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S. Grossman · SciRah

Researcher profile · Semantic Scholar

S. Grossman

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S. Grossman — researcher profile on SciRah

h-index: 37
Works: 110
Citations: 7,701

Most-cited papers

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300
S. Grossman, M. Deato, C. Brignone, Ho-Man Chan +4 more
2003Science526 citations
Semantic Scholar
Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein Complex*
F. Vázquez, S. Grossman, Yuki Takahashi, Mihail Rokas +2 more
2001Journal of Biological Chemistry430 citations Open access
Semantic Scholar
Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice.
Hanchen Li, Xueli Fan, R. Kovi, Yunju Jo +9 more
2007Cancer Research208 citations Open access
Semantic Scholar
p19ARF targets certain E2F species for degradation
F. Martelli, Timothy Hamilton, D. Silver, N. Sharpless +5 more
2001Proceedings of the National Academy of Sciences of the United States of America190 citations Open access
Semantic Scholar
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
Ding-Ding Shi, Marius S. Pop, R. Kulikov, Ian M. Love +2 more
2009Proceedings of the National Academy of Sciences of the United States of America180 citations Open access
Semantic Scholar
ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation
R. Pedeux, S. Sengupta, Jiang-Cheng Shen, O. Demidov +10 more
2005Molecular and Cellular Biology133 citations Open access
Semantic Scholar
The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells
Samisubbu R. Naidu, Ian M. Love, A. Imbalzano, S. Grossman +1 more
2009Oncogene132 citations Open access
Semantic Scholar
Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism*
Mu-Shui Dai, Ding-Ding Shi, Yetao Jin, Xiao-Xin Sun +3 more
2006Journal of Biological Chemistry131 citations Open access
Semantic Scholar
Targeting of C-Terminal Binding Protein (CtBP) by ARF Results in p53-Independent Apoptosis
S. Paliwal, S. Pande, R. Kovi, N. Sharpless +2 more
2006Molecular and Cellular Biology100 citations Open access
Semantic Scholar
Mdm2 facilitates the association of p53 with the proteasome
R. Kulikov, J. Letienne, M. Kaur, S. Grossman +2 more
2010Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Cell competition in intratumoral and tumor microenvironment interactions
Taylor M. Parker, Kartik Gupta, António M. Palma, Michail Yekelchyk +6 more
2021EMBO Journal87 citations Open access
Semantic Scholar
The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3
Ian M. Love, Pedja Šekaric, Ding-Ding Shi, S. Grossman +1 more
2012Cell Cycle83 citations Open access
Semantic Scholar
Physical and Functional Interactions between PML and MDM2*
Xiaolong Wei, Zhong K. Yu, A. Ramalingam, S. Grossman +3 more
2003Journal of Biological Chemistry83 citations Open access
Semantic Scholar
CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors
M. Michael Dcona, B. Morris, K. C. Ellis, S. Grossman
2017Cancer Biology & Therapy82 citations Open access
Semantic Scholar
Ubiquitin becomes ubiquitous in cancer
Ding-Ding Shi, S. Grossman
2010Cancer Biology & Therapy82 citations Open access
Semantic Scholar
A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway
C. Brignone, Kathleen Bradley, A. Kisselev, S. Grossman
2004Oncogene81 citations Open access
Semantic Scholar
The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor.
S. Paliwal, R. Kovi, B. Nath, Ya-Wen Chen +2 more
2007Cancer Research80 citations Open access
Semantic Scholar
Gastrointestinal Stromal Tumors: The GIST of Precision Medicine.
Mei-Sui Lin, S. Smith, A. Faber, J. Trent +3 more
2018Trends in Cancer78 citations Open access
Semantic Scholar
Therapeutic targeting of C-terminal binding protein in human cancer
M. Straza, S. Paliwal, R. Kovi, B. Rajeshkumar +6 more
2010Cell Cycle70 citations Open access
Semantic Scholar
CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.
S. Paliwal, Ngoc Ho, Daniel P. Parker, S. Grossman
2012Genes & cancer65 citations Open access
Semantic Scholar
Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.
C. Vaughan, Shilpa Singh, Brad Windle, W. A. Yeudall +4 more
2012Genes & cancer65 citations Open access
Semantic Scholar
p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.
Ya-Wen Chen, S. Paliwal, K. Draheim, S. Grossman +1 more
2008Cancer Research64 citations Open access
Semantic Scholar
An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis
Ramesh C. Kovi, S. Paliwal, S. Pande, S. Grossman
2009Cell Death and Differentiation59 citations Open access
Semantic Scholar
p66 Shc Tumor Levels Show a Strong Prognostic Correlation with Disease Outcome in Stage IIA Colon Cancer
S. Grossman, S. Lyle, M. Resnick, E. Sabo +7 more
2007Clinical Cancer Research47 citations Open access
Semantic Scholar
Classification of gastrointestinal stromal tumor syndromes.
P. Gopie, Lin Mei, A. Faber, S. Grossman +2 more
2018Endocrine-Related Cancer43 citations
Semantic Scholar
The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis
V. Muniz, J. M. Barnes, S. Paliwal, Xue-Feng Zhang +10 more
2011Molecular Cancer Research42 citations Open access
