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M. Sawaya · SciRah

Researcher profile · Semantic Scholar

M. Sawaya

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M. Sawaya — researcher profile on SciRah

h-index: 85
Works: 647
Citations: 31K

Most-cited papers

The Expanding Amyloid Family: Structure, Stability, Function, and Pathogenesis
M. Sawaya, M. Hughes, José A. Rodríguez, R. Riek +1 more
2021Cell397 citations Open access
Semantic Scholar
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
P. Seidler, K. Murray, D. Boyer, P. Ge +10 more
2022Nature Communications162 citations Open access
Semantic Scholar
Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43
Yi-Xiao Jiang, Qin Cao, M. Sawaya, R. Abskharon +7 more
2022Nature137 citations Open access
Semantic Scholar
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
Q. Cao, D. Boyer, M. Sawaya, P. Ge +1 more
2020Nature Structural & Molecular Biology118 citations Open access
Semantic Scholar
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid
Jia-Hui Lu, Q. Cao, M. Hughes, M. Sawaya +3 more
2020Nature Communications95 citations Open access
Semantic Scholar
Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation
R. Abskharon, M. Sawaya, D. Boyer, Q. Cao +3 more
2022bioRxiv81 citations Open access
Semantic Scholar
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Q. Cao, D. Boyer, M. Sawaya, R. Abskharon +6 more
2021Nature Structural & Molecular Biology78 citations Open access
Semantic Scholar
Isobutanol production freed from biological limits using synthetic biochemistry
Saken Sherkhanov, T. Korman, S. Chan, S. Faham +6 more
2020Nature Communications74 citations Open access
Semantic Scholar
Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines
Catharine Shipps, H. R. Kelly, Peter J. Dahl, Sophia M. Yi +7 more
2020Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils
R. Abskharon, Hope Pan, M. Sawaya, P. Seidler +23 more
2023Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold
R. Castells-Graells, K. Meador, M. Arbing, M. Sawaya +12 more
2023Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies
K. Murray, M. Hughes, Carolyn Hu, M. Sawaya +5 more
2022Nature Structural & Molecular Biology35 citations Open access
Semantic Scholar
Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface.
Chuanqi Sun, K. Zhou, Peter DePaola, W. Shin +6 more
2023Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade
G. Tetreau, A. Banneville, E. Andreeva, A. Brewster +34 more
2020Nature Communications33 citations Open access
Semantic Scholar
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease
R. Abskharon, P. Seidler, M. Sawaya, D. Cascio +12 more
2020Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Geometric Lessons and Design Strategies for Nanoscale Protein Cages.
J. Laniado, K. Cannon, Justin E. Miller, M. Sawaya +2 more
2021ACS Nano24 citations
Semantic Scholar
Extended β-Strands Contribute to Reversible Amyloid Formation.
K. Murray, Declan Evans, M. Hughes, M. Sawaya +3 more
2022ACS Nano23 citations
Semantic Scholar
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
E. Tayeb-Fligelman, Jeannette T. Bowler, C. Tai, M. Sawaya +24 more
2023Nature Communications22 citations Open access
Semantic Scholar
Computational design of mixed chirality peptide macrocycles with internal symmetry
V. Mulligan, Christine S. Kang, M. Sawaya, Stephen A. Rettie +8 more
2020Protein Science22 citations Open access
Semantic Scholar
A Suite of Designed Protein Cages Using Machine Learning and Protein Fragment-Based Protocols
K. Meador, R. Castells-Graells, Roman Aguirre, M. Sawaya +4 more
2024Structure19 citations Open access
Semantic Scholar
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity
Bryan D. Ryder, E. Ustyantseva, D. Boyer, Aydé Mendoza-Oliva +8 more
2024Structure18 citations Open access
Semantic Scholar
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
E. Tayeb-Fligelman, Xinyi Cheng, C. Tai, Jeannette T. Bowler +20 more
2021bioRxiv18 citations Open access
Semantic Scholar
De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals
G. Tetreau, M. Sawaya, E. De Zitter, E. Andreeva +59 more
2021Nature Communications18 citations Open access
Semantic Scholar
Racemic Peptides from Amyloid β and Amylin Form Rippled β-Sheets Rather Than Pleated β-Sheets.
Amaruka Hazari, M. Sawaya, Maria Sajimon, N. Vlahakis +3 more
2023Journal of the American Chemical Society13 citations
Semantic Scholar
Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices
Amber L H Gray, M. Sawaya, Debalina Acharyya, Jinchao Lou +5 more
2021Protein Science13 citations Open access
Semantic Scholar
Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization
J. Ochoa, V. Nguyen, M. Nie, M. Sawaya +2 more
2020Protein Science12 citations Open access
Semantic Scholar
Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED
L. Richards, Maria D. Flores, C. Millán, C. Glynn +6 more
2021bioRxiv10 citations Open access
Semantic Scholar
Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation
Jia-Hui Lu, Peng Ge, M. Sawaya, M. Hughes +6 more
2023Journal of Biological Chemistry9 citations Open access
Semantic Scholar
Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER
L. Richards, C. Millán, Jennifer Miao, M. Martynowycz +5 more
2020Acta Crystallographica Section D: Structural Biology9 citations Open access
Semantic Scholar
Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways
M. Aoki, J. Vinokur, Kento Motoyama, Rino Ishikawa +6 more
2022Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets
Jeannette T. Bowler, M. Sawaya, D. Boyer, D. Cascio +2 more
2022Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method
Gregory M. Rosenberg, R. Abskharon, D. Boyer, Peng Ge +2 more
2023PNAS Nexus6 citations Open access
Semantic Scholar
Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core
Logan S. Richards, Maria D. Flores, Samantha Zink, Natalie A. Schibrowsky +2 more
2023Structure6 citations Open access
Semantic Scholar
Rigidified Scaffolds for 3 Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets
R. Castells-Graells, K. Meador, M. Arbing, M. Sawaya +7 more
2022bioRxiv6 citations Open access
Semantic Scholar
The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey
Amaruka Hazari, M. Sawaya, N. Vlahakis, T. Johnstone +4 more
2022Chemical Science5 citations Open access
Semantic Scholar
Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation
Maria D. Flores, M. Sawaya, D. Boyer, S. Zink +6 more
2022bioRxiv5 citations Open access
Semantic Scholar
Formation of rippled β-sheets from mixed chirality linear and cyclic peptides—new structural motifs based on the pauling-corey rippled β-sheet
Amaruka Hazari, M. Sawaya, Hyeonju Lee, Maria Sajimon +4 more
2025Chemical Science4 citations Open access
Semantic Scholar
A Suite of Designed Protein Cages Using Machine Learning Algorithms and Protein Fragment-Based Protocols
K. Meador, R. Castells-Graells, Roman Aguirre, M. Sawaya +4 more
2023bioRxiv3 citations Open access
Semantic Scholar
Ab initio determination of peptide structures by MicroED
Chih-Te Zee, Ambarneil Saha, M. Sawaya, José A. Rodríguez
2020Methods in molecular biology3 citations Open access
Semantic Scholar
Crystal structure of MbnF: an NADPH-dependent flavin monooxygenase from Methylocystis strain SB2
Andrew Stewart, P. Dershwitz, Charles E. Stewart, M. Sawaya +5 more
2023Acta Crystallographica Section F Structural Biology Communications2 citations Open access
Semantic Scholar
Why amyloid fibrils have a limited width
D. Boyer, Nikos A. Mynhier, M. Sawaya
2021bioRxiv2 citations Open access
Semantic Scholar
Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments.
J. Ochoa, O. Mijares, Andrea A Acosta, Xavier Escoto +4 more
2021Acta Crystallographica Section F Structural Biology Communications2 citations Open access
Semantic Scholar
Amyloid fibrils in frontotemporal lobar degeneration with TDP-43 inclusions are composed of TMEM106B, rather than TDP-43
Yi-Xiao Jiang, Q. Cao, M. Sawaya, R. Abskharon +7 more
2022bioRxiv1 citations Open access
Semantic Scholar
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jia-Hui Lu, Q. Cao, M. Hughes, M. Sawaya +3 more
2020bioRxiv1 citations Open access
Semantic Scholar
Amyloid fibrils from frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) are composed of TMEM106B, rather than TDP-43
Yi-Xiao Jiang, Q. Cao, M. Sawaya, R. Abskharon +4 more
2022Biophysical Journal0 citations Open access
Semantic Scholar
Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation
Chuanqi Sun, K. Zhou, Peter DePaola, W. Shin +4 more
2022bioRxiv0 citations Open access
Semantic Scholar
Cryo-EM structure of amyloid fibril formed by α-synuclein familial A53E mutation
Chuanqi Sun, K. Zhou, Peter DePaola, W. Shin +4 more
20220 citations
Semantic Scholar
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3
Q. Cao, D. Boyer, M. Sawaya, D. Eisenberg
20210 citations
Semantic Scholar
SGMGGIT segment 58-64 from Keratin-8
K. Murray, M. Sawaya, D. Eisenberg
20210 citations
Semantic Scholar
AALALL segment from the Nucleoprotein of SARS-CoV-2, residues 217-222, crystal form 2
J. Lu, Chih-Te Zee, M. Sawaya, J. Rodriguez +1 more
20210 citations
Semantic Scholar

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