Researcher profile · Semantic Scholar

S. Purushothama

h-index: 15
Works: 34
Citations: 859

Most-cited papers

Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper.
B. Gorovits, S. Alley, S. Bilic, B. Booth +6 more
2013Bioanalysis156 citations
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2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, B
S. Piccoli, Devangi Mehta, A. Vitaliti, J. Allinson +69 more
2019Bioanalysis75 citations Open access
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Pre-existing Antibody: Biotherapeutic Modality-Based Review
B. Gorovits, A. Clements-Egan, M. Birchler, M. Liang +7 more
2016AAPS Journal75 citations Open access
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Anti-drug Antibody Validation Testing and Reporting Harmonization
H. Myler, J. Pedras-Vasconcelos, Kelli R Phillips, C. Hottenstein +38 more
2021AAPS Journal71 citations Open access
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Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum.
Dave Yeung, Shawn Ciotti, S. Purushothama, Elham Gharakhani +5 more
2016JIM - Journal of Immunological Methods65 citations
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Parallelism: considerations for the development, validation and implementation of PK and biomarker ligand-binding assays.
Lauren F. Stevenson, S. Purushothama
2014Bioanalysis49 citations
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Recommendations for the Development of Cell-Based Anti-Viral Vector Neutralizing Antibody Assays
B. Gorovits, M. Fiscella, Mike Havert, E. Koren +3 more
2020AAPS Journal48 citations
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Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies
M. Partridge, S. Purushothama, C. Elango, Yanmei Lu
2016Journal of Immunological Research47 citations Open access
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TG/FTIR/MS study of organic compounds evolved during the co-firing of coal and refuse-derived fuels
R. Lu, S. Purushothama, Xiao-Dong Yang, J. Hyatt +3 more
199641 citations
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Next Generation Ligand Binding Assays—Review of Emerging Technologies’ Capabilities to Enhance Throughput and Multiplexing
J. Mora, A. Chunyk, Mark Dysinger, S. Purushothama +3 more
2014AAPS Journal36 citations Open access
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2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays).
Lauren F. Stevenson, S. Richards, R. Pillutla, A. Torri +68 more
2018Bioanalysis33 citations
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Rotating disk electrode amperometric detection for a bead-based immunoassay
C.Ajith Wijayawardhana, S. Purushothama, M. Cousino, H. Halsall +1 more
199932 citations
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Small volume bead assay for ovalbumin with electrochemical detection.
S. Purushothama, Supaporn Kradtap, C. Wijayawardhana, H. Halsall +1 more
2001In Analysis24 citations
Semantic Scholar
Recommendations for the Assessment and Management of Pre-existing Drug-Reactive Antibodies During Biotherapeutic Development
L. Xue, A. Clements-Egan, L. Amaravadi, M. Birchler +6 more
2017AAPS Journal23 citations Open access
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Parallelism: the foundation of biomarker assay development and validation.
Devangi Mehta, S. Purushothama, Lauren F. Stevenson
2018Bioanalysis15 citations Open access
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Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development
Yanmei Lu, L. Khawli, S. Purushothama, F. Theil +1 more
2016Journal of Immunological Research15 citations Open access
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Emerging technologies for biotherapeutic bioanalysis from a high-throughput and multiplexing perspective: insights from an AAPS emerging technology action program committee.
S. Purushothama, Mark Dysinger, Yao Chen, Karolina Österlund +3 more
2018Bioanalysis12 citations
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Co-firing high-sulfur coals with refuse-derived fuel
Huiying Lu, S. Purushothama, J. Hyatt, Wei-ping Pan +4 more
199612 citations
Semantic Scholar
What is going on with my samples? A general approach to parallelism assessment and data interpretation for biomarker ligand-binding assays.
Shawn Ciotti, S. Purushothama, S. Ray
2013Bioanalysis10 citations
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Analysis of polynuclear aromatic hydrocarbons from coal fly ash
S. Purushothama, Wei-ping Pan, J. T. Riley, W. G. Lloyd
19989 citations
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Tissue distribution of 35S-metabolically labeled neublastin (BG00010) in rats.
N. Penner, S. Purushothama, B. Pepinsky
2020Journal of Pharmaceutical and Biomedical Analysis3 citations
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The need for a harmonized speech dataset for Alzheimer’s disease biomarker development
Nicole L. Bjorklund, H. Fillit, Kristina Malzbender, S. Purushothama +1 more
20203 citations Open access
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Well-developed ligand-binding assays demonstrate robust performance using singlet analysis.
Douglas Donaldson, S. Purushothama, E. David, Kristopher W King +3 more
2019Bioanalysis3 citations
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Correlation of red cell indices and hemoglobin concentration with serum ferritin among iron deficiency anemia patients
N. L. Sharanya Raj, U. Sharma, M. L. Revathi Devi, S. Purushothama +2 more
20202 citations Open access
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Biomarker assays: is it time for a standalone regulatory guidance?
Steve Keller, S. Purushothama
2018Bioanalysis2 citations Open access
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Correction to: Recommendations for the Development of Cell-Based Anti-Viral Vector Neutralizing Antibody Assays
B. Gorovits, M. Fiscella, Mike Havert, Eugen Koren +3 more
2020AAPS Journal1 citations Open access
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Unwanted Immunogenicity Responses to Biotherapeutics
S. Purushothama, B. Gorovits
2019Handbook of Biomarkers and Precision Medicine0 citations
Semantic Scholar
Cardiovascular disease among patients admitted to medicine intensive care unit (MICU) in tertiary care hospital
M. N. Arpith, M. L. Revathi Devi, S. Purushothama, S. Manjunatha
2018Indian Journal of Clinical Anatomy and Physiology0 citations Open access
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Development of a plug and play ImmunoPCR technique for the analysis of biomolecules.
S. Gopal, S. Purushothama, Alvydas Mikulskis, Lauren F. Stevenson
2017Bioanalysis0 citations
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Additional constraints during biomarker method development: case studies
Gilda Shayan, S. Gopal, S. Purushothama, Chase Shen
20160 citations
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Next Generation Ligand Binding Assays—Review of Emerging Technologies’ Capabilities to Enhance Throughput and Multiplexing
J. Mora, A. Chunyk, Mark Dysinger, S. Purushothama +3 more
2014AAPS Journal0 citations Open access
Semantic Scholar
Our thanks to all those who have helped with this issue of Bioanalysis. Listed below are authors, referees and others who have kindly given their time, effort and expertise; their generosity has helped establish this publication.
P. Abu-Rabie, J. Allinson, C. Baker-Lee, P. Bonate +37 more
20020 citations
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DEVELOPMENT OF IMMUNOMAGNETIC BEAD ASSAY WITH ELECTROCHEMICAL DETECTION FOR USE IN A MINIATURIZED SENSOR
S. Purushothama
20010 citations
Semantic Scholar
A Study of the Effect of the Extraction Procedure in the Analysis of Organic Compounds Adsorbed on Coal Ash
S. Purushothama
19960 citations
Semantic Scholar

L. Amaravadi

×4

H. Myler×4

M. Partridge×3

J. Pedras-Vasconcelos×3

Haoheng Yan×3

M. Milton×3

B. Long×3

V. Jawa×3