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Gerald C. Chu · SciRah

Researcher profile · Semantic Scholar

Gerald C. Chu

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Gerald C. Chu — researcher profile on SciRah

h-index: 34
Works: 55
Citations: 18K

Most-cited papers

Comprehensive Molecular Characterization of Human Colon and Rectal Cancer
Donna M. Matthew N. Kyle Huyen H. Jennifer A. Gerald Chr Muzny Bainbridge Chang Dinh Drummond Fowler Kovar, Donna M. Matthew N. Kyle Huyen H. Jennifer A. Gerald Chr Muzny Bainbridge Chang Dinh Drummond Fowler Kovar, D. Muzny, M. Bainbridge +334 more
2012Nature7,915 citations Open access
Semantic Scholar
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
J. Paik, Ramya Kollipara, Gerald C. Chu, H. Ji +12 more
2007Cell1,109 citations Open access
Semantic Scholar
P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
Hong-Wu Zheng, Hao-Qiang Ying, Haiyan Yan, A. Kimmelman +16 more
2008Nature752 citations Open access
Semantic Scholar
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
N. Bardeesy, Kuang-Hung Cheng, Justin H. Berger, Gerald C. Chu +7 more
2006Genes & Development694 citations Open access
Semantic Scholar
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
A. Kapoor, W. Yao, Hao-Qiang Ying, Su-Jun Hua +26 more
2014Cell679 citations Open access
Semantic Scholar
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
N. Bardeesy, Andrew J. Aguirre, Gerald C. Chu, Kuang-Hung Cheng +10 more
2006Proceedings of the National Academy of Sciences of the United States of America607 citations
Semantic Scholar
SMAD4–dependent barrier constrains prostate cancer growth and metastatic progression
Z. Ding, Chang-Jiun Wu, Gerald C. Chu, Yong-Hong Xiao +24 more
2011Nature510 citations Open access
Semantic Scholar
XBP‐1 is required for biogenesis of cellular secretory machinery of exocrine glands
Ann-Hwee Lee, Gerald C. Chu, N. Iwakoshi, L. Glimcher
2005EMBO Journal472 citations Open access
Semantic Scholar
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations
A. Yang, N. Rajeshkumar, Xiao-Xu Wang, S. Yabuuchi +5 more
2014Cancer Discovery465 citations Open access
Semantic Scholar
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Olivier Nolan-Stevaux, J. Lau, Morgan L. Truitt, Gerald C. Chu +3 more
2009Genes & Development398 citations Open access
Semantic Scholar
Oncogenic NRAS Signaling Differentially Regulates Survival and Proliferation in Melanoma
Lawrence N. Kwong, J. Costello, Huiyun Liu, Shan Jiang +12 more
2012Nature Medicine358 citations Open access
Semantic Scholar
Stromal biology of pancreatic cancer
Gerald C. Chu, A. Kimmelman, A. Hezel, R. DePinho
2007Journal of Cellular Biochemistry343 citations
Semantic Scholar
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Sharon Y. Gidekel Friedlander, Gerald C. Chu, Eric L. Snyder, Nomeda Girnius +5 more
2009Cancer Cell341 citations Open access
Semantic Scholar
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
D. Biancur, João A. Paulo, Beata Małachowska, Maria Quiles del Rey +9 more
2017Nature Communications303 citations Open access
Semantic Scholar
Animal models of human prostate cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
M. Ittmann, Jiao-Ti Huang, E. Radaelli, P. Martin +10 more
2013Cancer Research231 citations Open access
Semantic Scholar
Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo
Gerald C. Chu, N. R. Dunn, Dorian C. Anderson, Leif Oxburgh +1 more
2004Development224 citations Open access
Semantic Scholar
Genome unstable murine prostate cancers acquire genomic aberrations and bone metastatic features of the human disease
Z. Ding, Chang-Jiun Wu, M. Jaskelioff, E. Ivanova +20 more
2012Cell209 citations Open access
Semantic Scholar
Pten is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network
Hao-Qiang Ying, Kutlu G. Elpek, Anant Vinjamoori, Stephanie M. Zimmerman +24 more
2011Cancer Discovery208 citations Open access
Semantic Scholar
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer
A. Boutin, Wen-Ting Liao, Melody Wang, Soyoon Hwang +14 more
2017Genes & Development177 citations Open access
Semantic Scholar
Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms
A. Hezel, S. Gurumurthy, Z. Granot, A. Swisa +5 more
2008Molecular and Cellular Biology173 citations Open access
Semantic Scholar
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
A. Kimmelman, A. Hezel, Andrew J. Aguirre, Hong-Wu Zheng +25 more
2008Proceedings of the National Academy of Sciences of the United States of America164 citations Open access
Semantic Scholar
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis
Bo-Yi Gan, Carol S. Lim, Gerald C. Chu, Su-Jun Hua +13 more
2010Cancer Cell150 citations Open access
Semantic Scholar
A T CELL REDIRECTING BISPECIFIC G-PROTEIN COUPLED RECEPTOR CLASS 5 MEMBER DxCD3 ANTIBODY TO TREAT MULTIPLE MYELOMA.
Kodandaram Pillarisetti, S. Edavettal, Mark Mendonca, Ying-Zhe Li +15 more
2020Blood145 citations Open access
Semantic Scholar
Pro-invasion metastasis drivers in early stage melanoma are oncogenes
Kenneth L. Scott, C. Nogueira, T. Heffernan, R. van Doorn +18 more
2011Cancer Cell144 citations Open access
Semantic Scholar
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
