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M. Gama · SciRah

Researcher profile · Semantic Scholar

M. Gama

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M. Gama — researcher profile on SciRah

h-index: 21
Works: 48
Citations: 1,214

Most-cited papers

Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease
M. Castro-Caldas, A. Carvalho, E. Rodrigues, Colin J. Henderson +3 more
2012Molecular Neurobiology145 citations
Semantic Scholar
Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope?
A. Carvalho, O. Firuzi, M. Gama, J. van Horssen +1 more
2017Current Drug Targets121 citations
Semantic Scholar
Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease
S. Moreira, Inês Fonseca, M. J. Nunes, Alexandra Rosa +7 more
2017Experimental Neurology101 citations Open access
Semantic Scholar
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease
Alexandra Rosa, S. Duarte-Silva, A. Silva-Fernandes, M. J. Nunes +6 more
2018Molecular Neurobiology82 citations Open access
Semantic Scholar
Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease.
Alexandra Rosa, Inês Fonseca, M. J. Nunes, S. Moreira +5 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease78 citations Open access
Semantic Scholar
S‐Glutathionylation of Keap1: a new role for glutathione S‐transferase pi in neuronal protection
A. Carvalho, C. Marques, R. Guedes, M. Castro-Caldas +3 more
2016FEBS Letters78 citations Open access
Semantic Scholar
Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway
M. Castro-Caldas, A. Carvalho, E. Rodrigues, C. Henderson +2 more
2012Molecular Neurobiology50 citations
Semantic Scholar
Transcriptional regulation of the human CYP46A1 brain‐specific expression by Sp transcription factors
I. Milagre, M. J. Nunes, M. Gama, R. F. Silva +3 more
2008Journal of Neurochemistry49 citations
Semantic Scholar
Sp proteins play a critical role in histone deacetylase inhibitor‐mediated derepression of CYP46A1 gene transcription
M. J. Nunes, I. Milagre, M. Schnekenburger, M. Gama +2 more
2010Journal of Neurochemistry46 citations
Semantic Scholar
Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells
Inês Fonseca, G. Gordino, S. Moreira, M. J. Nunes +5 more
2016Molecular Neurobiology43 citations
Semantic Scholar
Association of A313 G polymorphism (GSTP1*B) in the glutathione‐S‐transferase P1 gene with sporadic Parkinson's disease
R. Vilar, H. Coelho, E. Rodrigues, M. Gama +3 more
2007European Journal of Neurology38 citations
Semantic Scholar
Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease
P. Dionisio, Sara R. Oliveira, M. M. Gaspar, M. Gama +3 more
2019Cell Death and Disease37 citations Open access
Semantic Scholar
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
Miguel Moutinho, M. J. Nunes, J. Correia, M. Gama +6 more
2016Scientific Reports37 citations Open access
Semantic Scholar
GSTpi Expression in MPTP-Induced Dopaminergic Neurodegeneration of C57BL/6 Mouse Midbrain and Striatum
M. Castro-Caldas, Andreia Neves Carvalho, I. Peixeiro, E. Rodrigues +2 more
2009Journal of Molecular Neuroscience35 citations
Semantic Scholar
Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux
M. J. Nunes, Miguel Moutinho, M. Gama, C. Rodrigues +1 more
2013PLoS ONE34 citations Open access
Semantic Scholar
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells
Miguel Moutinho, M. J. Nunes, A. Gomes, M. Gama +4 more
2014Molecular Neurobiology32 citations
Semantic Scholar
Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy
Mariana Oliveira Mendes, A. Rosa, A. Carvalho, M. J. Nunes +8 more
2019Molecular and cellular neurosciences29 citations Open access
Semantic Scholar
Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance
Carlota Leonardo-Sousa, A. Carvalho, Romina A. Guedes, Pedro M P Fernandes +4 more
2022Molecules26 citations Open access
Semantic Scholar
Ubiquitin–Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice
A. Carvalho, C. Marques, E. Rodrigues, C. Henderson +3 more
2012Molecular Neurobiology23 citations
Semantic Scholar
Chromatin-Modifying Agents Increase Transcription of CYP46A1, a Key Player in Brain Cholesterol Elimination
I. Milagre, M. J. Nunes, Miguel Moutinho, I. Rivera +4 more
2011Journal of Alzheimer's Disease22 citations
Semantic Scholar
Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y neuroblastoma cells.
M. Castro-Caldas, I. Milagre, E. Rodrigues, M. Gama
2009Neuroscience Letters22 citations
Semantic Scholar
Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter
I. Milagre, M. J. Nunes, M. Castro-Caldas, Miguel Moutinho +2 more
2012Journal of Neurochemistry20 citations
Semantic Scholar
Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells.
I. Milagre, M. Olin, M. J. Nunes, Miguel Moutinho +4 more
2012Neurochemistry International14 citations
Semantic Scholar
Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway
M. J. Nunes, Miguel Moutinho, I. Milagre, M. Gama +1 more
2012Journal of Lipid Research11 citations Open access
Semantic Scholar
