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P. Bonate · SciRah

Researcher profile · Semantic Scholar

P. Bonate

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P. Bonate — researcher profile on SciRah

h-index: 35
Works: 165
Citations: 4,960

Most-cited papers

Pharmacokinetics
P. Bonate
2011441 citations
Semantic Scholar
Discovery and development of clofarabine: a nucleoside analogue for treating cancer
P. Bonate, L. Arthaud, W. Cantrell, Katherine K. Stephenson +2 more
2006Nature reviews. Drug discovery251 citations
Semantic Scholar
Scientific white paper on concentration-QTc modeling
C. Garnett, P. Bonate, Q. Dang, G. Ferber +7 more
2017Journal of Pharmacokinetics and Pharmacodynamics234 citations
Semantic Scholar
Phase II Study Evaluating 2 Dosing Schedules of Oral Foretinib (GSK1363089), cMET/VEGFR2 Inhibitor, in Patients with Metastatic Gastric Cancer
M. Shah, Z. Wainberg, D. Catenacci, H. Hochster +14 more
2013PLoS ONE207 citations Open access
Semantic Scholar
A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1.
E. Lukina, N. Watman, Elsa Avila Arreguin, M. Banikazemi +11 more
2010Blood154 citations Open access
Semantic Scholar
Population Pharmacokinetics of Isavuconazole from Phase 1 and Phase 3 (SECURE) Trials in Adults and Target Attainment in Patients with Invasive Infections Due to Aspergillus and Other Filamentous Fungi
Amit Desai, L. Kovanda, D. Kowalski, Qiaoyang Lu +2 more
2016Antimicrobial Agents and Chemotherapy130 citations Open access
Semantic Scholar
Population pharmacokinetics-pharmacodynamics of alemtuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response.
D. Mould, A. Baumann, J. Kuhlmann, M. Keating +5 more
2007British Journal of Clinical Pharmacology122 citations Open access
Semantic Scholar
Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi
Amit Desai, L. Kovanda, W. Hope, D. Andes +5 more
2017Antimicrobial Agents and Chemotherapy107 citations Open access
Semantic Scholar
Isavuconazole Population Pharmacokinetic Analysis Using Nonparametric Estimation in Patients with Invasive Fungal Disease (Results from the VITAL Study)
L. Kovanda, Amit Desai, Qiaoyang Lu, R. Townsend +3 more
2016Antimicrobial Agents and Chemotherapy70 citations Open access
Semantic Scholar
Safety, Tolerability, and Pharmacokinetics of Eliglustat Tartrate (Genz‐112638) After Single Doses, Multiple Doses, and Food in Healthy Volunteers
M. Peterschmitt, A. Burke, L. Blankstein, Sharon E. Smith +5 more
2011Journal of clinical pharmacology63 citations
Semantic Scholar
Phase I and Pharmacokinetic Study of Tasidotin Hydrochloride (ILX651), a Third-Generation Dolastatin-15 Analogue, Administered Weekly for 3 Weeks Every 28 Days in Patients with Advanced Solid Tumors
A. Mita, L. Hammond, P. Bonate, G. Weiss +8 more
2006Clinical Cancer Research56 citations Open access
Semantic Scholar
A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development
A. Ruiz-Garcia, P. Baverel, D. Bottino, Michael Dolton +11 more
2023Journal of Pharmacokinetics and Pharmacodynamics52 citations Open access
Semantic Scholar
Confidence and Prediction Intervals for Pharmacometric Models
A. Kümmel, P. Bonate, J. Dingemanse, Andreas Krause
2018CPT: Pharmacometrics & Systems Pharmacology48 citations Open access
Semantic Scholar
Two heads are better than one: current landscape of integrating QSP and machine learning
Tong-Li Zhang, I. Androulakis, P. Bonate, Limei Cheng +5 more
2022Journal of Pharmacokinetics and Pharmacodynamics46 citations Open access
Semantic Scholar
