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Matthew A. Hulverson · SciRah

Researcher profile · Semantic Scholar

Matthew A. Hulverson

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Matthew A. Hulverson — researcher profile on SciRah

h-index: 25
Works: 71
Citations: 2,080

Most-cited papers

Pharmacokinetics, safety and efficacy of Bumped Kinase Inhibitor (BKI) 1553 in a pregnant sheep model of neosporosis
R. Sánchez, I. Ferre, M. Re, J. Regidor-Cerrillo +13 more
2017464 citations
Semantic Scholar
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B. Baragaña, B. Forte, Ryan Choi, Stephen Nakazawa-Hewitt +73 more
2019Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Development of an Orally Available and Central Nervous System (CNS)-Penetrant Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-à-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis
R. Vidadala, Kasey L. Rivas, K. Ojo, Matthew A. Hulverson +22 more
2016Journal of Medicinal Chemistry93 citations Open access
Semantic Scholar
A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.
K. Ojo, Richard T. Eastman, R. Vidadala, Zhongsheng Zhang +17 more
2014Journal of Infectious Diseases93 citations Open access
Semantic Scholar
Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi
Joseph D. Planer, Matthew A. Hulverson, Jennifer A. Arif, Ranae M. Ranade +2 more
2014PLoS Neglected Tropical Diseases81 citations Open access
Semantic Scholar
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.
Deborah A. Schaefer, Dana P. Betzer, Kylie D Smith, Zachary G Millman +14 more
2016Journal of Infectious Diseases71 citations Open access
Semantic Scholar
Substituted 2-Phenyl-Imidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis
H. Tatipaka, J. R. Gillespie, A. Chatterjee, N. Norcross +14 more
2014Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy
Matthew A. Hulverson, S. Vinayak, Ryan Choi, Deborah A. Schaefer +16 more
2017Journal of Infectious Diseases61 citations Open access
Semantic Scholar
Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review
W. Van Voorhis, J. S. Doggett, M. Parsons, Matthew A. Hulverson +11 more
2017Experimental parasitology60 citations Open access
Semantic Scholar
Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib
F. Buckner, M. T. Bahia, P. Suryadevara, K. White +10 more
2012Antimicrobial Agents and Chemotherapy58 citations Open access
Semantic Scholar
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
S. N. Hewitt, David M. Dranow, B. G. Horst, Jan Abendroth +22 more
2016ACS Infectious Diseases51 citations Open access
Semantic Scholar
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis
D. A. Patrick, J. R. Gillespie, J. McQueen, Matthew A. Hulverson +6 more
2016Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
Ryan Choi, Matthew A. Hulverson, Wenlin Huang, R. Vidadala +22 more
2020International Journal of Parasitology47 citations Open access
Semantic Scholar
Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection
Samuel L. M. Arnold, Ryan Choi, Matthew A. Hulverson, Deborah A. Schaefer +12 more
2017Journal of Infectious Diseases46 citations Open access
Semantic Scholar
Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis
Joachim Müller, A. Aguado-Martínez, L. Ortega-Mora, J. Moreno-Gonzalo +9 more
2017Journal of Antimicrobial Chemotherapy45 citations Open access
Semantic Scholar
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection
Frederick S. Buckner, Ranae M. Ranade, J. R. Gillespie, S. Shibata +14 more
2019Antimicrobial Agents and Chemotherapy44 citations Open access
Semantic Scholar
Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum
K. M. Hennessey, Ilse C Rogiers, Han-Wei Shih, Matthew A. Hulverson +7 more
2018PLoS Neglected Tropical Diseases41 citations Open access
Semantic Scholar
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
Wenlin Huang, K. Ojo, Zhongsheng Zhang, Kasey L. Rivas +22 more
2015ACS Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis
Sangun Lee, M. Ginese, Gillian Beamer, Hillary Danz +10 more
2018Antimicrobial Agents and Chemotherapy37 citations Open access
Semantic Scholar
A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.
Alejandro Castellanos-González, Hayley Sparks, S. Nava, Wenlin Huang +8 more
2016Journal of Infectious Diseases34 citations Open access
Semantic Scholar
In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
D. Imhof, N. Anghel, Pablo A. Winzer, V. Balmer +11 more
2021International Journal for Parasitology: Drugs and Drug Resistance31 citations Open access
Semantic Scholar
Development of 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors for Cryptosporidiosis therapy
Wenlin Huang, Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold +9 more
2019Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis
Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold, Deborah A. Schaefer +22 more
2017International Journal of Parasitology31 citations Open access
Semantic Scholar
Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites
R. Sánchez-Sánchez, I. Ferre, M. Re, P. Vázquez +18 more
2018International Journal for Parasitology: Drugs and Drug Resistance26 citations Open access
Semantic Scholar
5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors
Zhongsheng Zhang, C. Koh, Ranae M. Ranade, S. Shibata +10 more
2016ACS Infectious Diseases26 citations Open access
Semantic Scholar
Selective inhibition of Sarcocystis neurona calcium-cependent protein kinase 1 for equine protozoal myeloencephalitis therapy
