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J. Helleman · SciRah

Researcher profile · Semantic Scholar

J. Helleman

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J. Helleman — researcher profile on SciRah

h-index: 29
Works: 88
Citations: 2,870

Most-cited papers

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes
C. Beaufort, J. Helmijr, A. Piskorz, M. Hoogstraat +10 more
2014PLoS ONE389 citations Open access
Semantic Scholar
miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells
M. V. van Jaarsveld, J. Helleman, A. Boersma, P. F. van Kuijk +8 more
2013Oncogene221 citations
Semantic Scholar
Association of an Extracellular Matrix Gene Cluster with Breast Cancer Prognosis and Endocrine Therapy Response
J. Helleman, M. Jansen, K. Ruigrok-Ritstier, I. V. van Staveren +7 more
2008Clinical Cancer Research181 citations Open access
Semantic Scholar
Molecular profiling of platinum resistant ovarian cancer
J. Helleman, M. Jansen, P. Span, I. V. van Staveren +8 more
2006International Journal of Cancer166 citations Open access
Semantic Scholar
MicroRNAs in ovarian cancer biology and therapy resistance.
M. V. van Jaarsveld, J. Helleman, E. Berns, E. Wiemer
2010International Journal of Biochemistry and Cell Biology154 citations
Semantic Scholar
Active surveillance for prostate cancer: a systematic review of contemporary worldwide practices
N. Kinsella, J. Helleman, S. Bruinsma, S. Carlsson +3 more
2018Translational Andrology and Urology146 citations Open access
Semantic Scholar
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
X. Trinh, W. Tjalma, P. Vermeulen, G. G. Van den Eynden +6 more
2009British Journal of Cancer132 citations Open access
Semantic Scholar
Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)
H. Burger, A. Zoumaro-Djayoon, Awm Boersma, J. Helleman +4 more
2010British Journal of Pharmacology124 citations Open access
Semantic Scholar
Large cribriform growth pattern identifies ISUP grade 2 prostate cancer at high risk for recurrence and metastasis
E. Hollemans, Esther I. Verhoef, C. Bangma, J. Rietbergen +3 more
2018Modern Pathology119 citations Open access
Semantic Scholar
Reasons for Discontinuing Active Surveillance: Assessment of 21 Centres in 12 Countries in the Movember GAP3 Consortium
M. van Hemelrijck, X. Ji, J. Helleman, M. Roobol +8 more
2018European Urology97 citations Open access
Semantic Scholar
Mismatch repair and treatment resistance in ovarian cancer
J. Helleman, I. V. van Staveren, W. Dinjens, P. F. van Kuijk +5 more
2006BMC Cancer94 citations Open access
Semantic Scholar
Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture.
J. Helleman, M. Smid, M. Jansen, M. V. D. van der Burg +1 more
2010Gynecologic Oncology85 citations
Semantic Scholar
miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway
M. V. van Jaarsveld, P. F. van Kuijk, A. Boersma, J. Helleman +6 more
2015Molecular Cancer78 citations Open access
Semantic Scholar
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma
B. Leonard, G. Starrett, M. Maurer, A. Oberg +12 more
2016Clinical Cancer Research58 citations Open access
Semantic Scholar
Integrated genomics of chemotherapy resistant ovarian cancer: a role for extracellular matrix, TGFbeta and regulating microRNAs.
J. Helleman, M. Jansen, C. Burger, M. V. D. van der Burg +1 more
2010International Journal of Biochemistry and Cell Biology55 citations
Semantic Scholar
Cribriform architecture in radical prostatectomies predicts oncological outcome in Gleason score 8 prostate cancer patients
E. Hollemans, Esther I. Verhoef, C. Bangma, J. Rietbergen +8 more
2020Modern Pathology53 citations Open access
Semantic Scholar
Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer
M. Jansen, K. Ruigrok-Ritstier, L. Dorssers, I. V. van Staveren +8 more
2009Breast Cancer Research and Treatment45 citations
Semantic Scholar
NeuroSAFE in radical prostatectomy increases the rate of nerve‐sparing surgery without affecting oncological outcome
Margaretha A. van der Slot, M. D. den Bakker, Tamara S. C. Tan, S. Remmers +13 more
2022BJU International44 citations Open access
