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T. Hamill · SciRah

Researcher profile · Semantic Scholar

T. Hamill

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T. Hamill — researcher profile on SciRah

h-index: 24
Works: 72
Citations: 2,092

Most-cited papers

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
Amy S. Espeseth, Peter J. Felock, A. Wolfe, M. Witmer +8 more
2000Proceedings of the National Academy of Sciences of the United States of America332 citations Open access
Semantic Scholar
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
H. Burns, K. van Laere, S. Sanabria-Bohórquez, T. Hamill +25 more
2007Proceedings of the National Academy of Sciences of the United States of America303 citations Open access
Semantic Scholar
Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers
T. Hamill, Stephen Krause, Christine Ryan, C. Bonnefous +16 more
2005Synapse137 citations
Semantic Scholar
[18F]FPEB, a Novel PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors (mGluR5): A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry
D. Wong, R. Waterhouse, H. Kuwabara, Jongho Kim +7 more
2013Journal of Nuclear Medicine103 citations Open access
Semantic Scholar
Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB.
Shil Patel, T. Hamill, Brett M. Connolly, E. Jagoda +2 more
2007Nuclear Medicine and Biology99 citations
Semantic Scholar
Nonpeptide αvβ3 Antagonists. 1. Transformation of a Potent, Integrin-Selective αIIbβ3 Antagonist into a Potent αvβ3 Antagonist
M. Duggan, L. Duong, J. Fisher, T. Hamill +12 more
200068 citations Open access
Semantic Scholar
Visualization and Quantification of Neurokinin-1 (NK1) Receptors in the Human Brain
J. Hietala, M. Nyman, O. Eskola, A. Laakso +14 more
2005Molecular Imaging and Biology59 citations
Semantic Scholar
Non-invasive radiotracer imaging as a tool for drug development.
R. Gibson, H. Burns, T. Hamill, W. Eng +2 more
2000Current pharmaceutical design55 citations
Semantic Scholar
Kinetic analysis of the cannabinoid-1 receptor PET tracer [18F]MK-9470 in human brain
S. Sanabria-Bohórquez, T. Hamill, K. Goffin, I. de Lepeleire +3 more
2010European Journal of Nuclear Medicine and Molecular Imaging51 citations Open access
Semantic Scholar
Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ).
O. Solin, O. Eskola, T. Hamill, J. Bergman +11 more
2004Molecular Imaging and Biology49 citations
Semantic Scholar
Asymmetric Michael additions of ester enolates to enantiomerically pure vinylic sulfoxides: synthesis of 3-substituted glutarate esters in high enantiomeric purity
G. Posner, M. Weitzberg, T. Hamill, E. Asirvatham +2 more
198649 citations
Semantic Scholar
Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development.
H. Burns, T. Hamill, W. Eng, Barbara Francis +2 more
1999Current Opinion in Chemical Biology48 citations
Semantic Scholar
Equivalent Dynamic Human Brain NK1‐Receptor Occupancy Following Single‐Dose i.v. Fosaprepitant vs. Oral Aprepitant as Assessed by PET Imaging
K. van Laere, J. D. de Hoon, G. Bormans, M. Koole +18 more
2012Clinical pharmacology and therapy47 citations
Semantic Scholar
Inverse agonist histamine H3 receptor PET tracers labelled with carbon‐11 or fluorine‐18
T. Hamill, Nagaaki Sato, Makoto Jitsuoka, S. Tokita +11 more
2009Synapse40 citations
Semantic Scholar
Screening Cascade and Development of Potential Positron Emission Tomography Radiotracers for mGluR5: In vitro and In vivo Characterization
Shil Patel, Obinna Ndubizu, T. Hamill, Ashok Chaudhary +3 more
2005Molecular Imaging and Biology38 citations
Semantic Scholar
Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets.
R. A. Bednar, S. L. Gaul, T. Hamill, M. Egbertson +4 more
1998Journal of Pharmacology and Experimental Therapeutics38 citations
Semantic Scholar
Erythrocyte porphobilinogen synthase activity as an indicator of lead exposure in children.
J. Chisolm, D. Thomas, T. Hamill
1985Clinical Chemistry38 citations
Semantic Scholar
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
Ping Liu, L. Lin, T. Hamill, James P. Jewell +21 more
2007Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
An asymmetric total synthesis of fragrant spiro[4.5]decane sesquiterpene (-)-.beta.-vetivone via an enantiomerically pure vinylic sulfoxide
G. Posner, T. Hamill
198835 citations
Semantic Scholar
NMR studies of the conjugation of mechlorethamine with glutathione.
Michael P. Gamcsik, T. Hamill, Michael E. Colvin
1990Journal of Medicinal Chemistry34 citations
Semantic Scholar
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.
Ping Liu, T. Hamill, M. Chioda, H. Chobanian +40 more
2013ACS Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey
D. Eddins, T. Hamill, Vanita Puri, Christopher E. Cannon +6 more
2013Psychopharmacology30 citations
Semantic Scholar
The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
T. Hamill, W. Eng, Andrew S. R. Jennings, Richard T. Lewis +14 more
2011Synapse30 citations
Semantic Scholar
