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J. Arts · SciRah

Researcher profile · Semantic Scholar

J. Arts

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J. Arts — researcher profile on SciRah

h-index: 24
Works: 65
Citations: 1,860

Most-cited papers

JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
J. Arts, P. King, A. Mariën, W. Floren +18 more
2009Clinical Cancer Research211 citations Open access
Semantic Scholar
Regulation of endothelial cell t-PA synthesis and release.
T. Kooistra, Y. Schrauwen, J. Arts, J. Emeis
1994International journal of hematology165 citations
Semantic Scholar
Microbiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development
R. Tito, Sara Verbandt, Marta Aguirre Vazquez, Leo Lahti +9 more
2024Nature Medicine146 citations Open access
Semantic Scholar
Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation.
J. Arts, M. Lansink, J. Grimbergen, K. Toet +1 more
1995Biochemical Journal115 citations Open access
Semantic Scholar
Inhibition of Histone Deacetylases by Chlamydocin Induces Apoptosis and Proteasome-Mediated Degradation of Survivin
S. de Schepper, Hélène Bruwiere, T. Verhulst, U. Steller +5 more
2003Journal of Pharmacology and Experimental Therapeutics91 citations
Semantic Scholar
Mdm2 facilitates the association of p53 with the proteasome
R. Kulikov, J. Letienne, M. Kaur, S. Grossman +2 more
2010Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies
J. Arts, P. Angibaud, A. Mariën, W. Floren +11 more
2007British Journal of Cancer84 citations Open access
Semantic Scholar
Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.
Sarah Deleu, M. Lemaire, J. Arts, E. Menu +7 more
2009Cancer Research81 citations Open access
Semantic Scholar
Histone deacetylase inhibitors: from chromatin remodeling to experimental cancer therapeutics.
J. Arts, S. de Schepper, K. van Emelen
2003Current Medicinal Chemistry80 citations
Semantic Scholar
The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias
K. Kojima, Jared K. Burks, J. Arts, M. Andreeff
2010Molecular Cancer Therapeutics78 citations Open access
Semantic Scholar
Leveraging premalignant biology for immune-based cancer prevention
A. Spira, M. Disis, J. Schiller, E. Vilar +10 more
2016Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
The effects of JNJ-26481585, a novel hydroxamate-based histone deacetylase inhibitor, on the development of multiple myeloma in the 5T2MM and 5T33MM murine models
Sarah Deleu, M. Lemaire, J. Arts, E. Menu +7 more
2009Leukemia55 citations Open access
Semantic Scholar
Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts.
Cyrus Chargari, C. Leteur, E. Angevin, T. Bashir +5 more
2011Cancer Letters54 citations
Semantic Scholar
Preclinical anti‐myeloma activity of the novel HDAC‐inhibitor JNJ‐26481585
T. Stühmer, J. Arts, M. Chatterjee, J. Borawski +5 more
2010British Journal of Haematology54 citations Open access
Semantic Scholar
Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro.
J. Arts, Ingrid Herr, Mirian Lansink, Peter Angel +1 more
1997Nucleic Acids Research49 citations Open access
Semantic Scholar
Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2
K. Chang, J. Willis, J. Reumers, M. Taggart +14 more
2018Annals of Oncology45 citations Open access
Semantic Scholar
Role of c-Jun and proximal phorbol 12-myristate-13-acetate-(PMA)-responsive elements in the regulation of basal and PMA-stimulated plasminogen-activator inhibitor-1 gene expression in HepG2.
J. Arts, J. Grimbergen, Piter J. Bosma, H. Rahmsdorf +1 more
1996European Journal of Biochemistry43 citations
Semantic Scholar
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration
J. Arts, Eike K. Mahlandt, Max L. B. Grönloh, L. Schimmel +16 more
2021bioRxiv37 citations Open access
Semantic Scholar
On the role of c-Jun in the induction of PAI-1 gene expression by phorbol ester, serum, and IL-1alpha in HepG2 cells.
J. Arts, J. Grimbergen, K. Toet, T. Kooistra
1999Arteriosclerosis, Thrombosis and Vascular Biology37 citations Open access
Semantic Scholar
Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms
Anna Kuchnio, E. Samakai, E. Hug, Meritxell Balmaña +21 more
2023Blood31 citations Open access
Semantic Scholar
Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor.
W. Tong, Yue Wei, W. Stevenson, S. Kuang +4 more
2010Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis30 citations
Semantic Scholar
Studies on the mechanism of fibrate-inhibited expression of plasminogen activator inhibitor-1 in cultured hepatocytes from cynomolgus monkey.
J. Arts, M. Kockx, H. Princen, T. Kooistra
1997Arteriosclerosis, Thrombosis and Vascular Biology30 citations
Semantic Scholar
Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells
A. Vanderborght, A. Valckx, J. van Dun, T. Grand-Perret +4 more
2006Oncogene28 citations Open access
Semantic Scholar
Initial Testing of JNJ-26854165 (Serdemetan) by the Pediatric Preclinical Testing Program
Malcolm A. Smith, R. Gorlick, E. A. Kolb, R. Lock +11 more
2011Pediatric Blood & Cancer27 citations Open access
Semantic Scholar
Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells.
T. Kooistra, Mirian Lansink, J. Arts, Thomas Sitter +1 more
1995European Journal of Biochemistry23 citations Open access