Semantic Scholar
Impaired cisplatin influx in an A2780 mutant cell line: Evidence for a putative, cis-configuration-specific, platinum influx transporter
J. Helleman, K. Burger, I. H. Hamelers, A. Boersma +3 more
2006Cancer Biology & Therapy44 citations
Semantic Scholar
Concordance of cribriform architecture in matched prostate cancer biopsy and radical prostatectomy specimens
E. Hollemans, Esther I. Verhoef, C. Bangma, I. Schoots +4 more
2019Histopathology42 citations Open access
Semantic Scholar
TP53 Mutations in Serum Circulating Cell-Free Tumor DNA As Longitudinal Biomarker for High-Grade Serous Ovarian Cancer
S. Vitale, F. Groenendijk, R. van Marion, C. Beaufort +10 more
2020Biomolecules38 citations Open access
Semantic Scholar
Health Policy for Prostate Cancer Early Detection in the European Union and the Impact of Opportunistic Screening: PRAISE-U Consortium
K. Beyer, R. Leenen, L. Venderbos, J. Helleman +15 more
2024Journal of Personalized Medicine36 citations Open access
Semantic Scholar
Prostate Carcinoma Grade and Length But Not Cribriform Architecture at Positive Surgical Margins Are Predictive for Biochemical Recurrence After Radical Prostatectomy
E. Hollemans, Esther I. Verhoef, C. Bangma, J. Rietbergen +3 more
2019American Journal of Surgical Pathology36 citations Open access
Semantic Scholar
Prostate Cancer Early Detection in the European Union and UK.
R. Leenen, L. Venderbos, J. Helleman, J. Gómez Rivas +17 more
2024European Urology35 citations Open access
Semantic Scholar
Clinical outcome comparison of Grade Group 1 and Grade Group 2 prostate cancer with and without cribriform architecture at the time of radical prostatectomy
E. Hollemans, Esther I. Verhoef, C. Bangma, J. Rietbergen +3 more
2020Histopathology35 citations Open access
Semantic Scholar
Adherence to Active Surveillance Protocols for Low-risk Prostate Cancer: Results of the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance Initiative.
A. Kalapara, J. Verbeek, D. Nieboer, M. Fahey +9 more
2020European Urology Oncology33 citations
Semantic Scholar
Systematic Review on the Cost Effectiveness of Prostate Cancer Screening in Europe
P. Vynckier, L. Annemans, Sarah Raes, C. Amrouch +18 more
2024European Urology31 citations Open access
Semantic Scholar
Microarray-Based Oncogenic Pathway Profiling in Advanced Serous Papillary Ovarian Carcinoma
X. Trinh, W. Tjalma, L. Dirix, P. Vermeulen +7 more
2011PLoS ONE30 citations Open access
Semantic Scholar
The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines.
Jörgen Bierau, A. V. van Gennip, J. Helleman, A. van Kuilenburg
2001Biochemical Pharmacology30 citations
Semantic Scholar
Personalised biopsy schedules based on risk of Gleason upgrading for patients with low‐risk prostate cancer on active surveillance
A. Tomer, D. Nieboer, M. Roobol, A. Bjartell +74 more
2020BJU International29 citations Open access
Semantic Scholar
Intraoperative assessment and reporting of radical prostatectomy specimens to guide nerve‐sparing surgery in prostate cancer patients (NeuroSAFE)
Margaretha A. van, der Slot, M. D. den Bakker, S. Klaver +11 more
2020Histopathology27 citations Open access
Semantic Scholar
Serum proteomic patterns for ovarian cancer monitoring
J. Helleman, D. Van Der Vlies, Machiel H. Jansen, T. Luider +3 more
2007International Journal of Gynecologic Cancer26 citations Open access
Semantic Scholar
Prostate Cancer Patients Under Active Surveillance with a Suspicious Magnetic Resonance Imaging Finding Are at Increased Risk of Needing Treatment: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium
J. Olivier, Weiyu Li, D. Nieboer, J. Helleman +16 more
2022European Urology Open Science25 citations Open access
Semantic Scholar
Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry.
C. Bangma, Paul Doan, Lin Zhu, S. Remmers +22 more
2024European Urology Oncology23 citations Open access
Semantic Scholar
Cyclopentenyl cytosine primes SK‐N‐BE(2)c neuroblastoma cells for cytarabine toxicity
J. Bierau, A. V. van Gennip, R. Leen, J. Helleman +2 more
2003International Journal of Cancer22 citations Open access
