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Bin-Nan Wu · SciRah

Researcher profile · Semantic Scholar

Bin-Nan Wu

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Bin-Nan Wu — researcher profile on SciRah

h-index: 26
Works: 139
Citations: 2,454

Most-cited papers

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation
Yu-Chi Cheng, Lichao Chu, Jun-Yih Chen, Su-Ling Hsieh +3 more
2020Cells182 citations Open access
Semantic Scholar
Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination.
Lichao Chu, Kuang-I Cheng, Jun-Yih Chen, Yu-Chi Cheng +5 more
2019Phytomedicine66 citations
Semantic Scholar
Hyposmotic challenge inhibits inward rectifying K+ channels in cerebral arterial smooth muscle cells.
Bin-Nan Wu, Kevin D. Luykenaar, J. Brayden, W. Giles +3 more
2007American Journal of Physiology. Heart and Circulatory Physiology57 citations
Semantic Scholar
Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery.
Yi-Ling Lin, Zen-Kong Dai, R. Lin, K. Chu +3 more
2010Phytomedicine52 citations
Semantic Scholar
Eugenolol and Glyceryl-Isoeugenol Suppress LPS-Induced INOS Expression by Down-Regulating NF-κB and AP-1 through Inhibition of Mapks and AKT/IκBα Signaling Pathways in Macrophages
J. Yeh, Jong-Hau Hsu, Y. Hong, J.-R. Wu +4 more
201147 citations Open access
Semantic Scholar
The xanthine derivative KMUP‐1 inhibits models of pulmonary artery hypertension via increased NO and cGMP‐dependent inhibition of RhoA/Rho kinase
Hui-Hsuan Chung, Zen-Kong Dai, Bin-Nan Wu, J. Yeh +4 more
2010British Journal of Pharmacology46 citations Open access
Semantic Scholar
Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model
Jun-Yih Chen, Lichao Chu, Kuang-I Cheng, Su-Ling Hsieh +2 more
2018Scientific Reports44 citations Open access
Semantic Scholar
KMUP‐1 attenuates isoprenaline‐induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways
J. Yeh, Jong-Hau Hsu, Ping‐Ju Wu, S. Liou +5 more
2010British Journal of Pharmacology43 citations Open access
Semantic Scholar
Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model.
Yi-Lun Lee, Kun-Ling Lin, Shu-Mien Chuang, Yung-Chin Lee +6 more
2017American Journal of Pathology42 citations Open access
Semantic Scholar
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats
Yu-Chi Cheng, Yu-Min Chiu, Zen-Kong Dai, Bin-Nan Wu
2021Cells38 citations Open access
Semantic Scholar
Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway
Jiunn-Ren Wu, J. Yeh, S. Liou, Zen-Kong Dai +2 more
2016International Journal on Biological Sciences38 citations Open access
Semantic Scholar
Atorvastatin prevents neuroinflammation in chronic constriction injury rats through nuclear NFκB downregulation in the dorsal root ganglion and spinal cord.
Lichao Chu, Jun-Yih Chen, Pao-Chu Wu, Bin-Nan Wu
2015ACS Chemical Neuroscience38 citations
Semantic Scholar
Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats.
Kuang-I Cheng, Sin-Lan Chen, Jong-Hau Hsu, Yu-Chi Cheng +5 more
2021Phytomedicine35 citations
Semantic Scholar
Xanthine derivative KMUP-1 reduces inflammation and hyperalgesia in a bilateral chronic constriction injury model by suppressing MAPK and NFκB activation.
Zen-Kong Dai, Ting-Chun Lin, J. Liou, Kuang-I Cheng +4 more
2014Molecular Pharmaceutics32 citations
Semantic Scholar
Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages
Erna Sulistyowati, Mei-Yueh Lee, Lintlyun Wu, Jong-Hau Hsu +4 more
2018Molecules30 citations Open access
Semantic Scholar
Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence
Cheng-Yu Long, Kun-Ling Lin, Yung-Chin Lee, Shu-Mien Chuang +6 more
2020Scientific Reports26 citations Open access
Semantic Scholar
Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction
Hsiang-Chun Lee, Chih-Chieh Chen, Wei-Chung Tsai, Hsin-Ting Lin +5 more
2017Scientific Reports26 citations Open access
Semantic Scholar
Effects of Secretome from Fat Tissues on Ion Currents of Cardiomyocyte Modulated by Sodium-Glucose Transporter 2 Inhibitor
S. Jhuo, I. Liu, Wei-Chung Tsai, Te-Wu Chou +4 more
2020Molecules25 citations Open access
Semantic Scholar
Pre-germinated brown rice prevents high-fat diet induced hyperglycemia through elevated insulin secretion and glucose metabolism pathway in C57BL/6J strain mice
