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S. Jacob · SciRah

Researcher profile · Semantic Scholar

S. Jacob

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S. Jacob — researcher profile on SciRah

h-index: 12
Works: 31
Citations: 517

Most-cited papers

Platelet MHC Class I Mediates CD8+ T Cell Suppression During Sepsis.
Li Guo, Si-Kui Shen, J. Rowley, Neal D. Tolley +16 more
2021Blood112 citations Open access
Semantic Scholar
To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase
G. Marathe, C. Pandit, C. Lakshmikanth, Vyala Hanumanthareddy Chaithra +2 more
2014Journal of Lipid Research79 citations Open access
Semantic Scholar
Sepsis: in search of cure
C. Lakshmikanth, S. Jacob, Vyala Hanumanthareddy Chaithra, H. Castro-Faria-Neto +1 more
2016Inflammation Research69 citations Open access
Semantic Scholar
Mitofusin-2 Regulates Platelet Mitochondria and Function
S. Jacob, Yasuhiro Kosaka, Seema Bhatlekar, F. Denorme +24 more
2023Circulation Research35 citations
Semantic Scholar
The fate of mitochondria during platelet activation
A. Grichine, S. Jacob, A. Eckly, Joran Villaret +11 more
2023Blood Advances31 citations Open access
Semantic Scholar
Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF
Vyala Hanumanthareddy Chaithra, S. Jacob, C. Lakshmikanth, M. Sumanth +8 more
2018Journal of Lipid Research30 citations Open access
Semantic Scholar
MAPK-interacting kinase 1 (Mnk1) regulates platelet production, activation, and thrombosis.
B. Manne, Robert A. Campbell, Seema Bhatlekar, A. Ajanel +14 more
2022Blood27 citations Open access
Semantic Scholar
CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.
Emilie Montenont, Seema Bhatlekar, S. Jacob, Yasuhiro Kosaka +8 more
2021Blood Advances26 citations Open access
Semantic Scholar
Escherichia coli Braun Lipoprotein (BLP) exhibits endotoxemia – like pathology in Swiss albino mice
C. Lakshmikanth, S. Jacob, A. Kudva, C. Latchoumycandane +9 more
2016Scientific Reports24 citations Open access
Semantic Scholar
p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice.
K. Abhilasha, M. Sumanth, Vyala Hanumanthareddy Chaithra, S. Jacob +8 more
2019Free Radical Biology & Medicine23 citations
Semantic Scholar
Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils.
M. Sumanth, S. Jacob, K. Abhilasha, B. Manne +9 more
2020Journal of Leukocyte Biology15 citations Open access
Semantic Scholar
Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance
S. Jacob, C. Lakshmikanth, Vyala Hanumanthareddy Chaithra, T. R. S. Kumari +3 more
2016PLoS ONE13 citations Open access
Semantic Scholar
Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses
M. Sumanth, K. Abhilasha, S. Jacob, Vyala Hanumanthareddy Chaithra +5 more
2019bioRxiv7 citations Open access
Semantic Scholar
Interferon a-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation
Seema Bhatlekar, S. Jacob, Emilia A Tugolukova, B. Manne +7 more
2021Haematologica4 citations Open access
Semantic Scholar
Megakaryocyte-Specific Knockout of the Mir-99b/let7e/125a Cluster Lowers Platelet Count without Altering Platelet Function
Seema Bhatlekar, S. Jacob, B. Manne, Guo Li +9 more
2021Blood Cells, Molecules & Diseases4 citations Open access
Semantic Scholar
NFKB2 Defects
S. Jacob, Julie E. Feusier, Karin Chen
2018Humoral Primary Immunodeficiencies4 citations
Semantic Scholar
Mitochondrial Fission Protein Drp1 Regulates Platelet Function
S. Jacob, Marina Tistao, Abigail Ajanel Gomez, F. Denorme +6 more
2023Blood3 citations Open access
Semantic Scholar
Differential glycosylation of alpha-1-acid glycoprotein (AGP-1) contributes to its functional diversity
M. Sumanth, S. Jacob, K. Abhilasha, B. Manne +9 more
2020bioRxiv3 citations Open access
Semantic Scholar
Interference of phenol during quantification of a bacterial lipoprotein
C. Lakshmikanth, S. Jacob, A. Divya, A. Rao +1 more
20163 citations
Semantic Scholar
Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation
Li Guo, S. Jacob, B. Manne, E. Kolawole +12 more
2023Haematologica2 citations Open access
Semantic Scholar
Functional classification of platelet gene variants using CRISPR HDR in CD34+ cell-derived megakaryocytes
Yasuhiro Kosaka, Brandon L. Lopez, Nina Kishimoto, S. Jacob +9 more
2025American Journal of Human Genetics1 citations Open access
Semantic Scholar
Multiplexed Functional Assessment of Glanzmann Thrombasthenia Variants
Yasuhiro Kosaka, S. Jacob, J. Di Paola, Justyne E. Ross +6 more
2023Blood1 citations Open access
Semantic Scholar
Actin Bundling Protein L-Plastin Regulates Megakaryocyte Membrane Rigidity and Platelet Spreading
Li Guo, Seema Bhatlekar, S. Jacob, B. Manne +9 more
2022Blood1 citations
Semantic Scholar
Platelet-activating factor and oxidized phosphatidylcholines do not suppress endotoxin-induced pro-inflammatory signaling among human myeloid and endothelial cells
S. Jacob, C. Lakshmikanth, T. McIntyre, G. Marathe
20171 citations Open access
Semantic Scholar
Prospective Evaluation of Systemic Coagulation Function During Anti-Amyloid Monoclonal Antibody Therapy in Alzheimer’s Disease
Bethany C. Curd, Neal D. Tolley, Miriam Santo, Jack Foster +10 more
2026Journal of Thrombosis and Thrombolysis0 citations Open access
Semantic Scholar
The Actin Bundling Protein L-Plastin Mediates Platelet Force Generation and Thrombosis
Seema Bhatlekar, S. Jacob, Marina Tistao, Molly Y. Mollica +11 more
2023Blood0 citations Open access
Semantic Scholar
Actin Bundling Protein L-plastin Regulates Platelet Production, Spreading, and Thrombosis
Li Guo, S. Jacob, B. Manne, Seema Bhatlekar
2023JVS: Vascular Science0 citations Open access
Semantic Scholar
Abstract 142: Actin Bundling Protein L-plastin Regulates Platelet Production, Spreading and Thrombosis
Li Guo, S. Jacob, B. Manne, Seema Bhatlekar
2023Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
Mitofusin2 (MFN2) Preserves Mitochondrial Integrity and Function in Megakaryocytes and Platelets
S. Jacob, Yasuhiro Kosaka, Seema Bhatlekar, Alexandra Moody +16 more
2021Blood0 citations Open access
Semantic Scholar
Heterozygous Mutations in NFKB2 Exhibit a Broad Clinical Phenotype
E. Newman, Julie E. Feusier, S. Jacob, L. Jorde +17 more
20180 citations
Semantic Scholar
Sepsis: in search of cure
C. Lakshmikanth, S. Jacob, Vyala Hanumanthareddy Chaithra, H. C. de Castro-Faria-Neto +1 more
2016Inflammation Research0 citations Open access
Semantic Scholar

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