciRah

h-index: 34
Works: 148
Citations: 4,365

Most-cited papers

An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases
Shi-Hui Law, M. Chan, G. Marathe, F. Parveen +2 more
2019International Journal of Molecular Sciences731 citations Open access
Semantic Scholar
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease.
A. Akhmedov, T. Sawamura, Chu-Huang Chen, S. Kraler +2 more
2020European Heart Journal137 citations Open access
Semantic Scholar
Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis.
Nicole Stancel, Chih-Chieh Chen, Liang-Yin Ke, Chih-Sheng Chu +3 more
2016Clinical Chemistry128 citations
Semantic Scholar
VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis.
Chun-Wun Lu, Yi-Hsuan Lo, Chu-Huang Chen, Ching-Yi Lin +7 more
2017Cancer Letters113 citations
Semantic Scholar
Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
Hua-Chen Chan, Liang-Yin Ke, Chih-Sheng Chu, An-Sheng Lee +11 more
2013Blood91 citations Open access
Semantic Scholar
Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
Ming-Yi Shen, Fang-Yu Chen, Jing-Fang Hsu, Ru-Huei Fu +13 more
2016Blood83 citations Open access
Semantic Scholar
Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain
Chih-Hsien Hung, Cheng-Han Lee, Ming-Hsien Tsai, Chu-Huang Chen +4 more
2020Annals of the Rheumatic Diseases63 citations Open access
Semantic Scholar
Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: a novel cytoprotective role of aspirin in acute myocardial infarction.
Po-Yuan Chang, Yi‐Jie Chen, F. Chang, Jonathan T. Lu +6 more
2013Cardiovascular Research61 citations Open access
Semantic Scholar
Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo
Yu‐Chen Wang, An-Sheng Lee, Long-Sheng Lu, Liang-Yin Ke +13 more
2018Aging Cell57 citations Open access
Semantic Scholar
(PS)2: protein structure prediction server version 3.0
Tsun-Tsao Huang, Jenn-Kang Hwang, Chu-Huang Chen, Chih-Sheng Chu +2 more
2015Nucleic Acids Res.50 citations Open access
Semantic Scholar
Malondialdehyde mediates oxidized LDL-induced coronary toxicity through the Akt-FGF2 pathway via DNA methylation
Tzu‐Ching Yang, Yi‐Jie Chen, Shwu-Fen Chang, Chu-Huang Chen +2 more
2014Journal of Biomedical Sciences48 citations Open access
Semantic Scholar
Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor
Chih-Sheng Chu, Yu‐Chen Wang, Long-Sheng Lu, Brian Walton +7 more
2013PLoS ONE48 citations Open access
Semantic Scholar
Spotlight on very-low-density lipoprotein as a driver of cardiometabolic disorders: Implications for disease progression and mechanistic insights
Hsiang-Chun Lee, A. Akhmedov, Chu-Huang Chen
2022Frontiers in Cardiovascular Medicine43 citations Open access
Semantic Scholar
Update on ADAMTS13 and VWF in cardiovascular and hematological disorders.
O. Akyol, Sumeyya Akyol, Chu-Huang Chen
2016Clinica chimica acta; international journal of clinical chemistry37 citations
Semantic Scholar
Effects of Electronegative VLDL on Endothelium Damage in Metabolic Syndrome
Chu-Huang Chen, Jonathan T. Lu, Shu-Hua Chen, Roger Y. Huang +5 more
2012Diabetes Care37 citations Open access
Semantic Scholar
Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro.
Wei-Yu Chen, Fang-Yu Chen, An-Sheng Lee, Kuan-Hsiang Ting +6 more
2015Journal of Natural Products36 citations
Semantic Scholar
The Underlying Chemistry of Electronegative LDL’s Atherogenicity
Liang-Yin Ke, Nicole Stancel, H. Bair, Chu-Huang Chen
2014Current Atherosclerosis Reports34 citations
Semantic Scholar
Role of Low‐Density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus
Hua-Chen Chan, H. Chan, chan‐jung liang, Hsiang-Chun Lee +11 more
2020Arthritis & Rheumatology33 citations
Semantic Scholar
The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications.
Sumeyya Akyol, Jonathan T. Lu, O. Akyol, F. Akçay +3 more