Kuo-Ping Shen, Chi-Long Hao, H. Yen, Chun-Yen Chen +2 more
2014Journal of clinical biochemistry and nutrition25 citations Open access
Semantic Scholar
No Donor KMUP-1 Improves Hepatic Ischemia-Reperfusion and Hypoxic Cell Injury by Inhibiting Oxidative Stress and Pro-Inflammatory Signaling
K. Kuo, Bin-Nan Wu, E. Y. Chiu, C.-J. Tseng +4 more
2013International Journal of Immunopathology and Pharmacology25 citations Open access
Semantic Scholar
Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial
Kun-Ling Lin, Jian-He Lu, K. Chueh, Tai-Jui Juan +6 more
2021International Journal of Molecular Sciences24 citations Open access
Semantic Scholar
Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways
Yi-Lun Lee, Kun-Ling Lin, Bin-Nan Wu, Shu-Mien Chuang +4 more
2018Scientific Reports24 citations Open access
Semantic Scholar
Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho‐kinase pathway and NADPH oxidase
I-Chen Chen, M. Tan, Bin-Nan Wu, C. Chai +4 more
2017Pediatric Pulmonology24 citations
Semantic Scholar
Differential Effects of Central and Peripheral Fat Tissues on the Delayed Rectifier K+ Outward Currents in Cardiac Myocytes
Kun-Tai Lee, Paul Wei-Hua Tang, Wei-Chung Tsai, I. Liu +5 more
2013The Cardiology24 citations
Semantic Scholar
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine
S. Liou, T. T. Nguyen, Jong-Hau Hsu, Erna Sulistyowati +4 more
2020Antioxidants23 citations Open access
Semantic Scholar
Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression.
Yi-Ling Lin, R. Lin, Kuo-Pyng Shen, Zen-Kong Dai +3 more
2011Journal of Ethnopharmacology23 citations
Semantic Scholar
B‐type natriuretic peptide inhibits angiotensin II‐induced proliferation and migration of pulmonary arterial smooth muscle cells
Jong-Hau Hsu, S. Liou, San-Nan Yang, Bin-Nan Wu +4 more
2014Pediatric Pulmonology22 citations
Semantic Scholar
KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.
Zen-Kong Dai, Yun-Jen Cheng, Hui-Hsuan Chung, Jiunn-Ren Wu +2 more
2010Life Science22 citations
Semantic Scholar
VLDL from Metabolic Syndrome Individuals Enhanced Lipid Accumulation in Atria with Association of Susceptibility to Atrial Fibrillation
Hsiang-Chun Lee, Hsin-Ting Lin, Liang-Yin Ke, C. Wei +7 more
2016International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells
I'feng Ch'en, Zen-Kong Dai, D. Welsh, I. Chen +1 more
2011Journal of Biomedical Sciences21 citations Open access
Semantic Scholar
KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.
Hui-Hsuan Chung, Zen-Kong Dai, Bin-Nan Wu, J. Yeh +4 more
2010Vascular pharmacology21 citations
Semantic Scholar
Potential Actions of Baicalein for Preventing Vascular Calcification of Smooth Muscle Cells In Vitro and In Vivo
Erna Sulistyowati, Jong-Hau Hsu, Szu-Jung Lee, Shang-En Huang +5 more
2022International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Actions of KMUP‐1, a xanthine and piperazine derivative, on voltage‐gated Na+ and Ca2+‐activated K+ currents in GH3 pituitary tumour cells
Y. Lo, Yu-Ting Tseng, Chi-Ming Liu, Bin-Nan Wu +1 more
2015British Journal of Pharmacology20 citations Open access
Semantic Scholar
Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor Ameliorate Metabolic Disorder and Obesity Induced Cardiomyocyte Injury and Mitochondrial Remodeling
S. Jhuo, Yi-Hsiung Lin, I. Liu, Tsung-Hsien Lin +3 more
2023International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho‐kinase inhibitor fasudil
Zen-Kong Dai, Bin-Nan Wu, I-Chen Chen, C. Chai +5 more
2011Pediatric Pulmonology19 citations Open access
Semantic Scholar
Low Intensity Extracorporeal Shock Wave Therapy as a Novel Treatment for Stress Urinary Incontinence: A Randomized-Controlled Clinical Study
Kun-Ling Lin, K. Chueh, Jian-He Lu, Shu-Mien Chuang +7 more
2021Medicina18 citations Open access
Semantic Scholar
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
Meng-Luen Lee, Erna Sulistyowati, Jong-Hau Hsu, Bo-Yau Huang +4 more
2019Molecules18 citations Open access
Semantic Scholar
Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia‐induced apoptosis in endothelial progenitor cells