Semantic Scholar
Comedonecrosis Gleason pattern 5 is associated with worse clinical outcome in operated prostate cancer patients
Tim Hansum, E. Hollemans, Esther I. Verhoef, C. Bangma +9 more
2021Modern Pathology17 citations Open access
Semantic Scholar
Clinicopathological characteristics of glomeruloid architecture in prostate cancer
E. Hollemans, Esther I. Verhoef, C. Bangma, J. Rietbergen +8 more
2020Modern Pathology11 citations Open access
Semantic Scholar
Active Surveillance for Men Younger than 60 Years or with Intermediate-risk Localized Prostate Cancer. Descriptive Analyses of Clinical Practice in the Movember GAP3 Initiative
S. Remmers, J. Helleman, D. Nieboer, B. Trock +18 more
2022European Urology Open Science10 citations Open access
Semantic Scholar
Navigating through the Controversies and Emerging Paradigms in Early Detection of Prostate Cancer: Bridging the Gap from Classic RCTs to Modern Population-Based Pilot Programs
J. Gómez Rivas, R. Leenen, L. Venderbos, J. Helleman +10 more
2023Journal of Personalized Medicine8 citations Open access
Semantic Scholar
Consistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies.
T. van der Kwast, J. Helleman, D. Nieboer, S. Bruinsma +2 more
2019European Urology Oncology7 citations Open access
Semantic Scholar
Understanding the Barriers to Prostate Cancer Population-Based Early Detection Programs: The PRAISE-U BEST Survey
K. Beyer, R. Leenen, L. Venderbos, J. Helleman +17 more
2024Journal of Personalized Medicine6 citations Open access
Semantic Scholar
Improving the prediction of biochemical recurrence after radical prostatectomy with the addition of detailed pathology of the positive surgical margin and cribriform growth.
S. Remmers, E. Hollemans, D. Nieboer, H. Luiting +3 more
2021Annals of Diagnostic Pathology6 citations Open access
Semantic Scholar
Comparison of Characteristics, Follow-up and Outcomes of Active Surveillance for Prostate Cancer According to Ethnicity in the GAP3 Global Consortium Database
Kerri Beckmann, Aida Santaolalla, J. Helleman, P. Carroll +10 more
2021European Urology Open Science6 citations Open access
Semantic Scholar
Using the Movember Foundation’s GAP3 cohort to measure the effect of active surveillance on patient-reported urinary and sexual function—a retrospective study in low-risk prostate cancer patients
R. Crump, S. Remmers, M. van Hemelrijck, J. Helleman +3 more
2021Translational Andrology and Urology5 citations Open access
Semantic Scholar
Adverse Pathological Findings at Radical Prostatectomy following Active Surveillance: Results from the Movember GAP3 Cohort
C. Marenghi, Zhu-Qiang Qiu, J. Helleman, D. Nieboer +6 more
2022Cancers3 citations Open access
Semantic Scholar
Comparison of outcomes of different biopsy schedules among men on active surveillance for prostate cancer: An analysis of the G.A.P.3 global consortium database
K. Beckmann, C. Bangma, J. Helleman, A. Bjartell +7 more
2022The Prostate3 citations Open access
Semantic Scholar
Gene expression profiling of treatment resistance: hype or hope for therapeutic target identification.
J. Helleman, M. Jansen, E. Berns
2006International Journal of Gynecological Cancer3 citations
Semantic Scholar
PD17-03 PROSTATE CANCER PATIENTS THAT OPTED FOR ACTIVE SURVEILLANCE WHILE HAVING A SUSPICIOUS MRI ARE AT INCREASED RISK OF NEEDING TREATMENT. RESULTS OF THE MOVEMBER FOUNDATION’S GLOBAL ACTION PLAN PROSTATE CANCER ACTIVE SURVEILLANCE (GAP3) CONSORTIUM
Jonathan Olivier, Weiyu Li, D. Nieboer, J. Helleman +15 more
20212 citations
Semantic Scholar
A first step towards a global nomogram to predict disease progression for men on active surveillance
M. van Hemelrijck, Xin-Ge Ji, J. Helleman, M. Roobol +7 more
2021Translational Andrology and Urology1 citations Open access
Semantic Scholar
A first step towards a global nomogram to predict disease progression for men on active surveillance
M. van Hemelrijck, Xin-Ge Ji, J. Helleman, M. Roobol +7 more
2020European Urology Open Science1 citations Open access
Semantic Scholar

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