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M. Liang · SciRah

Researcher profile · Semantic Scholar

M. Liang

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M. Liang — researcher profile on SciRah

h-index: 27
Works: 75
Citations: 1,945

Most-cited papers

Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus
J. Riggs, R. Hanna, B. Rajan, K. Zerrouki +12 more
2018Lupus Science and Medicine133 citations Open access
Semantic Scholar
A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients
J.-L. Li, H.-L. Liu, X.-R. Zhang, J.-P. Xu +5 more
2009Gene Therapy126 citations Open access
Semantic Scholar
Clinical Activity, Tolerability, and Long-term Follow-up of Durvalumab in Patients With Advanced NSCLC.
S. Antonia, A. Balmanoukian, J. Brahmer, S. Ou +27 more
2019Journal of Thoracic Oncology90 citations Open access
Semantic Scholar
Detection of High- and Low-Affinity Antibodies Against a Human Monoclonal Antibody Using Various Technology Platforms
M. Liang, S. Klakamp, C. Funelas, Hong Lu +8 more
2007Assay and drug development technologies89 citations
Semantic Scholar
First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody–Drug Conjugate MEDI4276 in Patients with HER2-positive Advanced Breast or Gastric Cancer
M. Pegram, E. Hamilton, A. Tan, A. Storniolo +8 more
2021Molecular Cancer Therapeutics85 citations Open access
Semantic Scholar
2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, B
S. Piccoli, Devangi Mehta, A. Vitaliti, J. Allinson +69 more
2019Bioanalysis75 citations Open access
Semantic Scholar
Pre-existing Antibody: Biotherapeutic Modality-Based Review
B. Gorovits, A. Clements-Egan, M. Birchler, M. Liang +7 more
2016AAPS Journal75 citations Open access
Semantic Scholar
Anti-drug Antibody Validation Testing and Reporting Harmonization
H. Myler, J. Pedras-Vasconcelos, Kelli R Phillips, C. Hottenstein +38 more
2021AAPS Journal71 citations Open access
Semantic Scholar
Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody
Jackie Cheng, M. Liang, M. F. Carvalho, N. Tigue +3 more
2020Antibodies66 citations Open access
Semantic Scholar
Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development
M. Liang, M. Schwickart, A. Schneider, I. Vainshtein +3 more
2015Cytometry. Part B, Clinical cytometry61 citations Open access
Semantic Scholar
Pharmacogenomics and Translational Simulations to Bridge Indications for an Anti‐Interferon‐α Receptor Antibody
Bing Wang, B. Higgs, L. Chang, I. Vainshtein +9 more
2013Clinical pharmacology and therapy55 citations Open access
Semantic Scholar
Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2
Morse Faria, Marlking Peay, Brandon Lam, Eric Ma +5 more
2019Antibodies51 citations Open access
Semantic Scholar
PK-PD modeling of protein drugs: implications in assay development.
L. Roskos, A. Schneider, I. Vainshtein, M. Schwickart +4 more
2011Bioanalysis49 citations
Semantic Scholar
Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics.
D. Finch, M. Sleeman, J. Moisan, Franco Ferraro +20 more
2011Journal of Molecular Biology48 citations
Semantic Scholar
Phase I Study of MEDI3726: A Prostate-Specific Membrane Antigen-Targeted Antibody–Drug Conjugate, in Patients with mCRPC after Failure of Abiraterone or Enzalutamide
J. de Bono, M. Fleming, Judy S. Wang, R. Cathomas +12 more
2021Clinical Cancer Research42 citations
Semantic Scholar
Research Progress on the Protective Effect of Brown Algae-Derived Polysaccharides on Metabolic Diseases and Intestinal Barrier Injury
Ying Yang, M. Liang, Dan Ouyang, Haibin Tong +2 more
2022International Journal of Molecular Sciences41 citations Open access
Semantic Scholar