2017Trends in cardiovascular medicine32 citations Open access
Semantic Scholar
Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease
Chih-Sheng Chu, Hua-Chen Chan, Ming-Hsien Tsai, Nicole Stancel +11 more
2018Scientific Reports31 citations Open access
Semantic Scholar
Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines
An-Sheng Lee, Guei-Jane Wang, Hua-Chen Chan, Fang-Yu Chen +5 more
2012Apoptosis31 citations Open access
Semantic Scholar
Urinary adiponectin as a new diagnostic index for chronic kidney disease due to diabetic nephropathy
S. Yamakado, Hiroki Cho, Mikio Inada, Mika Morikawa +21 more
2019BMJ Open Diabetes Research & Care30 citations Open access
Semantic Scholar
Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF
Vyala Hanumanthareddy Chaithra, S. Jacob, C. Lakshmikanth, M. Sumanth +8 more
2018Journal of Lipid Research30 citations Open access
Semantic Scholar
Mesenchymal Stem Cell Derived Exosomes: A New Hope for the Treatment of Cardiovascular Disease?
Chen-Rong Tsao, Mau-Fang Liao, Min-hsiung Wang, Chien-Ming Cheng +1 more
2014Acta Cardiologica Sinica27 citations
Semantic Scholar
Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction
Hsiang-Chun Lee, Chih-Chieh Chen, Wei-Chung Tsai, Hsin-Ting Lin +5 more
2017Scientific Reports26 citations Open access
Semantic Scholar
Role of apolipoprotein E in electronegative low-density lipoprotein-induced mitochondrial dysfunction in cardiomyocytes.
Wei-Yu Chen, Yun-fang Chen, H. Chan, C. Chung +6 more
2020Metabolism: Clinical and Experimental25 citations
Semantic Scholar
Increased APOE glycosylation plays a key role in the atherogenicity of L5 low‐density lipoprotein
Liang-Yin Ke, Hua-Chen Chan, Chih-Chieh Chen, Chuan‐Fa Chang +6 more
2020The FASEB Journal25 citations Open access
Semantic Scholar
Oxidized ApoC1 on MALDI-TOF and glycated-ApoA1 band on gradient gel as potential diagnostic tools for atherosclerotic vascular disease.
Chiz-Tzung Chang, Hsin-Yi Liao, Chia-Ming Chang, Chia-Ying Chen +4 more
2013Clinica chimica acta; international journal of clinical chemistry24 citations
Semantic Scholar
Low-density lipoprotein electronegativity and risk of death after acute coronary syndromes: A case-cohort analysis.
S. Kraler, Florian A. Wenzl, J. Vykoukal, Johannes F. Fahrmann +14 more
2023Atherosclerosis23 citations Open access
Semantic Scholar
p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice.
K. Abhilasha, M. Sumanth, Vyala Hanumanthareddy Chaithra, S. Jacob +8 more
2019Free Radical Biology & Medicine23 citations
Semantic Scholar
Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
Kuan-Cheng Chang, An-Sheng Lee, Wei-Yu Chen, Yen-Nien Lin +9 more
2015Journal of Molecular and Cellular Cardiology23 citations
Semantic Scholar
Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.
A. Kakino, Y. Fujita, Liang-Yin Ke, Hua-Chen Chan +4 more
2020Journal of Lipid Research22 citations Open access
Semantic Scholar
Clinical Significance of Electronegative Low-Density Lipoprotein Cholesterol in Atherothrombosis
Chih-Sheng Chu, Shi-Hui Law, D. Lenzen, Yong-Hong Tan +6 more
2020Biomedicines22 citations Open access
Semantic Scholar
Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging‐associated tumorigenesis induced by ultraviolet B
Wen-Li Hsu, Ming-Hsien Tsai, Ching‐Ying Wu, Jui-Lin Liang +11 more
2019Aging Cell21 citations Open access
Semantic Scholar
Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in Uremia Patients on Maintenance Hemodialysis
Chiz-Tzung Chang, Guei-Jane Wang, Chin-Chi Kuo, Ju-Yi Hsieh +9 more
2016Medicine21 citations Open access
Semantic Scholar
VLDL from Metabolic Syndrome Individuals Enhanced Lipid Accumulation in Atria with Association of Susceptibility to Atrial Fibrillation
Hsiang-Chun Lee, Hsin-Ting Lin, Liang-Yin Ke, C. Wei +7 more
