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A. Kakino · SciRah

Researcher profile · Semantic Scholar

A. Kakino

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A. Kakino — researcher profile on SciRah

h-index: 19
Works: 67
Citations: 1,695

Most-cited papers

DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics
T. Ikura, S. Tashiro, A. Kakino, Hiroki Shima +16 more
2007Molecular and Cellular Biology407 citations Open access
Semantic Scholar
The Discovery of LOX-1, its Ligands and Clinical Significance
R. Yoshimoto, Y. Fujita, A. Kakino, Shin Iwamoto +2 more
2011Cardiovascular Drugs and Therapy155 citations Open access
Semantic Scholar
Lox-1: the multifunctional receptor underlying cardiovascular dysfunction.
S. Ogura, A. Kakino, Yuko Sato, Y. Fujita +4 more
2009Circulation Journal121 citations Open access
Semantic Scholar
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Koichi Sugimoto, T. Ishibashi, T. Sawamura, N. Inoue +13 more
2009Cardiovascular Research118 citations Open access
Semantic Scholar
LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
N. Inoue, T. Okamura, Y. Kokubo, Y. Fujita +12 more
2010Clinical Chemistry114 citations Open access
Semantic Scholar
Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Y. Fujita, A. Kakino, Norihisa Nishimichi, S. Yamaguchi +6 more
2009Clinical Chemistry91 citations
Semantic Scholar
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
M. Ishikawa, H. Ito, M. Akiyoshi, N. Kume +11 more
2012Arthritis & Rheumatism63 citations
Semantic Scholar
Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox
Taichi Nishizuka, Y. Fujita, Yuko Sato, Atushi Nakano +5 more
2011Proceedings of the Japan Academy. Series B, Physical and biological sciences63 citations Open access
Semantic Scholar
LOX-1: a multiligand receptor at the crossroads of response to danger signals
T. Sawamura, A. Kakino, Y. Fujita
2012Current Opinion in Lipidology56 citations
Semantic Scholar
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin‐like oxLDL receptor
Koichi Yamamoto, A. Kakino, H. Takeshita, Norihiro Hayashi +23 more
2015The FASEB Journal54 citations
Semantic Scholar
High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study
C. Yokota, T. Sawamura, M. Watanabe, Y. Kokubo +6 more
2016Journal of atherosclerosis and thrombosis51 citations Open access
Semantic Scholar
LOX-1 mediates vascular lipid retention under hypertensive state
Atushi Nakano, N. Inoue, Yuko Sato, Norihisa Nishimichi +7 more
2010Journal of Hypertension38 citations
Semantic Scholar
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Y. Fujita, S. Yamaguchi, A. Kakino, Shin Iwamoto +2 more
2011Clinical Chemistry36 citations Open access
Semantic Scholar
LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) Deletion Has Protective Effects on Stroke in the Genetic Background of Stroke-Prone Spontaneously Hypertensive Rat
Yi-Qiang Liang, A. Kakino, Y. Matsuzaka, T. Mashimo +9 more
2020Stroke25 citations Open access
Semantic Scholar
C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
Y. Fujita, A. Kakino, M. Harada-Shiba, Yuko Sato +3 more
2010Clinical Chemistry23 citations
Semantic Scholar
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor
Toshimasa Takahashi, Yi-Bin Huang, Koichi Yamamoto, Go Hamano +20 more
2021iScience22 citations Open access
Semantic Scholar
Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.
A. Kakino, Y. Fujita, Liang-Yin Ke, Hua-Chen Chan +4 more
2020Journal of Lipid Research22 citations Open access
Semantic Scholar
Developmental Endothelial Locus-1 (Del-1) Inhibits Oxidized Low-Density Lipoprotein Activity by Direct Binding, and Its Overexpression Attenuates Atherogenesis in Mice.
A. Kakino, Y. Fujita, A. Nakano, Sayaka Horiuchi +1 more