Semantic Scholar
Mechanisms of mutant p53 stabilization in cancer.
R. Frum, S. Grossman
2014Sub-cellular biochemistry39 citations
Semantic Scholar
Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication
Shilpa Singh, C. Vaughan, R. Frum, S. Grossman +2 more
2017Journal of Clinical Investigation37 citations Open access
Semantic Scholar
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.
Ian M. Love, S. Grossman
2012Genes & cancer36 citations Open access
Semantic Scholar
Pancreatic cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid
P. Bhoopathi, B. Quinn, Qin Gui, Xue-Ning Shen +5 more
2014Cancer Research35 citations Open access
Semantic Scholar
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design
B. Hilbert, S. Grossman, C. A. Schiffer, William E. Royer
2014FEBS Letters35 citations Open access
Semantic Scholar
Comparison of histopathology and RT-qPCR amplification of guanylyl cyclase C for detection of colon cancer metastases in lymph nodes
J. Haince, M. Houde, G. Beaudry, S. L'esperance +9 more
2010Journal of Clinical Pathology34 citations
Semantic Scholar
p53 Ubiquitination and proteasomal degradation.
Ian M. Love, Ding-Ding Shi, S. Grossman
2013Methods in molecular biology32 citations
Semantic Scholar
The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing
R. Frum, Shilpa Singh, C. Vaughan, N. Mukhopadhyay +4 more
2013Nucleic Acids Research32 citations Open access
Semantic Scholar
hHR23B is required for genotoxic-specific activation of p53 and apoptosis
M. Kaur, Marius S. Pop, Ding-Ding Shi, Chrystelle Brignone +1 more
2007Oncogene32 citations Open access
Semantic Scholar
Rising incidence and racial disparities of early-onset pancreatic cancer in the United States, 1995–2018
Brian Z. Huang, Li-Hua Liu, Juan-Juan Zhang, S. Pandol +2 more
2022Gastroenterology31 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).
S. Korwar, B. Morris, Hardik I. Parikh, Robert A. Coover +7 more
2016Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells
Jagruti H. Patel, Somesh Baranwal, Ian M. Love, Nirmita J. Patel +2 more
2014Cell Cycle30 citations Open access
Semantic Scholar
Azacitidine/Decitabine Synergism with the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML Models
Peter G. Smith, T. Traore, S. Grossman, U. Narayanan +4 more
201128 citations
Semantic Scholar
Structure-guided design of a high affinity inhibitor to human CtBP
B. Hilbert, B. Morris, K. C. Ellis, J. Paulsen +3 more
2015ACS Chemical Biology26 citations Open access
Semantic Scholar
Transforming activity and therapeutic targeting of C-terminal Binding Protein 2 in Apc mutated neoplasia
E. T. Sumner, Ayesha T. Chawla, Agnes D. Cororaton, Jennifer E. Koblinski +6 more
2017Oncogene25 citations Open access
Semantic Scholar
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
C. Vaughan, Shilpa Singh, M. Subler, J. Windle +8 more
2021Nature Communications24 citations Open access
Semantic Scholar
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis
Boxiao Ding, Alexander Haidurov, Ayesha T. Chawla, Anita Parmigiani +7 more
2019OncoTarget24 citations Open access
Semantic Scholar
CtBP—a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma
Ayesha T. Chawla, K. Chougoni, Prashant J. Joshi, Agnes D. Cororaton +9 more
2019Oncogenesis23 citations Open access
Semantic Scholar
Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter
C. Vaughan, Isabella Pearsall, Shilpa Singh, Brad Windle +4 more
2016OncoTarget22 citations Open access
Semantic Scholar
Treating hepatocellular carcinoma with sorafenib in liver transplant patients: an initial experience.
R. F. Saidi, Shimul A. Shah, A. Rawson, S. Grossman +2 more
2010Transplantation Proceedings22 citations
Semantic Scholar
CtBP determines ovarian cancer cell fate through repression of death receptors
Boxiao Ding, F. Yuan, Priyadarshan K. Damle, L. Litovchick +2 more
2020Cell Death and Disease19 citations Open access
Semantic Scholar
Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells
C. Vaughan, Shilpa Singh, S. Grossman, Brad Windle +2 more
2017Molecular Oncology19 citations Open access
Semantic Scholar
DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination
Oluwatoyin Akande, Priyadarshan K. Damle, Marius S. Pop, N. Sherman +3 more
2019Cell Reports18 citations Open access
Semantic Scholar
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination
R. Frum, Ian M. Love, Priyadarshan K. Damle, N. Mukhopadhyay +3 more
2016Molecular Cancer Research18 citations Open access
Semantic Scholar

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Ian M. Love×9
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Ding-Ding Shi×6
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Shilpa Singh×6

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R. Kovi — researcher profile on SciRah

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K. C. Ellis — researcher profile on SciRah

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Brad Windle — researcher profile on SciRah

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Marius S. Pop — researcher profile on SciRah