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U. Diczfalusy · SciRah

Researcher profile · Semantic Scholar

U. Diczfalusy

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U. Diczfalusy — researcher profile on SciRah

h-index: 59
Works: 163
Citations: 12K

Most-cited papers

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease Published, JLR Papers in Press, October 1, 2003. DOI 10.1194/jlr.M300320-JLR200
M. Heverin, N. Bogdanovic, D. Lütjohann, T. Bayer +5 more
2004Journal of Lipid Research326 citations Open access
Semantic Scholar
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.
H. Marschall, Martin Wagner, G. Zollner, P. Fickert +10 more
2005Gastroenterology317 citations
Semantic Scholar
Oxysterols: Friends, Foes, or Just Fellow Passengers?
I. Björkhem, U. Diczfalusy
2002Arteriosclerosis, Thrombosis and Vascular Biology293 citations
Semantic Scholar
Crossing the barrier: Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M500024-JLR200 net flux of 27-hydroxycholesterol into the human brain
M. Heverin, S. Meaney, D. Lütjohann, U. Diczfalusy +2 more
2005Journal of Lipid Research242 citations Open access
Semantic Scholar
4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.
U. Diczfalusy, H. Nylén, P. Elander, L. Bertilsson
2011British Journal of Clinical Pharmacology215 citations Open access
Semantic Scholar
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
U. Diczfalusy, Katarina Olofsson, A. Carlsson, Mei-jiao Gong +4 more
2009Journal of Lipid Research194 citations Open access
Semantic Scholar
4&bgr;-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
U. Diczfalusy, J. Miura, H. Roh, R. Mirghani +9 more
2008Pharmacogenetics & Genomics168 citations
Semantic Scholar
Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1)
Y. Ohyama, S. Meaney, M. Heverin, L. Ekström +8 more
2006Journal of Biological Chemistry154 citations Open access
Semantic Scholar
On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.
S. Meaney, K. Bodin, U. Diczfalusy, I. Björkhem
2002Journal of Lipid Research153 citations Open access
Semantic Scholar
Metabolism of 4β-Hydroxycholesterol in Humans*
K. Bodin, U. Andersson, E. Rystedt, Ewa C. S. Ellis +5 more
2002Journal of Biological Chemistry152 citations Open access
Semantic Scholar
Novel pathways of bile acid metabolism involving CYP3A4.
K. Bodin, U. Lindbom, U. Diczfalusy
2005Biochimica et Biophysica Acta149 citations
Semantic Scholar
Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4β‐Hydroxycholesterol
K. P. Kanebratt, U. Diczfalusy, T. Backström, E. Sparve +4 more
2008Clinical pharmacology and therapy140 citations
Semantic Scholar
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.
U. Diczfalusy, Kajsa P. Kanebratt, E. Bredberg, T. Andersson +2 more
2009British Journal of Clinical Pharmacology138 citations Open access
Semantic Scholar
Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status.
L. Iuliano, F. Micheletta, S. Natoli, S. Corradini +5 more
2003Analytical Biochemistry136 citations
Semantic Scholar
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers Published, JLR Papers in Press, February 1, 2003. DOI 10.1194/jlr.M200434-JLR200
V. Leoni, T. Masterman, P. Patel, S. Meaney +2 more
2003Journal of Lipid Research136 citations Open access
Semantic Scholar
Transcriptional Regulation of Human CYP27 Integrates Retinoid, Peroxisome Proliferator-Activated Receptor, and Liver X Receptor Signaling in Macrophages
A. Szántó, Szilvia Benkő, I. Szatmári, B. Bálint +9 more
2004Molecular and Cellular Biology129 citations Open access
Semantic Scholar
Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis.
V. Leoni, T. Masterman, U. Diczfalusy, G. De Luca +2 more
2002Neuroscience Letters127 citations
Semantic Scholar
Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid Published, JLR Papers in Press, January 24, 2007.
S. Meaney, M. Heverin, U. Panzenboeck, L. Ekström +7 more
2007Journal of Lipid Research126 citations Open access
Semantic Scholar
Diagnostic use of cerebral and extracerebral oxysterols
V. Leoni, T. Masterman, Fariba S Mousavi, B. Wretlind +4 more
2004Clinical Chemistry and Laboratory Medicine123 citations
Semantic Scholar
Cholesterol-24S-hydroxylase (CYP46A1) Is Specifically Expressed in Neurons of the Neural Retina
L. Bretillon, U. Diczfalusy, I. Björkhem, M. Maire +5 more
2007Current Eye Research98 citations
Semantic Scholar
Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.
Mats Allmyr, G. Panagiotidis, E. Sparve, U. Diczfalusy +1 more
2009Basic & Clinical Pharmacology & Toxicology94 citations
Semantic Scholar
Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy.
M. Arca, S. Natoli, F. Micheletta, S. Riggi +6 more
2007Free Radical Biology & Medicine87 citations
Semantic Scholar
In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress.
Hanna Larsson, Y. Böttiger, L. Iuliano, U. Diczfalusy
2007Free Radical Biology & Medicine86 citations Open access
Semantic Scholar
On the formation and possible biological role of 25-hydroxycholesterol.
U. Diczfalusy
2013Biochimie82 citations
Semantic Scholar
Mechanism of Accumulation of Cholesterol and Cholestanol in Tendons and the Role of Sterol 27-hydroxylase (CYP27A1)
S. von Bahr, T. Movin, N. Papadogiannakis, I. Pikuleva +3 more
2002Arteriosclerosis, Thrombosis and Vascular Biology82 citations