Characterization of Antibody-Drug Conjugate Pharmacokinetics and in Vivo Biotransformation Using Quantitative Intact LC-HRMS and Surrogate Analyte LC-MRM.
Yue Huang, Si Mou, Yadi Wang, Ruipeng Mu +2 more
2021Analytical Chemistry41 citations Open access
Semantic Scholar
Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals
I. Vainshtein, L. Roskos, Jackie Cheng, M. Sleeman +2 more
2014Pharmaceutical Research39 citations Open access
Semantic Scholar
Role of receptor occupancy assays by flow cytometry in drug development
Jennifer J. Stewart, Cherie Green, N. Jones, M. Liang +12 more
2016Cytometry. Part B, Clinical cytometry37 citations Open access
Semantic Scholar
Mechanistic Modeling of Antigen Sink Effect for Mavrilimumab Following Intravenous Administration in Patients With Rheumatoid Arthritis
Bing Wang, Yvonne Y. Lau, M. Liang, I. Vainshtein +5 more
2012Journal of clinical pharmacology34 citations
Semantic Scholar
2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays).
Lauren F. Stevenson, S. Richards, R. Pillutla, A. Torri +68 more
2018Bioanalysis33 citations
Semantic Scholar
Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.
A. Wayne, N. Shah, D. Bhojwani, L. Silverman +8 more
2017Blood31 citations Open access
Semantic Scholar
Phase I Study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.
A. Wayne, N. Shah, D. Bhojwani, L. Silverman +8 more
2017Blood30 citations Open access
Semantic Scholar
Interference in immunoassays to support therapeutic antibody development in preclinical and clinical studies.
M. Schwickart, I. Vainshtein, Rozanne Lee, A. Schneider +1 more
2014Bioanalysis29 citations
Semantic Scholar
Pharmacokinetics of MEDI4736, a fully human anti-PDL1 monoclonal antibody, in patients with advanced solid tumors.
D. Fairman, R. Narwal, M. Liang, P. Robbins +9 more
201428 citations
Semantic Scholar
Recommendations for the development and validation of flow cytometry‐based receptor occupancy assays
Cherie Green, Jennifer J. Stewart, Carl-Magnus Högerkorp, A. Lackey +12 more
2016Cytometry. Part B, Clinical cytometry27 citations Open access
Semantic Scholar
Protein engineering and preclinical development of a GM‐CSF receptor antibody for the treatment of rheumatoid arthritis
Ralph Minter, E. S. Cohen, Bing Wang, M. Liang +16 more
2013British Journal of Pharmacology27 citations Open access
Semantic Scholar
Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics
Ruipeng Mu, Jiaqi Yuan, Yue Huang, John K. Meissen +3 more
2022BioDrugs25 citations Open access
Semantic Scholar
Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling
N. Michaud, Youzhen Wang, K. McEachern, J. J. Jordan +18 more
2013Molecular Cancer Therapeutics24 citations
Semantic Scholar
Recommendations for the Assessment and Management of Pre-existing Drug-Reactive Antibodies During Biotherapeutic Development
L. Xue, A. Clements-Egan, L. Amaravadi, M. Birchler +6 more
2017AAPS Journal23 citations Open access
Semantic Scholar
Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-PSMA PBD Antibody-Drug Conjugate.
Yue Huang, Chris DelNagro, K. Balic, William R. Mylott +11 more
2020Analytical Chemistry22 citations Open access
Semantic Scholar
HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles
M. Shata, Enass A Abdel-Hameed, S. Rouster, Li Yu +5 more
2019Pathogens and Immunity22 citations Open access
Semantic Scholar
Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia
N. Shah, D. Bhojwani, K. August, A. Baruchel +19 more
2020Pediatric Blood & Cancer21 citations Open access
Semantic Scholar
Molecular Engineering II: Antibody Affinity
L. Roskos, S. Klakamp, M. Liang, R. Arends +1 more
200820 citations
Semantic Scholar
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