2016Circulation Journal20 citations Open access
Semantic Scholar
Pitavastatin Reduces Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands in Hypercholesterolemic Humans
Tetsuya Matsumoto, M. Fujita, T. Sawamura, A. Kakino +12 more
2010Lipids20 citations
Semantic Scholar
Detection of a High Ratio of Soluble to Membrane‐Bound LOX‐1 in Aspirated Coronary Thrombi From Patients With ST‐Segment–Elevation Myocardial Infarction
An-Sheng Lee, Yu‐Chen Wang, Shih-Sheng Chang, P. Lo +7 more
2020Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease18 citations Open access
Semantic Scholar
LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men
T. Okamura, A. Sekikawa, T. Sawamura, T. Kadowaki +21 more
2013Atherosclerosis18 citations Open access
Semantic Scholar
An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
Shin Iwamoto, Y. Fujita, A. Kakino, Kazuki Yanagida +3 more
2011Journal of atherosclerosis and thrombosis17 citations Open access
Semantic Scholar
Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin
C. Yokoyama, Takuma Aoyama, Takahiro Ido, A. Kakino +7 more
2016PLoS ONE16 citations Open access
Semantic Scholar
LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen
Kayo Takahashi, J. Aono, Y. Nakao, Mika Hamaguchi +9 more
2022Hypertension Research15 citations
Semantic Scholar
The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men.
A. Hirata, A. Kakino, T. Okamura, Y. Usami +9 more
2020Atherosclerosis14 citations
Semantic Scholar
Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Mai Nakayachi, J. Ito, Chiyomi Hayashida, Yoko Ohyama +8 more
2015Bone14 citations
Semantic Scholar
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane
Serina Yokoyama, Tatsuo Kawai, Koichi Yamamoto, Yi-Bin Huang +14 more
2021Scientific Reports11 citations Open access
Semantic Scholar
A Novel Cell-Free, Non-Fluorescent Method to Measure LOX-1-Binding Activity Corresponding to The Functional Activity of HDL
A. Kakino, Y. Usami, Sayaka Horiuchi, Y. Fujita +4 more
2019Journal of atherosclerosis and thrombosis11 citations Open access
Semantic Scholar
LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells
Victor J F Kitano, Yoko Ohyama, Chiyomi Hayashida, J. Ito +8 more
2020Journal of Cell Science10 citations
Semantic Scholar
Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2
Marumi Ohno, M. Sasaki, Y. Orba, Toshiki Sekiya +8 more
2021Viruses9 citations Open access
Semantic Scholar
123I–Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
Atushi Nakano, H. Kawashima, Y. Miyake, T. Zeniya +9 more
2018Nuclear medicine and molecular imaging8 citations Open access
Semantic Scholar
LOX-1 in Ischemic Stroke
T. Sawamura, Y. Fujita, Sayaka Horiuchi, A. Kakino
2017Journal of atherosclerosis and thrombosis7 citations Open access
Semantic Scholar
Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct‐acting antivirals
S. Joshita, Y. Yamashita, Toru Okamoto, Y. Usami +6 more
2021Hepatology Research6 citations
Semantic Scholar
Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model
Marumi Ohno, A. Kakino, Toshiki Sekiya, Naoki Nomura +3 more
2021Scientific Reports6 citations Open access
Semantic Scholar
Evolving concepts of low‐density lipoprotein: From structure to function
Chu-Huang Chen, Tatsuya Sawamura, A. Akhmedov, Ming-Hsien Tsai +5 more
2025European Journal of Clinical Investigation5 citations Open access
Semantic Scholar
NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.
Kento Hosomi, H. Kawashima, Atsushi Nakano, A. Kakino +10 more
2022Cardiovascular Research5 citations Open access
Semantic Scholar
Oxidized LDL enhances Gq signaling and aldosterone production by angiotensin II via the AT1-LOX-1 receptor complex in adrenal cells
