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D. Lucas · SciRah

Researcher profile · Semantic Scholar

D. Lucas

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D. Lucas — researcher profile on SciRah

h-index: 48
Works: 187
Citations: 8,955

Most-cited papers

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
R. Lapalombella, Qing-Xiang Sun, Katie E. Williams, Larissa Tangeman +19 more
2012Blood302 citations Open access
Semantic Scholar
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy.
J. Woyach, Kelly A. Smucker, Lisa L. Smith, A. Lozanski +19 more
2014Blood293 citations Open access
Semantic Scholar
Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug Resistance Mechanisms in a Leukemia Model
Patrick D. Halley, C. Lucas, Emily Mcwilliams, M. Webber +5 more
2015Small195 citations Open access
Semantic Scholar
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
D. Lucas, Ryan B. Edwards, G. Lozanski, Derek A. West +16 more
2009Blood168 citations Open access
Semantic Scholar
Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals
R. Lapalombella, Yuh-Ying Yeh, Liwen Wang, A. Ramanunni +25 more
2012Cancer Cell157 citations Open access
Semantic Scholar
Next generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematologic malignancies
Zachary A. Hing, H. Fung, Parvathi Ranganathan, Shaneice R. Mitchell +19 more
2015Leukemia134 citations Open access
Semantic Scholar
Potential of Plant-Derived Natural Products in the Treatment of Leukemia and Lymphoma
D. Lucas, Patrick C Still, L. Pérez, M. Grever +1 more
2010Current Drug Targets124 citations Open access
Semantic Scholar
Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia.
R. Claus, D. Lucas, S. Stilgenbauer, A. Ruppert +16 more
2012Journal of Clinical Oncology123 citations Open access
Semantic Scholar
ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
Emilia Mahoney, D. Lucas, Sneha V. Gupta, Amy J. Wagner +14 more
2012Blood112 citations Open access
Semantic Scholar
BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor
H. Ozer, Dalia El-Gamal, B. Powell, Zachary A. Hing +43 more
2018Cancer Discovery107 citations Open access
Semantic Scholar
Rocaglamide, Silvestrol and Structurally Related Bioactive Compounds from Aglaia Species
L. Pan, J. Woodard, D. Lucas, J. Fuchs +1 more
2014Natural product reports (Print)98 citations Open access
Semantic Scholar
Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts.
S. Vasu, Shun He, C. Cheney, B. Gopalakrishnan +18 more
2016Blood83 citations Open access
Semantic Scholar
Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL.
Shih-Shih Chen, R. Claus, D. Lucas, Lianbo Yu +8 more
2011Blood73 citations Open access
Semantic Scholar
Resistance to the Translation Initiation Inhibitor Silvestrol is Mediated by ABCB1/P-Glycoprotein Overexpression in Acute Lymphoblastic Leukemia Cells
Sneha V. Gupta, E. Sass, Melanie E. Davis, Ryan B. Edwards +12 more
2011AAPS Journal72 citations Open access
Semantic Scholar
Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia.
R. Claus, D. Lucas, A. Ruppert, Katie E. Williams +19 more
2014Blood71 citations Open access
Semantic Scholar
Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer
T. Kogure, A. Kinghorn, Irene K. Yan, B. Bolon +3 more
2013PLoS ONE69 citations Open access
Semantic Scholar
Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukemia and non-Hodgkin’s lymphoma: Dose-limiting myelosuppression without evidence of DNA hypomethylation
K. Blum, Zhongfa Liu, D. Lucas, Ping Chen +12 more
2010British Journal of Haematology67 citations Open access
Semantic Scholar
Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias
W. Blum, M. Phelps, Rebecca B. Klisovic, Darlene M. Rozewski +11 more
2010Haematologica65 citations Open access
Semantic Scholar
Phase 2 Study of Ibrutinib in Classic and Variant Hairy Cell Leukemia.
K. Rogers, L. Andritsos, Wei Lai, Eric M. McLaughlin +20 more
2021Blood63 citations Open access
Semantic Scholar
The Novel Deacetylase Inhibitor AR-42 Demonstrates Pre-Clinical Activity in B-Cell Malignancies In Vitro and In Vivo
D. Lucas, L. Alinari, Derek A. West, Melanie E. Davis +16 more
2010PLoS ONE61 citations Open access
Semantic Scholar
Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia
H. Alachkar, R. Santhanam, J. Harb, D. Lucas +10 more
2013Journal of Hematology & Oncology56 citations Open access
Semantic Scholar
Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcγRIIIa-158 V/F polymorphism.
K. Blum, Sin-Ho Jung, Jeffrey L. Johnson, T. Lin +5 more
2010Annals of Oncology56 citations Open access
Semantic Scholar
Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry
U. V. V. Vijaya Saradhi, Sneha V. Gupta, Ming H. Chiu, Jiang Wang +10 more
2011AAPS Journal54 citations Open access
Semantic Scholar
Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity
Yulin Ren, Wei-Lun Chen, D. Lantvit, E. Sass +10 more
2016Journal of Natural Products52 citations Open access
Semantic Scholar
Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia
Bhavana Bhatnagar, Ann-Kathrin Eisfeld, D. Nicolet, K. Mrózek +9 more
2016British Journal of Haematology51 citations Open access
Semantic Scholar
The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors
