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Wenlin Huang · SciRah

Researcher profile · Semantic Scholar

Wenlin Huang

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Wenlin Huang — researcher profile on SciRah

h-index: 20
Works: 31
Citations: 942

Most-cited papers

Development of an Orally Available and Central Nervous System (CNS)-Penetrant Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-à-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis
R. Vidadala, Kasey L. Rivas, K. Ojo, Matthew A. Hulverson +22 more
2016Journal of Medicinal Chemistry93 citations Open access
Semantic Scholar
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.
Deborah A. Schaefer, Dana P. Betzer, Kylie D Smith, Zachary G Millman +14 more
2016Journal of Infectious Diseases71 citations Open access
Semantic Scholar
Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold
Zhongsheng Zhang, K. Ojo, R. Vidadala, Wenlin Huang +18 more
2013ACS Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Indolizine Derivatives as HIV‐1 VIF–ElonginC Interaction Inhibitors
Wenlin Huang, T. Zuo, Xiao Luo, Hong-Wei Jin +5 more
2013Chemical Biology and Drug Design53 citations
Semantic Scholar
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
Ryan Choi, Matthew A. Hulverson, Wenlin Huang, R. Vidadala +22 more
2020International Journal of Parasitology47 citations Open access
Semantic Scholar
Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection
Samuel L. M. Arnold, Ryan Choi, Matthew A. Hulverson, Deborah A. Schaefer +12 more
2017Journal of Infectious Diseases46 citations Open access
Semantic Scholar
Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline.
Xiao-Jing Yang, Wei-Wei Li, Yingqiong Sun, Xiucai Guo +3 more
2017Chemical Research in Toxicology45 citations
Semantic Scholar
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection
Frederick S. Buckner, Ranae M. Ranade, J. R. Gillespie, S. Shibata +14 more
2019Antimicrobial Agents and Chemotherapy44 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors
Wenlin Huang, T. Zuo, Hong-Wei Jin, Zhen-Ming Liu +4 more
2013Molecular diversity44 citations
Semantic Scholar
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
Wenlin Huang, K. Ojo, Zhongsheng Zhang, Kasey L. Rivas +22 more
2015ACS Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo
Kai Wang, Dong-Ju Lin, Xiucai Guo, Wenlin Huang +2 more
2017Toxins36 citations Open access
Semantic Scholar
Chemical Reactivity of Emodin and Its Oxidative Metabolites to Thiols.
Bo-Yang Qin, Yang Xu, Jiaming Chen, Wenlin Huang +2 more
2016Chemical Research in Toxicology35 citations
Semantic Scholar
A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.
Alejandro Castellanos-González, Hayley Sparks, S. Nava, Wenlin Huang +8 more
2016Journal of Infectious Diseases34 citations Open access
Semantic Scholar
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections
O. Faghih, Zhongsheng Zhang, Ranae M. Ranade, J. R. Gillespie +8 more
2017Antimicrobial Agents and Chemotherapy32 citations Open access
Semantic Scholar
Development of 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors for Cryptosporidiosis therapy
Wenlin Huang, Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold +9 more
2019Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone.
Hui Wang, Yukun Feng, Qian Wang, Xiucai Guo +3 more
2016Chemical Research in Toxicology29 citations
Semantic Scholar
5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors
Zhongsheng Zhang, C. Koh, Ranae M. Ranade, S. Shibata +10 more
2016ACS Infectious Diseases26 citations Open access
Semantic Scholar
Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors
Wenlin Huang, Zhongsheng Zhang, Ximena Barros-Álvarez, C. Koh +8 more
2016European journal of medicinal chemistry24 citations Open access
Semantic Scholar
One Health Therapeutics: Target-Based Drug Development for Cryptosporidiosis and Other Apicomplexa Diseases
W. Van Voorhis, Matthew A. Hulverson, Ryan Choi, Wenlin Huang +22 more
2020Veterinary parasitology23 citations Open access
Semantic Scholar
Chemical Interaction of Protein Cysteine Residues with Reactive Metabolites of Methyleugenol.
Yukun Feng, Hui Wang, Qian Wang, Wenlin Huang +2 more
2017Chemical Research in Toxicology23 citations
Semantic Scholar
5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
Wenlin Huang, Matthew A. Hulverson, Zhongsheng Zhang, Ryan Choi +8 more
2016Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.
N. Anghel, Pablo A. Winzer, D. Imhof, Joachim Müller +14 more
2020bioRxiv17 citations Open access
Semantic Scholar
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
Matthew A. Hulverson, I. Bruzual, Erin V. McConnell, Wenlin Huang +15 more
2018Journal of Infectious Diseases16 citations Open access
Semantic Scholar
Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Wenlin Huang, Zhongsheng Zhang, Ranae M. Ranade, J. R. Gillespie +7 more
2017Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum
Wenlin Huang, Ryan Choi, Matthew A. Hulverson, Zhongsheng Zhang +10 more
2017Antimicrobial Agents and Chemotherapy16 citations Open access
Semantic Scholar
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.
Zhongsheng Zhang, X. Barros-Álvarez, J. R. Gillespie, Ranae M. Ranade +11 more
2020RSC Medicinal Chemistry11 citations Open access
Semantic Scholar
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer +19 more
2023Antimicrobial Agents and Chemotherapy6 citations Open access
Semantic Scholar
7H-pyrrolo[2,3-d]pyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo[3,4-d]pyrimidin-4-amine based inhibitors.
R. Vidadala, Martin G. Golkowski, Matthew A. Hulverson, Ryan Choi +10 more
2018ACS Infectious Diseases6 citations Open access
Semantic Scholar
Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1
Ryan Choi, Matthew A. Hulverson, Deborah A. Schaefer, Dana P. Betzer +19 more
2025PLoS Neglected Tropical Diseases3 citations Open access
Semantic Scholar
Effective Treatment using Bumped Kinase Inhibitor 1708 in a Calf Clinical Model of Cryptosporidiosis.
Deborah A. Schaefer, Dana P. Betzer, K. Ackman, Elizabeth Carranza-Acevedo +13 more
2026Journal of Infectious Diseases0 citations Open access
Semantic Scholar
Interpretable rule-based knowledge acquisition for characterizing fungal virulence factors
Wenlin Huang
20140 citations
Semantic Scholar

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