H. Zheng, H. Ying, H. Yan, A. Kimmelman +16 more
2008Cold Spring Harbor Symposia on Quantitative Biology133 citations Open access
Semantic Scholar
Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
R. Wiedemeyer, Cameron W. Brennan, T. Heffernan, Yong-Hong Xiao +14 more
2008Cancer Cell131 citations Open access
Semantic Scholar
Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation
G. David, K. B. Grandinetti, Patricia M. Finnerty, N. Simpson +2 more
2008Proceedings of the National Academy of Sciences of the United States of America128 citations Open access
Semantic Scholar
TGFβ superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population
Leif Oxburgh, Gerald C. Chu, Simon K. Michael, E. Robertson
2004Development118 citations Open access
Semantic Scholar
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Hao-Qiang Ying, A. Kimmelman, C. Lyssiotis, Su-Jun Hua +27 more
2012Cell117 citations Open access
Semantic Scholar
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development
Ivan P. Moskowitz, Jun Wang, Michael A. Peterson, William T. Pu +10 more
2011Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma
P. Olson, Gerald C. Chu, S. R. Perry, Olivier Nolan-Stevaux +1 more
2011Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Mutant N-Ras protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression
Yu-Fang Wang, S. Velho, E. Vakiani, Shouyong Peng +8 more
2012Cancer Discovery59 citations Open access
Semantic Scholar
Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen
G. Raffel, Gerald C. Chu, J. Jesneck, Dana E. Cullen +3 more
2008Molecular and Cellular Biology54 citations Open access
Semantic Scholar
A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia.
Priyanka Nair-Gupta, M. Diem, Dara A. Reeves, Wei-Rong Wang +16 more
2020Blood Advances36 citations Open access
Semantic Scholar
Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer
A. Kapoor, W. Yao, Hao-Qiang Ying, Su-Jun Hua +26 more
2019Cell32 citations Open access
Semantic Scholar
Development of a CD123xCD3 Bispecific Antibody (JNJ-63709178) for the Treatment of Acute Myeloid Leukemia (AML)
F. Gaudet, Jennifer F. Nemeth, R. Mcdaid, Ying-Zhe Li +19 more
201627 citations
Semantic Scholar
Abstract 5567:In vivoadministration of the STING agonist, JNJ-67544412, leads to complete regression of established murine subcutaneous tumors
M. Smith, D. Chin, S. Chan, Sally Mahady +10 more
2020Immunology9 citations
Semantic Scholar
Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Hao-Qiang Ying, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan +27 more
20128 citations
Semantic Scholar
Abstract 5538: Arv7 validation in castrate resistant prostate tumors utilizing Rnascopein situhybridization assay
T. Cash-Mason, J. Wong, Martínez Martínez, Michael Sharp +6 more
2018Clinical research7 citations
Semantic Scholar
Corrigendum: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
Lawrence N. Kwong, J. Costello, Huiyun Liu, Shan Jiang +12 more
2012Nature Medicine3 citations Open access
Semantic Scholar
Summary Differential requirements for Smad 4 in TGF β-dependent patterning of the early mouse embryo
Gerald C. Chu, N. R. Dunn, Dorian C. Anderson, Leif Oxburgh +1 more
2 citations
Semantic Scholar
Abstract 5662: JNJ-67571244: A novel anti-CD33 C2 domain binding bispecific antibody with potent T cell redirection activity
Priyanka Nair-Gupta, M. Diem, Dara A. Reeves, Wei-Rong Wang +15 more
2020Immunology1 citations
Semantic Scholar
Abstract A11: Preclinical assessment of CD3 bispecific antibody efficacy: A comparison of humanized mouse models bearing xenografts and syngeneic mouse models using surrogate antibodies
M. Kay, Krista Menard, Damon Hamon, Darlene Pizutti +15 more
20181 citations
Semantic Scholar
Abstract PR01: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
A. Kapoor, W. Yao, Hao-Qiang Ying, Su-Jun Hua +26 more
20141 citations
Semantic Scholar
Abstract A15: Development of a cloud-based histology database for collaborative cancer research
Ke-Cheng Cheng, Gerald C. Chu, Ruslan Sivak, D. Dao
20141 citations
Semantic Scholar
Abstract 953: Efficacy of amivantamab, a bispecific EGFR/MET antibody, correlates with EGFR expression and signaling in NSCLC models with wild-type EGFR
Benjamin J. Henley, Kristen M. Chevalier, M. Smith, Smruthi Vijayaraghaven +9 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 4127: Niraparib is active against prostate xenograft models that are wild type or defective for DNA damage repair genes
L. Snyder, Krista Menard, G. Ndikuyeze, Holly M. Nguyen +6 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract IA24: YAP in cancer and inflammation
Guo-Can Wang, Xin Lu, D. Chakravarti, A. Kapoor +21 more
2020Oral Presentations - Invited Abstracts0 citations
Semantic Scholar
Abstract 2134: Niraparib combined with abiraterone acetate inhibits the growth of BRCA2wtprostate tumors
R. Damle, R. Hawkins, Jennifer Hosbach, G. Ndikuyeze +9 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 3813: Development of JNJ-64164711, a low fucose anti-GITR antibody for enhanced depletion of tumor regulatory T cells (Tregs)
C. Holland, J. Kehoe, J. Hailey, Rupesh K. Nanjunda +18 more
2018Immunology0 citations
Semantic Scholar

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