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J. Pothof · SciRah

Researcher profile · Semantic Scholar

J. Pothof

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J. Pothof — researcher profile on SciRah

h-index: 28
Works: 53
Citations: 4,792

Most-cited papers

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
M. Baar, R. Brandt, D. Putavet, Julian D. D. Klein +17 more
2017Cell1,311 citations Open access
Semantic Scholar
The central role of DNA damage in the ageing process
B. Schumacher, J. Pothof, J. Vijg, J. Hoeijmakers
2021Nature778 citations Open access
Semantic Scholar
MicroRNA‐mediated gene silencing modulates the UV‐induced DNA‐damage response
J. Pothof, Nicole S. Verkaik, W. V. van Ijcken, E. Wiemer +6 more
2009EMBO Journal246 citations Open access
Semantic Scholar
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.
J. Pothof, G. van Haaften, K. Thijssen, Ravi S. Kamath +4 more
2003Genes & Development239 citations Open access
Semantic Scholar
Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice
W. Vermeij, M. Dollé, E. Reiling, D. Jaarsma +20 more
2016Nature225 citations Open access
Semantic Scholar
miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells
M. V. van Jaarsveld, J. Helleman, A. Boersma, P. F. van Kuijk +8 more
2013Oncogene221 citations
Semantic Scholar
Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II
Barbara Steurer, R. C. Janssens, Bart Geverts, M. E. Geijer +8 more
2018Proceedings of the National Academy of Sciences of the United States of America202 citations Open access
Semantic Scholar
Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation
J. Bakkers, C. Kramer, J. Pothof, N. Quaedvlieg +2 more
2004Development149 citations Open access
Semantic Scholar
Genome-wide RNA polymerase stalling shapes the transcriptome during aging
A. Gyenis, Jiang Chang, Joris Demmers, Serena T. Bruens +7 more
2023Nature Genetics120 citations Open access
Semantic Scholar
Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.
W. Vermeij, J. Hoeijmakers, J. Pothof
2016Annual Review of Pharmacology and Toxicology111 citations Open access
Semantic Scholar
MicroRNAs, the DNA damage response and cancer.
Maikel D. Wouters, D. V. van Gent, J. Hoeijmakers, J. Pothof
2011Mutation research100 citations Open access
Semantic Scholar
Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.
G. van Haaften, R. Romeijn, J. Pothof, W. Koole +4 more
2006Current Biology89 citations Open access
Semantic Scholar
Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer
M. Jager, F. Blokzijl, E. Kuijk, Johanna Bertl +10 more
2019Genome Research83 citations Open access
Semantic Scholar
Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures
Myrrhe van Spronsen, E. V. van Battum, M. Kuijpers, V. Vangoor +7 more
2013PLoS ONE79 citations Open access
Semantic Scholar
miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway
M. V. van Jaarsveld, P. F. van Kuijk, A. Boersma, J. Helleman +6 more
2015Molecular Cancer78 citations Open access
Semantic Scholar
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
Saurabh Gombar, H. Jung, F. Dong, B. Calder +8 more
2012BMC Genomics75 citations Open access
Semantic Scholar
Aging: not all DNA damage is equal.
W. Vermeij, J. Hoeijmakers, J. Pothof
2014Current Opinion in Genetics and Development68 citations
Semantic Scholar
Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans.
M. Tijsterman, J. Pothof, R. Plasterk
2002Genetics65 citations
Semantic Scholar
MicroRNA responses and stress granule formation modulate the DNA damage response
J. Pothof, Nicole S. Verkaik, J. Hoeijmakers, D. V. van Gent
2009Cell Cycle55 citations Open access
Semantic Scholar
Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma
Elham Aida Farshadi, Jiang Chang, Bharath Sampadi, M. Doukas +6 more
2021Clinical Cancer Research53 citations Open access
Semantic Scholar
DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity
M. V. van Jaarsveld, Maikel D. Wouters, A. Boersma, M. Smid +7 more
2013Molecular Oncology51 citations Open access
Semantic Scholar
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
M. van Sluis, Qing Yu, Melanie van der Woude, Camila Gonzalo-Hansen +22 more
2024Nature Cell Biology49 citations Open access
Semantic Scholar
Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis
Kyra N. Smit, Jiang Chang, K. Derks, J. Vaarwater +7 more
2019Cancers39 citations Open access
Semantic Scholar
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice
M. de Boer, Maaike Te Lintel Hekkert, Jiang Chang, B. V. van Thiel +27 more
2023Aging Cell34 citations Open access
Semantic Scholar
The DNA damage response: the omics era and its impact
K. Derks, J. Hoeijmakers, J. Pothof
2014DNA Repair33 citations Open access
