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F. Buckner · SciRah

Researcher profile · Semantic Scholar

F. Buckner

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F. Buckner — researcher profile on SciRah

h-index: 46
Works: 143
Citations: 7,037

Most-cited papers

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Shilpi Khare, A. Nagle, Agnes Biggart, Yin H. Lai +31 more
2016Nature380 citations Open access
Semantic Scholar
Genomic-scale prioritization of drug targets: the TDR Targets database
Fernán Agüero, B. Al-Lazikani, M. Aslett, M. Berriman +24 more
2008Nature reviews. Drug discovery312 citations Open access
Semantic Scholar
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
A. Nagle, Shilpi Khare, A. Kumar, F. Supek +7 more
2014Chemical Reviews311 citations Open access
Semantic Scholar
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with anti-malarial activity in mice
Ramesh Gujjar, A. Marwaha, Farah El Mazouni, John White +9 more
2009Journal of Medicinal Chemistry230 citations Open access
Semantic Scholar
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.
Christopher Mehlin, Erica E. Boni, F. Buckner, Linnea Engel +14 more
2006Molecular and biochemical parasitology (Print)202 citations
Semantic Scholar
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors
K. Ojo, E. T. Larson, K. Keyloun, L. Castaneda +14 more
2010Nature Structural &Molecular Biology189 citations Open access
Semantic Scholar
Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice
Ramesh Gujjar, Farah El Mazouni, K. White, John White +12 more
2011Journal of Medicinal Chemistry157 citations Open access
Semantic Scholar
Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease
James M. Kraus, C. Verlinde, Mandana Karimi, G. Lepesheva +2 more
2009Journal of Medicinal Chemistry135 citations Open access
Semantic Scholar
Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington
F. Buckner, Denise J. McCulloch, Vidya L. Atluri, M. Blain +10 more
2020Clinical Infectious Diseases105 citations Open access
Semantic Scholar
Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease
F. Buckner, J. Urbina
2012International Journal for Parasitology: Drugs and Drug Resistance103 citations Open access
Semantic Scholar
Second Generation Analogs of the Cancer Drug Clinical Candidate Tipifarnib for Anti-Chagas Disease Drug Discovery
James M. Kraus, H. Tatipaka, Sarah McGuffin, N. Chennamaneni +5 more
2010Journal of Medicinal Chemistry99 citations Open access
Semantic Scholar
Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation Published, JLR Papers in Press, December 7, 2005.
Richard T. Eastman, F. Buckner, K. Yokoyama, M. Gelb +1 more
2006Journal of Lipid Research99 citations Open access
Semantic Scholar
Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy
K. Ojo, J. R. Gillespie, Aaron Riechers, A. Napuli +8 more
2008Antimicrobial Agents and Chemotherapy94 citations Open access
Semantic Scholar
Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening
Esther Bettiol, Marie Samanovic, A. S. Murkin, J. Raper +2 more
2009PLoS Neglected Tropical Diseases88 citations Open access
Semantic Scholar
The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.
O. Hucke, M. Gelb, C. Verlinde, F. Buckner
2005Journal of Medicinal Chemistry83 citations Open access
Semantic Scholar
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
T. Arakaki, F. Buckner, J. R. Gillespie, N. A. Malmquist +8 more
2008Molecular Microbiology82 citations Open access
Semantic Scholar
Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi
Joseph D. Planer, Matthew A. Hulverson, Jennifer A. Arif, Ranae M. Ranade +2 more
2014PLoS Neglected Tropical Diseases81 citations Open access
Semantic Scholar
Colorimetric assay for screening compounds against Leishmania amastigotes grown in macrophages.
F. Buckner, Aaron J. Wilson
2005American Journal of Tropical Medicine and Hygiene76 citations Open access
Semantic Scholar
Advances in Chagas disease drug development: 2009-2010
F. Buckner, N. Navabi
2010Current Opinion in Infectious Diseases69 citations Open access
Semantic Scholar
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J. Bosch, M. Robien, Christopher Mehlin, Erica E. Boni +21 more
2006Journal of Medicinal Chemistry69 citations
Semantic Scholar
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase
A. Marwaha, John White, Farah El Mazouni, Sharon A. Creason +5 more
2012Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Pravin M. Bendale, Srinivas Olepu, P. Suryadevara, Vivek Bulbule +14 more
2007Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Substituted 2-Phenyl-Imidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis
H. Tatipaka, J. R. Gillespie, A. Chatterjee, N. Norcross +14 more
2014Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.
F. Buckner
2008Advances in Experimental Medicine and Biology60 citations
Semantic Scholar
Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib
F. Buckner, M. T. Bahia, P. Suryadevara, K. White +10 more
2012Antimicrobial Agents and Chemotherapy58 citations Open access
Semantic Scholar
Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long‐wavelength ultraviolet irradiation