Rajeswaran Mani, Swagata Goswami, B. Gopalakrishnan, R. Ramaswamy +15 more
2018Haematologica43 citations Open access
Semantic Scholar
Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells.
E. Hertlein, G. Triantafillou, E. Sass, J. Hessler +7 more
2010Blood43 citations Open access
Semantic Scholar
Dual Targeting of the Cyclin/Rb/E2F and Mitochondrial Pathways in Mantle Cell Lymphoma with the Translation Inhibitor Silvestrol
L. Alinari, C. Prince, Ryan B. Edwards, William H. Towns +9 more
2012Clinical Cancer Research41 citations Open access
Semantic Scholar
Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines
Kazuya Takahashi, T. Inukai, T. Imamura, Mio Yano +19 more
2017PLoS ONE39 citations Open access
Semantic Scholar
Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia
D. Papaioannou, D. Nicolet, S. Volinia, K. Mrózek +17 more
2017Haematologica36 citations Open access
Semantic Scholar
Trametinib for the Treatment of IGHV4–34, MAP2K1 Mutant Variant Hairy Cell Leukemia
L. Andritsos, N. Grieselhuber, M. Anghelina, K. Rogers +12 more
2017Leukemia and Lymphoma36 citations Open access
Semantic Scholar
p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.
Jing-Fang Zhang, Guangyao Kong, Adhithi Rajagopalan, Li Lu +17 more
2017Blood35 citations Open access
Semantic Scholar
Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity
K. Callahan, Mohammad Minhajuddin, Cheryl A Corbett, E. Lagadinou +12 more
2014Leukemia35 citations Open access
Semantic Scholar
The Proteasome Inhibitor Carfilzomib Functions Independently of p53 To Induce Cytotoxicity and an Atypical NF-κB Response in Chronic Lymphocytic Leukemia Cells
Sneha V. Gupta, E. Hertlein, Yanhui Lu, E. Sass +8 more
2013Clinical Cancer Research35 citations Open access
Semantic Scholar
Bioactive Constituents of Indigofera spicata
L. Pérez, Jie Li, D. Lantvit, L. Pan +6 more
2013Journal of Natural Products31 citations Open access
Semantic Scholar
Co-Treatment of Hairy Cell Leukemia and Melanoma with the BRAF Inhibitor Dabrafenib
J. Blachly, G. Lozanski, D. Lucas, M. Grever +2 more
2015The Journal of the National Comprehensive Cancer Network30 citations Open access
Semantic Scholar
Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis
Rajbir Singh, A. Mortazavi, K. Telu, Prabakaran Nagarajan +6 more
2013Nucleic Acids Research30 citations Open access
Semantic Scholar
Discovery of Anticancer Agents of Diverse Natural Origin
A. Kinghorn, E. C. D. de Blanco, D. Lucas, H. L. Rakotondraibe +13 more
2016Anticancer Research29 citations Open access
Semantic Scholar
Sorbicillinoid Analogues with Cytotoxic and Selective Anti-Aspergillus Activities from Scytalidium album
T. El-Elimat, H. Raja, M. Figueroa, S. Swanson +6 more
2014Journal of antibiotics (Tokyo. 1968)27 citations Open access
Semantic Scholar
The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia
Cecelia R. Miller, A. Ruppert, S. Fobare, Timothy L Chen +13 more
2017OncoTarget26 citations Open access
Semantic Scholar
The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease
John T Patton, Mark E. Lustberg, G. Lozanski, Sabrina L. Garman +10 more
2014OncoTarget26 citations Open access
Semantic Scholar
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.
Tasneem Motiwala, N. Zanesi, Jharna Datta, Satavisha Roy +13 more
2011Blood22 citations Open access
Semantic Scholar
Second malignancies in B-cell chronic lymphocytic leukaemia: possible association with human papilloma virus
J. Flynn, L. Andritsos, D. Lucas, J. Byrd
2010British Journal of Haematology21 citations Open access
Semantic Scholar
Proteomic profiling identifies specific histone species associated with leukemic and cancer cells
Rajbir Singh, S. Harshman, A. Ruppert, A. Mortazavi +6 more
2015Clinical Proteomics20 citations Open access
Semantic Scholar
Potentiating Effect of the Flavonolignan (-)-Hydnocarpin in Combination with Vincristine in a Sensitive and P-gp-Expressing Acute Lymphoblastic Leukemia Cell Line
L. Pérez, L. Pan, E. Sass, Sneha V. Gupta +3 more
2012Phytotherapy Research17 citations Open access
Semantic Scholar
Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study
G. Lozanski, A. Ruppert, N. Heerema, A. Lozanski +8 more
2012Leukemia and Lymphoma17 citations Open access
Semantic Scholar
High-Sensitivity TFA-free LC-MS for Profiling Histones
J. You, Liwen Wang, M. Saji, S. Olesik +4 more
2011Proteomics17 citations Open access
Semantic Scholar
Reduced dose pentostatin for initial management of hairy cell leukemia patients who have active infection or risk of hemorrhage is safe and effective
L. Andritsos, Neil Dunavin, G. Lozanski, Jeffrey A. Jones +5 more
2015Haematologica13 citations Open access
Semantic Scholar
Phase I Dose Escalation Trial of the Novel Proteasome Inhibitor Carfilzomib in Patients with Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Farrukh T. Awan, J. Flynn, Jeffrey A. Jones, L. Andritsos +11 more
2015Leukemia and Lymphoma13 citations Open access
Semantic Scholar
NF-κB p50 (nfkb1) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia.
Timothy L Chen, Minh H Tran, Aparna S. Lakshmanan, Bonnie K. Harrington +8 more
2017Blood12 citations Open access
Semantic Scholar

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