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I. Björkhem · SciRah

Researcher profile · Semantic Scholar

I. Björkhem

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I. Björkhem — researcher profile on SciRah

h-index: 93
Works: 682
Citations: 33K

Most-cited papers

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
S. Zimmer, A. Grebe, S. S. Bakke, Niklas Bode +21 more
2016Science Translational Medicine331 citations Open access
Semantic Scholar
Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease.
I. Björkhem, Anita Lövgren-Sandblom, V. Leoni, S. Meaney +5 more
2013Neuroscience Letters107 citations Open access
Semantic Scholar
Cholestenoic acids regulate motor neuron survival via liver X receptors.
S. Theofilopoulos, William J. Griffiths, P. J. Crick, Shan-Zheng Yang +32 more
2014Journal of Clinical Investigation105 citations Open access
Semantic Scholar
Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
A. Saeed, G. Genové, Tian-hang Li, D. Lütjohann +8 more
2014Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial
L. Schöls, Tim W. Rattay, P. Martus, C. Meisner +30 more
2017Brain : a journal of neurology103 citations Open access
Semantic Scholar
Can LDL cholesterol be too low? Possible risks of extremely low levels
Anders G. Olsson, B. Angelin, Gerd Assmann, Christoph J. Binder +12 more
2017Journal of Internal Medicine94 citations
Semantic Scholar
Evidence for sex difference in the CSF/plasma albumin ratio in ~20 000 patients and 335 healthy volunteers
Cristina Parrado-Fernández, K. Blennow, M. Hansson, V. Leoni +2 more
2018Journal of Cellular and Molecular Medicine83 citations Open access
Semantic Scholar
Dietary cholesterol supplementation to a plant-based diet suppresses the complete pathway of cholesterol synthesis and induces bile acid production in Atlantic salmon (Salmo salar L.)
T. Kortner, I. Björkhem, A. Krasnov, Gerrit Timmerhaus +1 more
2014British Journal of Nutrition83 citations Open access
Semantic Scholar
Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?
Silvia Maioli, Ann Båvner, Zeina Ali, M. Heverin +8 more
2013PLoS ONE80 citations Open access
Semantic Scholar
27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation
M. Ismail, Laura Mateos, Silvia Maioli, Paula Merino-Serrais +10 more
2017Journal of Experimental Medicine73 citations Open access
Semantic Scholar
Five decades with oxysterols.
I. Björkhem
2013Biochimie72 citations
Semantic Scholar
Enhanced production of 24S‐hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo
M. Shafaati, M. Olin, Ann Båvner, H. Pettersson +4 more
2011Journal of Internal Medicine72 citations Open access
Semantic Scholar
Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells.
M. Zandl-Lang, Elham Fanaee-Danesh, Yi-Dan Sun, N. Albrecher +12 more
2018Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids70 citations
Semantic Scholar
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
I. Björkhem, U. Diczfalusy, A. Lövgren-Sandblom, L. Starck +8 more
2014Journal of Lipid Research65 citations Open access
Semantic Scholar
27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.
M. Heverin, Silvia Maioli, T. Pham, Laura Mateos +5 more
2015Behavioural Brain Research63 citations
Semantic Scholar
27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons
Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernández +7 more
2018Cerebral Cortex62 citations Open access
Semantic Scholar
Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis
A. Mignarri, A. Magni, M. del Puppo, G. Gallus +3 more
2016Journal of Inherited Metabolic Disease61 citations
Semantic Scholar
Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice
Gregor Lorbek, M. Perše, S. Horvat, I. Björkhem +1 more
2013Molecules56 citations Open access
Semantic Scholar
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1
Zeina Ali, M. Heverin, M. Olin, Jure Acimovic +6 more
2013Journal of Lipid Research56 citations Open access
Semantic Scholar
The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter
Jenny Zolotushko, H. Flusser, B. Markus, I. Shelef +5 more
2011European Journal of Human Genetics56 citations Open access
Semantic Scholar
Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis
Joseph B Lin, N. Mast, I. Bederman, Yong Li +3 more
2016Journal of Lipid Research54 citations Open access
Semantic Scholar
Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism
Ewa C. S. Ellis, Scott Nauglers, P. Parini, Lisa-Mari Mörk +8 more
2013PLoS ONE51 citations Open access
Semantic Scholar
Bile components and lecithin supplemented to plant based diets do not diminish diet related intestinal inflammation in Atlantic salmon
T. Kortner, M. Penn, I. Björkhem, K. Måsøval +1 more
2016BMC Veterinary Research49 citations Open access
Semantic Scholar
Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.)
A. K. Hansen, T. Kortner, A. Krasnov, I. Björkhem +2 more
2020BMC Veterinary Research48 citations Open access
Semantic Scholar
Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
Gregor Lorbek, M. Perše, J. Jeruc, P. Juvan +7 more
2015Scientific Reports47 citations Open access
Semantic Scholar
