A. Brunger

Most-cited papers

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
Jia-Jie Diao, Rong Liu, Yueguang Rong, Ming-Lei Zhao +9 more
2015Nature557 citations Open access
Semantic Scholar
Structure of photosystem II and substrate binding at room temperature
I. Young, M. Ibrahim, R. Chatterjee, S. Gul +64 more
2016Nature342 citations Open access
Semantic Scholar
The Primed SNARE-Complexin-Synaptotagmin Complex for Neuronal Exocytosis
Qiang-Jun Zhou, Peng Zhou, Austin L. Wang, Dick Wu +3 more
2017Nature257 citations Open access
Semantic Scholar
Mechanistic insights into the recycling machine of the SNARE complex
Ming-Lei Zhao, Shen-Ping Wu, Qiang-Jun Zhou, S. Vivona +3 more
2015Nature246 citations Open access
Semantic Scholar
Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18
Y. Lai, Ucheor B. Choi, J. Leitz, H. Rhee +8 more
2017Neuron216 citations Open access
Semantic Scholar
Molecular mechanisms of fast neurotransmitter release
A. Brunger, Ucheor B. Choi, Y. Lai, J. Leitz +1 more
2018Annual Review of Biophysics158 citations Open access
Semantic Scholar
The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines
Yousuf A. Khan, K. I. White, A. Brunger
2021Critical reviews in biochemistry and molecular biology122 citations Open access
Semantic Scholar
Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors
David C. Martinelli, Kylie S Chew, A. Rohlmann, Matthew Y. Lum +5 more
2016Neuron115 citations Open access
Semantic Scholar
Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals
M. Uervirojnangkoorn, O. Zeldin, A. Lyubimov, J. Hattne +4 more
2015eLife105 citations Open access
Semantic Scholar
Mosquito larvicide BinAB revealed by de novo phasing with an X-ray laser
J. Colletier, M. Sawaya, M. Gingery, José A. Rodríguez +20 more
2016Nature98 citations Open access
Semantic Scholar
Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis
Shen Wang, Ucheor B. Choi, J. Gong, Xiao-Yu Yang +5 more
2017EMBO Journal81 citations Open access
Semantic Scholar
The pre-synaptic fusion machinery
A. Brunger, Ucheor B. Choi, Y. Lai, J. Leitz +2 more
2019Current Opinion in Structural Biology80 citations Open access
Semantic Scholar
A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions
T. D. Murray, A. Lyubimov, C. Ogata, Huy Vo +3 more
2015Acta Crystallographica Section D: Biological Crystallography72 citations Open access
Semantic Scholar
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
Y. Lai, G. Fois, J. Flores, M. Tuvim +11 more
2022Nature68 citations Open access
Semantic Scholar
High-density grids for efficient data collection from multiple crystals
E. L. Baxter, L. Águila, R. Alonso-Mori, C. Barnes +29 more
2016Acta Crystallographica Section D: Structural Biology64 citations Open access
Semantic Scholar
C-terminal domain of mammalian complexin-1 localizes to highly curved membranes
J. Gong, Y. Lai, Xiaohong Li, Mengxian Wang +10 more
2016Proceedings of the National Academy of Sciences of the United States of America61 citations Open access
Semantic Scholar
Prefused lysosomes cluster on autophagosomes regulated by VAMP8
Qi-Xin Chen, M. Hao, Lei Wang, Lin-Sen Li +8 more
2020Cell Death and Disease55 citations Open access
Semantic Scholar
Morphologies of synaptic protein membrane fusion interfaces
P. Gipson, Y. Fukuda, R. Danev, Y. Lai +3 more
2017Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Ca2+-triggered synaptic vesicle fusion initiated by release of inhibition
A. Brunger, J. Leitz, Qiang-Jun Zhou, Ucheor B. Choi +1 more
2018Trends in Cell Biology51 citations Open access
Semantic Scholar
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle
Kailu Yang, Chu-Chu Wang, K. I. White, R. Pfuetzner +2 more
2022Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion
Seth Malmersjö, S. Di Palma, Jia-Jie Diao, Y. Lai +8 more
2016EMBO Journal49 citations Open access
Semantic Scholar
Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation
Chun-Xiao Song, Jia-Jie Diao, A. Brunger, S. Quake
2016Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
N-terminal domain of complexin independently activates calcium-triggered fusion
Y. Lai, Ucheor B. Choi, Yunxiang Zhang, Ming-Lei Zhao +4 more
2016Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
Kailu Yang, Chu-Chu Wang, Alex J. B. Kreutzberger, Ravi Ojha +16 more
2022bioRxiv41 citations Open access
Semantic Scholar
Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
Stijn van Dorp, Ruo-Yi Qiu, Ucheor B. Choi, Min-Nie M. Wu +4 more