Richard T. Eastman, L. Barrett, K. Dupuis, F. Buckner +1 more
2005Transfusion55 citations
Semantic Scholar
Delusional parasitosis: six-year experience with 23 consecutive cases at an academic medical center.
A. Boggild, B. Nicks, Leslianne E Yen, W. Van Voorhis +3 more
2010International Journal of Infectious Diseases50 citations Open access
Semantic Scholar
Structure of Leishmania major Methionyl-tRNA Synthetase in Complex with Intermediate Products Methionyladenylate and Pyrophosphate
E. T. Larson, Jessica E. Kim, F. Zucker, Angela M. Kelley +8 more
2010Biochimie49 citations Open access
Semantic Scholar
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis
D. A. Patrick, J. R. Gillespie, J. McQueen, Matthew A. Hulverson +6 more
2016Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Buffer Optimization of Thermal Melt Assays of Plasmodium Proteins for Detection of Small-Molecule Ligands
Gregory J. Crowther, A. Napuli, Andrew P. Thomas, D. J. Chung +12 more
2009Journal of biomolecular screening46 citations Open access
Semantic Scholar
Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
E. Torres-Santos, M. I. Sampaio-Santos, F. Buckner, K. Yokoyama +3 more
2009Journal of Antimicrobial Chemotherapy46 citations Open access
Semantic Scholar
Hydroxychloroquine for Treatment of SARS‐CoV‐2 Infection? Improving Our Confidence in a Model‐Based Approach to Dose Selection
Samuel L. M. Arnold, F. Buckner
2020Clinical and Translational Science42 citations Open access
Semantic Scholar
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
E. T. Larson, Wei Deng, B. Krumm, A. Napuli +11 more
2008Journal of Molecular Biology42 citations Open access
Semantic Scholar
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
F. Buckner, Richard T. Eastman, K. Yokoyama, M. Gelb +1 more
2005Current opinion in investigational drugs42 citations
Semantic Scholar
1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy
Andriy Buchynskyy, J. R. Gillespie, Z. Herbst, Ranae M. Ranade +2 more
2017ACS Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
Heterologous Expression of L. major proteins in S. cerevisiae: a test of solubility, purity, and gene recoding
Erin Quartley, A. Alexandrov, M. Mikucki, F. Buckner +4 more
2009Journal of Structural and Functional Genomics41 citations Open access
Semantic Scholar
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer
E. T. Larson, Jessica E. Kim, L. Castaneda, A. Napuli +8 more
2011Journal of Molecular Biology40 citations Open access
Semantic Scholar
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs
E. Merritt, T. Arakaki, J. R. Gillespie, E. T. Larson +11 more
2010Journal of Molecular Biology40 citations Open access
Semantic Scholar
Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure—Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation
S. Fletcher, C. Cummings, Kasey L. Rivas, William P. Katt +7 more
2008Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Fragment-based cocktail crystallography by the Medical Structural Genomics of Pathogenic Protozoa Consortium
C. Verlinde, E. Fan, S. Shibata, Zong-Sheng Zhang +18 more
2009Current Topics in Medicinal Chemistry39 citations Open access
Semantic Scholar
Structural genomics of pathogenic protozoa: an overview.
E. Fan, D. Baker, S. Fields, M. Gelb +35 more
2008Methods in molecular biology39 citations
Semantic Scholar
Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase
W. Van Voorhis, Kasey L. Rivas, Pravin M. Bendale, L. Nallan +16 more
2007Antimicrobial Agents and Chemotherapy38 citations Open access
Semantic Scholar
Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease
P. Suryadevara, Srinivas Olepu, Jeffrey W. Lockman, Junko Ohkanda +8 more
2009Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
M. Glenn, Sung-Youn Chang, Carrie Hornéy, Kasey L. Rivas +11 more
2006Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Experimental chemotherapy and approaches to drug discovery for Trypanosoma cruzi infection.
F. Buckner
2011Advances in Parasitology33 citations
Semantic Scholar
Recent highlights in anti-protozoan drug development and resistance research.
F. Buckner, N. Waters, V. Avery
2012International Journal for Parasitology: Drugs and Drug Resistance29 citations Open access
Semantic Scholar
5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors
Zhongsheng Zhang, C. Koh, Ranae M. Ranade, S. Shibata +10 more
2016ACS Infectious Diseases26 citations Open access
Semantic Scholar
Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design
C. Koh, Jessica E. Kim, A. Napoli, C. Verlinde +4 more
2013Molecular and biochemical parasitology (Print)26 citations Open access
Semantic Scholar
High-throughput screening of amastigotes of Leishmania donovani clinical isolates against drugs using a colorimetric β-lactamase assay
Swati Mandal, M. Maharjan, S. Ganguly, M. Chatterjee +3 more
2009Indian journal of experimental biology25 citations
Semantic Scholar
New Class of Antitrypanosomal Agents Based on Imidazopyridines.
D. G. Silva, J. R. Gillespie, Ranae M. Ranade, Z. Herbst +4 more
2017ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar

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