Clinical and molecular characterization of hereditary spastic paraplegias: A next-generation sequencing panel approach
Daniela Burguêz, M. Polese-Bonatto, L. Scudeiro, I. Björkhem +6 more
2017Journal of Neurological Sciences46 citations
Semantic Scholar
Sterols and Oxysterols in Plasma from Smith-Lemi-Opitz Syndrome Patients
W. Griffiths, J. Abdel-Khalik, P. J. Crick, M. Ogundare +11 more
2016Journal of Steroid Biochemistry and Molecular Biology46 citations Open access
Semantic Scholar
Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier.
Alexandra Kober, Anil Paul Chirackal Manavalan, Carmen Tam‐Amersdorfer, Andreas Holmér +8 more
2017Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids45 citations
Semantic Scholar
Cholesterol, Oxysterol, Triglyceride, and Coenzyme Q Homeostasis in ALS. Evidence against the Hypothesis That Elevated 27-Hydroxycholesterol Is a Pathogenic Factor
Anna Wuolikainen, Jure Acimovic, A. Lövgren-Sandblom, P. Parini +2 more
2014PLoS ONE45 citations Open access
Semantic Scholar
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
S. Theofilopoulos, Willy Antoni Abreu de Oliveira, Shan-Zheng Yang, Eylan Yutuc +8 more
2019Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Diagnostic Power of 24S-Hydroxycholesterol in Cerebrospinal Fluid: Candidate Marker of Brain Health
V. Leoni, A. Solomon, A. Lövgren-Sandblom, L. Minthon +5 more
2013Journal of Alzheimer's Disease42 citations
Semantic Scholar
On the fluxes of side-chain oxidized oxysterols across blood-brain and blood-CSF barriers and origin of these steroids in CSF (Review).
I. Björkhem, V. Leoni, P. Svenningsson
2019Journal of Steroid Biochemistry and Molecular Biology41 citations
Semantic Scholar
7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier
A. Saeed, Federico Floris, U. Andersson, I. Pikuleva +6 more
2014Journal of Lipid Research41 citations Open access
Semantic Scholar
Choline and phosphatidylcholine, but not methionine, cysteine, taurine and taurocholate, eliminate excessive gut mucosal lipid accumulation in Atlantic salmon (Salmo salar L)
Å. Krogdahl, A. K. Hansen, T. Kortner, I. Björkhem +3 more
202037 citations Open access
Semantic Scholar
Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium.
Yi-Dan Sun, S. Kopp, J. Strutz, C. C. Gali +10 more
2018Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids37 citations
Semantic Scholar
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
Miguel Moutinho, M. J. Nunes, J. Correia, M. Gama +6 more
2016Scientific Reports37 citations Open access
Semantic Scholar
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum*
N. Mast, Kyle W. Anderson, Joseph B Lin, Yong Li +4 more
2017Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)
N. Mast, Joseph B Lin, Kyle W. Anderson, I. Björkhem +1 more
2017PLoS ONE34 citations Open access
Semantic Scholar
27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
A. Sandebring-Matton, Julen Goikolea, I. Björkhem, L. Paternain +8 more
2021Alzheimer's Research & Therapy32 citations Open access
Semantic Scholar
Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration
Raul Loera-Valencia, M. Ismail, Julen Goikolea, Maria Lodeiro +8 more
2021Molecular Neurobiology32 citations Open access
Semantic Scholar
Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling
Ž. Urlep, Gregor Lorbek, M. Perše, J. Jeruc +8 more
2017Scientific Reports32 citations Open access
Semantic Scholar
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells
Miguel Moutinho, M. J. Nunes, A. Gomes, M. Gama +4 more
2014Molecular Neurobiology32 citations
Semantic Scholar
ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis
Á. Baldán, Ayelet Gonen, Christina Choung, Xu-Chu Que +6 more
2014Journal of Immunology32 citations Open access
Semantic Scholar
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
María Latorre-Leal, Patricia Rodriguez-Rodriguez, L. Franchini, Orestis Nikolidakis +18 more
2024Science Advances31 citations Open access
Semantic Scholar
Dose–response relationship between dietary choline and lipid accumulation in pyloric enterocytes of Atlantic salmon (Salmo salar L.) in seawater
A. K. Hansen, T. Kortner, V. Denstadli, K. Måsøval +3 more
2020British Journal of Nutrition29 citations Open access
Semantic Scholar
mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5
S. Hauser, Marion Poenisch, Yvonne Schelling, Philip Höflinger +10 more
2019Molecular Therapy: Methods & Clinical Development28 citations Open access
Semantic Scholar
Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.
L. Novakova, M. Axelsson, C. Malmeström, H. Zetterberg +3 more
2015Journal of Neurological Sciences28 citations
Semantic Scholar
Cerebrotendinous xanthomatosis
I. Björkhem
2013Current Opinion in Lipidology28 citations
Semantic Scholar
First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods
D. Lütjohann, I. Björkhem, S. Friedrichs, A. Kerksiek +46 more
2019Journal of Steroid Biochemistry and Molecular Biology27 citations Open access
Semantic Scholar
24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome
I. Björkhem, Kalicharan Patra, A. Boxer, P. Svenningsson
2018Frontiers in Neurology25 citations Open access
Semantic Scholar

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