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F. Theil · SciRah

Researcher profile · Semantic Scholar

F. Theil

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F. Theil — researcher profile on SciRah

h-index: 32
Works: 71
Citations: 5,936

Most-cited papers

Surface-enhanced Raman spectroscopy (SERS): progress and trends
D. Cialla, Annegret März, René Böhme, F. Theil +3 more
2012Analytical and Bioanalytical Chemistry857 citations
Semantic Scholar
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.
P. Poulin, F. Theil
2002Journal of Pharmacy and Science583 citations
Semantic Scholar
A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.
P. Poulin, F. Theil
2000Journal of Pharmacy and Science416 citations
Semantic Scholar
Effects of charge on antibody tissue distribution and pharmacokinetics.
C. Boswell, Devin B. Tesar, Kiran Mukhyala, F. Theil +2 more
2010Bioconjugate chemistry383 citations
Semantic Scholar
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.
P. Poulin, F. Theil
2002Journal of Pharmacy and Science306 citations
Semantic Scholar
Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data
R. Deng, S. Iyer, F. Theil, D. Mortensen +2 more
2011mAbs284 citations Open access
Semantic Scholar
Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges.
Y. Vugmeyster, Xin Xu, F. Theil, L. Khawli +1 more
2012World Journal of Biological Chemsitry240 citations Open access
Semantic Scholar
A strategy for risk mitigation of antibodies with fast clearance
I. Hötzel, F. Theil, L. J. Bernstein, S. Prabhu +9 more
2012mAbs238 citations Open access
Semantic Scholar
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
C. Boswell, E. Mundo, Crystal Zhang, D. Bumbaca +15 more
2011Bioconjugate chemistry208 citations
Semantic Scholar
Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs.
P. Poulin, Kerstin Schoenlein, F. Theil
2001Journal of Pharmacy and Science206 citations
Semantic Scholar
Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.
F. Theil, T. Guentert, S. Haddad, P. Poulin
2003Toxicology Letters199 citations
Semantic Scholar
A possible mechanism for the emergence of an additional band gap due to a Ti–O–C bond in the TiO2–graphene hybrid system for enhanced photodegradation of methylene blue under visible light
S. Umrao, Shiju Abraham, F. Theil, Shobhit A Pandey +8 more
2014145 citations
Semantic Scholar
Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration
Yanan Zheng, Devin B. Tesar, Lisa J. Benincosa, Herbert Birnböck +27 more
2012mAbs144 citations Open access
Semantic Scholar
Whole body physiologically-based pharmacokinetic models: their use in clinical drug development
A. Edginton, F. Theil, W. Schmitt, S. Willmann
2008Expert Opinion on Drug Metabolism & Toxicology144 citations
Semantic Scholar
Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response
H. Wong, Edna F. Choo, B. Alicke, Xiao Ding +7 more
2012Clinical Cancer Research126 citations Open access
Semantic Scholar
Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-α Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys
R. Deng, K. Loyet, S. Lien, S. Iyer +5 more
2010Drug Metabolism And Disposition117 citations
Semantic Scholar
Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods.
P. Poulin, F. Theil
2009Journal of Pharmacy and Science114 citations
Semantic Scholar
Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model
C. Pastuskovas, E. Mundo, S. Williams, Tapan K. Nayak +21 more
2012Molecular Cancer Therapeutics111 citations Open access
Semantic Scholar
Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states.
A. Deo, F. Theil, J. Nicolas
2013Molecular Pharmaceutics89 citations
Semantic Scholar
Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes.
O. Luttringer, F. Theil, T. Lavé, Karin Wernli-Kuratli +2 more
2002Biochemical Pharmacology89 citations
Semantic Scholar
Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice
R. Deng, Y. Meng, K. Hoyte, Jeff Lutman +6 more
2012mAbs84 citations Open access
Semantic Scholar
Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins
Alison Smith, H. Manoli, Stacey Jaw, Kimberley Frutoz +3 more
2016Journal of Immunological Research75 citations Open access
Semantic Scholar
Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.
O. Luttringer, F. Theil, P. Poulin, A. Schmitt-Hoffmann +2 more
2003Journal of Pharmacy and Science75 citations
Semantic Scholar
Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737
R. G. Ridley, Hugues Matile, Catherine Jaquet, A. Dorn +13 more
1997Antimicrobial Agents and Chemotherapy57 citations Open access
Semantic Scholar
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine.
P. Angehrn, S. Buchmann, C. Funk, Erwin Goetschi +11 more
2004Journal of Medicinal Chemistry51 citations
Semantic Scholar
Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications.
G. Ferl, F. Theil, H. Wong
2016Biopharmaceutics & drug disposition46 citations Open access
Semantic Scholar
Frozen in Time: Kinetically Stabilized Amorphous Solid Dispersions of Nifedipine Stable after a Quarter Century of Storage.