J. Douthwaite, J. Moisan, C. Privezentzev, B. Soskic +23 more
2017Journal of Immunology19 citations
Semantic Scholar
A High-Throughput Hybridoma Selection Method Using Fluorometric Microvolume Assay Technology
Rozanne Lee, My-An Tran, M. Nocerini, M. Liang
2008Journal of biomolecular screening18 citations Open access
Semantic Scholar
Isolation of high-affinity, neutralizing anti-idiotype antibodies by phage and ribosome display for application in immunogenicity and pharmacokinetic analyses.
Stacey E. Chin, Franco Ferraro, M. Groves, M. Liang +2 more
2015JIM - Journal of Immunological Methods17 citations
Semantic Scholar
An immunoinhibition approach to overcome the impact of pre-existing antibodies on cut point establishment for immunogenicity assessment of moxetumomab pasudotox.
A. Schneider, I. Vainshtein, L. Roskos, Carlos Chávez +2 more
2016JIM - Journal of Immunological Methods15 citations
Semantic Scholar
A new method for identification of outliers in immunogenicity assay cut point data.
Jian-Chun Zhang, R. Arends, R. Kubiak, L. Roskos +4 more
2020JIM - Journal of Immunological Methods14 citations
Semantic Scholar
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination
Ruipeng Mu, Yue-Hui Huang, Jerome Bouquet, Jiaqi Yuan +12 more
2022Analytical Chemistry13 citations Open access
Semantic Scholar
A phase I dose-escalation study of MEDI-575, a PDGFRα monoclonal antibody, in adults with advanced solid tumors
C. Becerra, P. Conkling, N. Vogelzang, H. Wu +5 more
2014Cancer Chemotherapy and Pharmacology13 citations Open access
Semantic Scholar
High-sensitivity quantification of antisense oligonucleotides for pharmacokinetic characterization.
Shilpi Mahajan, Hui Zhao, K. Kovacina, E. Lachacz +3 more
2022Bioanalysis12 citations Open access
Semantic Scholar
Development of a new ARCHITECT automated periostin immunoassay.
Nicolette M. Jeanblanc, Philip M. Hemken, Maria J. Datwyler, S. Brophy +10 more
2017Clinica chimica acta; international journal of clinical chemistry12 citations Open access
Semantic Scholar
Pharmacokinetic and pharmacodynamic comparability study of moxetumomab pasudotox, an immunotoxin targeting CD22, in cynomolgus monkeys.
Bing Wang, M. Liang, Z. Yao, I. Vainshtein +9 more
2013Journal of Pharmacy and Science11 citations
Semantic Scholar
Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia
D. Kuruvilla, Y. Chia, K. Balic, Nai-Shun Yao +8 more
2020British Journal of Clinical Pharmacology10 citations Open access
Semantic Scholar
A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains.
I. Vainshtein, Bo Sun, L. Roskos, M. Liang
2020JIM - Journal of Immunological Methods10 citations
Semantic Scholar
Pharmacokinetics and pharmacodynamics of MEDI4736, a fully human anti-programmed death ligand 1 (PD-L1) monoclonal antibody, in patients with advanced solid tumors.
Xuyang Song, Min Pak, Carlos Chávez, M. Liang +8 more
201510 citations
Semantic Scholar
Identification and elimination of target-related matrix interference in a neutralizing anti-drug antibody assay.
M. Schwickart, Freshta Mehrzai, J. Pearson, Nabila Shaghasi +5 more
2014JIM - Journal of Immunological Methods10 citations Open access
Semantic Scholar
Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization
Yue Huang, Ruipeng Mu, David Wen, J. Grimsby +2 more
2021PLoS ONE9 citations Open access
Semantic Scholar
Development and analytical performance of a new ARCHITECT automated dipeptidyl peptidase-4 immunoassay
Philip M. Hemken, Nicolette M. Jeanblanc, T. Rae, S. Brophy +12 more
2017Practical Laboratory Medicine8 citations Open access
Semantic Scholar

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