Semantic Scholar
Histone Deacetylase Inhibitors: From Chromatin Remodelling to Experimental Cancer Therapeutics
J. Arts, S. de Schepper, K. van Emelen
200519 citations
Semantic Scholar
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
P. Angibaud, J. Arts, K. van Emelen, V. Poncelet +18 more
2005European journal of medicinal chemistry16 citations
Semantic Scholar
JNJ-26854165 - a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies
J. Arts, M. Page, A. Valckx, C. Blattner +20 more
200814 citations
Semantic Scholar
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.
P. Angibaud, K. van Emelen, L. Decrane, S. V. Van Brandt +23 more
2010Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry,Biology and Clinical Benefit
P. ten Holte, K. van Emelen, M. Janicot, P. Fong +2 more
200711 citations
Semantic Scholar
Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling
J. Arts, Eike K. Mahlandt, L. Schimmel, Max L. B. Grönloh +8 more
2021Frontiers in Immunology9 citations Open access
Semantic Scholar
A first-in-man phase I study of R306465, a histone deacetylase (HDAC) inhibitor exploring pharmacokinetics (PK) and pharmacodynamics (PD) utilizing an electrochemiluminescent immunoassay in patients (p) with advanced tumours
P. Fong, S. Settatree, R. Sinha, A. Hardcastle +6 more
20078 citations
Semantic Scholar
Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors
A. Belien, S. de Schepper, W. Floren, Boudewijn Janssens +8 more
2006Molecular Cancer Therapeutics8 citations Open access
Semantic Scholar
A first-in-class HDM2-inhibitor (JNJ-26854165) in phase I development shows potent activity against multiple myeloma (MM) cells in vitro and ex vivo
T. Stühmer, J. Arts, P. King, M. Page +3 more
20087 citations
Semantic Scholar
A novel experimental approach for the selective isolation and characterization of human RNase MRP
Merel Derksen, Vicky Mertens, Eline A. Visser, J. Arts +2 more
2022RNA Biology3 citations Open access
Semantic Scholar
Inhibition of the Human Double Minute (HDM)-2 E3 Ubiquitin Ligase Activates Different Programmed Cell Death (PCD) Pathways in Models of Non-Hodgkin Lymphoma (NHL) with Wild Type (wt) and Mutant (mut) p53
Richard J. Jones, J. Arts, R. Orlowski
20083 citations
Semantic Scholar
Assay development for high throughput screening of p21(Waf1/Cip1) protein expression in intact cells using fluorometric microvolume assay technology.
T. Grand-Perret, M. Cik, J. Arts, A. Vander Borght +5 more
2004Drugs under experimental and clinical research3 citations
Semantic Scholar
Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR)
G. Saxty, R. Akkari, P. Angibaud, J. Arts +30 more
20112 citations
Semantic Scholar
JNJ-26481585, a novel “second-generation” oral pan-histone deacetylase (HDAC) inhibitor, shows broad-spectrum preclinical antitumoral activity against solid and hematological malignancies
J. Arts, A. Marien, P. King, W. Floren +12 more
20072 citations
Semantic Scholar
Studies on the mechanism of sodium butyrate-stimulated t-PA expression in cultured human endothelial cells. Effects of trichostain A and 2-deoxy-D-glucose
J. Arts, T. Kooistra
19952 citations
Semantic Scholar
Plasminogen activator regulation studies following transfection of human endothelial cells
R. Hanemaaijer, J. Arts, L. le Clercq, T. Kooistm +1 more
19942 citations
Semantic Scholar
Abstract 189: Developing a patient-derived organoid biobank, suitable for large scale drug screenings
L. Fielmich, Annemarie Buijs, Daniele Mori, B. Viergever +13 more
2023Cancer Research1 citations
Semantic Scholar
Abstract 5441: Preclinical assessment of the HDAC inhibitor JNJ-26481585: potentin vivoactivity across a broad spectrum of human tumor xenografts
I. Hickson, P. King, A. Marien, L. Janssen +6 more
20101 citations
Semantic Scholar
Discovery of JNJ-89853413, a First-in-Class CD33xVδ2 T-Cell Engager for the Treatment of Acute Myeloid Leukemia
Sara El Ashkar, L. Kallal, Kavita Raman, R. P. Dash +17 more
2024Blood0 citations
Semantic Scholar
UvA-DARE ( Digital Academic Repository ) Filling the gaps The endothelium in regulating vascular leakage and leukocyte extravasation
L. Schimmel, J. Arts, Ivar, Noordstra +6 more
20180 citations
Semantic Scholar
Abstract 4388: Characterisation of molecular events across the colorectal cancer progression axis
J. Reumers, L. Van Wesenbeeck, E. Ciamporcero, Gerald C. Chu +8 more
20170 citations
Semantic Scholar
Transcriptome profiling of the colorectal adenoma–adenocarcinoma sequence
J. Reumers, L. Van Wesenbeeck, Gerald C. Chu, S. Gaj +4 more
20160 citations
Semantic Scholar
Abstract A143: A preclinical in vivo model to assess pharmacodynamic inhibition of ACK1.
M. Albertella, Shilina Roman, M. Briggs, A. Cranston +10 more
20130 citations
Semantic Scholar
Abstract A15: High-Content screen for inhibitors of cell migration in cancer metastasis using adenoviral knock-down
R. de Pril, A. Lekkerkerker, Desire van Steenhoven, Ilhem Maghrani +4 more
20120 citations
Semantic Scholar
Abstract 2606: Rational combinations with the HDAC inhibitor, JNJ-26481585, in prostate cancer
I. Hickson, A. Marien, M. Janssen, M. Derks +14 more
20110 citations
Semantic Scholar

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