Semantic Scholar
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid
T. Booiman, F. Wit, I. Maurer, D. De Francesco +92 more
2017Open Forum Infectious Diseases32 citations Open access
Semantic Scholar
MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells
Joey Riepsaame, A. van Oudenaren, B. J. H. den Broeder, W. V. van Ijcken +2 more
2013Frontiers in Immunology32 citations Open access
Semantic Scholar
Different responses to DNA damage determine ageing differences between organs
Maria Vougioukalaki, Joris Demmers, W. Vermeij, M. Baar +11 more
2022Aging Cell30 citations Open access
Semantic Scholar
In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals
Joost P. M. Melis, K. Derks, T. Pronk, Paul F. K. Wackers +8 more
2014Archives of Toxicology27 citations
Semantic Scholar
BACH2: a Marker of DNA Damage and Aging
L. M. Uittenboogaard, César Páyan-Gomez, J. Pothof, W. V. van Ijcken +4 more
2013DNA Repair27 citations Open access
Semantic Scholar
Deciphering the RNA landscape by RNAome sequencing
K. Derks, Branislav Mišovic, M. van den Hout, C. Kockx +6 more
2015RNA Biology25 citations Open access
Semantic Scholar
The kinase RSK2 modulates the sensitivity of ovarian cancer cells to cisplatin.
M. V. van Jaarsveld, I. Blijdorp, A. Boersma, J. Pothof +3 more
2013European Journal of Cancer21 citations
Semantic Scholar
Attenuated XPC Expression Is Not Associated with Impaired DNA Repair in Bladder Cancer
K. Naipal, A. Raams, Serena T. Bruens, I. Brandsma +8 more
2015PLoS ONE10 citations Open access
Semantic Scholar
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation
A. Theil, Alex Pines, T. Kalaycı, J. M. Heredia-Genestar +16 more
2023EMBO Molecular Medicine9 citations Open access
Semantic Scholar
Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII
Antonios Papadakis, A. Gyenis, J. Pothof, J. Hoeijmakers +2 more
2023Nature Genetics8 citations
Semantic Scholar
Spatiotemporal aspects of MicroRNA-mediated gene regulation.
J. Pothof, D. V. van Gent
2011Advances in Experimental Medicine and Biology8 citations
Semantic Scholar
Deficiency of nucleotide excision repair explains mutational signature observed in cancer
M. Jager, F. Blokzijl, E. Kuijk, Johanna Bertl +10 more
2017bioRxiv5 citations Open access
Semantic Scholar
A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, H. Odijk +7 more
2025Small Methods3 citations Open access
Semantic Scholar
Nucleotide Excision Repair
N. Jaspers, W. J. Lans, J. Marteijn, Hervé Menoni +3 more
20013 citations
Semantic Scholar
Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.
Alba Muniesa-Vargas, C. Ribeiro-Silva, Carlota Davó-Martínez, A. Raams +9 more
2026Journal of Cell Biology2 citations
Semantic Scholar
RNAome sequencing delineates the complete RNA landscape
K. Derks, J. Pothof
2015Genomics Data2 citations Open access
Semantic Scholar
DNA damage and repair: from premature aging and cancer to longevity
J. Hoeijmakers, George A. Garinis, B. Schumacher, J. Pothof +7 more
20082 citations
Semantic Scholar
Mathematical model of transcription loss due to accumulated DNA damage
M. Raseta, Shannon C Dealy, Jacinta van de Grint, Jiang Chang +2 more
2024bioRxiv1 citations Open access
Semantic Scholar
Abstract 1657: Mapping mechanisms of radiotherapy resistance in prostate cancer
Serena T. Bruens, C. Milanese, Nicole S. Verkaik, P. Mastroberardino +9 more
20161 citations
Semantic Scholar
3rd US-EU Workshop Systems level understanding of DNA damage responses
M. Sander, Thomas J. Begley, C. Desaintes, A. Gavin +7 more
2010Mutation research1 citations Open access
Semantic Scholar
Transcriptional stress in aging: integrating experimental data and modeling to quantify DNA damage accumulation
Jacinta van de Grint, M. Raseta, Renata M C Brandt, Yvette van Loon +5 more
2025Frontiers in Molecular Biosciences0 citations Open access
Semantic Scholar
Regulation of XPG-DNA damage binding dynamics by pre- and post-incision nucleotide excision repair factors and EXO1
Alba Muniesa-Vargas, C. Ribeiro-Silva, Bart Geverts, Carlota Davó-Martínez +8 more
2024bioRxiv0 citations Open access
Semantic Scholar
Author response: Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy
A. O. Pasternak, J. Vroom, N. Kootstra, F. Wit +88 more
20210 citations Open access
Semantic Scholar
Abstract 2843: TASC1, a selective anti-senescence therapeutic which potently and selectively counteract resistance to chemo- and radiotherapy
M. Baar, D. Putavet, J. Pothof, J. Hoeijmakers +1 more
20160 citations
Semantic Scholar
In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals
Joost P. M. Melis, K. Derks, T. Pronk, Paul F. K. Wackers +8 more
2014Archives of Toxicology0 citations
Semantic Scholar

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