Jiunn-Ren Wu, Jong-Hau Hsu, Zen-Kong Dai, Bin-Nan Wu +3 more
2016The Journal of pharmacy and pharmacology18 citations
Semantic Scholar
Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin
S. Jhuo, I. Liu, W. Tasi, Te-Wu Chou +4 more
2021International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats
Erna Sulistyowati, Ren-Long Jan, S. Liou, Ying-Fu Chen +3 more
2019Journal of Traditional and Complementary Medicine17 citations Open access
Semantic Scholar
Endothelial nitric oxide synthase‐enhancing G‐protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin‐1‐dependent and endothelin‐1‐independent pathways in a monocrotaline model
Chung‐Pin Liu, Zen-Kong Dai, C. Huang, J. Yeh +3 more
2014Kaohsiung Journal of Medical Sciences17 citations Open access
Semantic Scholar
KMUP‐3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP‐9/TIMP‐1 balance
Chung‐Pin Liu, J. Yeh, Bin-Nan Wu, C. Chai +2 more
2011British Journal of Pharmacology17 citations Open access
Semantic Scholar
Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes
Yi-Lin Shiou, Hsin-Ting Lin, Liang-Yin Ke, Bin-Nan Wu +5 more
2019Journal of Clinical Medicine16 citations Open access
Semantic Scholar
The Prostate 69 : 610 ^ 623 ( 2009 ) Piperazine-Designed a 1 A / a 1 D-AdrenoceptorBlocker KMUP-1 andDoxazosin ProvideDown-Regulationof AndrogenReceptor andPSAin Prostatic LNCaPCells Growthand Specifically inXenografts
Chi-Ming Liu, Y. Lo, Ming-Hong Tai, Bin-Nan Wu +5 more
200916 citations
Semantic Scholar
Eugenosedin‐A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high‐fat diet
Kuo-Ping Shen, Hui-li Lin, Su-Ling Hsieh, Aij-Lie Kwan +2 more
2009The Journal of pharmacy and pharmacology16 citations
Semantic Scholar
In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis
Shang-En Huang, Erna Sulistyowati, Yu-Ying Chao, Bin-Nan Wu +3 more
2021Biomedicines14 citations Open access
Semantic Scholar
Eugenosedin‐A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide‐induced diabetic rats
Kuo-Ping Shen, Hui-li Lin, H. Yen, Su-Ling Hsieh +2 more
2017Kaohsiung Journal of Medical Sciences14 citations Open access
Semantic Scholar
Isoeugenodilol inhibits smooth muscle cell proliferation and neointimal thickening after balloon injury via inactivation of ERK1/2 pathway.
J. Yeh, S. Liou, Yu Chang, Shin-Wha Lin +4 more
2008Journal of Biomedical Sciences14 citations
Semantic Scholar
Potassium-Channel Openers KMUP-1 and Pinacidil Prevent Subarachnoid Hemorrhage–Induced Vasospasm by Restoring the BKCa-Channel Activity
Jun-Yih Chen, Kuang-I Cheng, Y. Tsai, Yi-Ren Hong +4 more
2012Shock13 citations Open access
Semantic Scholar
Inhaled KMUP-1 Prevents Allergic Pulmonary Vascular Inflammation and Remodeling via NO and Suppressed MMP-9 and ICAM-1/VCAM-1.
Chung‐Pin Liu, Chung-Han Hsieh, Bin-Nan Wu, J. Yeh +3 more
2012Inflammation & Allergy - Drug Targets13 citations
Semantic Scholar

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Zen-Kong Dai×23
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Zen-Kong Dai — researcher profile on SciRah
J. Yeh×22
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J. Yeh — researcher profile on SciRah
I. Chen×21
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I. Chen — researcher profile on SciRah
Jong-Hau Hsu×13
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Jong-Hau Hsu — researcher profile on SciRah

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Jiunn-Ren Wu — researcher profile on SciRah

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S. Liou — researcher profile on SciRah

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W. Lai — researcher profile on SciRah

Jun-Yih Chen×6

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Jun-Yih Chen — researcher profile on SciRah

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C. Chai — researcher profile on SciRah

Chung‐Pin Liu×6

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Chung‐Pin Liu — researcher profile on SciRah

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Y. Juan — researcher profile on SciRah

Erna Sulistyowati×6

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Erna Sulistyowati — researcher profile on SciRah