2016International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
The Sizes and Composition of HDL-Cholesterol Are Significantly Associated with Inflammation in Rheumatoid Arthritis Patients
Ching-Kun Chang, E. Chiang, KUANGH-HSI Chang, Kuo-Tung Tang +4 more
2023International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Association between Negatively Charged Low-Density Lipoprotein L5 and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients
Chun-Yu Chang, Chu-Huang Chen, Yi-Ming Chen, Tsu-Yi Hsieh +4 more
2019Journal of Clinical Medicine19 citations Open access
Semantic Scholar
Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL
An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Jing-Fang Hsu +6 more
2014Cardiovascular Diabetology19 citations Open access
Semantic Scholar
An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimer’s Disease
Hua-Chen Chan, Liang-Yin Ke, Hsiao-Ting Lu, Shih-Feng Weng +7 more
2020Biomedicines18 citations Open access
Semantic Scholar
Detection of a High Ratio of Soluble to Membrane‐Bound LOX‐1 in Aspirated Coronary Thrombi From Patients With ST‐Segment–Elevation Myocardial Infarction
An-Sheng Lee, Yu‐Chen Wang, Shih-Sheng Chang, P. Lo +7 more
2020Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease18 citations Open access
Semantic Scholar
Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice
Ying-Feng Lin, Ching-Kuan Liu, Hsiang-Chun Lee, Mei-Chuan Chou +3 more
2021Scientific Reports17 citations Open access
Semantic Scholar
Association of Electronegative LDL with Macrophage Foam Cell Formation and CD11c Expression in Rheumatoid Arthritis Patients
Ching-Kun Chang, Po-Ku Chen, J. Lan, Shih-Hsin Chang +4 more
2020International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes
Yi-Lin Shiou, Hsin-Ting Lin, Liang-Yin Ke, Bin-Nan Wu +5 more
2019Journal of Clinical Medicine16 citations Open access
Semantic Scholar
Combined LDL and VLDL Electronegativity Correlates with Coronary Heart Disease Risk in Asymptomatic Individuals
Ming-Yi Shen, Jing-Fang Hsu, Fang-Yu Chen, Jonathan T. Lu +7 more
2019Journal of Clinical Medicine15 citations Open access
Semantic Scholar
Electronegative Low-Density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated With Metabolic Syndrome
Liang-Yin Ke, Hua-Chen Chan, H. Chan, F. Kalu +10 more
2017Journal of Clinical Endocrinology and Metabolism15 citations Open access
Semantic Scholar
Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea
Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu +2 more
2021Molecular Neurobiology14 citations
Semantic Scholar
Age-dependent impact of new ESC-Guideline recommended door-to-balloon times on mid-term survival in acute ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.
Yu‐Chen Wang, Ying-ying Huang, P. Lo, Kuan-Cheng Chang +2 more
2016International Journal of Cardiology14 citations
Semantic Scholar
Identification of the HDL-ApoCIII to VLDL-ApoCIII ratio as a predictor of coronary artery disease in the general population: The Chin-Shan Community Cardiovascular Cohort (CCCC) study in Taiwan
Po-Yuan Chang, Chii-Ming Lee, H. Hsu, Hung-Ju Lin +5 more
2012Lipids in Health and Disease14 citations Open access
Semantic Scholar
Four Statin Benefit Groups Defined by The 2013 ACC/AHA New Cholesterol Guideline are Characterized by Increased Plasma Level of Electronegative Low-Density Lipoprotein.
Chih-Sheng Chu, Liang-Yin Ke, Hua-Chen Chan, Hsiu-Chua Chan +9 more
2016Acta Cardiologica Sinica13 citations
Semantic Scholar

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Chih-Sheng Chu×14
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Hua-Chen Chan×14
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Chia-Ming Chang×9

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