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Susan L. Garson · SciRah

Researcher profile · Semantic Scholar

Susan L. Garson

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Susan L. Garson — researcher profile on SciRah

h-index: 23
Works: 41
Citations: 2,310

Most-cited papers

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Christopher D. Cox, M. J. Breslin, D. B. Whitman, John D. Schreier +24 more
2010Journal of Medicinal Chemistry353 citations Open access
Semantic Scholar
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
Lei Ma, Matthew A. Seager, M. Wittmann, M. Jacobson +24 more
2009Proceedings of the National Academy of Sciences of the United States of America289 citations Open access
Semantic Scholar
Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist
C. Winrow, Anthony L. Gotter, Christopher D. Cox, S. Doran +10 more
2011Journal of neurogenetics270 citations
Semantic Scholar
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
C. Winrow, Anthony L. Gotter, Christopher D. Cox, P. Tannenbaum +11 more
2012Neuropharmacology134 citations
Semantic Scholar
Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties
Paul J. Coleman, John D. Schreier, Christopher D. Cox, M. J. Breslin +22 more
2012ChemMedChem115 citations
Semantic Scholar
Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition
Jason M. Uslaner, S. Tye, D. Eddins, Xiaohai Wang +17 more
2013Science Translational Medicine95 citations
Semantic Scholar
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
Anthony L. Gotter, C. Winrow, J. Brunner, Susan L. Garson +16 more
2013BMC Neuroscience90 citations Open access
Semantic Scholar
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
Anthony L. Gotter, M. Forman, C. M. Harrell, J. Stevens +15 more
2016Scientific Reports81 citations Open access
Semantic Scholar
Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.
V. Uebele, Anthony L. Gotter, C. Nuss, R. Kraus +13 more
2009Journal of Clinical Investigation81 citations Open access
Semantic Scholar
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
C. Winrow, K. Tanis, D. Reiss, Alison M. Rigby +11 more
2010Neuropharmacology80 citations
Semantic Scholar
Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an N,N‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats
D. B. Whitman, Christopher D. Cox, M. J. Breslin, Karen M. Brashear +18 more
2009ChemMedChem69 citations
Semantic Scholar
Discovery of 5′′‐Chloro‐N‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia
A. J. Roecker, Swati P. Mercer, John D. Schreier, Christopher D. Cox +19 more
2014ChemMedChem65 citations
Semantic Scholar
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
V. Uebele, C. Nuss, Steven V. Fox, Susan L. Garson +19 more
2009Cell Biochemistry and Biophysics57 citations
Semantic Scholar
Correction for d'Errico et al., Additional evidence on the use of personal ornaments in the Middle Paleolithic of North Africa
Matthew A. Seager, M. Wittmann, M. Jacobson, Denise J. Bickel +30 more
2009Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators
Anthony L. Gotter, Susan L. Garson, J. Stevens, Regina L. Munden +10 more
2014BMC Neuroscience48 citations Open access
Semantic Scholar
Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators
Andres D. Ramirez, Anthony L. Gotter, Steven V. Fox, P. Tannenbaum +13 more
2013Frontiers in Neuroscience41 citations Open access
Semantic Scholar
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
P. Tannenbaum, J. Stevens, Jacquelyn Binns, Alan T. Savitz +10 more
2014Frontiers in Behavioral Neuroscience40 citations Open access
Semantic Scholar
Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABAA Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats
Steven V. Fox, Anthony L. Gotter, S. Tye, Susan L. Garson +13 more
2013Neuropsychopharmacology39 citations Open access
Semantic Scholar
Pyridyl amides as potent inhibitors of T-type calcium channels.
Thomas S. Reger, Zhi-Qiang Yang, Kelly-Ann S. Schlegel, Youheng Shu +18 more
2011Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.
J. Barrow, K. E. Rittle, Thomas S. Reger, Zhi-Qiang Yang +18 more
2010ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
A. J. Roecker, Thomas S. Reger, M. Mattern, Swati P. Mercer +22 more
2014Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists.
Kelly-Ann S. Schlegel, Zhi-Qiang Yang, Thomas S. Reger, Youheng Shu +18 more
2010Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.
Paul J. Coleman, John D. Schreier, A. J. Roecker, Swati P. Mercer +12 more
2010Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Swati P. Mercer, A. J. Roecker, Susan L. Garson, D. Reiss +14 more
2013Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
I. Raheem, M. J. Breslin, Joseph G. Bruno, Tamara D. Cabalu +16 more
2015Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
S. Kuduk, Jason W Skudlarek, C. Dimarco, Joseph G. Bruno +13 more
2015Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
T-type calcium channels regulate cortical plasticity in-vivo
V. Uebele, C. Nuss, V. Santarelli, Susan L. Garson +11 more
2009NeuroReport19 citations Open access
Semantic Scholar
Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.
Zhi-Qiang Yang, Kelly-Ann S. Schlegel, Youheng Shu, Thomas S. Reger +26 more
2010ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
A. J. Roecker, Swati P. Mercer, J. Bergman, Kevin F. Gilbert +13 more
2015Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Pharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross
J. Brunner, Anthony L. Gotter, J. Millstein, Susan L. Garson +14 more
2011Journal of neurogenetics11 citations Open access
Semantic Scholar
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
A. J. Roecker, Swati P. Mercer, C. M. Harrell, Susan L. Garson +9 more
2014Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Jason W. Skudlarek, C. Dimarco, K. Babaoglu, A. J. Roecker +17 more
2017Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Cover Picture: Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012)
Paul J. Coleman, John D. Schreier, Christopher D. Cox, M. J. Breslin +22 more
20125 citations
Semantic Scholar
Histamine H3 inverse agonist PET tracers labelled with carbon-11 or fluorine-18
T. Hamill, Nagaaki Sato, Makoto Jitsuoka, Shigeru Tokita +17 more
20085 citations
Semantic Scholar
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
Anthony L. Gotter, C. Winrow, J. Brunner, Susan L. Garson +16 more
2013BMC Neuroscience4 citations Open access
Semantic Scholar
P4‐333: Cogtest is more sensitive than the ADAS‐Cog in detecting change in clinical trials of early Alzheimer's disease
M. Wittmann, Guangping Xu, Michelle S. Pearson, Susan L. Garson +6 more
20083 citations
Semantic Scholar
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAAreceptor modulators
Anthony L. Gotter, Susan L. Garson, J. Stevens, Regina L. Munden +10 more
2014BMC Neuroscience2 citations Open access
Semantic Scholar
T-type calcium regulate cortical plasticity in-vivo NR-D-08-7049 (NeuroReport (2009) 20, (257-262))
V. Uebele, C. Nuss, V. Santarelli, Susan L. Garson +11 more
20091 citations Open access
Semantic Scholar
Cover Picture: Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia (ChemMedChem 2/2014)
A. J. Roecker, Swati P. Mercer, John D. Schreier, Christopher D. Cox +19 more
20140 citations Open access
Semantic Scholar
Correction for Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation, by Lei
Lei Ma, Matthew A. Searer, M. Wittmann, M. Jacobson +24 more
20090 citations
Semantic Scholar
Making Middle Leadership Visible: Representations of Identity and Influence in Australian Independent Secondary Schools
Susan L. Garson
0 citations Open access
Semantic Scholar

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J. Renger×37
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C. Winrow×27
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Steven V. Fox×27
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Anthony L. Gotter×24
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×20

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C. M. Harrell×19

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Paul J. Coleman×19

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T. Prueksaritanont×16

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