Semantic Scholar
Comparison of Endogenous 4β-Hydroxycholesterol with Midazolam as Markers for CYP3A4 Induction by Rifampicin
L. Björkhem-Bergman, T. Backström, H. Nylén, Y. Rönquist-Nii +4 more
2013Drug Metabolism And Disposition78 citations
Semantic Scholar
Vitamin E Supplementation in Patients With Carotid Atherosclerosis: Reversal of Altered Oxidative Stress Status in Plasma but not in Plaque
F. Micheletta, S. Natoli, Maria Misuraca, E. Sbarigia +2 more
2004Arteriosclerosis, Thrombosis and Vascular Biology73 citations Open access
Semantic Scholar
Analysis of cholesterol oxidation products in biological samples.
U. Diczfalusy
2004Journal of AOAC International72 citations Open access
Semantic Scholar
Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy.
P. Stenvinkel, U. Diczfalusy, B. Lindholm, O. Heimbürger
2004Nephrology, Dialysis and Transplantation70 citations Open access
Semantic Scholar
CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4β-hydroxycholesterol levels
F. Josephson, Leif Bertilsson, Y. Böttiger, L. Flamholc +4 more
2008European Journal of Clinical Pharmacology68 citations
Semantic Scholar
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
I. Björkhem, U. Diczfalusy, A. Lövgren-Sandblom, L. Starck +8 more
2014Journal of Lipid Research65 citations Open access
Semantic Scholar
4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.
D. Lütjohann, M. Marinova, B. Schneider, J. Oldenburg +4 more
2009International journal of clinical pharmacology and therapeutics63 citations
Semantic Scholar
Metabolism of 4 beta -hydroxycholesterol in humans.
K. Bodin, U. Andersson, E. Rystedt, Ewa C. S. Ellis +5 more
2002Journal of Biological Chemistry62 citations
Semantic Scholar
Amidoxime Reductase System Containing Cytochrome b5 Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria*
E. Neve, Å. Nordling, T. Andersson, U. Hellman +3 more
2011Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians
E. Gebeyehu, E. Engidawork, A. Bijnsdorp, A. Aminy +2 more
2011The Pharmacogenomics Journal59 citations
Semantic Scholar
Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.
T. Tuomainen, U. Diczfalusy, J. Kaikkonen, K. Nyyssönen +1 more
2003Free Radical Biology & Medicine59 citations
Semantic Scholar
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages
T. Blom, N. Bäck, A. Mutka, R. Bittman +5 more
2010Circulation Research54 citations Open access
Semantic Scholar
Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study.
Qing Lu, I. Björkhem, B. Wretlind, U. Diczfalusy +2 more
2005Clinical science53 citations
Semantic Scholar
Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.
Cynthia Fourgeux, L. Martine, I. Björkhem, U. Diczfalusy +5 more
2009Investigative Ophthalmology and Visual Science52 citations Open access
Semantic Scholar
Studies on the Cholesterol-Free Mouse: Strong Activation of LXR-Regulated Hepatic Genes When Replacing Cholesterol With Desmosterol
M. Heverin, S. Meaney, A. Brafman, M. Shafir +9 more
2007Arteriosclerosis, Thrombosis and Vascular Biology51 citations Open access
Semantic Scholar
A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction.
Yvonne Mårde Arrhén, H. Nylén, A. Lövgren-Sandblom, Kajsa P. Kanebratt +2 more
2013British Journal of Clinical Pharmacology50 citations Open access
Semantic Scholar
Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients
A. Habtewold, W. Amogne, E. Makonnen, G. Yimer +7 more
2012The Pharmacogenomics Journal49 citations Open access
Semantic Scholar
Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.
K. Wide, Hanna Larsson, L. Bertilsson, U. Diczfalusy
2008British Journal of Clinical Pharmacology47 citations Open access
Semantic Scholar
Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism.
Anita Lövgren-Sandblom, M. Heverin, Hanna Larsson, E. Lundström +3 more
2007Journal of chromatography. B, Analytical technologies in the biomedical and life sciences45 citations
Semantic Scholar
Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin
M. Niemi, K. Kivistö, U. Diczfalusy, K. Bodin +3 more
2006Pharmacogenetics & Genomics43 citations
Semantic Scholar
Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation
Hadi Molanaei, P. Stenvinkel, A. Qureshi, J. Carrero +5 more
2012European Journal of Clinical Pharmacology33 citations
Semantic Scholar
CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity
M. A. Hayes, Xue-Qing Li, G. Grönberg, U. Diczfalusy +1 more
2016Drug Metabolism And Disposition29 citations
Semantic Scholar
Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment.
E. Ngaimisi, O. Minzi, S. Mugusi, P. Sasi +10 more
2014Journal of Antimicrobial Chemotherapy28 citations
Semantic Scholar
First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods
D. Lütjohann, I. Björkhem, S. Friedrichs, A. Kerksiek +46 more
2019Journal of Steroid Biochemistry and Molecular Biology27 citations Open access
Semantic Scholar
High preoperative recipient plasma 7β‐hydroxycholesterol is associated with initial poor graft function after liver transplantation
S. Corradini, F. Micheletta, S. Natoli, M. Iappelli +9 more
2005Liver transplantation26 citations Open access
Semantic Scholar

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M. Heverin×6
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