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D. Perrotti · SciRah

Researcher profile · Semantic Scholar

D. Perrotti

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D. Perrotti — researcher profile on SciRah

h-index: 61
Works: 216
Citations: 16K

Most-cited papers

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
M. Fabbri, A. Paone, Federica Calore, R. Galli +15 more
2012Proceedings of the National Academy of Sciences of the United States of America1,509 citations Open access
Semantic Scholar
Targeting A Tumor Suppressor To Suppress Tumor Growth: News and Views on Protein Phosphatase 2A (PP2A) as a Target for Anti-cancer Therapy
D. Perrotti, P. Neviani
2013The Lancet Oncology372 citations Open access
Semantic Scholar
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
S. Saddoughi, S. Gencer, Y. Peterson, Katherine E. Ward +15 more
2012EMBO Molecular Medicine275 citations Open access
Semantic Scholar
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.
P. Neviani, J. Harb, Joshua J. Oaks, R. Santhanam +41 more
2013Journal of Clinical Investigation211 citations Open access
Semantic Scholar
Targeted Delivery of microRNA-29b by Transferrin Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia
Xiaomeng Huang, S. Schwind, Bo Yu, R. Santhanam +16 more
2013Clinical Cancer Research182 citations Open access
Semantic Scholar
Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation
A. Mishra, Shu-Jun Liu, G. Sams, Douglas P. Curphey +22 more
2012Cancer Cell164 citations Open access
Semantic Scholar
Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status
G. di Leva, C. Piovan, Pierluigi Gasparini, Apollinaire Ngankeu +18 more
2013PLoS Genetics154 citations Open access
Semantic Scholar
Bone Marrow Niche Trafficking of miR-126 Controls Self-Renewal of Leukemia Stem Cells in Chronic Myelogenous Leukemia
Bin Zhang, L. Nguyen, Ling Li, Dan-Dan Zhao +28 more
2018Nature Medicine148 citations Open access
Semantic Scholar
miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eµ-miR-155 transgenic mouse model
S. Sandhu, S. Volinia, S. Costinean, Marco Galasso +7 more
2012Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
Semantic Scholar
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.
Christopher J. Walker, Joshua J. Oaks, R. Santhanam, P. Neviani +19 more
2013Blood134 citations Open access
Semantic Scholar
Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.
W. Blum, S. Schwind, Somayeh S. Tarighat, S. Geyer +19 more
2012Blood134 citations Open access
Semantic Scholar
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
Arelis Salas, S. Ponnusamy, Can E. Senkal, Marisa Meyers-Needham +17 more
2011Blood115 citations Open access
Semantic Scholar
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.
Joshua J. Oaks, R. Santhanam, Christopher J. Walker, S. Roof +22 more
2013Blood114 citations Open access
Semantic Scholar
Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells.
Amy Cook, Liang Li, Yin-Wei Ho, A. Lin +6 more
2014Blood110 citations Open access
Semantic Scholar
miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR
M. Y. Balkhi, O. Iwenofu, N. Bakkar, K. Ladner +8 more
2013Science Signaling96 citations Open access
Semantic Scholar
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia
Jihane Khalife, H. Radomska, R. Santhanam, Xiaomeng Huang +20 more
2015Leukemia80 citations Open access
Semantic Scholar
Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: A novel epigenetic-targeting approach in acute myeloid leukemia
Alice S. Mims, Alison R. Walker, Xiaomeng Huang, J. Sun +20 more
2012Leukemia65 citations Open access
Semantic Scholar
Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia
Xiaomeng Huang, S. Schwind, R. Santhanam, Ann-Kathrin Eisfeld +14 more
2016OncoTarget63 citations Open access
Semantic Scholar
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-activated Leukemias
Nidal E. Muvarak, Shannon Kelley, C. Robert, M. Baer +5 more
2015Molecular Cancer Research62 citations Open access
Semantic Scholar
From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies
Maria Ciccone, G. Calin, D. Perrotti
2015Frontiers in Oncology62 citations Open access
Semantic Scholar
Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second-generation tyrosine kinase inhibitors
Georgios Nteliopoulos, A. Bazeos, S. Claudiani, G. Gerrard +12 more
2019Haematologica61 citations Open access
Semantic Scholar
SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.
H. Alachkar, R. Santhanam, K. Maharry, K. Metzeler +27 more
2014Journal of Clinical Investigation61 citations Open access
Semantic Scholar
Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.
Christopher J. Hickey, S. Schwind, H. Radomska, A. Dorrance +23 more
2013Blood59 citations Open access
Semantic Scholar
Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia
H. Alachkar, R. Santhanam, J. Harb, D. Lucas +10 more
2013Journal of Hematology & Oncology56 citations Open access
Semantic Scholar
Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development.
F. Pichiorri, Sung-Suk Suh, A. Rocci, L. De Luca +15 more
2016Cancer Cell46 citations Open access
Semantic Scholar
BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia
K. Šrůtová, N. Čuřík, P. Burda, F. Savvulidi +9 more
2018Haematologica45 citations Open access
Semantic Scholar
The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells.
R. Trotta, David Ciarlariello, Jessica Dal Col, H. Mao +6 more
2011Blood42 citations Open access
Semantic Scholar
Concurrent inhibition of Pim and FLT3 kinases enhances apoptosis of FLT3-ITD acute myeloid leukemia cells through increased Mcl-1 proteasomal degradation
Shivani Kapoor, K. Natarajan, Patrick R. Baldwin, Kshama A. Doshi +10 more
2017Clinical Cancer Research41 citations Open access
Semantic Scholar
SETting OP449 into the PP2A-Activating-Drug family
P. Neviani, D. Perrotti
2014Clinical Cancer Research35 citations Open access
Semantic Scholar
Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML
Bin Zhang, L. Nguyen, Dan-Dan Zhao, D. Frankhouser +26 more
2021Journal of Hematology & Oncology34 citations Open access
Semantic Scholar
Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions
Giovannino Silvestri, R. Trotta, Lorenzo Stramucci, Justine Ellis +34 more
2020Blood Cancer Discovery31 citations Open access
Semantic Scholar
Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis
Bin Zhang, Dan-Dan Zhao, Fang Chen, D. Frankhouser +29 more
2023Nature Communications29 citations Open access
Semantic Scholar
PP2A-activating drugs enhance FLT3 inhibitor efficacy through AKT inhibition-dependent GSK-3β-mediated c-Myc and Pim-1 proteasomal degradation
Mario Scarpa, Prerna Singh, Christopher Bailey, Jonelle K Lee +8 more
2021Molecular Cancer Therapeutics26 citations Open access
Semantic Scholar
Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay
D. Perrotti, Giovannino Silvestri, Lorenzo Stramucci, Justine E Yu +1 more
2017Current Drug Targets23 citations Open access
Semantic Scholar
Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target
JG Harb, P. Neviani, BJ Chyla, JJ Ellis +9 more
2013Leukemia23 citations Open access
Semantic Scholar
Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway
Ann-Kathrin Eisfeld, S. Schwind, Ravi Patel, Xiaomeng Huang +11 more
2014Science Signaling22 citations Open access
Semantic Scholar
Correction: Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status
G. di Leva, C. Piovan, Pierluigi Gasparini, Apollinaire Ngankeu +18 more
2013PLoS Genetics22 citations Open access
Semantic Scholar
The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues
R. Van Etten, S. Koschmieder, F. Delhommeau, D. Perrotti +8 more
2011Haematologica22 citations Open access
Semantic Scholar
Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
Kshama A. Doshi, R. Trotta, K. Natarajan, F. Rassool +4 more
2016OncoTarget20 citations Open access
Semantic Scholar
BCR–ABL1 kinase-dependent alteration of mRNA metabolism: potential alternatives for therapeutic intervention
D. Perrotti, J. Harb
2011Leukemia and Lymphoma15 citations Open access
Semantic Scholar
Cytoplasmic DROSHA and Non-canonical Mechanisms of MiR-155 Biogenesis in FLT3-ITD Acute Myeloid Leukemia
L. Nguyen, Bin Zhang, Dinh Hoa Hoang, Dan-Dan Zhao +17 more
2021Leukemia14 citations Open access
Semantic Scholar
Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia
K. Laidlaw, S. Berhan, Su-Hu Liu, Giovannino Silvestri +7 more
2016OncoTarget14 citations Open access
Semantic Scholar
Spred1 deficit promotes treatment resistance and transformation of chronic phase CML
Junjing Qiao, Chen Liang, Dan-Dan Zhao, L. Nguyen +16 more
2021Leukemia11 citations Open access
Semantic Scholar
Chronic myeloid leukemia: the basis of treatment for tomorrow
A. Carella, J. Goldman, G. Martinelli, J. Melo +1 more
2011Haematologica11 citations Open access
Semantic Scholar
Retraction Notice to: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development
F. Pichiorri, S. Suh, A. Rocci, L. De Luca +15 more
2022Cancer Cell9 citations Open access
Semantic Scholar
Advances in the biology and therapy of chronic myeloid leukemia (CML): Proceedings from the 6th Post-ASH International CML and Myeloproliferative Neoplasms Workshop
R. Van Etten, M. Mauro, J. Radich, J. Goldman +11 more
2012Leukemia and Lymphoma9 citations Open access
Semantic Scholar
Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia”
D. Perrotti, A. Agarwal, C. Lucas, G. Narla +4 more
2019Science Translational Medicine6 citations Open access
Semantic Scholar
FTY720 Restores PP2A Tumor Suppressor Activity in Polycythemia Vera CD34+ Progenitors Through Inhibition of Jak2 V617F- and PI-3Kγ-Dependent SET Serine Phosphorylation and Enhancement of NOS-Dependent PP2A Tyrosine Nitration
Joshua J. Oaks, A. Mukhopadhyay, R. Santhanam, S. Saddoughi +8 more
20116 citations
Semantic Scholar
Precision immunotherapy, mutational landscape, and emerging tools to optimize clinical outcomes in patients with classical myeloproliferative neoplasms
T. Mughal, T. Lion, O. Abdel-Wahab, R. Mesa +7 more
2018Hematological Oncology4 citations Open access
Semantic Scholar
Twisting IL-1 signaling to kill CML stem cells.
Lorenzo Stramucci, D. Perrotti
2016Blood4 citations
Semantic Scholar

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