Population pharmacokinetics of immediate‐ and prolonged‐release tacrolimus formulations in liver, kidney and heart transplant recipients
Zheng Lu, P. Bonate, J. Keirns
2019British Journal of Clinical Pharmacology37 citations Open access
Semantic Scholar
Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints.
L. Kovanda, R. Petraitienė, V. Petraitis, T. Walsh +3 more
2016Journal of Antimicrobial Chemotherapy36 citations Open access
Semantic Scholar
Pharmacokinetics in Drug Development
P. Bonate, D. Howard
2016Cambridge International Law Journal36 citations
Semantic Scholar
The Art of Modeling
P. Bonate
201133 citations
Semantic Scholar
Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity
Ruo-Li Bai, Michael C. Edler, P. Bonate, T. Copeland +3 more
2008Molecular Pharmacology32 citations Open access
Semantic Scholar
Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer
P. Bonate, C. Cunningham, P. Gaynon, S. Jeha +6 more
2011Cancer Chemotherapy and Pharmacology31 citations
Semantic Scholar
Clinical and Pharmacokinetic Study of Clofarabine in Chronic Lymphocytic Leukemia: Strategy for Treatment
V. Gandhi, W. Plunkett, P. Bonate, M. Du +3 more
2006Clinical Cancer Research26 citations Open access
Semantic Scholar
Methods and strategies for assessing uncontrolled drug–drug interactions in population pharmacokinetic analyses: results from the International Society of Pharmacometrics (ISOP) Working Group
P. Bonate, M. Ahamadi, N. Budha, A. de la Peña +7 more
2016Journal of Pharmacokinetics and Pharmacodynamics25 citations
Semantic Scholar
Modeling Tumor Growth in Oncology
P. Bonate
201125 citations
Semantic Scholar
Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale
P. Bonate, Tian-Li Wang, P. Passier, W. Bagchus +5 more
2018Journal of Pharmacokinetics and Pharmacodynamics23 citations Open access
Semantic Scholar
Nonlinear Mixed Effects Models: Theory
P. Bonate
201123 citations
Semantic Scholar
Modeling tumor growth kinetics after treatment with pazopanib or placebo in patients with renal cell carcinoma
P. Bonate, A. Suttle
2013Cancer Chemotherapy and Pharmacology19 citations
Semantic Scholar
A Comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors
A. Naing, R. Kurzrock, L. Adams, J. Kleha +6 more
2012Investigational new drugs19 citations
Semantic Scholar
Conditional modeling of antibody titers using a zero-inflated poisson random effects model: application to Fabrazyme®
P. Bonate, Crystal C C Sung, Karen Welch, S. Richards
2009Journal of Pharmacokinetics and Pharmacodynamics19 citations
Semantic Scholar
Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates.
Yukio Otsuka, S. Poondru, P. Bonate, Rachel H. Rose +3 more
2023Journal of Pharmacokinetics and Pharmacodynamics18 citations Open access
Semantic Scholar
Training the next generation of pharmacometric modelers: a multisector perspective
P. Bonate, Jeffrey S. Barrett, Sihem Ait-Oudhia, R. Brundage +15 more
2023Journal of Pharmacokinetics and Pharmacodynamics17 citations Open access
Semantic Scholar
Correction to: Scientific white paper on concentration-QTc modeling
C. Garnett, P. Bonate, Q. Dang, G. Ferber +7 more
2018Journal of Pharmacokinetics and Pharmacodynamics17 citations Open access
Semantic Scholar
Comprar Pharmacokinetic-pharmacodynamic modeling and simulation | P. Bonate | 9781441938961 | Springer
P. Bonate
201116 citations
Semantic Scholar
Population Pharmacokinetic Modeling of VL-2397, a Novel Systemic Antifungal Agent: Analysis of a Single- and Multiple-Ascending-Dose Study in Healthy Subjects