Activation of the Unfolded Protein Response in Parkinson's disease
A. Carvalho, Catarina Ranito, C. Tavares, M. Castro-Caldas +4 more
2019Frontiers in Cellular Neuroscience8 citations Open access
Semantic Scholar
Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration.
M. J. Nunes, A. Carvalho, C. Sá-Lemos, M. Colaço +11 more
2023European Journal of Cell Biology7 citations Open access
Semantic Scholar
NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.
Inês Caria, M. J. Nunes, V. Ciraci, A. Carvalho +7 more
2023Biochimica et Biophysica Acta - Molecular Basis of Disease7 citations Open access
Semantic Scholar
Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease
M. J. Nunes, A. Carvalho, A. Rosa, P. Videira +3 more
2024Journal of molecular medicine5 citations Open access
Semantic Scholar
New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies
Romina A. Guedes, Jorge Grilo, A. Carvalho, Pedro M P Fernandes +9 more
2023Pharmaceuticals3 citations Open access
Semantic Scholar
Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration.
M. J. Nunes, A. Carvalho, J. Reis, D. Costa +15 more
2023Biochimica et Biophysica Acta - Molecular Basis of Disease3 citations Open access
Semantic Scholar
Tauroursodeoxycholic Acid Prevents MPTP-Induced Dopaminergic Cell Death in a Mouse Model of Parkinson’s Disease
M. Castro-Caldas, A. Carvalho, E. Rodrigues, C. Henderson +3 more
2012Molecular Neurobiology3 citations
Semantic Scholar
Erratum to: Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells
Inês Fonseca, G. Gordino, S. Moreira, M. J. Nunes +5 more
2016Molecular Neurobiology2 citations Open access
Semantic Scholar
CYP46A1 expression modulates mitochondrial function and integrity in Niemann-Pick type C disease
E. Rodrigues, D. Costa, Miguel Moutinho, M. Nunes +7 more
2019Frontiers in Cellular Neuroscience1 citations Open access
Semantic Scholar
Unanswered role of cholesterol homeostasis in Parkinson’s disease
M. Nunes, Inês Caria, A. Carvalho, D. Costa +4 more
2019Frontiers in Cellular Neuroscience1 citations Open access
Semantic Scholar
P2–046: Trichostatin A, a histone deacetylase inhibitor, modulates signaling pathways involved in the control of neuronal cholesterol metabolism
M. J. Nunes, Miguel Moutinho, M. Gama, E. Rodrigues
20131 citations
Semantic Scholar
DNA Demethylation and histone deacetylation inhibition in the deprepression of CYP46A1 expression
I. Milagre, MJ Nunes, M. Gama, E. Rodrigues
20091 citations
Semantic Scholar
Redox proteome alterations in Parkinson’s disease: Insights into the role of redox-signalling and mitochondrial dynamics and function
D. A. Kovalchuk, S. Anjo, C. Munteanu, M. J. Nunes +6 more
2025Free Radical Biology & Medicine0 citations
Semantic Scholar
Cysteine redox post-translational modifications: the missing link between redox-signalling and mitochondrial dynamics and function in Parkinson’s disease?
D. A. Kovalchuk, S. Anjo, M. J. Nunes, V. Branco +8 more
2023Free Radical Biology & Medicine0 citations Open access
Semantic Scholar
Corrigendum to "Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy" [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1-9.].
Mariana Oliveira Mendes, A. Rosa, A. Carvalho, M. J. Nunes +8 more
2021Molecular and cellular neurosciences0 citations Open access
Semantic Scholar
PREDIS - STATE OF THE ART CLOUD MASSIVE FORECASTING
Ricardo Gonçalves, Miguel Louro, C. Calhau, R. Pereira +6 more
2021CIRED 2021 - The 26th International Conference and Exhibition on Electricity Distribution0 citations
Semantic Scholar
Glans Resurfacing in Carcinoma in situ of the Penis: A Case Report
R. Catarino, A. Cardoso, C. Ferreira, Diogo Pereira +7 more
20200 citations Open access
Semantic Scholar
Targeting cholesterol metabolism in neuroblastoma by acting on HDACs
M. J. Nunes, D. Costa, Rita Mendes De Almeida, M. Castro-Caldas +2 more
2019Frontiers in Cellular Neuroscience0 citations Open access
Semantic Scholar
S-glutathionylation and endoplasmic reticulum stress in Parkinson's disease
A. Carvalho, C. Tavares, E. Rodrigues, M. Castro-Caldas +2 more
20180 citations
Semantic Scholar
Effect of proteasome inhibition on MPP+-induced GSTP1 expression in SH-SY5Y cells
A. Carvalho, C. Marques, E. Rodrigues, P. Pereira +1 more
20090 citations
Semantic Scholar
GSTpi mediates MPTP-induced JNK activation in the nigrostriatal pathways
M. Gama, M. Castro-Caldas, A. Carvalho, E. Rodrigues +2 more
20090 citations
Semantic Scholar
P3‐257: Derepression of the CYP46A1 gene transcription by histone deacetylase inhibition
E. Rodrigues, M. J. Nunes, I. Milagre, M. Gama
20080 citations
Semantic Scholar
P3‐242: Role of Sp proteins in the transcriptional regulation of the brain‐specific CYP46A1 gene
I. Milagre, M. J. Nunes, M. Gama, R. F. Silva +3 more
20080 citations
Semantic Scholar
Repression of the human CYP46A1 promoter by retinoic acid
I. Milagre, M. J. Nunes, M. Gama, J. Pascussi +2 more
20070 citations
Semantic Scholar

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