F. Theil, S. Anantharaman, Samuel O Kyeremateng, H. van Lishaut +4 more
2017Molecular Pharmaceutics40 citations Open access
Semantic Scholar
Maximizing tumour exposure to anti‐neuropilin‐1 antibody requires saturation of non‐tumour tissue antigenic sinks in mice
D. Bumbaca, H. Xiang, C. Boswell, R. Port +8 more
2012British Journal of Pharmacology38 citations Open access
Semantic Scholar
Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans
Y. Xin, S. Bai, L. Damico-Beyer, D. Jin +9 more
2012Pharmaceutical Research37 citations
Semantic Scholar
Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow
C. Boswell, Gregory Z. Ferl, E. Mundo, D. Bumbaca +4 more
2011PLoS ONE37 citations Open access
Semantic Scholar
A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human.
P. Poulin, S. Ekins, F. Theil
2011Toxicology and Applied Pharmacology37 citations
Semantic Scholar
Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology.
S. Prabhu, C. A. Boswell, D. Leipold, L. Khawli +5 more
2011Therapeutic delivery34 citations
Semantic Scholar
Extraordinary Long-Term-Stability in Kinetically Stabilized Amorphous Solid Dispersions of Fenofibrate.
F. Theil, Johanna Milsmann, Samuel O Kyeremateng, S. Anantharaman +2 more
2017Molecular Pharmaceutics28 citations
Semantic Scholar
Current challenges and opportunities in nonclinical safety testing of biologics.
S. Kronenberg, A. Baumann, L. de Haan, H. Hinton +4 more
2013Drug Discovery Today24 citations
Semantic Scholar
New challenges and opportunities in nonclinical safety testing of biologics.
A. Baumann, Kelly M. Flagella, R. Forster, L. de Haan +5 more
2014Regulatory toxicology and pharmacology : RTP23 citations
Semantic Scholar
Interplay of Dissolution, Solubility, and Nonsink Permeation Determines the Oral Absorption of the Hedgehog Pathway Inhibitor GDC-0449 in Dogs: An Investigation Using Preclinical Studies and Physiologically Based Pharmacokinetic Modeling
H. Wong, F. Theil, Yong Cui, James C. Marsters +8 more
2010Drug Metabolism And Disposition23 citations
Semantic Scholar
Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.
C. Boswell, G. Ferl, E. Mundo, Michelle G. Schweiger +5 more
2010Molecular Pharmaceutics23 citations
Semantic Scholar
Insights into the Mechanism of Polymer Coating Self-Healing Using Raman Spectroscopy
Simona Vasiliu, B. Kampe, F. Theil, B. Dietzek +4 more
2014Applied Spectroscopy21 citations
Semantic Scholar
Ruthenium dye functionalized gold nanoparticles and their spectral responses
Linda Zedler, F. Theil, A. Csáki, W. Fritzsche +4 more
201221 citations
Semantic Scholar
Crystallization Risk Assessment of Amorphous Solid Dispersions by Physical Shelf-Life Modeling: A Practical Approach.
Bo Liu, F. Theil, Kristin Lehmkemper, David Gessner +2 more
2021Molecular Pharmaceutics18 citations
Semantic Scholar
Manufacturing Amorphous Solid Dispersions with a Tailored Amount of Crystallized API for Biopharmaceutical Testing.
F. Theil, Johanna Milsmann, S. Anantharaman, H. van Lishaut
2018Molecular Pharmaceutics18 citations Open access
Semantic Scholar
Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development
Yanmei Lu, L. Khawli, S. Purushothama, F. Theil +1 more
2016Journal of Immunological Research15 citations Open access
Semantic Scholar
Ru dye functionalized Au-SiO2@TiO2 and Au/Pt-SiO2@TiO2 nanoassemblies for surface-plasmon-induced visible light photocatalysis.
F. Theil, A. Dellith, J. Dellith, A. Undisz +5 more
2014Journal of Colloid and Interface Science13 citations
Semantic Scholar
An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.
P. Poulin, D. Dambach, D. H. Hartley, Kevin A. Ford +8 more
2013Journal of Pharmacy and Science13 citations
Semantic Scholar
Evidence for SERRS Enhancement in the Spectra of Ruthenium Dye–Metal Nanoparticle Conjugates
F. Theil, Linda Zedler, Annegret März, Wei Xie +6 more
201313 citations
Semantic Scholar
Population pharmacokinetic and pharmacodynamic modeling of MNRP1685A in cynomolgus monkeys using two-target quasi-steady-state (QSS) model
Y. Xin, H. Xiang, D. Jin, F. Theil +3 more
2012Journal of Pharmacokinetics and Pharmacodynamics11 citations
Semantic Scholar
Glycoconjugated Rhenium(I) and 99m‐Technetium(I) Carbonyl Complexes from Pyridyltriazole Ligands Obtained by “Click Chemistry”
J. Czaplewska, F. Theil, E. Altuntaş, T. Niksch +8 more
201410 citations
Semantic Scholar
Adding a new Dimension to the Amorphous Solid Dispersion Phase Diagram: Studying Dissolution Kinetics of Crystalline Drugs in a Polymer Matrix using temperature dependent XRPD and DSC.
V. Seiler, F. Theil, N. Nagel, H. van Lishaut
2022Journal of Pharmacy and Science8 citations
Semantic Scholar
In Vitro–In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Antibody Therapeutics
C. Boswell, R. Deng, Ke-Dan Lin, W. Putnam +5 more
20098 citations
Semantic Scholar
ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins
Hong-Hui Zhou, F. Theil
20156 citations
Semantic Scholar

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