2020bioRxiv40 citations Open access
Semantic Scholar
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex
Ucheor B. Choi, Ming-Lei Zhao, Yunxiang Zhang, Y. Lai +1 more
2016eLife40 citations Open access
Semantic Scholar
Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism
Anna J. Khalaj, F. Sterky, A. Sclip, Jochen Schwenk +3 more
2020Journal of Cell Biology37 citations Open access
Semantic Scholar
The Core Complex of the Ca2+-Triggered Presynaptic Fusion Machinery
A. Brunger, J. Leitz
2022Journal of Molecular Biology34 citations Open access
Semantic Scholar
Author response: Structural principles of SNARE complex recognition by the AAA+ protein NSF
K. I. White, Ming-Lei Zhao, Ucheor B. Choi, R. Pfuetzner +1 more
201832 citations Open access
Semantic Scholar
Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex
A. Lyubimov, M. Uervirojnangkoorn, O. Zeldin, Qiang-Jun Zhou +7 more
2016eLife30 citations Open access
Semantic Scholar
Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering
Hongki Song, T. Torng, Amy S. Orr, A. Brunger +1 more
2021bioRxiv24 citations Open access
Semantic Scholar
The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography
I. Mathews, Kim Allison, Thomas Robbins, A. Lyubimov +8 more
2017Biochemistry24 citations Open access
Semantic Scholar
IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images
A. Lyubimov, M. Uervirojnangkoorn, O. Zeldin, A. Brewster +5 more
2016Journal of Applied Crystallography24 citations Open access
Semantic Scholar
Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin
Yunxiang Zhang, Jia-Jie Diao, K. Colbert, Y. Lai +9 more
2015Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Synaptic vesicle fusion: today and beyond
N. Brose, A. Brunger, D. Cafiso, E. Chapman +12 more
2019Nature Structural & Molecular Biology22 citations
Semantic Scholar
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
Ying Lai, Chun-Yu Zhao, Zhi-Qi Tian, Chu-Chu Wang +16 more
2023Proceedings of the National Academy of Sciences of the United States of America21 citations Open access
Semantic Scholar
Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
Klaudia Jaczynska, Luis Esquivies, R. Pfuetzner, Baris Alten +5 more
2022FEBS Open Bio17 citations Open access
Semantic Scholar
Molecular Characterization of AMPA-Receptor-Containing Vesicles
J. Peters, J. Leitz, J. Oses-Prieto, A. Burlingame +1 more
2021Frontiers in Molecular Neuroscience17 citations Open access
Semantic Scholar
Beyond the MUN domain, Munc13 controls priming and depriming of synaptic vesicles
Jeremy Leitz, Chu-Chu Wang, Luis Esquivies, R. Pfuetzner +4 more
2024Cell Reports16 citations Open access
Semantic Scholar
Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control
Yan Gao, Yousuf A. Khan, Weike Mo, K. I. White +5 more
2023Cell Reports12 citations Open access
Semantic Scholar
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18
Y. Lai, A. Brunger
20188 citations Open access
Semantic Scholar
Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin.
Jiu-Sheng Lin, H. van den Bedem, A. Brunger, M. Wilson
2016Acta Crystallographica Section D: Structural Biology8 citations Open access
Semantic Scholar
A feature-guided, focused 3D signal permutation method for subtomogram averaging
J. Peters, J. Leitz, Qiang Guo, F. Beck +2 more
2022Journal of Structural Biology7 citations Open access
Semantic Scholar
Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
Y. Lai, M. Tuvim, J. Leitz, J. Peters +8 more
2022bioRxiv6 citations Open access
Semantic Scholar
CryoEM Models and Associated Data Submitted to the 2015/2016 EMDataBank Model Challenge
C. Lawson, A. Kryshtafovych, Wah K. Chiu, P. Adams +38 more
20184 citations
Semantic Scholar
Molecular Mechanisms of Synaptic Vesicle Priming
A. Brunger
20183 citations Open access
Semantic Scholar
Discovery of a drug to treat airway mucus hypersecretion
B. Dickey, Yin-Yan Lai, M. Frick, A. Brunger
2022Clinical and Translational Medicine2 citations Open access
Semantic Scholar
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
Y. Lai, G. Fois, J. Flores, M. Tuvim +11 more
20222 citations Open access
Semantic Scholar
Single SNARE Complex Recycling By NSF
Ucheor B. Choi, Ming-Lei Zhao, K. I. White, Qiang-Jun Zhou +2 more
20182 citations Open access
Semantic Scholar
Conformational dynamics of SNARE recycling mediated by NSF
Katie M. Dunleavy, Holland Matlock, C. Gething, Giovanni Howells +4 more
2022The FASEB Journal1 citations Open access
Semantic Scholar