11C-MK-8278 PET as a Tool for Pharmacodynamic Brain Occupancy of Histamine 3 Receptor Inverse Agonists
K. van Laere, S. Sanabria-Bohórquez, D. P. Mozley, Donald H. Burns +13 more
2014Journal of Nuclear Medicine27 citations Open access
Semantic Scholar
Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates
M. Belanger, Stephen Krause, Christine Ryan, S. Sanabria-Bohórquez +3 more
2008Nuclear medicine communications23 citations
Semantic Scholar
In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand.
Shil Patel, Stephen Krause, T. Hamill, Ashok Chaudhary +2 more
2003Life Science23 citations Open access
Semantic Scholar
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
W. Blackaby, Richard T. Lewis, Joanne L. M. Thomson, Andrew S. R. Jennings +16 more
2010ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
An in vitro assay for predicting successful imaging radiotracers.
Shil Patel, T. Hamill, E. Hostetler, H. Burns +1 more
2003Molecular Imaging and Biology21 citations
Semantic Scholar
The synthesis of a benzamidine-containing NR2B-selective NMDA receptor ligand labelled with tritium or fluorine-18
T. Hamill, J. Mccauley, H. Burns
200519 citations
Semantic Scholar
Characterization of the novel GlyT1 PET tracer [18F]MK‐6577 in humans
Aniket D. Joshi, S. Sanabria-Bohórquez, G. Bormans, M. Koole +7 more
2015Synapse17 citations
Semantic Scholar
PET Imaging Studies in Rhesus Monkey with the Cannabinoid-1 (CB1) Receptor Ligand [11C]CB-119
T. Hamill, L. Lin, W. Hagmann, Ping Liu +10 more
2009Molecular Imaging and Biology17 citations
Semantic Scholar
Erratum to: Kinetic analysis of the cannabinoid-1 receptor PET tracer [18F]MK-9470 in human brain
S. Sanabria-Bohórquez, T. Hamill, K. Goffin, I. de Lepeleire +3 more
2010European Journal of Nuclear Medicine and Molecular Imaging16 citations Open access
Semantic Scholar
Three-different-component [1+2+n]-annulation reactions: ionic and radical cyclizations
G. Posner, E. Asirvatham, T. Hamill, K. S. Webb
199016 citations
Semantic Scholar
Translational studies with [11C]MK-3168, a PET tracer for fatty acid amide hydrolase (FAAH)
Aniket D. Joshi, Wenping Li, S. Sanabria, M. Holahan +6 more
201213 citations
Semantic Scholar
Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function
S. Sanabria-Bohórquez, Aniket D. Joshi, M. Holahan, Lori Daneker +5 more
2012NeuroImage11 citations
Semantic Scholar
Evaluation of 11C-ABP688 and 18F-FPEB for imaging mGluR5 receptors in the human brain
H. Kuwabara, W. Chamroonrat, W. Mathews, R. Waterhouse +6 more
201110 citations
Semantic Scholar
A versatile, commercially available automated synthesizer for the development and production of pet radiotracers
E. Hostetler, T. Hamill, B. Francis, H. Burns
200110 citations
Semantic Scholar
Synthesis of 15N and 17O labelled phosphoramide mustards
S. M. Ludeman, E. M. Shulman-Roskes, M. P. Gamcsik, T. Hamill +3 more
199310 citations
Semantic Scholar
The synthesis of the αvβ3 integrin receptor ligand [125I]L‐775,219
T. Hamill, M. Duggan, J. Perkins
20019 citations
Semantic Scholar
The synthesis of tritium labelled neurokinin-1 receptor ligands
T. Hamill, H. Burns
20048 citations
Semantic Scholar
Kinetics of the conjugation of aniline mustards with glutathione and thiosulfate.
Michael P. Gamcsik, K. Millis, T. Hamill
1997Chemico-Biological Interactions8 citations Open access
Semantic Scholar
Automated one-step radiosynthesis of the CB1 receptor imaging agent [(18) F]MK-9470.
D. Thomae, Thomas J. Morley, T. Hamill, Vincent M. Carroll +7 more
2014Journal of labelled compounds & radiopharmaceuticals7 citations
Semantic Scholar
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.
M. Duggan, L. Duong, J. Fisher, T. Hamill +12 more
2000Journal of Medicinal Chemistry6 citations
Semantic Scholar
Radiosynthesis of a potent endothelin receptor antagonist: [11C] L-753,037
H. Ravert, W. B. Mathews, T. Hamill, H. Burns +1 more
20006 citations
Semantic Scholar
Synthesis of [18F]‐Substance‐P Antagonist‐Receptor Quantifier ([18F]SPA‐RQ)
Sofie Celen, K. Serdons, T. de Groot, T. Hamill +1 more
20125 citations
Semantic Scholar
Histamine H3 inverse agonist PET tracers labelled with carbon-11 or fluorine-18
T. Hamill, Nagaaki Sato, Makoto Jitsuoka, Shigeru Tokita +17 more
20085 citations
Semantic Scholar
Non‐peptide fibrinogen receptor antagonists. 41. The synthesis of [3H]L‐756,568
T. Hamill, J. Hutchinson, K. Brashear, G. D. Hartman
19985 citations
Semantic Scholar
Comparative study of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK6577 in baboons
M. Zheng, D. Holden, T. Hamill, Shu-Fei Lin +4 more
20134 citations
Semantic Scholar
The synthesis of [3H]L‐734,217, an orally active fibrinogen receptor antagonist
T. Hamill, M. Duggan, G. D. Hartman, W. F. Hoffman +2 more
19964 citations
Semantic Scholar
Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK‐6577 in baboons
M. Zheng, Shu-Fei Lin, D. Holden, M. Naganawa +7 more
2016Synapse3 citations
Semantic Scholar

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