L. Kovanda, S. Sullivan, Larry R. Smith, Amit Desai +2 more
2019Antimicrobial Agents and Chemotherapy15 citations Open access
Semantic Scholar
Clinical pharmacology of the antibody-drug conjugate enfortumab vedotin in advanced urothelial carcinoma and other malignant solid tumors.
M. Tang, Amit Garg, P. Bonate, J. Rosenberg +6 more
2022Journal of Clinical Oncology14 citations
Semantic Scholar
Physiologically‐Based Pharmacokinetic Modeling for the Prediction of a Drug–Drug Interaction of Combined Effects on P‐glycoprotein and Cytochrome P450 3A
Yukio Otsuka, M. Choules, P. Bonate, Kanji Komatsu
2020CPT: Pharmacometrics & Systems Pharmacology14 citations Open access
Semantic Scholar
Renal excretion of clofarabine: assessment of dose-linearity and role of renal transport systems on drug excretion.
A. Ajavon, P. Bonate, D. Taft
2010European Journal of Pharmaceutical Sciences14 citations
Semantic Scholar
The effects of active metabolites on parameter estimation in linear mixed effect models of concentration–QT analyses
P. Bonate
2013Journal of Pharmacokinetics and Pharmacodynamics12 citations
Semantic Scholar
Effect of Censoring Due to Progressive Disease on Tumor Size Kinetic Parameter Estimates
P. Bonate, B. Suttle
2013AAPS Journal11 citations Open access
Semantic Scholar
Pharmacokinetics in mice implanted with xenografted tumors after intravenous administration of tasidotin (ILX651) or its carboxylate metabolite
P. Bonate, David Beyerlein, Jennifer Crawford, Stephanie D. Roth +2 more
2007AAPS Journal9 citations Open access
Semantic Scholar
Abstract B6: A phase II study of the efficacy and safety of foretinib, a novel receptor tyrosine kinase inhibitor, given on an intermittent 5‐days‐on/9‐days‐off (5/9) schedule in patients with recurrent or metastatic squamous cell cancer of the head and neck
T. Seiwert, S. Swann, H. Kurz, P. Bonate +2 more
20097 citations
Semantic Scholar
Exposure–Response Analysis of Micafungin in Neonatal Candidiasis
L. Kovanda, T. Walsh, D. Benjamin, A. Arrieta +7 more
2018The Pediatric Infectious Disease Journal6 citations Open access
Semantic Scholar
Pharmacokinetics and pharmacodynamics of gilteritinib in patients with relapsed or refractory acute myeloid leukemia.
Catherine C. Smith, M. Levis, M. Litzow, A. Perl +10 more
20166 citations
Semantic Scholar
Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children
Noemi Hiroshige, J. Coulibaly, J. Huwyler, P. Bonate +1 more
2018Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar
Scientific white paper on concentration-QTc modeling
C. Garnett, P. Bonate, Q. Dang, G. Ferber +7 more
2017Journal of Pharmacokinetics and Pharmacodynamics5 citations
Semantic Scholar
Nonlinear Models and Regression
P. Bonate
20115 citations
Semantic Scholar
Comprar Pharmacokinetics in drug development: advances and applications, vol. 3 | P. Bonate | 9781441979360 | Springer
P. Bonate, D. Howard
20115 citations
Semantic Scholar
The Journal of Clinical Pharmacology: Highlights and Book Reviews
Robert R. Bies, P. Bonate
20065 citations Open access
Semantic Scholar
A pharmacometrician’s role in enhancing medication use in pregnancy and lactation
S. Quinney, P. Bonate
2020Journal of Pharmacokinetics and Pharmacodynamics4 citations Open access
Semantic Scholar
No Dose Adjustment Necessary for Isavuconazole in Obese Patients
Amit Desai, L. Kovanda, D. Andes, C. Lademacher +3 more
20164 citations Open access
Semantic Scholar
Clinical Trial Simulation: Theory
P. Bonate
20064 citations
Semantic Scholar

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