K. Ojo, S. Dangoudoubiyam, S. Verma, S. Scheele +13 more
2016International Journal of Parasitology25 citations Open access
Semantic Scholar
One Health Therapeutics: Target-Based Drug Development for Cryptosporidiosis and Other Apicomplexa Diseases
W. Van Voorhis, Matthew A. Hulverson, Ryan Choi, Wenlin Huang +22 more
2020Veterinary parasitology23 citations Open access
Semantic Scholar
Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy
R. Sánchez-Sánchez, I. Ferre, M. Re, J. J. Ramos +13 more
2019Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar
5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
Wenlin Huang, Matthew A. Hulverson, Zhongsheng Zhang, Ryan Choi +8 more
2016Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays
S. Scheele, J. Geiger, A. DeRocher, Ryan Choi +9 more
2018Antimicrobial Agents and Chemotherapy17 citations Open access
Semantic Scholar
Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro
Aruna Shrestha, K. Ojo, Florian Koston, B. Ruttkowski +13 more
2019International Journal for Parasitology: Drugs and Drug Resistance16 citations Open access
Semantic Scholar
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
Matthew A. Hulverson, I. Bruzual, Erin V. McConnell, Wenlin Huang +15 more
2018Journal of Infectious Diseases16 citations Open access
Semantic Scholar
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum
Wenlin Huang, Ryan Choi, Matthew A. Hulverson, Zhongsheng Zhang +10 more
2017Antimicrobial Agents and Chemotherapy16 citations Open access
Semantic Scholar
Pyrrolopyrimidine Bumped Kinase Inhibitors for Treatment of Cryptosporidiosis
Matthew A. Hulverson, Ryan Choi, R. Vidadala, G. R. Whitman +8 more
2021ACS Infectious Diseases13 citations Open access
Semantic Scholar
Evaluation of in vitro and in vivo antibiotic efficacy against a novel bioluminescent Shigella flexneri
Molly C. McCloskey, Shareef Shaheen, Lesley Rabago, Matthew A. Hulverson +3 more
2019Scientific Reports13 citations Open access
Semantic Scholar
An early treatment with BKI-1748 exhibits full protection against abortion and congenital infection in sheep experimentally infected with Toxoplasma gondii.
R. Sánchez-Sánchez, D. Imhof, Y. Hecker, I. Ferre +12 more
2023Journal of Infectious Diseases12 citations Open access
Semantic Scholar
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
N. Anghel, D. Imhof, Pablo A. Winzer, V. Balmer +11 more
2021International Journal for Parasitology: Drugs and Drug Resistance12 citations Open access
Semantic Scholar
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors
Andriy Buchynskyy, J. R. Gillespie, Matthew A. Hulverson, J. McQueen +5 more
2016Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium
Samuel L. M. Arnold, Ryan Choi, Matthew A. Hulverson, G. R. Whitman +9 more
2019Journal of Infectious Diseases10 citations Open access
Semantic Scholar
Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1
Jemma A Montgomery, P. Alday, Ryan Choi, Monique Khim +6 more
2025ACS Infectious Diseases9 citations Open access
Semantic Scholar
Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens
Jin Woo Lee, J. Collins, Matthew A. Hulverson, L. K. T. Aguila +7 more
2023Journal of Natural Products9 citations Open access
Semantic Scholar
Repurposing Infectious Disease Hits as Anti-Cryptosporidium Leads.
Matthew A. Hulverson, Ryan Choi, Molly C. McCloskey, G. R. Whitman +17 more
2021ACS Infectious Diseases9 citations Open access
Semantic Scholar
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice
M. F. D. de Sousa, D. Imhof, Kai Pascal Alexander Hänggeli, Ryan Choi +7 more
2024International Journal for Parasitology: Drugs and Drug Resistance8 citations Open access
Semantic Scholar
Treatment with BKI-1748 after Toxoplasma gondii systemic dissemination in experimentally infected pregnant sheep improves fetal and lamb mortality and morbidity and prevents congenital infection
R. Sánchez-Sánchez, A. Huertas-López, Andrea Largo-de la Torre, I. Ferre +10 more
2024Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy
Samantha A. Michaels, Matthew A. Hulverson, G. R. Whitman, L. Tran +5 more
2022Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer
T. Uo, K. Ojo, Cynthia C. T. Sprenger, Kathryn Soriano Epilepsia +23 more
2024Molecular Cancer Therapeutics6 citations Open access
Semantic Scholar
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer +19 more
2023Antimicrobial Agents and Chemotherapy6 citations Open access
Semantic Scholar
A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy
R. Sánchez-Sánchez, I. Ferre, M. Re, Bárbara Pérez-Arroyo +13 more
2021International Journal for Parasitology: Drugs and Drug Resistance6 citations Open access
Semantic Scholar
7H-pyrrolo[2,3-d]pyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo[3,4-d]pyrimidin-4-amine based inhibitors.
R. Vidadala, Martin G. Golkowski, Matthew A. Hulverson, Ryan Choi +10 more
2018ACS Infectious Diseases6 citations Open access
Semantic Scholar
Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development
Michael K. Fenwick, Alexandra R. Reers, Yi Liu, Rachael Zigweid +10 more
2023ACS Infectious Diseases5 citations Open access
Semantic Scholar

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Ryan Choi×39
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Dustin J Maly×20

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Samuel L. M. Arnold×18

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