Jittoku Ihara, Yi-Bin Huang, Y. Takami, Yu Guo +13 more
2025Hypertension Research4 citations Open access
Semantic Scholar
Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex
Jittoku Ihara, Yi-Bin Huang, Y. Takami, Yoichi Nozato +20 more
2024bioRxiv2 citations Open access
Semantic Scholar
Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaques.
C. T. Nguyen, M. Nakayama, H. Ishigaki, Yoshinori Kitagawa +7 more
2024Virology1 citations Open access
Semantic Scholar
Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study.
Mizuki Sata, A. Kakino, A. Hirata, Miho Iida +12 more
2021European Journal of Preventive Cardiology1 citations
Semantic Scholar
Adiponectin as a blocker of oxidized LDL
A. Kakino, Y. Fujita, T. Sawamura
20161 citations
Semantic Scholar
A Novel ELISA System for Measuring Modified LDL-Adiponectin Complex
Mai Sasaoka, A. Kakino, Roberto Villalobos-Labra, Yuki Yamashita +7 more
2025Journal of atherosclerosis and thrombosis0 citations Open access
Semantic Scholar
ESTABLISHMENT OF ELISA SYSTEM FOR MODIFIED LDLADIPONECTIN COMPLEX
Mai Sasaoka, A. Kakino, Roberto Villalobos-Labra, F. Spaans +2 more
2024Atherosclerosis0 citations
Semantic Scholar
P170 OXIDIZED LOW-DENSITY LIPOPROTEIN POTENTIATES ANGIOTENSIN II-INDUCED GQ ACTIVATION THROUGH THE AT1 - LOX1 RECEPTOR COMPLEX
Yoichi Nozato, Jittoku Ihara, Yi-Bin Huang, Y. Takami +6 more
2024Journal of Hypertension0 citations
Semantic Scholar
PS-BPB01-5: LOX-1 DEFICIENCY INCREASES RUPTURED ABDOMINAL AORTIC ANEURYSM VIA THINNING OF ADVENTITIAL COLLAGEN
Kayo Takahashi, J. Aono, Y. Nakao, Mika Hamaguchi +8 more
2023Journal of Hypertension0 citations Open access
Semantic Scholar
Endothelial LOX-1 plays a critical role in inflammatory thrombosis
A. Kakino, Y. Fujita, T. Sawamura
2020Proceedings for Annual Meeting of The Japanese Pharmacological Society0 citations Open access
Semantic Scholar
Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects
A. Kakino, Y. Fujita, Liang-Yin Ke, Hua-Chen Chan +4 more
2020Journal of Lipid Research0 citations Open access
Semantic Scholar
Serum modified HDL was associated with cardiovascular disease in a Japanese community-based cohort
T. Okamura, Mizuki Sata, Miho Iida, A. Kakino +6 more
2019European Journal of Public Health0 citations
Semantic Scholar
P3780Adiponectin forms a complex with electronegative L5 LDL in human plasma and inhibits its atherogenic effects
A. Kakino, Y. Fujita, Sayaka Horiuchi, Liang-Yin Ke +3 more
2018European Heart Journal0 citations Open access
Semantic Scholar
51Serum modified high density lipoprotein levels assessed by a novel assay was associated with coronary artery calcification in an apparently healthy population
T. Okamura, A. Kakino, K. Miura, A. Fujiyoshi +11 more
2018European Heart Journal0 citations
Semantic Scholar

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T. Sawamura×41
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T. Sawamura — researcher profile on SciRah
Y. Fujita×29
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Y. Fujita — researcher profile on SciRah
R. Yoshimoto×7
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R. Yoshimoto — researcher profile on SciRah
Yuko Sato×7
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T. Okamura — researcher profile on SciRah

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Y. Takami — researcher profile on SciRah

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Y. Usami — researcher profile on SciRah

Shin Iwamoto×5

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H. Takeshita×5

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Yoichi Nozato×5

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Yoichi Nozato — researcher profile on SciRah